Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90

Journal of Autoimmunity

Volumn 17, Issue 4, 2001, Pages 341-346

  Ripley, B J M ^a   Isenberg, D A ^b   Latchman, D S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autoantibodies; hsp90; IL 10; IL 6; SLE

Indexed keywords

AUTOANTIBODY; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 6; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0035700102     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2001.0549     Document Type: Article

References (20)

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5. Differential heat shock protein overexpression and its clinical relevance in systemic lupus erythematosus
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7. Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus
8. Detection of autoantibodies to the 90 kD heat shock protein in SLE and other autoimmune diseases
9. The tissue-specific elevation in synthesis of the 90 kd heat shock protein precedes the onset of disease in lupus prone MRL/1pr mice
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11. Elevated levels of the 90 kD heat shock protein in patients with system lupus erythematosus are dependent upon enhanced transcription of the hsp90 β gene
12. Interleukin-6 activates heat shock protein 90β gene expression
13. Interleukin-10 activates heat shock protein 90β gene expression
14. Elevated levels of endogenous IL-6 in systemic lupus erythematosus
15. Elevated interleukin 10 levels correlated with disease activity in systemic lupus erythematosus
16. Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies
17. The 1982 revised criteria for the classification of systemic lupus erythematosus
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