Role of MHC class I molecules in autoimmune disease

Critical Reviews in Immunology

Volumn 17, Issue 5-6, 1997, Pages 463-468

  Singer, Dinah S ^a   Mozes, Edna ^a,c   Kirshner, Susan ^a   Kohn, Leonard D ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Autoimmunity; cAMP; MHC class I; Regulation; Transcription

Indexed keywords

AUTOANTIGEN; BETA 2 MICROGLOBULIN; CYCLIC AMP; DNA ANTIBODY; LIOTHYRONINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SECRETORY PROTEIN; THYROID HORMONE; THYROTROPIN; THYROXINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; BLEPHARITIS; CONFERENCE PAPER; CYCLIC AMP RESPONSIVE ELEMENT; HORMONAL REGULATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTEMIC LUPUS ERYTHEMATOSUS; THYROID GLAND;

ANIMALS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; GENES, MHC CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT; THYROID GLAND;

EID: 0030722185     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Singer, D. S. and Maguire, J., Regulation of expression of MHC Class I genes, Crit. Rev. Immunol., 10, 235-257, 1990.
2. Ehrlich, R., Maguire, J., and Singer, D. S., Effects of in vivo Interferon treatment on Class I MHC gene expression in transgenic mice, Immunogenet., 30, 18-26, 1988.
3. Satz, M. and Singer, D. S., Effect of mouse Interferon on the expression of porcine MHC gene introduced into mouse L cells, J. Immunol., 132, 496-501, 1984.
4. Saji, M., Moriarty, J., Ban, T., Kohn, L. D., and Singer, D., Hormonal regulation of MHC Class I genes in rat thryroid FRTL-5 cells: TSH induces a cAMP-mediated decrease in Class I expression, Proc. Natl. Acad. Sci. U.S.A., 89, 1944-1948, 1992.
5. Saji, M., Moriarty, J., Ban, T., Singer, D. S., and Kohn, L. D., MHC Class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide, as well as Interferon, J. Clin. Endo. Metab., 75, 871-878, 1992.
6. Saji, M., Shong, M., Napolitano, G., Palmer, L., Taniguchi, S., Ohmori, M., Ohta, M., Suzuki, K., Kirshner, S., and Giuliani, C., et al., Regulation of MHC Class I gene expression in thyroid cells: role of the cAMP response element-like sequence, J. Biol. Chem., in press, 1997.
7. Giuliani, C., Saji, M., Napolitano, G., Palmer, L., Taniguchi, S., Shong, M., Singer, D. S., and Kohn, L. D., Hormonal modulation of MHC Class I gene expression involves an enhancer A-binding complex consisting of Fra-2 and the p50 subunit of NFkB, J. Biol. Chem., 270(May 12), 11453-11462, 1995.
8. Mozes, E. and Mendlovic, S., Role of anti-DNA idiotype antibodies in SLE, Curr. Rev. Immunol., 10, 329-345, 1990.
9. Mendlovic, S., Brocke, S., Shoenfeld, Y., Ben-Bassat, M., Meshorer, A., Bakimer, R., and Mozes, E., Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype, Proc. Natl. Acad. Sci. U.S.A., 85, 2260-2263, 1988.
10. Chan, C., Gery, I., Kohn, L., Nussenblatt, R., Mozes, E., and Singer, D. S., Periocular inflammation in mice with experimental systemic lupus erythematosus (SLE): a new experimental blepharitis and its modulation, J. Immunol., 154, 4830-4835, 1995.
11. Israel, E.J., Wilsker, D.F., Hayes, K.C., Schoen-feld, D., and Simister, N. E., Increased clearance of IgG in mice that lack beta-2 microglobulin: possible protective role of FcRn, Immunology, 89(4), 573-578, 1996.
12. Mozes, E., Kohn, L. D., Hakim, F., and Singer, D. S., Resistance of MHC Class I-deficient mice to experimental systemic lupus erythematosus, Science, 261 (July 2), 91-93, 1993.
13. Singer, D. S., Kohn, L. D., Zinger, H., and Mozes, E., Methimazole prevents induction of experimental systemic lupus erythematosus in mice, J. Immunol., 153, 873-880, 1994.