Links between complement deficiency and apoptosis

Arthritis Research

Volumn 3, Issue 4, 2001, Pages 207-210

  Botto, M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Apoptosis; Complement; Deficiency; SLE

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C4; EPITOPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL SURFACE; COMPLEMENT DEFICIENCY; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; IMMUNIZATION; MOUSE; NONHUMAN; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; APOPTOSIS; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT;

EID: 0034931306     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar301     Document Type: Article

References (28)

1. Complement deficiency and disease
2. Systemic lupus erythematosus, complement deficiency and apoptosis
3. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
4. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
5. A receptor for phosphatidylserine-specific clearance of apoptotic cells
6. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis
7. Human CD14 mediates recognition and phagocytosis of apoptotic cells
8. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
9. Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage apoptotic cells
10. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition
11. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: Role of membrane phosphatidylserine
12. Complement-dependent clearance of apoptotic cells by human macrophages
13. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
14. Novel packages of viral and self-antigens are generated during apoptosis
15. Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
16. Systemic exposure to irradiated apoptotic cells induces autoantibody production
17. vβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
18. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
19. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells
20. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function
21. Immunosuppressive effects of apoptotic cells
22. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
23. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: Complement deficiency and systemic lupus erythematosus revisited
24. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
25. C1q protects against the development of glomerulonephritis independently of C3 activation
26. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2
27. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
28. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus