The aging kidney

Kidney International

Volumn 54, Issue 6, 1998, Pages 2247-2265

  Rodríguez puyol, Diego ^a  

^a HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

Author keywords

Advanced glycosylation end products; Reactive oxygen intermediates; Renal parenchyma; Renin synthesis; Tubular dysfunction

Indexed keywords

AGED; AGING; CASE REPORT; CLINICAL EXAMINATION; EMERGENCY TREATMENT; FEMALE; GERIATRIC DISORDER; GERIATRIC PATIENT; HEMODYNAMICS; HUMAN; KIDNEY DISEASE; PRIORITY JOURNAL; REVIEW;

EID: 0031755420     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/4499994     Document Type: Review

References (113)

1. STADTMAN ER: Protein oxidation and aging. Science 257:1220-1224, 1992
2. DICE JF: Cellular and molecular mechanisms of aging. Physiol Rev 73:149-159, 1993
3. GUARENTE L: Do changes in chromosomes cause aging? Cell 86:9-12, 1996
4. CRISTOFALO VJ, PIGNOLO RJ: Replicative senescence of human fibroblast-like cells in culture. Physiol Rev 73:617-638, 1993
5. Yu BP: Aging and oxidative stress: Modulation by dietary restriction. Free Radic Biol Med 21:651-668, 1996
6. CADENAS E: Biochemistry of oxygen toxicity. Annu Rev Biochem 58:79-110, 1989
7. ORR WC, SOHAL RS: Extension of life-span by overexpression of Superoxide dismutase and catalase in Drosophila melanogaster. Science 263:1128-1130, 1994
8. LARSEN PL: Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci USA 90:8905-8909, 1993
9. BROWNLEE M: Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46:223-234, 1995
10. YAN SD, SCHMIDT AM, ANDERSON GM, ZHANG J, BRETT J, Zou YS, PINSKY D, STERN D: Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/ binding proteins. J Biol Chem 269:9889-9897, 1994
11. SCHLEICHER ED, WAGNER E, NERLICH AG: Increased accumulation of the glycoxidation product N-epsilon (carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 99:457-468, 1997
12. MEYER BR: Renal function in aging. J Am Geriatr Soc 37:791-800, 1989
13. LINDEMAN RD: Overview: Renal physiology and pathophysiology of aging. Am J Kidney Dis 4:275-282, 1990
14. CORTES P, ZHAO X, DUMIER F, TILLEY BC, ATHERTON J: Age-related changes in glomerular volume and hydroxyproline content in rat and human. J Am Soc Nephrol 2:1716-1725, 1992
15. GOLDSTEIN RS, TARLOFF JB, HOOK J: Age-related nephropathy in laboratory rats. FASEB J 2:2241-2251, 1988
16. BAYLIS C: Age-dependent glomerular damage in the rat. J Clin Invest 94:1823-1829, 1994
17. HAYASHIDA M, Yu BP, MASORO EJ, IWASAKE K, IKEDA T: An electron microscopic examination of age-related changes in the rat kidney: The influence of diet. Exp Gerontol 21:535-553, 1986
18. BELL RH JR, BORJESSON BS, WOLF PL, FERNANDEZ-CRUZ L, BRIMM JE, LEE S, SAYERS HG, ORLOFF MJ: Quantitative morphological studies of aging changes in the kidney of the Lewis rat. Renal Physiol 7:176-184, 1984
19. ABRASS CK, ADCOX MJ, RAUGI GJ: Aging-associated changes in renal extracellular matrix. Am J Pathol 146:742-752, 1995
20. RUIZ-TORRES MP, BOSCH RJ, O'VALLE F, GARCÍA DEL MORAL R, RAMÍREZ C, MASSEROLI M, PÍREZ-CABALLERO C, IGLESIAS MC, RODRÍGUEZ-PUYOL M, RODRÍGUEZ-PUYOL D: Age-related increased expression of TGF-β1 in the rat kidney. Relationship to morphologic changes. J Am Soc Nephrol, in press
21. PELEG I, GREENFELD Z, COOPERMAN H, SHOSHAN S: Type 1 and type III collagen mRNA levels in kidney regions of old and young rats. Matrix 13:281-287, 1993
22. HOLLENBERG NK, ADAMS DF, SOLOMON HS, RASHID A, ABRAMS HL, MERRILL JP: Senescence and the renal vasculature in normal man. Circ Res 34:309-316, 1974
23. NAEIJE R, FIASSE A, CARLIER E, OPSOMER M, LEEMAN M: Systemic and renal hemodynamic effects of angiotensin converting enzyme inhibition by zabicipril in young and in old normal men. Eur J Clin Pharmacol 44:35-39, 1993
24. BAYLIS C, FREDERICKS M, WILSON C, MUNGER K, COLLINS R: Renal vasodilatory response to intravenous glycine in the aging rat kidney. Am J Kidney Dis 15:244-251, 1990
25. RECKELHOFF JF, MANNING RD: Role of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats. Am J Physiol 265:R1126-R1131, 1993
26. TANK JI, VORA JP, HOUGHTON DC, ANDERSON S: Altered renal vascular responses in the aging rat kidney. Am J Physiol 266:F942-F948, 1994
27. RECKELHOFF JF, SAMSELL L, DEY R, RACUSEN L, BAYLIS C: The effect of aging on glomerular hemodynamics in the rat. Am J Kidney Dis 20:70-75, 1992
28. LINDEMAN RD, TOBIN J, SHOCK NW: Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33:278-285, 1985
29. VANZONNEVELD RJ: Some data on the genito-urinary system as found in old-age surveys in the Netherlands. Gerontol Clin 1:167-173, 1959
30. LOWENSTEIN J, FAULSTICK DA, YIENGST MJ: The glomerular clearance and renal transport of hemoglobin in adult males. J Clin Invest 40:1172-1177, 1969
31. RUIZ-TORRES P, GONZALEZ-RUBIO M, LUCIO-CAZAN̄A FJ, RUIZ-VILLAESPESA A, RODRIGUEZ-PUYOL M, RODRIGUEZ-PUYOL D: Reactive oxygen species and platelet-activating factor synthesis in age-related glomerulosclerosis. J Lab Clin Med 124:489-495, 1994
32. BAYLIS C, FREDERICKS M, LEYPOLDT K, FRIGON R, WILSON C, HENDERSON L: Mechanisms of proteinuria in aging rats. Mech Ageing Dev 45:111-126, 1988
33. MACIAS NUÑEZ J, GARCIA IGLESIAS C, BONDIA ROMAN A, RODRIGUEZ COMES JL, CORBACHO J, TABERNERO JM, DE CASTRO S: Renal handling of sodium in old people: A functional study. Age Ageing 7:178-181, 1978
34. LUFT F, WEINBERGER M, FINEBERG M, MILLER JZ, GRIM CE: Effects of age on renal sodium homeostasis and its relevance to sodium sensitivity. Am J Med 82:9-15, 1987
35. ROWE J, SHOCK N, DEFRONZO R: The influence of age on the renal response to water deprivation in man. Nephron 17:270-278, 1976
36. LEE DBN, YANAGAWA N, Jo O, Yu BP, BECK N: Phosphaturia of aging: Studies on mechanisms. Adv Exp Med Biol 178:103-108, 1984
37. - exchange activity in the aging rat. Am J Physiol 252:R681-R686, 1987
38. AGARWAL BN, CABEBE FG: Renal acidification in elderly subjects. Nephron 26:291-295, 1980
39. TSUNODA K, ABE K, GOTO T, YASUJIMA M, SATO M, OMATA K, SEINO M, YOSHINAGA K: Effect of age on the renin-angiotensin-aldosterone system in normal subjects: Simultaneous measurement of active and inactive renin, renin substrate, and aldosterone in plasma. J Clin Endocrinol Metab 62:384-389, 1986
40. JUNG FF, KENNEFICK TM, INGELFINGER JR, VORA JP, ANDERSON S: Down-regulation of the intrarenal renin-angiotensin system in the aging rat. J Am Soc Nephrol 5:1573-1580, 1995
41. CORMAN B, BARRAULT MB, KLINGLER C, HOUOT AM, MICHEL JB, DELLABRUNA R, PINET F, SOUBRIER F: Renin gene-expression in the aging kidney. Effect of sodium restriction. Mech Ageing Dev 84:1-13, 1995
42. 2D, and PTH. Am J Physiol 246:E266-E270, 1984
43. STRIKER GE, PETEN EP, YANG CW, STRIKHR LJ: Glomerulosclerosis: Studies of its pathogenesis in humans and animals. Contrib Nephrol 107:124-131, 1994
44. EGIDO J: Nephrology Forum: Vasoactive hormones and renal sclerosis. Kidney Int 49:578-597, 1996
45. ARDAILLOU R, BAUD L: Tumor necrosis factor in glomerular injury. Contrib Nephrol 118:59-67, 1996
46. BROWN Z, ROBSON RL, WESTWICK J: Regulation and expression of chemokines: Potential role in glomerulonephritis. J Leukoc Biol 59:75-80, 1996
47. SAVILL J, MOONEY A, HUGHES J: What role does apoptosis play in progression of renal disease? Curr Opin Nephrol Hypertens 5:369-374, 1996
48. BORDER WA, NOBLE NA: TGF-heta in kidney fibrosis: A target for gene therapy. Kidney Int 51:1388-1396, 1997
49. ANDERSON S, BRENNER BM: Effects of aging on the renal glomerulus. Am J Med 80:435-442, 1986
50. FOGO A, ICHIKAWA I: Growth of glomerular and interstitial cells. Am J Kidney Dis 17:666-669, 1991
51. CHOU JS, REISER IW, PORUSH JC: Aging and urinary excretion of epidermal growth-factor. Ann Clin Lab Sci 27:116-122, 1997
52. SCHAEFER L, TESCHNER M, LING H, OLDAKOWSKA U, HEIDLAND A, SCHAEFER RM: The aging rat kidney displays low glomerular and tubular proteinase activities. Am J Kidney Dis 24:499-504, 1994
53. RECKELHOFF JF, BAYLIS C: Glomerular metalloprotease activity is suppressed by androgens in the ageing kidney. J Am Soc Nephrol 3:1835-1838, 1993
54. BAYLIS C, SCHMIDT R: The aging glomerulus. Semin Nephrol 4:265-276, 1996
55. HILL C, LATELF AM, ENGELS M, SAMSLLL L, BAYLIS C: Basal and stimulated nitric-oxide in control of kidney function in the aging rat. Am J Physiol 41:R1727-R1753, 1997
56. HOLLENBERG NK, MOORE TJ: Age and the renal blood supply: Renal vascular responses to angiotensin converting enzyme inhibition in healthy humans. J Am Geriatr Soc 42:805-808, 1994
57. RECKELHOFF JF, KELLUM JA, BLANCHARD EJ, BACON EE, WESLEY AJ, KRUCKEBERG WC: Changes in nitric oxide precursor. L-arginine, and metabolites, nitrate and nitrite, with aging. Life Sci 55:1895-1902, 1994
58. VALDIVILLSO JM, REVERTE M, RIVAS-CABAN̄ERO L, LOPEZ-NOVOA JM: Increased severity of gentamicin nephrotoxicity in aging rats is mediated by a reduced glomerular nitric oxide production. Env Toxicol Pharmacol 2:73-75, 1996
59. HWANG SM, WILSON PD, LASKIN JD, DENHARDT DT: Age and development-related changes in osteopontin and nitric oxide synthase mRNA levels in human kidney proximal tubule epithelial cells: Contrasting responses to hypoxia and reoxygenation. J Cell Physiol 160:61-68, 1994
60. KOMATSUMOTO S, NARA M: Changes in the level of endothelin-1 with aging. Nippon Ronen Igakkai Zasshi 32:664-669, 1995
61. KUMAZAKI T, FUJII T, KOBAYASHI M, MITSUI Y: Aging and growth dependent modulation of endothelin-1 gene expression in human vascular endothelial cells. Exp Cell Res 211:6-11, 1994
62. SATO I, KAJI K, MORITA I, NAGAO M, MUROTA S: Augmentation of endothelin-1, prostacyclin and thromboxane A2 secretion associated with in vitro ageing in cultured human umbilical vein endothelial cells. Mech Ageing Dev 71:73-84, 1993
63. BAYLIS C, ENGELS K, HYMEL A, NAVAR LG: Plasma-renin activity and metabolic-clearance rate of angiotensin II in the unstressed aging rat. Mech Ageing Dev 97:163-172, 1997
64. BAYLIS C: Renal responses to acute angiotensin II (AII) inhibition and administered AII in the ageing, conscious chronically catheterized rat. Am J Kidney Dis 22:842-850, 1993
65. MENCONI M, TAYLOR L, MARTIN B, POLGAR P: A review: Prostaglandins, aging, and blood vessels. J Am Geriatr Soc 35:239-247, 1987
66. MORITOKI H, YOSHIKAWA T, HISAYAMA T, TAKEUCHI S: Possible mechanism of age-associated reduction of vascular relaxation caused by atrial natriuretic peptide. Eur J Pharmacol 210:61-68, 1992
67. LAKATTA EG: Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73:413-467, 1993
68. DEISHER TA, MANKANI S, HOFFMAN BB: Role of cyclic AMP-dependent protein kinase in the diminished β-adrenergic responsiveness of vascular smooth muscle with increasing age. J Pharmacol Exp Ther 249:812-819, 1989
69. CHIN JH, HIREMATH AN, HOFFMAN BB: cAMP signaling mechanisms with aging in rats. Mech Ageing Dev 86:11-26, 1996
70. ANDERSON S, RENNKE HG, ZATZ R: Glomerular adaptations with normal aging and with long-term converting enzyme inhibition in rats. Am J Physiol 267:F35-F43, 1994
71. HEGSTAD R, BROWN R, JIANG, N, KAO P, WEINSHILBOUM RM, STRONG C, WISGERHOF M: Aging and aldosterone. Am J Med 74:442-448, 1983
72. OHASHI M, FUJIO N, NAWATA H, KATO K, IBAYASHI H, KANGAWA K, MATSUO H: High plasma concentration of human atrial natriuretic peptide in aged man. J Clin Endocrinol Metab 64:81-85, 1987
73. OR K, RICHARDS A, ESPINER EA, YANDLE T, GILCHRIST N, SAINSBURY R: Effect of low dose infusions of atrial natriuretic peptide in healthy elderly males: Evidence for a postreceptor defect. J Clin Endocrinol Metab 76:1271-1274, 1993
74. PHILLIPS PA, BRETHERTON M, RISVANIS J, CASLEY D, JOHNSTON C, GRAY L: Effects of drinking on thirst and vasopressin in dehydrated elderly men. Am J Physiol 264:R877-R881, 1993
75. FAULL CM, HOLMES C, BAYLIS P: Water balance in elderly people: Is there a deficiency of vasopressin? Age Ageing 22:114-120, 1993
76. DAVIDSON YS, FOTHERINGHAM AP, DAVIES I, MORRIS JA: Age-related postreceptor mechanisms. Changes in adenylate-cyclase hut not phosphodiesterase in isolated mouse renal medullary collecting ducts. Exp Gerontol 30:595-604, 1995
77. KLINGLER C, PREISSER L, BARRAULT MB, LLUEL P, HORGEN L, TEILLET L, ANCHLLIN N, CORMAN B: Vasopressin V-2 receptor messenger-RNA expression and cAMP accumulation in aging rat kidney. Am J Physiol 41:R1775-R1782, 1997
78. PRASAD R, KINSELLA JL, SACKTOR B: Renal adaption to metabolic acidosis in senescent rats. Am J Physiol 255:F1183-F1190, 1988
79. CHEN ML, KING RS, ARMBRECHT HJ: Sodium-dependent phosphate transport in primary cultures of renal tubule cells from young and adult rats. J Cell Physiol 143:488-493, 1990
80. LEVI M, BAIRD BM, WILSON PV: Cholesterol modulates rat renal brush border membrane phosphate transport. J Clin Invest 85:231-237, 1990
81. SORRIBAS V, LOTSCHER M, LOFFING J, KAISSLING B, MURER H, LEVI M: Cellular mechanisms of the age-related decrease in renal phosphate reabsorption. Kidney Int 50:855-863, 1996
82. TOPPER JN, CAI J, FALB D, GIMBRONE MA JR: Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese Superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 93:10417-10422, 1996
83. YASUDA T, KONDO S, HOMMA T, HARRIS RC: Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest 98:1991-2000, 1996
84. BAUD L, ARDAILLOU R: Involvement of reactive oxygen species in kidney damage. Br Med Bull 49:621-629, 1993
85. DUQUH I, RODRIGUEZ-PUYOL M, RUIZ P, GONZALEZ-RUBIO M, DIEZ-MARQUES ML, RODRIGUEZ-PUYOL D: Calcium channel blockers inhibit hydrogen peroxide-induced proliferation of cultured rat mesangial cells. J Pharmacol Exp Ther 267:612-616, 1993
86. GONZALEZ-RUBIO M, VOIT S, RODRIGUEZ-PUYOL D, WEBER M, MARX M: Oxidative stress induces tyrosine phosphorylation of PDGF alpha and beta receptors and pp60c-src in mesangial cells. Kidney Int 50:164-173, 1996
87. HAGAR H, UEDA N, SHAH SV: Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Am J Physiol 271:F209-215, 1996
88. ARRIBAS-GOMEZ I, DUQUE-MARIN I, PEREZ DE LEMA G, DIEZ-MARQUES ML, LUCIO-CAZAN̄A J, RODRIGUEZ-PUYOL M, RODRIGUEZ-PUYOL D: A possible role for platelet-activating factor in the hydrogen peroxide-induced TXB2 and PGE2 glomerular synthesis. J Lipid Res 36:260-265, 1995
89. HUGHES AK, STRICKLETT PK, PADILLA E, KOHAN DE: Effect of reactive oxygen species on endothelin-1 production by human mesangial cells. Kidney Int 49:181-189, 1996
90. RODRÍGUEZ-PUYOL D, LÓPEZ-ONGILL S, LUCIO J, LAMAS S, RUIZ P, RODRÍGUEZ-PUYOL M: Modulation of pre-pro-endothelin and constitutive nitric oxide synthase mRNA expression by reactive oxygen species in bovine aortic endothelial cells (abstract). J Am Soc Nephrol 5:590A, 1994
91. KELM M, DAHMANN R, WINK D, FEELLISCH M: The nitric oxide/ superoxide assay. Insights into the biological chemistry of the NO/ O-2 interaction. J Biol Chem 272:9922-9932, 1997
92. LÓPEZ-ONGIL S, HERNÁNDEZ-PERERA O, NAVARRO-ANTOLÍN J, PÉREZ DE LEMA G, RODRÍGUEZ-PUYOL M, LAMAS S, RODRÍGUEZ-PUYOL D: Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of ecNOS in vascular endothelial cells. Br J Pharmacol 124:447-454, 1998
93. CHAUDHRI G, CLARK IA: Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor. J Immunol 143:1290-1294, 1989
94. AFFRES H, PEREZ J, HAGEGE J, FOUQUERAY B, KORNPROBST M, ARDAILLOU R, BAUD L: Desferrioxamine regulates tumor necrosis factor release in mesangial cells. Kidney Int 39:822-830, 1991
95. SATRIANO JA, SHULDINER M, HORA K, XING Y, SHAN Z, SCHLONDORFF D: Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase. J Clin Invest 92:1564-1571, 1993
96. GONZALEZ-RUBIO M, RUIZ-TORRES P, RODRIGUEZ-PUYOL M, LuCIO-CAZAN̄A FJ, RODRIGUEZ-PUYOL D: Glomerular effects of probucol in the early stages of aging in rats. Geriatr Nephrol Urol 4:161-164, 1995
97. VLASSARA H, BROWNLEE M, CERAMI A: Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors. J Exp Med 164:1301-1309, 1986
98. KIRSTEIN M, ASTON C, HINTZ R, VLASSARA H: Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins. J Clin Invest 90:439-446, 1992
99. DOIT T, VLASSARA H, KIRSTEIN M, YAMADA Y, STRIKER GE, STRIKER LJ: Receptor specific increase in extracellular matrix productions in mouse mesangial cells by advanced glycosylation end products is mediated via platelet derived growth factor. Proc Natl Acad Sci USA 89:2873-2877, 1992
100. VLASSARA H, STRIKER LJ, TEICHBERG S, FUH H, Li YM, STEFFES M: Advanced glycosylation endproducts induce glomerular sclerosis and albuminuria in normal rats. Proc Natl Acad Sci USA 91:11704-11708, 1994
101. TSILIBARY EC, KOLIAKOS GG, CHARONIS AS, VOGEL AM, REGER LA, FURCHT LT: The effect of nonenzymatic glucosylation on the binding of the main noncollagenous NC1 domain to type IV collagen. J Biol Chem 263:4302-4308, 1988
102. HAITOGLOU CS, TSILIBARY EC, BROWNLEE M, CHARONIS AS: Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen. J Biol Chem 267: 12404-12407, 1992
103. DODANE V, CHEVALIER J, BARIETY J, PRATZ J, CORMAN B: Longitudinal study of solute excretion and glomerular ultrastructure in an experimental model of aging rats free of kidney disease. Lab Invest 64:377-391, 1991
104. WEINDRUCH R, MASORO E: Concerns about rodent models for aging research. J Gerontol 46:887-888, 1991
105. PEREZ DE LEMA G, ARRIBAS I, RUIZ GINES JA, DE ARRIBA G, PRIETO A, RODRIGUEZ-PUYOL D, RODRIGUEZ-PUYOL M: Reactive oxygen species mediate the effects of cyclosporine A on human cultured mesangial cells. Transplant Proc 29:1241-1243, 1997
106. BENNET WM, LINDSLEY J, BUSS WC: The effects of age and dosage route on experimental cyclosporine nephrotoxicity. Transplantation 51:730-731, 1991
107. VIANELLO A, MASTROSIMONE S, CALCONI G, DA PORTO A, PALMINTERI G, D'ANNIBALE A, CALDATO C, MARESCO MC: Influence of donor age on cadaver kidney graft function and survival: univariate and multivariate analyses. Nephron 65:541-548, 1993
108. ONO H, ONO Y, FROHLICH ED: Nitric oxide synthase inhibition in spontaneously hypertensive rats. Systemic, renal, and glomerular hemodynamics. Hypertension 26:249-255, 1995
109. PRAGA M, HERNÁNDEZ E, MONTOYO C, ANDRÉS A, RUILOPE LM, RODICIO JL: Long-term beneficial effects of angiotensin-converting enzyme inhibition in patients with nephrotic proteinuria. Am J Kidney Dis 20:240-248, 1992
110. ZOJA C, REMUZZI A, CORNA D, PERICO N, BERTANI T, REMUZZI G: Renal protective effect of angiotensin-converting enzyme inhibition in aging rats. Am J Med 92(S 4B):60-63, 1992
111. REBOLLO P, BALTAR J, ORTEGA F, DÍEZ-CORTE C, UREN̄A A, NOVES M, ALVAREZ-GRANDE J: Factors which influence health related quality of life of elderly patients in renal replacement therapy (abstract). J Am Soc Nephrol 8:147A, 1997
112. BOULOUMIE A, BAUERSACHS J, LINZ W, SCHOLKENS BA, WIEMER G, FLEMING I, BUSSE R: Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and Superoxide anion production. Hypertension 30:934-941, 1997
113. PASCUAL J, LIAN̄O F, ORTUN̄O J: The elderly patient with acute renal failure. J Am Soc Nephrol 6:144-153, 1995