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Volumn 40, Issue 6, 2007, Pages 462-469

Immune regulation by Foxo transcription factors

Author keywords

Arthritis; Autoimmunity; B cells; Lupus; T cells; Transcription factors

Indexed keywords

B LYMPHOCYTE RECEPTOR; BIM PROTEIN; CASEIN KINASE I; CASEIN KINASE I INHIBITOR; CYCLIN DEPENDENT KINASE 2; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN 14 3 3; PROTEIN KINASE B; PROTEIN P53; PROTEIN SERINE THREONINE KINASE INHIBITOR; S PHASE KINASE ASSOCIATED PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 2; SMAD PROTEIN; STAT PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR RUNX; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 34548313701     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930701464913     Document Type: Review
Times cited : (40)

References (70)
  • 2
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili, D. and Arden, KC (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell, 117, pp. 421-426.
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 3
    • 33751296789 scopus 로고    scopus 로고
    • FOXO transcription factors: Key regulators of cell fate
    • Lam, EW, Francis, RE and Petkovic, M. (2006) FOXO transcription factors: Key regulators of cell fate. Biochem Soc Trans, 34, pp. 722-726.
    • (2006) Biochem Soc Trans , vol.34 , pp. 722-726
    • Lam, E.W.1    Francis, R.E.2    Petkovic, M.3
  • 4
    • 33746069404 scopus 로고    scopus 로고
    • In control of biology: Of mice, men and Foxes
    • Wijchers, PJ, Burbach, JP and Smidt, MP (2006) In control of biology: Of mice, men and Foxes. Biochem J, 397, pp. 233-246.
    • (2006) Biochem J , vol.397 , pp. 233-246
    • Wijchers, P.J.1    Burbach, J.P.2    Smidt, M.P.3
  • 6
    • 0035135841 scopus 로고    scopus 로고
    • Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    • Brunet, A., Park, J., Tran, H., Hu, LS, Hemmings, BA and Greenberg, ME (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol, 21, pp. 952-965.
    • (2001) Mol Cell Biol , vol.21 , pp. 952-965
    • Brunet, A.1    Park, J.2    Tran, H.3    Hu, L.S.4    Hemmings, B.A.5    Greenberg, M.E.6
  • 9
    • 1242276189 scopus 로고    scopus 로고
    • D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a
    • Rena, G., Bain, J., Elliott, M. and Cohen, P. (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep, 5, pp. 60-65.
    • (2004) EMBO Rep , vol.5 , pp. 60-65
    • Rena, G.1    Bain, J.2    Elliott, M.3    Cohen, P.4
  • 10
    • 0035340356 scopus 로고    scopus 로고
    • The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
    • Woods, YL, Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, TG and Cohen, P. (2001) The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem J, 355, pp. 597-607.
    • (2001) Biochem J , vol.355 , pp. 597-607
    • Woods, Y.L.1    Rena, G.2    Morrice, N.3    Barthel, A.4    Becker, W.5    Guo, S.6    Unterman, T.G.7    Cohen, P.8
  • 11
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang, H., Regan, KM, Lou, Z., Chen, J. and Tindall, DJ (2006) CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science, 314, pp. 294-297.
    • (2006) Science , vol.314 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 13
    • 0035171566 scopus 로고    scopus 로고
    • Regulation of the forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451
    • De Ruiter, ND, Burgering, BM and Bos, JL (2001) Regulation of the forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451. Mol Cell Biol, 21, pp. 8225-8235.
    • (2001) Mol Cell Biol , vol.21 , pp. 8225-8235
    • De Ruiter, N.D.1    Burgering, B.M.2    Bos, J.L.3
  • 20
  • 21
    • 33748335578 scopus 로고    scopus 로고
    • The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    • Nakae, J., Cao, Y., Daitoku, H., Fukamizu, A., Ogawa, W., Yano, Y. and Hayashi, Y. (2006) The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest, 116, pp. 2473-2483.
    • (2006) J Clin Invest , vol.116 , pp. 2473-2483
    • Nakae, J.1    Cao, Y.2    Daitoku, H.3    Fukamizu, A.4    Ogawa, W.5    Yano, Y.6    Hayashi, Y.7
  • 22
    • 0141706357 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
    • Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K. and Fukamizu, A. (2003) Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci USA, 100, pp. 11285-11290.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11285-11290
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Tanaka, K.4    Fukamizu, A.5
  • 23
    • 0038362751 scopus 로고    scopus 로고
    • Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
    • Plas, DR and Thompson, CB (2003) Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem, 278, pp. 12361-12366.
    • (2003) J Biol Chem , vol.278 , pp. 12361-12366
    • Plas, D.R.1    Thompson, C.B.2
  • 26
    • 0037438589 scopus 로고    scopus 로고
    • Common mechanism for oncogenic activation of MLL by forkhead family proteins
    • So, CW and Cleary, ML (2003) Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood, 101, pp. 633-639.
    • (2003) Blood , vol.101 , pp. 633-639
    • So, C.W.1    Cleary, M.L.2
  • 27
    • 13244287966 scopus 로고    scopus 로고
    • Regulation of FoxO activity by CBP/p300-mediated acetylation
    • van der Heide, LP and Smidt, MP (2005) Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem Sci, 30, pp. 81-86.
    • (2005) Trends Biochem Sci , vol.30 , pp. 81-86
    • van der Heide, L.P.1    Smidt, M.P.2
  • 28
    • 8544265317 scopus 로고    scopus 로고
    • Forkhead-box transcription factors and their role in the immune system
    • Coffer, PJ and Burgering, BM (2004) Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol, 4, pp. 889-899.
    • (2004) Nat Rev Immunol , vol.4 , pp. 889-899
    • Coffer, P.J.1    Burgering, B.M.2
  • 29
    • 33646189483 scopus 로고    scopus 로고
    • RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells
    • Yamamura, Y., Lee, WL, Inoue, K., Ida, H. and Ito, Y. (2006) RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem, 281, pp. 5267-5276.
    • (2006) J Biol Chem , vol.281 , pp. 5267-5276
    • Yamamura, Y.1    Lee, W.L.2    Inoue, K.3    Ida, H.4    Ito, Y.5
  • 30
    • 33745163907 scopus 로고    scopus 로고
    • Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a
    • You, H., Yamamoto, K. and Mak, TW (2006) Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci USA, 103, pp. 9051-9056.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9051-9056
    • You, H.1    Yamamoto, K.2    Mak, T.W.3
  • 31
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy, S., Nakamura, N., Sansal, I., Bergeron, L. and Sellers, WR (2002) A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell, 2, pp. 81-91.
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 33
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto, S. and Finkel, T. (2002) Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science, 295, pp. 2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 35
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
    • Castrillon, DH, Miao, L., Kollipara, R., Horner, JW and DePinho, RA (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science, 301, pp. 215-218.
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    DePinho, R.A.5
  • 36
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka, T., Biggs 3rd, WH, Tieu, D., Boyer, AD, Varki, NM, Cavenee, WK and Arden, KC (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA, 101, pp. 2975-2980.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2975-2980
    • Hosaka, T.1    Biggs III, W.H.2    Tieu, D.3    Boyer, A.D.4    Varki, N.M.5    Cavenee, W.K.6    Arden, K.C.7
  • 37
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • Nakae, J., Biggs 3rd, WH, Kitamura, T., Cavenee, WK, Wright, CV, Arden, KC and Accili, D. (2002) Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Gen, 32, pp. 245-253.
    • (2002) Nat Gen , vol.32 , pp. 245-253
    • Nakae, J.1    Biggs III, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 38
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    • Nakae, J., Kitamura, T., Kitamura, Y., Biggs 3rd, WH, Arden, KC and Accili, D. (2003) The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell, 4, pp. 119-129.
    • (2003) Dev Cell , vol.4 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3    Biggs III, W.H.4    Arden, K.C.5    Accili, D.6
  • 41
    • 33751268902 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling and FoxO transcription factors in rheumatoid arthritis
    • Reedquist, KA, Ludikhuize, J. and Tak, PP (2006) Phosphoinositide 3-kinase signalling and FoxO transcription factors in rheumatoid arthritis. Biochem Soc Trans, 34, pp. 727-730.
    • (2006) Biochem Soc Trans , vol.34 , pp. 727-730
    • Reedquist, K.A.1    Ludikhuize, J.2    Tak, P.P.3
  • 42
    • 33745309067 scopus 로고    scopus 로고
    • PI3-kinase and the control of T cell growth and proliferation by FoxOs
    • Fabre, S., Lang, V. and Bismuth, G. (2006) PI3-kinase and the control of T cell growth and proliferation by FoxOs. Bull Cancer, 93, pp. E36-E38.
    • (2006) Bull Cancer , vol.93
    • Fabre, S.1    Lang, V.2    Bismuth, G.3
  • 43
    • 0037094096 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
    • Stahl, M., Dijkers, PF, Kops, GJ, Lens, SM, Coffer, PJ, Burgering, BM and Medema, RH (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol, 168, pp. 5024-5031.
    • (2002) J Immunol , vol.168 , pp. 5024-5031
    • Stahl, M.1    Dijkers, P.F.2    Kops, G.J.3    Lens, S.M.4    Coffer, P.J.5    Burgering, B.M.6    Medema, R.H.7
  • 44
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema, RH, Kops, GJ, Bos, JL and Burgering, BM (2000) AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature, 404, pp. 782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 46
    • 15444369929 scopus 로고    scopus 로고
    • Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
    • Fabre, S., Lang, V., Harriague, J., Jobart, A., Unterman, TG, Trautmann, A. and Bismuth, G. (2005) Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control. J Immunol, 174, pp. 4161-4171.
    • (2005) J Immunol , vol.174 , pp. 4161-4171
    • Fabre, S.1    Lang, V.2    Harriague, J.3    Jobart, A.4    Unterman, T.G.5    Trautmann, A.6    Bismuth, G.7
  • 47
    • 1642305625 scopus 로고    scopus 로고
    • CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function
    • Pandiyan, P., Gartner, D., Soezeri, O., Radbruch, A., Schulze-Osthoff, K. and Brunner-Weinzierl, MC (2004) CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J Exp Med, 199, pp. 831-842.
    • (2004) J Exp Med , vol.199 , pp. 831-842
    • Pandiyan, P.1    Gartner, D.2    Soezeri, O.3    Radbruch, A.4    Schulze-Osthoff, K.5    Brunner-Weinzierl, M.C.6
  • 48
    • 33749516648 scopus 로고    scopus 로고
    • Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression
    • Charvet, C., Canonigo, AJ, Becart, S., Maurer, U., Miletic, AV, Swat, W., Deckert, M. and Altman, A. (2006) Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol, 177, pp. 5024-5031.
    • (2006) J Immunol , vol.177 , pp. 5024-5031
    • Charvet, C.1    Canonigo, A.J.2    Becart, S.3    Maurer, U.4    Miletic, A.V.5    Swat, W.6    Deckert, M.7    Altman, A.8
  • 50
    • 3042792367 scopus 로고    scopus 로고
    • GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis
    • Asselin-Labat, ML, David, M., Biola-Vidamment, A., Lecoeuche, D., Zennaro, MC, Bertoglio, J. and Pallardy, M. (2004) GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. Blood, 104, pp. 215-223.
    • (2004) Blood , vol.104 , pp. 215-223
    • Asselin-Labat, M.L.1    David, M.2    Biola-Vidamment, A.3    Lecoeuche, D.4    Zennaro, M.C.5    Bertoglio, J.6    Pallardy, M.7
  • 51
    • 4143129696 scopus 로고    scopus 로고
    • Regulation of NF-κB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
    • Lin, L., Hron, JD and Peng, SL (2004) Regulation of NF-κB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity, 21, pp. 203-213.
    • (2004) Immunity , vol.21 , pp. 203-213
    • Lin, L.1    Hron, J.D.2    Peng, S.L.3
  • 52
    • 33751206845 scopus 로고    scopus 로고
    • The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses
    • Sela, U., Dayan, M., Hershkoviz, R., Cahalon, L., Lider, O. and Mozes, E. (2006) The negative regulators Foxj1 and Foxo3a are up-regulated by a peptide that inhibits systemic lupus erythematosus-associated T cell responses. Eur J Immunol, 36, pp. 2971-2980.
    • (2006) Eur J Immunol , vol.36 , pp. 2971-2980
    • Sela, U.1    Dayan, M.2    Hershkoviz, R.3    Cahalon, L.4    Lider, O.5    Mozes, E.6
  • 54
    • 33847397525 scopus 로고    scopus 로고
    • Altered activation of AKT is required for the suppressive function of human CD4+CD25+T regulatory cells
    • Crellin, NK, Garcia, RV and Levings, MK (2007) Altered activation of AKT is required for the suppressive function of human CD4+CD25+T regulatory cells. Blood
    • (2007) Blood
    • Crellin, N.K.1    Garcia, R.V.2    Levings, M.K.3
  • 55
    • 0037017396 scopus 로고    scopus 로고
    • FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity
    • Dijkers, PF, Birkenkamp, KU, Lam, EW, Thomas, NS, Lammers, JW, Koenderman, L. and Coffer, PJ (2002) FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol, 156, pp. 531-542.
    • (2002) J Cell Biol , vol.156 , pp. 531-542
    • Dijkers, P.F.1    Birkenkamp, K.U.2    Lam, E.W.3    Thomas, N.S.4    Lammers, J.W.5    Koenderman, L.6    Coffer, P.J.7
  • 56
    • 2342622123 scopus 로고    scopus 로고
    • Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors
    • Yusuf, I., Zhu, X., Kharas, MG, Chen, J. and Fruman, DA (2004) Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors. Blood, 104, pp. 784-787.
    • (2004) Blood , vol.104 , pp. 784-787
    • Yusuf, I.1    Zhu, X.2    Kharas, M.G.3    Chen, J.4    Fruman, D.A.5
  • 57
    • 33644538251 scopus 로고    scopus 로고
    • FOXO transcription factors cooperate with δEF1 to activate growth suppressive genes in B lymphocytes
    • Chen, J., Yusuf, I., Andersen, HM and Fruman, DA (2006) FOXO transcription factors cooperate with δEF1 to activate growth suppressive genes in B lymphocytes. J Immunol, 176, pp. 2711-2721.
    • (2006) J Immunol , vol.176 , pp. 2711-2721
    • Chen, J.1    Yusuf, I.2    Andersen, H.M.3    Fruman, D.A.4
  • 58
    • 33846217464 scopus 로고    scopus 로고
    • B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Bruton's tyrosine kinase
    • Hinman, RM, Bushanam, JN, Nichols, WA and Satterthwaite, AB (2007) B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Bruton's tyrosine kinase. J Immunol, 178, pp. 740-747.
    • (2007) J Immunol , vol.178 , pp. 740-747
    • Hinman, R.M.1    Bushanam, J.N.2    Nichols, W.A.3    Satterthwaite, A.B.4
  • 59
    • 33646893537 scopus 로고    scopus 로고
    • Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene
    • Jacobsen, EA, Ananieva, O., Brown, ML and Chang, Y. (2006) Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene. J Immunol, 176, pp. 6831-6838.
    • (2006) J Immunol , vol.176 , pp. 6831-6838
    • Jacobsen, E.A.1    Ananieva, O.2    Brown, M.L.3    Chang, Y.4
  • 61
    • 0347361645 scopus 로고    scopus 로고
    • Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1
    • Crossley, LJ (2003) Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1. J Leukoc Biol, 74, pp. 583-592.
    • (2003) J Leukoc Biol , vol.74 , pp. 583-592
    • Crossley, L.J.1
  • 63
    • 20944443597 scopus 로고    scopus 로고
    • Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis
    • Jonsson, H., Allen, P. and Peng, SL (2005) Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Nat Med, 11, pp. 666-671.
    • (2005) Nat Med , vol.11 , pp. 666-671
    • Jonsson, H.1    Allen, P.2    Peng, S.L.3
  • 64
    • 33745817407 scopus 로고    scopus 로고
    • C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1
    • Fosbrink, M., Niculescu, F., Rus, V., Shin, ML and Rus, H. (2006) C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1. J Biol Chem, 281, pp. 19009-19018.
    • (2006) J Biol Chem , vol.281 , pp. 19009-19018
    • Fosbrink, M.1    Niculescu, F.2    Rus, V.3    Shin, M.L.4    Rus, H.5
  • 65
    • 33747019623 scopus 로고    scopus 로고
    • Mechanisms of disease: Transcription factors in inflammatory arthritis
    • Aud, D. and Peng, SL (2006) Mechanisms of disease: Transcription factors in inflammatory arthritis. Nat Clin Prac Rheum, 2, pp. 434-442.
    • (2006) Nat Clin Prac Rheum , vol.2 , pp. 434-442
    • Aud, D.1    Peng, S.L.2
  • 66
    • 13944256944 scopus 로고    scopus 로고
    • Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts
    • Yau, CY, Wheeler, JJ, Sutton, KL and Hedley, DW (2005) Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res, 65, pp. 1497-1504.
    • (2005) Cancer Res , vol.65 , pp. 1497-1504
    • Yau, C.Y.1    Wheeler, J.J.2    Sutton, K.L.3    Hedley, D.W.4
  • 67
  • 68
    • 17844365847 scopus 로고    scopus 로고
    • The psammaplysenes, specific inhibitors of FOXO1a nuclear export
    • Schroeder, FC, Kau, TR, Silver, PA and Clardy, J. (2005) The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod, 68, pp. 574-576.
    • (2005) J Nat Prod , vol.68 , pp. 574-576
    • Schroeder, F.C.1    Kau, T.R.2    Silver, P.A.3    Clardy, J.4
  • 69
    • 25444454350 scopus 로고    scopus 로고
    • Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export
    • Georgiades, SN and Clardy, J. (2005) Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export. Org Lett, 7, pp. 4091-4094.
    • (2005) Org Lett , vol.7 , pp. 4091-4094
    • Georgiades, S.N.1    Clardy, J.2
  • 70
    • 15044366139 scopus 로고    scopus 로고
    • Forkhead transcription factors in immunology
    • Jonsson, H. and Peng, SL (2005) Forkhead transcription factors in immunology. Cell Mol Life Sci, 62, pp. 397-409.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 397-409
    • Jonsson, H.1    Peng, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.