Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure

GLIA

Volumn 46, Issue 4, 2004, Pages 402-409

  Barcia, Carlos ^a   Sánchez Bahillo, Angel ^a   Fernández Villalba, Emiliano ^a   Bautista, Víctor ^a   Poza Y Poza, Máximo ^a   Fernández Barreiro, Andrés ^a   Hirsch, Etienne C ^b   Herrero, María Trinidad ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Dopaminergic degeneration; Inflammation; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CADAVER; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; INFLAMMATION; MACROGLIA; MICROGLIA; MONKEY; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; ZONA COMPACTA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; ENCEPHALITIS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HLA-DR ANTIGENS; IMMUNOHISTOCHEMISTRY; MACACA FASCICULARIS; MICROGLIA; NERVE DEGENERATION; PARKINSONIAN DISORDERS; SUBSTANTIA NIGRA; TIME; TYROSINE 3-MONOOXYGENASE;

EID: 2542455543     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.20015     Document Type: Article

References (30)

1. Barcia C, Bautista V, Sanchez-Bahillo A, Fernandez-Villalba E, Navarro-Ruiz JM, Barreiro AF, Poza Y Poza M, Herrero MT. 2003. Circadian determinations of cortisol, prolactin and melatonin in chronic methyl-phenyl-tetrahydropyridine-treated monkeys. Neuroendocrinology 78:118-128.
2. Beilke MA, Riding D, Hamilton R, Stone GA, Jordan EK, Brashears G, Nusbaum W, Huddleston D, Gibbs CJ Jr, Gravell M. 1991. HLA-DR expression in macaque neuroendothelial cells in vitro and during SIV encephalitis. J Neuroimmunol 33:129-143.
3. Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC. 2002. Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J Neurochem 82:615-624.
4. Czlonkowska A, Kohutnicka M, Kurkowska-Jastrzebska I, Czlonkowski A. 1996. Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model. Neurodegeneration 5:137-143.
5. Damier P, Hirsch EC, Zhang P, Agid Y, Javoy-Agid F. 1993. Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience 52:1-6.
6. Dexter DT, Carter CJ, Wells FR, Javoy-Agid F, Agid Y, Lees A, Jenner P, Marsden CD. 1989. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J Neurochem 52:381-389.
7. Gotz ME, Kunig G, Riederer P, Youdim MB. 1994. Oxidative stress: free radical production in neural degeneration. Pharmacol Ther 63:37-122.
8. Graeber MB, Bise KB, Mehraein P. 1994. CR3/43, a marker for activated microglia: application to diagnostic neuropathology. Neuropathol Appl Neurobiol 20:406-408.
9. Graybiel AM, Ragsdale CW Jr. 1978. Histochemically distinct compartments in the striatum of human, monkey, and cat demonstrated by acetylthiocholinesterase staining. Proc Natl Acad Sci USA 75:5723-5726.
10. Herrero MT, Hirsch EC, Kastner A, Ruberg M, Luquin MR, Laguna J, Javoy-Agid F, Obeso JA, Agid Y. 1993a. Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP? Neuroscience 56:499-511.
11. Herrero MT, Perez-Otano I, Oset C, Kastner A, Hirsch EC, Agid Y, Luquin MR, Obeso JA, Del Rio J. 1993b. GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys. Neuroscience 56:965-972.
12. Hirsch EC, Hunot S, Damier P, Faucheux B. 1998. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann Neurol 44:115-120.
13. Hirsch EC, Breidert T, Rousselet E, Hunot S, Hartmann A, Michel PP. 2003. The role of glial reaction and inflammation in Parkinson's disease. Ann NY Acad Sci 991:214-228.
14. Hunot S, Dugas N, Faucheux B, Hartmann A, Tardieu M, Debre P, Agid Y, Dugas B, Hirsch EC. 1999. FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J Neurosci 19:3440-3447.
15. Hunot S, Hirsch EC. 2003. Neuroinflammatory processes in Parkinson's disease. Ann Neurol 3:49-58.
16. Hurley SD, O'Banion MK, Song DD, Arana FS, Olschowka JA, Haber SN. 2003. Microglial response poorly correlated with neurodegeneration following chronic, low-dose MPTP-administration in monkeys. Exp Neurol 189:659-668.
17. Jenner P, Olanow CW. 1998. Understanding cell death in Parkinson's disease. Ann Neurol 44:72-84.
18. Kurkowska-Jastrzebska I, Wronska A, Kohutnicka M, Czlonkowski A, Czlonkowska A. 1999. The inflammatory reaction following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication in mouse. Exp Neurol 156:50-61.
19. Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D. 1999. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 46:598-605.
20. Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S. 1999. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 5:1403-1409.
21. Luquin MR, Laguna J, Obeso JA. 1992. Selective D2 receptor stimulation induces dyskinesia in parkinsonian monkeys. Ann Neurol 31:551-554.
22. McGeer PL, Itagaki S, Boyes BE, McGeer EG. 1988. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285-1291.
23. Olzewski J, Baxter D. 1954. Cytoarchitecture of the human brain stem. Philadelphia: J.B. Lippincott.
24. Otani I, Fujii Y, Akari H, Mukai R, Mori K, Ono F, Kojima E, machida M, Murakami K, Doi K, Yoshikawa Y. 1997. Effects of 6-chloro-2′,3′ -dideoxyguanosine (6-Cl-ddG) in surface lymph nodes of rhesus monkeys (macaca mulatta) chronically infected with simian immunodeficiency virus (SIVmac239). J Vet Med Sci 10:891-896.
25. Otto D, Unsicker K. 1993. FGF-2-mediated protection of cultured mesencephalic dopaminergic neurons against MPTP and MPP+: specificity and impact of culture conditions, non-dopaminergic neurons, and astroglial cells. J Neurosci Res 34:382-393.
26. Pakkenberg H, Andersen BB, Burns RS, Pakkenberg B. 1995. A stereological study of substantia nigra in young and old rhesus monkeys. Brain Res 693:201-206.
27. Schwartz AJ, Alvarez X, Lackner AA. 2002. Distribution and immunophenotype of DC-SIGN-expressing cells in SIV-infected and uninfected macaques. AIDS Res Hum Retroviruses 18:1021-1029.
28. Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. 1999. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 20:395-405.
29. Sterio DC. 1984. The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 134:127-136.
30. Tomac A, Lindqvist E, Lin LF, Ogren SO, Young D, Hoffer BJ, Olson L. 1984. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373:335-339.