Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons

Journal of Neuroscience

Volumn 22, Issue 3, 2002, Pages 782-790

  Gao, Hui Ming ^a,b   Hong, Jau Shyong ^b   Zhang, Wanqin ^a   Liu, Bin ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Dopamine; Microglia; Neurotoxicity; Parkinson's disease; Pesticides; Superoxide

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE; HERBICIDE; INTERLEUKIN 1BETA; NITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; GLIA; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MESENCEPHALON; MICROGLIA; MONOCYTE; NERVE CELL; NERVE CELL DEGENERATION; NEUROTOXICITY; NEUTROPHIL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

EID: 0036470165     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-03-00782.2002     Document Type: Article

References (44)

1. The role of microglia and astrocytes in CNS immune surveillance and immunopathology
2. NADPH oxidase: An update
3. Chronic systemic pesticide exposure reproduces features of Parkinson's disease
4. Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease
5. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
6. The genetics of Parkinson's disease
7. Free radicals as mediators of neuronal injury
8. Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson's disease
9. Microglia as mediators of inflammatory and degenerative diseases
10. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
11. 15N]nitrate in biological fluids
12. Mitochondrial dysfunction in Parkinson's disease
13. NAD(P)H oxidase: Role in cardiovascular biology and disease
14. 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
15. A case-control study of Parkinson's disease in an urban population of southern Israel
16. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
17. Parkinson's disease, pesticides, mitochondrial dysfunction
18. Understanding cell death in Parkinson's disease
19. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
20. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
21. Microglia: A sensor for pathological events in the CNS
22. Epidemiology versus genetics in Parkinson's disease: Progress in resolving an age-old debate
23. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
24. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
25. Role of nitric oxide in inflammation-mediated neurodegeneration
26. Molecular consequences of activated microglia in the brain: Overactivation induces apoptosis
27. Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage
28. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
29. + transporters are distinct proteins
30. The microestimation of succinate and the extinction coefficient of cytochrome c
31. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
32. Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons
33. Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
34. Etiology and pathogenesis of Parkinson's disease
35. Autosomal dominant Parkinson's disease
36. Environmental risk factors and Parkinson's disease: A metaanalysis
37. Parkinson's disease mortality and pesticide exposure in California, 1984-1994
38. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils
39. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
40. Functional plasticity of microglia: A review
41. NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: Pharmacological characterization
42. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's disease
43. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
44. Daphnoretin-induced respiratory burst in rat neutrophils is, probably, mainly through protein kinase C activation