Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36223-36232

  Kaul, Sunil ^a,b   Murphy, Patrick J M ^a,b   Chen, Jun ^a,b   Brown, Lloyd ^a,b   Pratt, William B ^a,b   Simons Jr , S Stoney ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CHEMICAL BONDS; HORMONES; MUTAGENESIS; PROTEINS;

LIGAND BINDING; MUTATIONS;

BIOCHEMISTRY;

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; STEROID;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA BINDING; GENE MUTATION; LIGAND BINDING; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; RAT; STEROID BINDING; TRANSACTIVATION;

ANIMALS; CELL-FREE SYSTEM; COS CELLS; DEXAMETHASONE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOCORTICOIDS; GLUTATHIONE TRANSFERASE; HSP90 HEAT-SHOCK PROTEINS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GLUCOCORTICOID; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0037184112     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206748200     Document Type: Article

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