메뉴 건너뛰기




Volumn 140, Issue 1, 2012, Pages 131-140

Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein

Author keywords

ARE; Baicalein; Hepatic metabolic enzymes; Microarray; Nrf2

Indexed keywords

BAICALEIN; LIVER ENZYME; MESSENGER RNA; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR NRF2;

EID: 84862823177     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.12.046     Document Type: Article
Times cited : (27)

References (62)
  • 1
    • 0025217479 scopus 로고
    • Biliary excretion of metabolites of baicalin and baicalein in rats
    • K. Abe, O. Inoue, and E. Yumioka Biliary excretion of metabolites of baicalin and baicalein in rats Chemical & Pharmaceutical Bulletin 38 1990 209 211
    • (1990) Chemical & Pharmaceutical Bulletin , vol.38 , pp. 209-211
    • Abe, K.1    Inoue, O.2    Yumioka, E.3
  • 2
    • 79955466298 scopus 로고    scopus 로고
    • The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers
    • A. Anwar-Mohamed, O.S. Degenhardt, M.A. Gendy, J.M. Seubert, S.R. Kleeberger, and A.O. El-Kadi The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers Toxicology In Vitro 25 2011 785 795
    • (2011) Toxicology in Vitro , vol.25 , pp. 785-795
    • Anwar-Mohamed, A.1    Degenhardt, O.S.2    Gendy, M.A.3    Seubert, J.M.4    Kleeberger, S.R.5    El-Kadi, A.O.6
  • 3
    • 79951633215 scopus 로고    scopus 로고
    • Does hepatic steatosis affect drug metabolizing enzymes in the liver?
    • C. Buechler, and T.S. Weiss Does hepatic steatosis affect drug metabolizing enzymes in the liver? Current Drug Metabolism 12 2011 24 34
    • (2011) Current Drug Metabolism , vol.12 , pp. 24-34
    • Buechler, C.1    Weiss, T.S.2
  • 4
  • 5
    • 80053627860 scopus 로고    scopus 로고
    • A genome-wide microarray highlights the anti-inflammatory genes targeted by oolong tea theasinensin A in macrophages
    • J. Chen, S. Qin, J. Xiao, S. Tanigawa, T. Uto, F. Hashimoto, M. Fujii, and D.X. Hou A genome-wide microarray highlights the anti-inflammatory genes targeted by oolong tea theasinensin A in macrophages Nutrition and Cancer 63 2011 1064 1073
    • (2011) Nutrition and Cancer , vol.63 , pp. 1064-1073
    • Chen, J.1    Qin, S.2    Xiao, J.3    Tanigawa, S.4    Uto, T.5    Hashimoto, F.6    Fujii, M.7    Hou, D.X.8
  • 6
    • 77955721833 scopus 로고    scopus 로고
    • Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl) hexyl isothiocyanate in macrophages
    • J. Chen, T. Uto, S. Tanigawa, T. Yamada-Kato, M. Fujii, and D.X. Hou Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl) hexyl isothiocyanate in macrophages Experimental and Therapeutic Medicine 1 2010 33 40
    • (2010) Experimental and Therapeutic Medicine , vol.1 , pp. 33-40
    • Chen, J.1    Uto, T.2    Tanigawa, S.3    Yamada-Kato, T.4    Fujii, M.5    Hou, D.X.6
  • 7
    • 33749235315 scopus 로고    scopus 로고
    • Baicalein inhibition of oxidative-stress induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6
    • Y.C. Chen, J.M. Chow, C.W. Lin, C.Y. Wu, and S.C. Shen Baicalein inhibition of oxidative-stress induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6 Toxicology and Applied Pharmacology 216 2006 263 273
    • (2006) Toxicology and Applied Pharmacology , vol.216 , pp. 263-273
    • Chen, Y.C.1    Chow, J.M.2    Lin, C.W.3    Wu, C.Y.4    Shen, S.C.5
  • 8
    • 0242694978 scopus 로고    scopus 로고
    • Enzyme Induction and Dietary Chemicals as Approaches to Cancer Chemoprevention: The Seventh DeWitt S. Goodman Lecture
    • A.H. Conney Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture Cancer Research 63 2003 7005 7031 (Pubitemid 37413433)
    • (2003) Cancer Research , vol.63 , Issue.21 , pp. 7005-7031
    • Conney, A.H.1
  • 9
    • 33646177187 scopus 로고    scopus 로고
    • Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases
    • J.D. Deschamps, V.A. Kenyon, and T.R. Holman Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases Bioorganic & Medicinal Chemistry 14 2006 4295 4301
    • (2006) Bioorganic & Medicinal Chemistry , vol.14 , pp. 4295-4301
    • Deschamps, J.D.1    Kenyon, V.A.2    Holman, T.R.3
  • 12
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • DOI 10.1093/toxsci/59.1.169
    • A. Enomoto, K. Itoh, E. Nagayoshi, J. Haruta, T. Kimura, T. O'Connor, T. Harada, and M. Yamamoto High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes Toxicological Sciences 59 2001 169 177 (Pubitemid 32117993)
    • (2001) Toxicological Sciences , vol.59 , Issue.1 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6    Harada, T.7    Yamamoto, M.8
  • 14
    • 80053953558 scopus 로고    scopus 로고
    • The ethanol extract of Scutellaria baicalensis and it active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells
    • J. Gao, W.A. Morgan, A. Sanchez-Medina, and O. Corcoran The ethanol extract of Scutellaria baicalensis and it active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells Toxicology and Applied Pharmacology 254 2011 221 228
    • (2011) Toxicology and Applied Pharmacology , vol.254 , pp. 221-228
    • Gao, J.1    Morgan, W.A.2    Sanchez-Medina, A.3    Corcoran, O.4
  • 15
    • 58149512737 scopus 로고    scopus 로고
    • Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
    • L. Guo, Q. Li, Q. Xia, S. Dial, and P. Fu Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract Food and Chemical Toxicology 47 2009 433 442
    • (2009) Food and Chemical Toxicology , vol.47 , pp. 433-442
    • Guo, L.1    Li, Q.2    Xia, Q.3    Dial, S.4    Fu, P.5
  • 16
    • 33746736380 scopus 로고    scopus 로고
    • Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death
    • DOI 10.1167/iovs.04-1369
    • A. Hanneken, F.F. Lin, J. Johnson, and P. Maher Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death Investigative Ophthalmology & Visual Science 47 2006 3164 3177 (Pubitemid 351639797)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.7 , pp. 3164-3177
    • Hanneken, A.1    Lin, F.-F.2    Johnson, J.3    Maher, P.4
  • 17
    • 2142764409 scopus 로고    scopus 로고
    • Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells
    • DOI 10.1016/j.mrfmmm.2003.11.014, PII S0027510704000612
    • A.J. Harris, S.L. Dial, and D.A. Casciano Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells Mutation Research 549 2004 79 99 (Pubitemid 38553977)
    • (2004) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.549 , Issue.1-2 , pp. 79-99
    • Harris, A.J.1    Dial, S.L.2    Casciano, D.A.3
  • 18
    • 0035965945 scopus 로고    scopus 로고
    • Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
    • DOI 10.1016/S0304-3835(01)00695-4, PII S0304383501006954
    • J.D. Hayes, and M. McMahon Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention Cancer Letters 174 2001 103 113 (Pubitemid 33026113)
    • (2001) Cancer Letters , vol.174 , Issue.2 , pp. 103-113
    • Hayes, J.D.1    McMahon, M.2
  • 19
    • 77950188189 scopus 로고    scopus 로고
    • Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: The big picture
    • J. Helleman, M. Smid, M.P. Jansen, M.E. Van der Burg, and E.M. Berns Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture Gynecologic Oncology 117 2010 170 176
    • (2010) Gynecologic Oncology , vol.117 , pp. 170-176
    • Helleman, J.1    Smid, M.2    Jansen, M.P.3    Van Der Burg, M.E.4    Berns, E.M.5
  • 21
    • 38449116664 scopus 로고    scopus 로고
    • Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway
    • C.J. Hsieh, K. Hall, T. Ha, C. Li, G. Krishnaswamy, and S.C. David Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway Clinical and Molecular Allergy 5 2007 5
    • (2007) Clinical and Molecular Allergy , vol.5 , pp. 5
    • Hsieh, C.J.1    Hall, K.2    Ha, T.3    Li, C.4    Krishnaswamy, G.5    David, S.C.6
  • 23
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes and Development 13 1999 76 86 (Pubitemid 29045117)
    • (1999) Genes and Development , vol.13 , Issue.1 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 24
    • 77649271223 scopus 로고    scopus 로고
    • The rise of antioxidant signaling - The evolution and hermetic actions of Nrf2
    • M. Jonathan, and M. Yamamoto The rise of antioxidant signaling - the evolution and hermetic actions of Nrf2 Toxicology and Applied Pharmacology 244 2010 4 15
    • (2010) Toxicology and Applied Pharmacology , vol.244 , pp. 4-15
    • Jonathan, M.1    Yamamoto, M.2
  • 25
    • 0141482095 scopus 로고    scopus 로고
    • Involvement of nuclear factor-κB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis
    • DOI 10.1055/s-2003-42779
    • B.Y. Kang, S.W. Chung, S.H. Kim, D. Cho, and T.S. Kim Involvement of nuclear factor-kappaB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis Planta Medica 69 2003 687 691 (Pubitemid 37215014)
    • (2003) Planta Medica , vol.69 , Issue.8 , pp. 687-691
    • Kang, B.Y.1    Chung, S.W.2    Kim, S.H.3    Cho, D.4    Kim, T.S.5
  • 28
    • 77958570942 scopus 로고    scopus 로고
    • Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides
    • M.A. Lea, C. Ibeh, J.K. Deutsch, I. Hamid, and C. desBordes Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides Anticancer Research 30 2010 3629 3635
    • (2010) Anticancer Research , vol.30 , pp. 3629-3635
    • Lea, M.A.1    Ibeh, C.2    Deutsch, J.K.3    Hamid, I.4    Desbordes, C.5
  • 29
    • 0034964158 scopus 로고    scopus 로고
    • Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
    • E.L. LeCluyse Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation European Journal of Pharmaceutical Sciences 13 2001 343 368
    • (2001) European Journal of Pharmaceutical Sciences , vol.13 , pp. 343-368
    • Lecluyse, E.L.1
  • 30
    • 2342514015 scopus 로고    scopus 로고
    • An important role of Nrf2-ARE pathway in the cellular defense mechanism
    • J.M. Lee, and J.A. Johnson An important role of Nrf2-ARE pathway in the cellular defense mechanism Journal of Biochemistry and Molecular Biology 37 2004 139 143 (Pubitemid 38608865)
    • (2004) Journal of Biochemistry and Molecular Biology , vol.37 , Issue.2 , pp. 139-143
    • Lee, J.-M.1    Johnson, J.A.2
  • 31
    • 43049143059 scopus 로고    scopus 로고
    • HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway
    • DOI 10.1152/physiolgenomics.00263.2007
    • J.I. Lee, J.J. Dominy, A.K. Sikalidis, L.L. Hirschberger, W. Wang, and M.H. Stipanuk HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway Physiological Genomics 33 2008 218 229 (Pubitemid 351629530)
    • (2008) Physiological Genomics , vol.33 , Issue.2 , pp. 218-229
    • Lee, J.-I.1    Dominy Jr., J.E.2    Sikalidis, A.K.3    Hirschberger, L.L.4    Wang, W.5    Stipanuk, M.H.6
  • 32
    • 34249802923 scopus 로고    scopus 로고
    • Pathway analysis identifies perturbation of genetic networks induced by butyrate in a bovine kidney epithelial cell line
    • DOI 10.1007/s10142-006-0043-2
    • C.J. Li, R.W. Li, Y.H. Wang, and T.H. Elsasser Pathway analysis identifies perturbation of genetic networks induced by butyrate in a bovine kidney epithelial cell line Functional & Integrative Genomics 7 2007 193 205 (Pubitemid 46844600)
    • (2007) Functional and Integrative Genomics , vol.7 , Issue.3 , pp. 193-205
    • Li, C.-J.1    Li, R.W.2    Wang, Y.-H.3    Elsasser, T.H.4
  • 33
    • 77953812705 scopus 로고    scopus 로고
    • Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways
    • Y. Li, Q. Wang, X. Yao, and Y. Li Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways European Journal of Pharmacology 640 2010 46 54
    • (2010) European Journal of Pharmacology , vol.640 , pp. 46-54
    • Li, Y.1    Wang, Q.2    Yao, X.3    Li, Y.4
  • 34
    • 38749154690 scopus 로고    scopus 로고
    • Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: Comparison of primary human hepatocytes to HepG2 cells
    • DOI 10.1124/dmd.107.017608
    • M.J. Liguori, E.A. Blomme, and J.F. Waring Trovafloxacin-induced gene expression changes in liver-derived in vitro system: comparison of primary human hepatocytes to HepG2 cells Drug Metabolism and Disposition 36 2008 223 233 (Pubitemid 351185733)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.2 , pp. 223-233
    • Liguori, M.J.1    Blomme, E.A.G.2    Waring, J.F.3
  • 35
    • 20144385916 scopus 로고    scopus 로고
    • Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: Direct cross-talk between phase I and II drug-metabolizing enzymes
    • DOI 10.1074/jbc.M412081200
    • W. Miao, L. Hu, P.J. Scrivens, and G. Batist Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes The Journal of Biological Chemistry 280 2005 20340 20348 (Pubitemid 40776732)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.21 , pp. 20340-20348
    • Miao, W.1    Hu, L.2    Scrivens, P.J.3    Batist, G.4
  • 36
    • 0034685897 scopus 로고    scopus 로고
    • Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
    • DOI 10.1074/jbc.M000361200
    • T. Nguyen, H.C. Huang, and C.B. Pickett Transcriptional regulation of the antioxidant response element: activation by Nrf2 and repression by MafK The Journal of Biological Chemistry 275 2000 15466 15473 (Pubitemid 30337278)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.20 , pp. 15466-15473
    • Nguyen, T.1    Huang, H.C.2    Pickett, C.B.3
  • 37
    • 77955503750 scopus 로고    scopus 로고
    • Inhibition of beta-catenin/Tcf signaling by flavonoids
    • S. Park, and J. Choi Inhibition of beta-catenin/Tcf signaling by flavonoids Journal of Cellular Biochemistry 110 2010 1376 1385
    • (2010) Journal of Cellular Biochemistry , vol.110 , pp. 1376-1385
    • Park, S.1    Choi, J.2
  • 38
    • 0036301269 scopus 로고    scopus 로고
    • Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells
    • DOI 10.1080/00498250210128675
    • C. Rodriguez-Antona, M.T. Donato, A. Boobis, R.J. Edwards, P.S. Watts, J.V. Castell, and M.J. Gomez-Lechon Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells Xenobiotica 32 2002 505 520 (Pubitemid 34743622)
    • (2002) Xenobiotica , vol.32 , Issue.6 , pp. 505-520
    • Rodriguez-Antona, C.1    Donato, M.T.2    Boobis, A.3    Edwards, R.J.4    Watts, P.S.5    Castell, J.V.6    Gomez-Lechon, M.-J.7
  • 40
    • 70449707485 scopus 로고    scopus 로고
    • Acetyl derivate of quercetin increased the sensitivity of human leukemia cells toward apoptosis
    • K. Sakao, M. Fujii, and D.X. Hou Acetyl derivate of quercetin increased the sensitivity of human leukemia cells toward apoptosis Biofactors 35 2009 399 405
    • (2009) Biofactors , vol.35 , pp. 399-405
    • Sakao, K.1    Fujii, M.2    Hou, D.X.3
  • 41
    • 79952990726 scopus 로고    scopus 로고
    • Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia
    • N.K. Sethy, M. Singh, R. Kumar, G. Ilavazhagan, and K. Bhargava Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia Functional & Integrative Genomics 11 2011 119 137
    • (2011) Functional & Integrative Genomics , vol.11 , pp. 119-137
    • Sethy, N.K.1    Singh, M.2    Kumar, R.3    Ilavazhagan, G.4    Bhargava, K.5
  • 42
    • 0033794615 scopus 로고    scopus 로고
    • Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin
    • D.E. Shieh, L.T. Liu, and C.C. Lin Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin Anticancer Research 20 2000 2861 2865
    • (2000) Anticancer Research , vol.20 , pp. 2861-2865
    • Shieh, D.E.1    Liu, L.T.2    Lin, C.C.3
  • 43
    • 34249065209 scopus 로고    scopus 로고
    • Orphan nuclear receptors in drug discovery
    • DOI 10.1016/j.drudis.2007.04.006, PII S1359644607001754
    • Y. Shi Orphan nuclear receptors in drug discovery Drug Discovery Today 12 2007 440 445 (Pubitemid 46783687)
    • (2007) Drug Discovery Today , vol.12 , Issue.11-12 , pp. 440-445
    • Shi, Y.1
  • 46
    • 77950850484 scopus 로고    scopus 로고
    • Baicalin, an emerging multi-therapeutic agent: Pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives
    • N.R. Srinivas Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives Xenobiotica 40 2010 357 367
    • (2010) Xenobiotica , vol.40 , pp. 357-367
    • Srinivas, N.R.1
  • 47
    • 34247282872 scopus 로고    scopus 로고
    • Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin
    • DOI 10.1016/j.freeradbiomed.2007.02.017, PII S0891584907001487
    • S. Tanigawa, M. Fujii, and D.X. Hou Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin Free Radical Biology & Medicine 42 2007 1690 1703 (Pubitemid 46617147)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.11 , pp. 1690-1703
    • Tanigawa, S.1    Fujii, M.2    Hou, D.-X.3
  • 48
    • 72449122331 scopus 로고    scopus 로고
    • Drug metabolism for the perplexed medicinal chemist
    • B. Testa Drug metabolism for the perplexed medicinal chemist Chemistry & Biodiversity 6 2009 2055 2070
    • (2009) Chemistry & Biodiversity , vol.6 , pp. 2055-2070
    • Testa, B.1
  • 49
    • 33845442015 scopus 로고    scopus 로고
    • Baicalein and 12/15-lipoxygenase in the ischemic brain
    • DOI 10.1161/01.STR.0000249004.25444.a5, PII 0000767020061200000037
    • K. Van Leyen, H.Y. Kim, S.R. Lee, G. Jin, K. Arai, and E.H. Lo Baicalein and 12/15-lipoxygenase in the ischemic brain Stroke 37 2006 3014 3018 (Pubitemid 44900824)
    • (2006) Stroke , vol.37 , Issue.12 , pp. 3014-3018
    • Van Leyen, K.1    Kim, H.Y.2    Lee, S.-R.3    Jin, G.4    Arai, K.5    Lo, E.H.6
  • 51
    • 0033022302 scopus 로고    scopus 로고
    • Inhibitory effects of baicalein and wogonin on lipopolysaccharide- induced nitric oxide production in macrophages
    • I. Wakabayashi Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages Pharmacology & Toxicology 84 1999 288 291 (Pubitemid 29282218)
    • (1999) Pharmacology and Toxicology , vol.84 , Issue.6 , pp. 288-291
    • Wakabayashi, I.1
  • 52
    • 77956226747 scopus 로고    scopus 로고
    • Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells
    • L. Wang, Y. Ling, Y. Chen, C.L. Li, F. Feng, Q.D. You, N. Lu, and Q.L. Guo Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells Cancer Letters 297 2010 42 48
    • (2010) Cancer Letters , vol.297 , pp. 42-48
    • Wang, L.1    Ling, Y.2    Chen, Y.3    Li, C.L.4    Feng, F.5    You, Q.D.6    Lu, N.7    Guo, Q.L.8
  • 54
    • 0042904900 scopus 로고    scopus 로고
    • Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties
    • DOI 10.1124/dmd.31.8.1035
    • S. Wilkening, F. Stahl, and A. Bader Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties Drug Metabolism and Disposition 36 2003 1035 1042 (Pubitemid 36975674)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.8 , pp. 1035-1042
    • Wilkening, S.1    Stahl, F.2    Bader, A.3
  • 55
    • 33646542712 scopus 로고    scopus 로고
    • Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity
    • K.J. Woo, J.H. Lim, S.I. Suh, Y.K. Kwon, S.W. Shin, S.C. Kim, Y.H. Choi, J.W. Park, and T.K. Kwon Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity Immunobiology 211 2006 359 368
    • (2006) Immunobiology , vol.211 , pp. 359-368
    • Woo, K.J.1    Lim, J.H.2    Suh, S.I.3    Kwon, Y.K.4    Shin, S.W.5    Kim, S.C.6    Choi, Y.H.7    Park, J.W.8    Kwon, T.K.9
  • 58
    • 0035851148 scopus 로고    scopus 로고
    • Orphan nuclear receptors: The exotics of xenobiotics
    • W. Xie, and R.M. Evans Orphan nuclear receptors: the exotics of xenobiotics The Journal of Biological Chemistry 276 2001 37739 37742
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 37739-37742
    • Xie, W.1    Evans, R.M.2
  • 59
    • 23344450788 scopus 로고    scopus 로고
    • Induction of phase I, II and III drug metabolism/transport by xenobiotics
    • C. Xu, C.Y. Li, and A.N. Kong Induction of phase I, II and III drug metabolism/transport by xenobiotics Archives of Pharmacal Research 28 2005 249 268 (Pubitemid 44698742)
    • (2005) Archives of Pharmacal Research , vol.28 , Issue.3 , pp. 249-268
    • Xu, C.1    Li, C.Y.-T.2    Kong, A.-N.T.3
  • 61
    • 77958140054 scopus 로고    scopus 로고
    • The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer
    • D.D. Zhang The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer Antioxidants & Redox Signaling 11 2010 1623 1626
    • (2010) Antioxidants & Redox Signaling , vol.11 , pp. 1623-1626
    • Zhang, D.D.1
  • 62
    • 0346121452 scopus 로고    scopus 로고
    • Flavonoids as aryl hydrocarbon receptor agonists/antagonists: Effects of structure and cell context
    • S. Zhang, C. Qin, and S.H. Safe Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context Environmental Health Perspectives 111 2003 1877 1882 (Pubitemid 37541197)
    • (2003) Environmental Health Perspectives , vol.111 , Issue.16 , pp. 1877-1882
    • Zhang, S.1    Qin, C.2    Safe, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.