Enzyme Induction and Dietary Chemicals as Approaches to Cancer Chemoprevention: The Seventh DeWitt S. Goodman Lecture

Cancer Research

Volumn 63, Issue 21, 2003, Pages 7005-7031

  Conney, Allan H ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CAFFEINE; CURCUMIN; EPIGALLOCATECHIN GALLATE; FINASTERIDE; TAMOXIFEN;

APOPTOSIS; BREAST CANCER; CANCER INCIDENCE; CANCER PREVENTION; CANCER RESEARCH; CANCER RISK; CHEMICAL CARCINOGENESIS; COLON CANCER; CONFERENCE PAPER; DNA DAMAGE; ENZYME INDUCTION; ESOPHAGUS CANCER; HUMAN; MOUTH CANCER; PRECANCER; PRIORITY JOURNAL; PROSTATE CANCER; SKIN CANCER; STOMACH CANCER; TEA;

ANIMALS; ANTICARCINOGENIC AGENTS; CAFFEINE; CATECHIN; CHEMOPREVENTION; CURCUMIN; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; NEOPLASMS;

EID: 0242694978     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (386)

1. Richardson, H. L., Stier, A. R., and Borsos-Nacht-Nebel. E. Liver tumor inhibition and adrenal histologic responses in rats to which 3′-methyl-4-dimethylaminoazo-benzene and 20-methyleholanlhrene were simultaneously administered. Cancer Res., 12: 356-361, 1952.
2. Conney, A. H. Studies on the demethylation and reduction of aminoazo dyes. Masters thesis. Madison, Wisconsin: Memorial Library, University of Wisconsin, Madison, 1954.
3. Conney, A. H., Miller, E. C., and Miller, J. A. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res., 16: 450-459, 1956.
4. Miller, E. C., Miller, J. A., Brown, R. R., and MacDonald, J. C. On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene. Cancer Res., 18: 469-477, 1958.
5. Conney, A. H., Miller, E. C., and Miller, J. A. Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. J. Biol. Chem., 228: 753-766. 1957.
6. Wattenberg, L. W., and Leong, J. L. Histochemical demonstration of reduced pyridine nucleotide-dependent polycyclic hydrocarbon-metabolizing systems. J. Histochem. Cytochem., 10: 412-420, 1962.
7. Wattenberg, L. W., Leong, J. L., and Strand, P. L. Benzpyrene hydroxylase activity in the gastrointestinal tract. Cancer Res., 22: 1120-1125, 1962.
8. Gelboin, H. V., and Blackburn, N. R. The stimulatory effet of 3-methylcholan-threne on benzpyrene hydroxylase activity in several rat tissues: Inhibition by actinomycin D and puromycin. Cancer Res., 24: 356-360, 1964.
9. Nebert, D. W., and Gelboin., H. V. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains and developmental and hormonal states. Arch. Biochem. Biophys., 134: 76-89, 1969.
10. Welch, R. M., Harrison, Y. E., Gommi, B. W., Poppers, P. J., Finster, M., and Conney, A. H. Stimulatory effect of cigarette smoking on the hydroxylation of 3, 4-benzpyrene and the N-demethylation of 3-methyl-4-monomethylaminoazobenzene by enzymes in human placenta. Clin. Pharmacol. Ther., 10: 100-109, 1969.
11. Schlede, E., and Conney, A. H. Induction of benzol(a)pyrene hydroxylase activity in rat skin. Life Sci., 9: 1295-1303, 1970.
12. Conney, A. H., and Burns, J. J. Stimulatory effect of foreign compounds on ascorbic acid biosynthesis and on drug-metabolizing enzymes. Nature (Lond.), 184: 363-364, 1959.
13. Conney, A. H., Davison, C., Gastel, R., and Burns, J. J. Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs. J. Pharmacol. Exp. Ther., 130: 1-8, 1960.
14. Remmer, H., and Alsleben, B. Die Aktivierung der Entigiftung in den Lebermikrosomen während der Gewöhnung. Klin. Wochenschr., 36: 332-333, 1958.
15. Remmer, H. Die Beschleunigung der Evipanoxydation und der Demethylierung von Methylaminoantipyrin durch Barbiturate. Arch. Exper. Pathol. Pharmakol., 237: 296-307, 1959.
16. Kato, R. Modificato quadro farmacologico di alcuni farmaci in animali pretrattati-48 ore prima-con altri farmaci. Atti Soc. Lombarda Science Med-Biology. 14: 783-786, 1959.
17. Kato, R., Chiesara, E., and Frontino, G. Induction of hepatic carisoprodol metabolizing enzyme by pretreatment with some neuropsychotropic drugs in rats. Jpn. J. Pharmacol., 11: 31-36, 1961.
18. Conney, A. H. Induction of drug-metabolizing enzymes: A path to the discovery of multiple cytochromes P450. Annu. Rev. Pharmacol. Toxicol., 43: 1-30, 2003.
19. Conney, A. H. Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev., 19: 317-366, 1967.
20. Conney, A. H., and Burns, J. J. Metabolic interactions among environmental chemicals and drugs. Science (Wash. DC), 178: 576-586, 1972.
21. Conney, A. H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res., 42: 4875-4917, 1982.
22. Schlede, E., Kuntzman, R., Haber, S., and Conney, A. H. Effect of enzyme induction on the metabolism and tissue distribution of benzo(α)pyrene. Cancer Res., 30: 2893-2897, 1970.
23. Schlede, E., Kuntzman, R., and Conney, A. H. Stimulatory effect of benzo(α)pyrene and phenobarbital pretreatment on the biliary excretion of benzo(α)pyrene metabolites in the rat. Cancer Res., 30: 2898-2904, 1970.
24. Welch, R. M., Gommi, B., Alvares, A. P., and Conney, A. H. Effect of enzyme induction on the metabolism of benzo[a]pyrene and 3-methyl-4-monomethylaminoazobenzene in the pregnant and fetal rat. Cancer Res., 32: 973-978, 1972.
25. Acros, J. C., Conney, A. H., and Buu-Hoi, N. P. Induction of microsomal enzyme synthesis by polycyclic aromatic hydrocarbons of different molecular sizes. J. Biol. Chem., 236: 1291-1296, 1961.
26. Huggins, C., Grand, L. C., and Brillantes, F. P. Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression. Nature (Lond.). 189: 204-207, 1961.
27. Huggins, C., and Morii, S. Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz[a]anthracene. J. Exp. Med., 114: 741-760, 1961.
28. Dao, T. L., and Tanaka, Y. Inhibitory effect of polynuclear hydrocarbons and amphenone analogs on induction of acute adrenal necrosis by 7, 12-dimethylbenz[a]anthracene. Cancer Res., 23: 1148-1152, 1963.
29. Huggins, C., and Fukunishi, R. Molecular structure of aromatics related to their ability to induce adrenal protection. Arzneimittelforschung., 14: 834-836, 1964.
30. 3. J. Exp. Med., 119: 923-942, 1964.
31. Huggins, C., Grand, L., and Fukunishi, R. Aromatic influences on the yields of mammary cancers following administration of 7, 12-dimethylbenz[a]athracene. Proc. Natl. Acad. Sci. USA, 51: 737-742, 1964.
32. Huggins, C., and Pataki, J. Aromatic azo derivatives preventing mammary cancer and adrenal injury from 7, 12-dimethylbenz(a)anthracene. Proc. Natl. Acad. Sci. USA, 53: 791-796, 1965.
33. Williams-Ashman, H. G., and Huggins, C. Oxidation of reduced pyridine nucleotides in mammary gland and adipose tissue following treatment with polynuclear hydrocarbons. Med. Exp., 4: 223-226, 1961.
34. Huggins, C. Prevention of hydrocarbon-induced leukemia and mammary cancer. In: C. Huggins (ed.), Experimental Leukemia and Mammary Cancer: Induction, Prevention, Cure, pp. 143-155. Chicago: University of Chicago Press, 1979.
35. Conney, A. H., and Levin, W. Induction of hepatic 7, 12-dimethylbenz[a]anthracene metabolism by polycyclic aromatic hydrocarbons and aromatic azo derivatives. Life Sci., 5: 465-471, 1966.
36. Levin, W., and Conney, A. H. Stimulatory effect of polycyclic hydrocarbons and aromatic azo derivatives on the metabolism of 7, 12-dimethylbenz[a]anthracene. Cancer Res., 27: 1931-1938, 1967.
37. Jellinck, P. H., and Goudy, B. Protective action of polycyclic hydrocarbons against induction of adrenal necrosis by dimethylbenzanthracene. Science (Wash. DC), 152: 1375-1376, 1966.
38. 14C by rat liver and other tissues. Pharmacology (Basel). 16: 131-141, 1967.
39. DiGiovanni, J., Berry, D. L., Slaga, T. J., and Juchau, M. R. Studies on the relationships between induction of biotransformation and tumor-initiating activity of 7, 12-dimethylbenz[a]anthracene in mouse skin. In: P. W. Jones and P. Leber (eds.), Polynuclear Aromatic Hydrocarbons, pp. 553-568. Ann Arbor. MI: Ann Arbor Science Publishers, Inc., 1979.
40. DiGiovanni, J., Kishore, G. S., Slaga, T. J., and Boutwell, R. K. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced alterations in oxidative and nonoxidative biotransformation of PAH in mouse skin: role of anticarcinogenesis by TCDD. In: O. Bjorseth and A. J. Dennis (eds.), Polynuclear Aromatic Hydrocarbons: Chemistry and Biological Effects, pp. 935-954. Columbus, OH: Battalle Press, 1980.
41. Wattenberg, L. W., and Leong, J. L. Inhibition of the carcinogenic action of benzo[a]pyrene by flavones. Cancer Res., 30: 1922-1925, 1970.
42. Wattenberg, L. W., and Loub, W. D. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res., 38: 1410-1413, 1978.
43. Wheatley, D. N. Enhancement and inhibition of the induction by 7, 12-dimethylbenz[a]anthracene of mammary tumours in female Sprague-Dawley rats. Br. J. Cancer. 22: 787-797, 1968.
44. Wattenberg, L. W., and Leong, J. L. Inhibition of the carcinogenic action of 7, 12-dimethylbenz[a]anthracene by β-napthoflavone. Proc. Soc. Exp. Biol. Med., 128: 940-943, 1968.
45. Kovacs, K., and Somogyi, A. Suppression by spironolactone of 7, 12-dimethylbenz[a]anthmcene-induced mammary tumors. Eur. J. Cancer (Oxford). 6: 195-201, 1970.
46. Silinskas, K. C., and Okey, A. B. Protection by 1, 1, 1-trichloro-2, 2-bis(p-chlorophenyl)ethane (DDT) against mammary tumors and leukemia during prolonged feeding of 7, 12-dimethylbenz[a]anthracene to female rats. J. Natl. Cancer Inst., 55: 653-657, 1975.
47. Peraino, C., Fry, R. J., and Staffeldt, E. Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene. Cancer Res., 31: 1506-1512, 1971.
48. Makiura, S., Aoe, H., Sugihara, S., Hirao, K., and Arai, M. Inhibitory effect of polychlorinated biphenyls on liver tumorigenesis in rats treated with 3′-methyl-4-dimethylaminoazobenzene, N-2-fluorenylacetamide, and diethylnitrosamine. J. Natl. Cancer Inst., 53: 1253-1257, 1974.
49. Tawfic, H. N. Studies on ear duct tumors in rats. II. Inhibitory effect of methylcholanthrene and 1, 2-benzanthracene on tumor formation by 4-dimethylaminostilbene. Acta Pathol. Jpn., 15: 255-260, 1965.
50. Yamamoto, R. S., Weisburger, J. H., and Weisburger, E. K. Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors. Cancer Res., 31: 483-486, 1971.
51. McLean, A. E., and Marshall, A. Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone. Br. J. Exp. Pathol., 52: 323-329, 1971.
52. 1-hepatocarcinogenesis in rats by β-naphthoflavone. Carcinogenesis (Lond.), 6: 675-678, 1985.
53. Kunz, W., Schaude, G., and Thomas, C. Die beeinflussung der nitrosamincarcinogenese durch phenobarbital und halogenkohlenwasserstoffe. Z. Krebsforsch., 72: 291-301, 1969.
54. Meechan, R. J., McCafferty, D. E., and Jones, R. S. 3-Methylcholanthrene as an inhibitor of hepatic cancer induced by 3′ 3-methyl-4-dimethylaminoazobenzene in the diet of rats: A determination of the time relationships. Cancer Res., 13: 802, 1953.
55. Ishidate, M., Watanabe, M., and Odashima, S. Effect of barbital on carcinogenic action and metabolism of 4-dimethylaminoazobenzene. Gann. 58: 267-281, 1967.
56. Tanaka, T., Mori, Y., Morishita, Y., Hara, A., Ohno, T., Kojima, T., and Mori, H. Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats. Carcinogenesis (Lond.). 11: 1403-1406, 1990.
57. Grubbs, C. J., Steele, V. E., Casebolt, T., Juliana, M. M., Eto, I., Whitaker, L. M., Dragnev, K. H., Kelloff, G. J., and Lubet, R. L. Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res., 15: 709-716, 1995.
58. Wattenberg, L. W., and Leong, J. L. Effects of phenothiazines on protective systems against polycyclic hydrocarbons. Cancer Res., 25: 365-370, 1965.
59. Miller, J. A., Cramer, J. W., and Miller, E. C. The N- and ring-hydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat. Cancer Res., 20: 950-962, 1960.
60. Snyderwine, E. G., Nouso, K., and Schut, H. A. Effect of 3-methylcholanthrene induction on the distribution and DNA adduction of amino-3-methylimidazo[4, 5-f]quinoline (IQ) in F344 rats. Food Chem. Toxicol., 31: 415-423, 1993.
61. Takahashi, N., Dashwood, R. H., Bjeldanes, L. F., Bailey, G. S., and Williams, D. E. Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout. Food Chem. Toxicol., 33: 111-120, 1995.
62. 1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes. Carcinogenesis (Lond.), 17: 79-87, 1996.
63. Wislocki, P. G., Miller, E. C., Miller, J. A., McCoy, E. C., and Rosenkranz, H. S. Carcinogenic and mutagenic activities of safrole, 1′-hydroxysafrole, and some known or possible metabolites. Cancer Res., 37: 1883-1891, 1977.
64. Anderson, L. M., Jones, A. B., Riggs, C. W., and Ohshima, M. Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism. Carcinogenesis (Lond.), 6: 1389-1393, 1985.
65. Anderson, L. M., Jones, A. B., Riggs, C. W., and Kovatch, R. M. Modification of transplacental tumorigenesis by 3-methylcholanthrene in mice by genotype at the Ah locus and pretreatment with β-naphthoflavone. Cancer Res., 49: 1676-1681, 1989.
66. Miller, M. S. Transplacental lung carcinogenesis: a pharmacogenetic mouse model for the modulatory role of cytochrome P4501A1 on lung cancer initiation. Chem. Res. Toxicol., 7: 471-481, 1994.
67. Gelboin, H. V., Wiebel, F., and Diamond, L. Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7, 8-benzoflavone. Science (Wash. DC), 170: 169-171, 1970.
68. Kinoshita, N., and Gelboin, H. V. Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7, 8-benzoflavone on tumorigenesis and macromolecule binding. Proc. Natl. Acad. Sci. USA, 69: 824-828, 1972.
69. Cai, Y., Kleiner, H., Johnston, D., Dubowski, A., Bostic. S., Ivie, W., and DiGiovanni, J. Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7, 12-dimethylbenz[a]anthracene in SENCAR mice. Carcinogenesis (Lond.), 18: 1521-1527, 1997.
70. Kleiner, H., Reed, M. J., and DiGiovanni, J. Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7, 12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells. Chem. Res. Toxicol., 16: 415-422, 2003.
71. Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii-Kuriyama, Y., and Ishikawa, T. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. USA, 97: 779-782, 2000.
72. Uno, S., Dalton, T. P., Shertzer, H. G., Genter, M. B., Warshawsky, D., Talaska, G., and Nebert, D. W. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyplal(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochem. Biophys. Res. Commun., 289: 1049-1056, 2001.
73. 1 by hepatocytes isolated from rats following the in vivo administration of some xenobiotics. Carcinogenesis (Lond.), 4: 1007-1012, 1983.
74. 1 by rat hepatic microsomes induced by polyhalogenated biphenyl congeners. Appl. Environ. Microbiol., 49: 882-886, 1985.
75. 1-9α-hydroxylase activity in rat liver parenchymal and non-parenchymal cells. Arch. Toxicol., 70: 553-558, 1996.
76. Lin, L., Yang, F., Ye, Z., Xu. E., Yang, C., Zhang, C., Wu, D., and Nebert, D. W. Case-control study of cigarette smoking and primary hepatoma in an aflatoxinendemic region of China: a protective effect. Pharmacogenetics, 1: 79-85, 1991.
77. 1 metabolism. Carcinogenesis (Lond.), 19: 403-411, 1998.
78. Henderson, C. J., Smith, A. G., Ure, J., Brown, K., Bacon, E. J., and Wolf, C. R. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc. Natl. Acad. Sci. USA, 95: 5275-5280, 1998.
79. Alexandrov, K., Cascorbi, I., Rojas, M., Bouvier, G., Kriek, E., and Bartsch, H. CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation. Carcinogenesis (Lond.), 23: 1969-1977, 2002.
80. Inscoe, J. K., and Axelrod, J. Some factors affecting glucuronide formation in vitro. J. Pharmacol. Exp. Ther., 129: 128-131, 1960.
81. Catz, C., and Yaffe, S. J. Pharmacological modification of bilirubin conjugation in the newbom. Am. J. Dis. Child., 104: 516-517, 1962.
82. Arias, I. M., Gartner, L., Furman, M., and Wolfson, S. Studies on the effect of several drugs on hepatic glucuronide formation in newbom rats and humans. Ann. N. Y. Acad. Sci., 111: 274-280, 1963.
83. Crigler, J. F., and Gold, N. I. Sodium phenobarbital-induced decrease in serum bilirubin in an infant with congenital nonhemolytic jaundice and kernicterus. J. Clin. Investig., 45: 998-999, 1966.
84. Yaffe, S. J., Levy, G., Matsuzawa, T., and Baliah, T. Enhancement of glucuronideconjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital. N. Engl. J. Med., 275: 1461-1466, 1966.
85. Maurer, H. M., Wolff, J. A., Finster, M., Poppers, P. J., Pantuck, E., Kuntzman, R., and Conney, A. H. Reduction in concentration of total serum bilirubin in offspring of women treated with phenobarbitone during pregnancy. Lancet, ii: 122-124, 1968.
86. Wattenberg, L. W. Chemoprophylaxis of carcinogenesis: a review. Cancer Res., 26: 1520-1526, 1966.
87. Wattenberg, L. W. Chemoprevention of cancer. Cancer Res., 45: 1-8, 1985.
88. Ulland, B. M., Weisburger, J. H., Yamamoto, R. S., and Weisburger, E. K. Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats. Food Cosmet. Toxicol., 11: 199-207, 1973.
89. Wattenberg, L. W. Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin. J. Natl. Cancer Inst., 48: 1425-1430, 1972.
90. Wattenberg, L. W. Inhibition of carcinogenic effects of diethylnitrosamine and 4-nitroquinoline-N-oxide by antioxidants. Fed. Proc., 31: 633, 1972.
91. Wattenberg, L. W. Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole. J. Natl. Cancer Inst., 50: 1541-1544, 1973.
92. Wattenberg, L. W., Speier, J., and Kotake, A. Effects of antioxidants on metabolism of aromatic polycyclic hydrocarbons. Adv. Enzyme Regul., 14: 313-322, 1976.
93. Speier, J. L., and Wattenberg, L. W. Alterations in microsomal metabolism of benzo[a]pyrene in mice fed butylated hydroxyanisole. J. Natl. Cancer Inst., 55: 469-472, 1975.
94. Benson, A. M., Batzinger, R. P., Ou, S. Y., Bueding, E., Cha, Y. N., and Talalay, P. Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo[a]pyrene by dietary antioxidants. Cancer Res., 38: 4486-4495, 1978.
95. Cha, Y. N., Martz, F., and Bueding, E. Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole. Cancer Res., 38: 4496-4498, 1978.
96. Benson, A. M., Cha, Y. N., Bueding, E., Heine, H. S., and Talalay, P. Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tertbutyl-4-hydroxyanisole. Cancer Res., 39: 2971-2977, 1979.
97. Benson, A. M., Hunkeler, M. J., and Talalay, P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity: Proc. Natl. Acad. Sci. USA, 77: 5216-5220, 1980.
98. Talalay, P. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors, 12: 5-11, 2000.
99. Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J., and Talalay, P. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc. Natl. Acad. Sci. USA, 98: 3404-3409, 2001.
100. Dinkova-Kostova, A. T., Abeygunawardana, C., and Talalay, P. Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. J. Med. Chem., 41: 5287-5296, 1998.
101. Talalay, P., and Fahey, J. W. Phytochemicals Phytochernicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J. Nutr., 131: 3027S-3033S, 2001.
102. Talalay, P., Dinkova-Kostova, A. T., and Holtzelaw, W. D. Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis. Adv. Enzyme Regul., 43: 121-134, 2003.
103. Ramos-Gomez, M., Kwak, M. K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., and Kensler, T. W. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl. Acad. Sci. USA, 98: 3410-3415, 2001.
104. Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., and Talalay, P. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. USA, 99: 11908-11913, 2002.
105. De Long, M. J., Dolan, P., Santamaria, A. B., and Bueding, E. 1, 2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells. Carcinogenesis (Lond.), 7: 977-980, 1986.
106. Zhang, Y., Talalay, P., Cho, C. G., and Posner, G. H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA, 89: 2399-2403, 1992.
107. Egner, P. A., Kensler, T. W., Prestera, T., Talalay, P., Libby, A. H., Joyner, H. H., and Curphey, T. J. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis (Lond.), 15: 177-181, 1994.
108. Zhang, Y., Kensler, T. W., Cho, C. G., Posner, G. H., and Talalay, P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbomyl isothiocyanates. Proc. Natl. Acad. Sci. USA, 91: 3147-3150, 1994.
109. 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1, 2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res., 51: 5501-5506, 1991.
110. Kensler, T. W., Groopman, J. D., Sutter, T. R., Curphey, T. J., and Roebuck, B. D. Development of cancer chemopreventive agents: oltipraz as a paradigm. Chem. Res. Toxicol., 12: 113-126, 1999.
111. Guo, Z., Smith, T. J., Wang, E., Sadrieh, N., Ma, Q., Thomas, P. E., and Yang, C. S. Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. Carcinogenesis (Lond.), 13: 2205-2210, 1992.
112. Guo, Z., Smith, T. J., Wang, E., Eklind, K. I., Chung, F. L., and Yang, C. S. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis (Lond.), 14: 1167-1173, 1993.
113. 1 metabolism in human hepatocytes in primary culture. Cancer Res., 55: 5574-5579, 1995.
114. Langouet, S., Furge, L. L., Kerriguy, N., Nakamura, K., Guillouzo, A., and Guengerich, F. P. Inhibition of human cytochrome P450 enzymes by 1, 2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Chem. Res. Toxicol., 13: 245-252, 2000.
115. 1 biotransformation in rat liver: implications for human chemointervention. Cancer Res., 56: 2306-2313, 1996.
116. Sofowora, G. G., Choo, E. F., Mayo, G., Shyr, Y., and Wilkinson, G. R. In vivo inhibition of human CYP1A2 activity by oltipraz. Cancer Chemother. Pharmacol., 47: 505-510, 2001.
117. 1 by oltipraz in residents of Qidong, People's Republic of China. J. Natl. Cancer Inst., 91: 347-354, 1999.
118. Kensler, T. W., Egner, P. A., Wang, J. B., Zhu, Y. R., Zhang, B. C., Qian, G. S., Kung, S. Y., Gange, S. J., Jacobson, L. P., Munoz, A., and Groopman, J. D. Strategies for chemoprevention of liver cancer. Eur. J. Cancer Prev., 11: S58-S64, 2002.
119. Williams, G. M., and Numoto, S. Promotion of mouse liver neoplasms by the organochlorine pesticides chlordane and heptachlor in comparison to dichlorodiphenyltrichloroethane. Carcinogenesis (Lond.), 5: 1689-1696, 1984.
120. Bailey, G. S., Hendricks, J. D., Shelton, D. W., Nixon, J. E., and Pawlowski, N. E. Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol. J. Natl. Cancer Inst., 78: 931-934, 1987.
121. 1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer Res., 51: 2362-2365, 1991.
122. Kim, D. J., Han, B. S., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., and Tsuda, H. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis (Lond.), 18: 377-381, 1997.
123. Dashwood, R. H. Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables? Chem. Biol. Interact., 110: 1-5, 1998.
124. 1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study. Carcinogenesis (Lond.), 20: 453-458, 1999.
125. Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., and Dashwood, R. H. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1, 2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4, 5-f]quinoline. Carcinogenesis (Lond.), 22: 309-314, 2001.
126. Stoner, G., Casto, B., Ralston, S., Roebuck, B., Pereira, C., and Bailey, G. Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol. Carcinogenesis (Lond.), 23: 265-272, 2002.
127. Zhu, B. T., Lech, J., Rosen, R. T., and Conney, A. H. Effect of dietary 2(3)-tertbutyl-4-hydroxyanisole on the metabolism and action of estradiol and estrone in female CD-1 mice. Cancer Res., 57: 2419-2427, 1997.
128. Conney, A. H., Pantuck, E. J., Hsiao, K-C., Garland, W. A., Anderson, K. E., Alvares, A. P., and Kappas, A. Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin. Pharmacol. Ther., 20: 633-642, 1976.
129. Kappas, A., Alvares, A. P., Anderson, K. E., Pantuck, E. J., Pantuck, C. B., Chang, R. L., and Conney, A. H. Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clin. Pharmacol. Ther., 23: 445-450, 1978.
130. Alvares, A. P., Anderson, K. E., Conney, A. H., and Kappas, A. Interactions between nutritional factors and drug biotransformations in man. Proc. Natl. Acad. Sci. USA, 73: 2501-2504, 1976.
131. Kappas, A., Anderson, K. E., Conney, A. H., and Alvares, A. P. Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin. Pharmacol. Ther., 20: 643-653, 1976.
132. Pantuck, E. J., Pantuck, C. B., Garland, W. A., Min, B. H., Wattenberg, L. W., Anderson, K. E., Kappas, A., and Conney, A. H. Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clin. Pharmacol. Ther., 25: 88-95, 1979.
133. Pantuck, E. J., Pantuck, C. B., Anderson, K. E., Wattenberg, L. W., Conney, A. H., and Kappas, A. Effect of brussels sprouts and cabbage on drug conjugation. Clin. Pharmacol. Ther., 35: 161-169, 1984.
134. Hoensch, H. P., Steinhardt, H. J., Weiss, G., Haug, D., Maier, A., and Malchow, H. Effects of semisynthetic diets on xenobiotic-metabolizing enzyme activity and morphology of small intestinal mucosa in humans. Gastroenterology, 86: 1519-1530, 1984.
135. Murray, S., Lake, B. G., Gray, S., Edwards, A. J., Springall, C., Bowey, E. A., Williamson, G., Boobis, A. R., and Gooderham, N. J. Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man. Carcinogenesis (Lond.), 22: 1413-1420, 2001.
136. Hecht, S. S., Chung, F. L., Richie, J. P., Jr., Akerkar, S. A., Borukhova, A., Skowronski, L., and Carmella, S. G. Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol. Biomark. Prev., 4: 877-884, 1995.
137. Hecht, S. S., Carmella, S. G., and Murphy, S. E. Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol. Biomark. Prev., 8: 907-913, 1999.
138. Chen, L., Mohr, S. N., and Yang, C. S. Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers. Clin. Pharmacol. Ther., 60: 651-660, 1996.
139. Leclercq, I., Desager, J. P., and Horsmans, Y. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin. Pharmacol. Ther., 64: 144-149, 1998.
140. Bailey, D. G., Spence, J. D., Munoz, C., and Amold, J. M. Interaction of citrus juices with felodipine and nifedipine. Lancet, 337: 268-269, 1991.
141. Lown, K. S., Bailey, D. G., Fontana, R. J., Janardan, S. K., Adair, C. H., Fortlage, L. A., Brown, M. B., Guo, W., and Watkins, P. B. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J. Clin. Investig., 99: 2545-2553, 1997.
142. Conney, A. H., and Klutch, A. Increased activity of androgen hydroxylases in liver microsomes of rats pretreated with phenobarbital and other drugs. J. Biol. Chem., 238: 1611-1617, 1963.
143. Conney, A. H., Levin, W., Jacobson, M., and Kuntzman, R. Effects of drugs and environmental chemicals on steroid metabolism. Clin. Pharmacol. Ther., 14: 727-741, 1973.
144. Levin, W., Welch, R. M., and Conney, A. H. Effect of phenobarbital and other drugs on the metabolism and uterotropic action of estradiol-17β and estrone. J. Pharmacol. Exp. Ther., 159: 362-371, 1968.
145. Levin, W., Welch, R. M., and Conney, A. H. Decreased uterotropic potency of oral contraceptives in rats pretreated with phenobarbital. Endocrinology. 83: 149-156, 1968.
146. Welch, R. M., Levin, W., Kuntzman, R., Jacobson, M., and Conney, A. H. Effect of halogenated hydrocarbon insecticides on the metabolism and uterotropic action of estrogens in rats and mice. Toxicol. Appl. Pharmacol., 19: 234-246, 1971.
147. Levin, W., Kuntzman, R., and Conney, A. H. Stimulatory effect of phenobarbital on the metabolism of the oral contraceptive 17α -ethynylestradiol-3-methyl ether (mestranol) by rat liver microsomes. Pharmacology (Basel), 19: 249-255, 1979.
148. Kuntzman, R., Sansur, M., and Conney, A. H. Effect of drugs and insecticides on the anesthetic action of steroids. Endocrinology, 77: 952-954, 1965.
149. Conney, A. H., Jacobson, M., Levin, W., Schneidman, K., and Kuntzman, R. Decreased central depressant effect of progesterone and other steroids in rats pretreated with drugs and insecticides. J. Pharmacol. Exp. Ther., 154: 310-318, 1966.
150. Levin, W., Welch, R. M., and Conney, A. H. Inhibitory effect of phenobarbital or chlordane pretreatment on the androgen-induced increase in seminal vesicle weight in the rat. Steroids, 13: 155-161, 1969.
151. Levin, W., Welch, R. M., and Conney, A. H. Increased liver microsomal androgen metabolism by phenobarbital: Correlation with decreased androgen action on the seminal vesicles of the rat. J. Pharmacol. Exp. Ther., 188: 287-292, 1974.
152. Suchar, L. A., Chang, R. L., Thomas, P. E., Rosen, R. T., Lech, J., and
153. Conney, A. H., Jacobson, M., Schneidman, K., and Kuntzman, R. Induction of liver microsomal cortisol 6-hydroxylase by diphenylhydantoin or phenobarbital: an explanation for the increased excretion of 6-hydroxycortisol in humans treated with these drugs. Life Sci., 4: 1091-1098, 1965.
154. Burstein, S., and Klaiber, E. L. Phenobarbital-induced increase in 6β-hydroxycortisol excretion: Clue to its significance in human urine. J. Endocrinol. Metab., 25: 293-296, 1965.
155. Park, B. K. Assessment of urinary 6β-hydroxycortisol as an in vivo index of mixed-function oxygenase activity. Br. J. Clin. Pharmacol., 12: 97-102, 1981.
156. Roots, I., Holbe, R., Hovermann, W., Nigam, S., Heinemeyer, G., and Hildebrandt, A. G. Quantitative determination by HPLC of urinary 6β-hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs. Eur. J. Clin. Pharmacol., 16: 63-71, 1979.
157. Werk, F. E., Jr., MacGee, J., and Sholiton, L. J. Effect of diphenylhydantoin on cortisol metabolism in man. J. Clin. Investig., 43: 1824-1835, 1964.
158. Kuntzman, R., Jacobson, M., Levin, W., and Conney, A. H. Stimulatory effect of N-phenylbarbital (phetharbital) on cortisol hydroxylation in man. Biochem. Pharmacol., 17: 565-571, 1968.
159. Poland, A., Smith, D., Kuntzman, R., Jacobson, M., and Conney, A. H. Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects. Clin. Pharmacol. Ther., 11: 724-732, 1970.
160. Southren, A. L., Gordon, G. G., Tochimoto, S., Krikun, E., Krieger, D., Jacobson, M., and Kuntzman, R. Effect of N-phenylbarbital (phetharbital) on the metabolism of testosterone and cortisol in man. J. Clin. Endocrinol. Metab., 29: 251-256, 1969.
161. Brooks, S. M., Werk, E. E., Ackerman, S. J., Sullivan, I., and Thrasher, K. Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma. N. Engl. J. Med., 286: 1125-1128, 1972.
162. Breckenridge, A. M., Back, D. J., Cross, K., Crawford, F., MacIver, M., Orme, L. E., Rowe, P. H., and Smith, E. Influence of environmental chemicals on drug therapy in humans: studies with contraceptive steroids. In: D. Evered and G. Lawrenson (eds.), Environmental Chemicals, Enzyme Function and Human Disease, Ciba Foundation symposium 76 (new series), pp. 289-306. Amsterdam: Excerpta Medica, 1980.
163. Bolt, H. M., Kappus, H., and Bolt, M. Effect of rifampicin treatment on the metabolism of oestradiol and 17α-ethinyloestradiol by human liver microsomes. Eur. J. Clin. Pharmacol., 8: 301-307, 1975.
164. Breckenridge, A. M., Back, D. J., Crawford, F. E., MacIver, M., Orme, L. E., Park, B. K., Rowe, P. H., and Smith, E. Drug interactions with contraceptive steroids. Symp. Medical Hoechst. 14: 607-613, 1979.
165. Osbome, M. P., Telang, N. T., Kaur, S., and Bradlow, H. L. Influence of chemopreventive agents on estradiol metabolism and mammary preneoplasia in the C3H mouse. Steroids, 55: 114-119, 1990.
166. Jellinck, P. H., Michnovicz, J. J., and Bradlow, H. L. Influence of indole-3-carbinol on the hepatic microsomal formation of catechol estrogens. Steroids, 56: 446-450, 1991.
167. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem. Pharmacol., 45: 1129-1136, 1993.
168. Bradlow, H. L., Michnovicz, J. J., Telang, N. T., and Osborne, M. P. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis (Lond.), 12: 1571-1574, 1991.
169. Kojima, T., Tanaka, T., and Mori, H. Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol. Cancer Res., 54: 1446-1449, 1994.
170. Welsch, C. W. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res., 45: 3415-3443, 1985.
171. Michnovicz, J. J., and Bradlow, H. L. Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutr. Cancer, 16: 59-66, 1991.
172. Bradlow, H. L., Michnovicz, J. J., Halper, M. P., Miller, D., Wong, G. Y., and Osborne, M. P. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol. Biomark. Prev., 3: 591-595, 1994.
173. Bradlow, H. L., and Michnovicz, J. J. A new approach to the prevention of breast cancer. Proc. Royal Soc. Edinburgh, 95B: 77-86, 1989.
174. Bradlow, H. L., Sepkovic, D. W., Telang, N. T., and Osborne, M. P. Indole-3-carbinol: A novel approach to breast cancer prevention. Ann. N. Y. Acad. Sci., 768: 180-200, 1995.
175. Lemon, H. M., Heidel, J. W., and Rodriguez-Sierra, J. F. Increased catechol estrogen metabolism as a risk factor for nonfamilial breast cancer. Cancer (Phila.), 69: 457-465, 1992.
176. Adlercreutz, H., Gorbach, S. L., Goldin, B. R., Woods, M. N., Dwyer, T. J., and Hamalainen, E. Estrogen metabolism and excretion in Oriental and Caucasian women. J. Natl. Cancer Inst., 86: 1076-1082, 1994.
177. Adlercreutz, H., Gorbach, S. L., Goldin, B. R., Woods, M. N., Dwyer, T. J., Hockerstedt, K., Wahala, K., Hase, T., Hamalainen, E., and Fotsis, T. Diet and urinary estrogen profile in various populations. A preliminary report. Polycyclic Arom. Comp., 6: 261-273, 1994.
178. Bjeldanes, L. F., Kim, J-Y., Grose, K. R., Bartholomew, J. C., and Bradfield, C. A. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Proc. Natl. Acad. Sci. USA, 88: 9543-9547, 1991.
179. Spink, D. C., Lincoln, D. W., 2nd, Dickerman, H. W., and Gierthy, J. F. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17β-estradiol metabolism in MCF-7 breast tumor cells. Proc. Natl. Acad. Sci. USA, 87: 6917-6921, 1990.
180. Spink, D. C., Eugster, H. P., Lincoln, D. W., 2nd, Schuetz, J. D., Schuetz, E. G., Johnson, J. A., Kaminsky, L. S., and Gierthy, J. F. 17β-estradiol hydroxylation catalyzed by human cytochrome P4501a1: a comparison of the activities induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch. Biochem. Biophys., 293: 342-348, 1992.
181. Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., Walker, N. J., and Sutter, T. R. 17β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. USA, 93: 9776-9781, 1996.
182. Li, J. J., and Li, S. A. Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism. Fed. Proc., 46: 1858-1863, 1987.
183. Liehr, J. G., and Sirbasku, D. A. Estrogen-dependent kidney tumors. In: M. Taub (ed.), Tissue Culture of Epithelial Cells, pp. 205-234. New York; Plenum Press, 1985.
184. Liehr, J. G., Fang, W. F., Sirbasku, D. A., and Ari-Ulubelen, A. Carcinogenicity of catechol estrogens in Syrian hamsters. J. Steroid Biochem., 24: 353-356, 1986.
185. Newbold, R. R., and Liehr, J. G. Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. Cancer Res., 60: 235-237, 2000.
186. Romkes, M., and Safe, S. Comparative activities of 2, 3, 7, 8-tetmchlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. Toxicol. Appl. Pharmacol., 92: 368-380, 1988.
187. Umbreit, T. H., Hesse, E. J., Macdonald, G. J., and Gallo, M. A. Effects of TCDD-estradiol interactions in three strains of mice. Toxicol. Lett., 40: 1-9, 1988.
188. DeVito, M. J., Thomas, T., Martin, E., Umbreit, T. H., and Gallo, M. A. Antiestrogenic action of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice. Toxicol. Appl. Pharmacol., 113: 284-292, 1992.
189. Gierthy, J. F., Lincoln, D. W., Gillespie, M. B., Seeger, J. I., Martinez, H. L., Dickerman, H. W., and Kumar, S. A. Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Cancer Res., 47: 6198-6203, 1987.
190. Gierthy, J. F., Bennett, J. A., Bradley, L. M., and Cutler, D. S. Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2. 3, 7, 8-tetrachlorodibenzo-p-dioxin. Cancer Res., 53: 3149-3153, 1993.
191. Zhu, B. T., and Conney, A. H. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Res., 58: 2269-2277, 1998.
192. Zhu, B. T., and Conney, A. H. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis (Lond.), 19: 1-27, 1998.
193. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., Hummel, R. A., and Humiston, C. G. Results of a two-year chronic toxicity and oncogenicity study of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol., 46: 279-303, 1978.
194. Bertazzi, P. A., Zocchetti, C., Pesatori, A. C., Guercilena, S., Sanarico, M., and Radice, L. Ten-year mortality study of the population involved in the Seveso incident in 1976. Am. J. Epidemiol., 129: 1187-1200, 1989.
195. Bertazzi, A., Pesatori, A. C., Consonni, D., Tironi, A., Landi, M. T., and Zocchetti, C. Cancer incidence in a population accidentally exposed to 2, 3, 7, 8-tetrachlorodibenzo-para-dioxin. Epidemiology, 4: 398-406, 1993.
196. Bertazzi, P. A., Consonni, D., Bachetti, S., Rubagotti, M., Baccarelli, A., Zocchetti, C., and Pesatori, A. C. Health effects of dioxin exposure: a 20-year mortality study. Am. J. Epidemiol., 153: 1031-1044, 2001.
197. Welch, R. M., Harrison, Y. E., Conney, A. H., Poppers, P. J., and Finster, M. Cigarette smoking: stimulatory effect on metabolism of 3, 4-benzpyrene by enzymes in human placenta. Science (Wash. DC), 160: 541-542, 1968.
198. Pantuck, E. J., Kuntzman, R., and Conney, A. H. Decreased concentration of phenacetin in plasma of cigarette smokers. Science (Wash. DC), 175: 1248-1250, 1972.
199. Pantuck, E. J., Hsiao, K. C., Maggio, A., Nakamura, K., Kuntzman, R., and Conney, A. H. Effect of cigarette smoking on phenacetin metabolism. Clin. Pharmacol. Ther., 15: 9-17, 1974.
200. Pasanen, M., Haaparanta, T., Sundin, M., Sivonen, P., Vakakangas, K., Raunio, H., Hines, R., Gustafsson, J. A., and Pelkonen, O. Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities. Toxicology, 62: 175-187, 1990.
201. Zhu, B. T., Cai, M. X., Spink, D. C., Hussain, M. M., Busch, C. M., Ranzini, A. C., Lai, Y. L., Lambert, G. H., Thomas, P. E., and Conney, A. H. Stimulatory effect of cigarette smoking on the 15α-hydroxylation of estradiol by human term placenta. Clin. Pharmacol. Ther., 71: 311-324, 2002.
202. Michnovicz, J. J., Hershcopf, R. J., Naganuma, H., Bradlow, H. L., and Fishman, J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N. Engl. J. Med., 315: 1305-1309, 1986.
203. Michnovicz, J. J., Naganuma, H., Hershcopf, R. J., Bradlow, H. L., and Fishman, J. Increased urinary catechol estrogen excretion in female smokers. Steroids, 52: 69-83, 1988.
204. MacMahon, B., Trichopoulos, D., Cole, P., and Brown, J. Cigarette smoking and urinary estrogens. N. Engl. J. Med., 307: 1062-1065, 1982.
205. Jensen, J., Christiansen, C., and Rodbro, P. Cigarette smoking, serum estrogens, and bone loss during hormone-replacement therapy early after menopause. N. Engl. J. Med., 313: 973-975, 1985.
206. Geisler, J., Omsjo, L. H., Helle, S. I., Ekse, D., Silsand, T., and Lonning, P. E. Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking. J. Endocrinol., 162: 265-270, 1999.
207. Sterzik, K., Strehler, E., De Santo, M., Trumpp, N., Abt, M., Rosenbusch, B., and Schneider, A. Influence of smoking on fertility in women attending an in vitro fertilization program. Fertil. Steril., 65: 810-814, 1996.
208. Key, T. J., Pike, M. C., Brown, J. B., Hermon, C., Allen, D. S., and Wang, D. Y. Cigarette smoking and urinary oestrogen excretion in premenopausal and post-menopausal women. Br. J. Cancer, 74: 1313-1316, 1996.
209. Baron, J. A. Smoking and estrogen-related disease. Am. J. Epidemiol., 119: 9-22, 1984.
210. Jensen, J., and Christiansen, C. Effects of smoking on serum lipoproteins and bone mineral content during postmenopausal hormone replacement therapy. Am. J. Obstet. Gynecol., 159: 820-825, 1988.
211. Baron, J. A., La Vecchia, C., and Levi, F. The antiestrogenic effect of cigarette smoking in women. Am. J. Obstet. Gynecol., 162: 502-514, 1990.
212. Lesko, S. M., Rosenberg, L., Kaufman, D. W., Helmrich, S. P., Miller, D. R., Strom, B., Schottenfeld, D., Rosenshein, N. B., Knapp, R. C., and Lewis, J. Cigarette smoking and the risk of endometrial cancer. N. Engl. J. Med., 313: 593-596, 1985.
213. Terry, P. D., Rohan, T. E., Franceschi, S., and Weiderpass, E. Cigarette smoking and the risk of endometrial cancer. Lancet Oncol., 3: 470-480, 2002.
214. Baron, J. A. Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious. Br. Med. Bull., 52: 58-73, 1996.
215. Khaw, K. T., Tazuke, S., and Barrett-Connor, E. Cigarette smoking and levels of adrenal androgens in postmenopausal women. N. Engl. J. Med., 318: 1705-1709, 1988.
216. Austin, H., Drews, C., and Partridge, E. E. A case-control study of endometrial cancer in relation to cigarette smoking, serum estrogen levels, and alcohol use. Am. J. Obstet. Gynecol., 169: 1086-1091, 1993.
217. Terry, P. D., and Rohan, T. E. Cigarette smoking and the risk of breast cancer in women: a review of the literature. Cancer Epidemiol. Biomark. Prev., 11: 953-971, 2002.
218. Band, P. R., Le, N. D., Fang. R., and Deschamps, M. Carcinogenic and endocrine disrupting effects of cigarette smoke and risk of breast cancer. Lancet. 360: 1044-1049, 2002.
219. Russo, I. H. Cigarette smoking and risk of breast cancer in women. Lancet, 360: 1033-1034, 2002.
220. Brunet, J. S., Ghadirian, P., Rebbeck, T. R., Lerman, C., Garber, J. E., Tonin, P. N., Abrahamson, J., Foulkes, W. D., Daly, M., Wagner-Costalas, J., Godwin, A., Olopade, O. I., Moslehi, R., Liede, A., Futreal, P. A., Weber, B. L., Lenoir, G. M., Lynch, H. T., and Narod, S. A. Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. J. Natl. Cancer Inst., 90: 761-766, 1998.
221. Baron, J. A., and Haile, R. W. Protective effect of cigarette smoking on breast cancer risk in women with BRCA1 or BRCA2 mutations. J. Natl. Cancer Inst., 90: 726-727, 1998.
222. Couch, F. J., Cerhan, J. R., Vierkant, R. A., Grabrick, D. M., Therneau, T. M., Pankratz, V. S., Hartmann, L. C., Olson, J. E., Vachon, C. M., and Sellers, T. A. Cigarette smoking increases risk for breast cancer in high-risk breast cancer families. Cancer Epidemiol. Biomark. Prev., 10: 327-332, 2001.
223. Mittler, J. C., Pogach, L., and Ertel, N. H. Effects of chronic smoking on testosterone metabolism in dogs. J. Steroid Biochem., 18: 759-763, 1983.
224. Morrison, A. S. Prostatic hypertrophy in greater Boston. J. Chronic Dis., 31: 357-362, 1978.
225. Matzkin, H., and Soloway, M. S. Cigarette smoking: a review of possible associations with benign prostatic hyperplasia and prostate cancer. Prostate, 22: 277-290, 1993.
226. Lotufo, P. A., Lee, I. M., Ajani, U. A., Hennekens, C. H., and Manson, J. E. Cigarette smoking and risk of prostate cancer in the physicians' health study (United States). Int. J. Cancer, 87: 141-144, 2000.
227. Giovannucci, E., Rimm, E. B., Ascherio, A., Colditz, G. A., Spiegelman, D., Stampfer, M. J., and Willett, W. C. Smoking and risk of total and fatal prostate cancer in United States health professionals. Cancer Epidemiol. Biomark. Prev., 8: 277-282, 1999.
228. Lumey, L. H., Pittman, B., Zang, E. A., and Wynder, E. L. Cigarette smoking and prostate cancer: no relation with six measures of lifetime smoking habits in a large case-control study among U. S. whites. Prostate, 33: 195-200, 1997.
229. Rodriguez, C., Tatham, L. M., Thun, M. J., Calle, E. E., and Heath, C. W., Jr. Smoking and fatal prostate cancer in a large cohort of adult men. Am. J. Epidemiol., 145: 466-475, 1997.
230. Platz, E. A., Rimm, E. B., Kawachi, I., Colditz, G. A., Stampfer. M. J., Willett, W. C., and Giovannucci, E. Alcohol consumption, cigarette smoking, and risk of benign prostatic hyperplasia. Am. J. Epidemiol., 149: 106-115, 1999.
231. Doll, R., and Peto, R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer. Inst., 66: 1191-1308, 1981.
232. Doll, R. The lessons of life: keynote address to the nutrition and cancer conference. Cancer Res., 52: 2024s-2029s, 1992.
233. Steinmetz, K. A., and Potter, J. D. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control, 2: 325-357, 1991.
234. Block, G., Patterson, B., and Subar, A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer, 18: 1-29, 1992.
235. Helzlsouer, K. J., Block, G., Blumberg, J., Diplock, A. T., Levine, M., Mamett, L. J., Schulplein, R. J., Spence, J. T., and Simic, M. G. Summary of the round table discussion on strategies for cancer prevention: diet, food, additives, supplements, and drugs. Cancer Res., 54: 2044s-2051s, 1994.
236. Potter, J. D. Colorectal cancer: molecules and populations. J. Natl. Cancer Inst., 91: 916-932, 1999.
237. Kim. Y-I. Nutrition and Cancer. In: B. A. Bowman and R. M. Russell (eds.). Present knowledge in nutrition. Ed. 8. pp. 573-589. Washington, D. C.: International Life Sciences Institute Press, 2001.
238. Wattenberg, L. W. Chemoprevention of cancer by naturally occurring and synthetic compounds. In: L. W. Wattenberg, M. Lipkin, C. W. Boone, and G. J. Kelloff (eds.), Cancer Chemoprevention, pp. 19-39. Boca Raton, FL: CRC Press, 1992.
239. Wattenberg, L. W. An overview of chemoprevention: current status and future prospects. Proc. Soc. Exp. Biol. Med., 216: 133-141, 1997.
240. Sporn, M. B., and Newton, D. L. Chemoprevention of cancer with retinoids. Fed. Proc., 38: 2528-2534, 1979.
241. Kamm, J. J., Dashman, T., Conney, A. H., and Burns. J. J. Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine. Proc. Natl. Acad. Sci. USA, 70: 747-749, 1973.
242. Kamm, J. J., Dashman, T., Conney, A. H., and Burns, J. J. Effect of ascorbic acid on amine-nitrite toxicity. Ann. N. Y. Acad. Sci., 258: 169-174, 1975.
243. Kuenzig, W., Chau, J., Norkus, E., Holowaschenko, H., Newmark, H., Mergens, W., and Conney, A. H. Caffeic and ferulic acid as blockers of nitrosamine formation. Carcinogenesis (Lond.), 5: 309-313, 1984.
244. Norkus, E. P., Kuenzig, W. A., Chau, J., Mergens, W. J., and Conney, A. H. Inhibitory effect of α-tocopherol on the formation of nitrosomorpholine in mice treated with morpholine and exposed to nitrogen dioxide. Carcinogenesis (Lond.). 7: 357-360, 1986.
245. 1 metabolism in human liver microsomes by naturally occurring flavonoids. Cancer Res., 41: 67-72, 1981.
246. Wood, A. W., Huang, M. T., Chang, R. L., Newmark, H. L., Lehr, R. E., Yagi, H., Sayer, J. M., Jerina, D. M., and Conney, A. H. Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid. Proc. Natl. Acad. Sci. USA, 79: 5513-5517, 1982.
247. Huang, M-T., Wood. A. W., Newmark, H. L., Sayer, J. M., Yagi, H., Jerina, D. M., and Conney, A. H. Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Carcinogenesis (Lond.). 4: 1631-1637, 1983.
248. Huang, M-T., Chang, R. L., Wood, A. W., Newmark, H. L., Sayer, J. M., Yagi. H., Jerina, D. M., and Conney, A. H. Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by tannic acid, hydroxylated anthraquinones and hydroxylated cinnamic acid derivatives. Carcinogenesis (Lond.), 6: 237-242, 1985.
249. Chopra, R. N., Chopra, I. C., Handa, K. L., and Kapur, L. D. Indigenous Drugs of India (2nd ed.), pp. 325-327. Calcutta: Dhur, 1958.
250. Nadkarni, K. M. Curcuma longa, In: K. M. Nadkarni (ed.) India Materia Medica, pp. 414-416. Bombay: Popular Prakashan Publishing, 1976.
251. Sharma, O. P. Antioxidant activity of curcumin and related compounds. Biochem. Pharmacol., 25: 1811-1812, 1976.
252. Toda, S., Miyase, T., Arichi, H., Tanizawa, H., and Takino, Y. Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem. Pharm. Bull. (Tokyo)., 33: 1725-1728, 1985.
253. Srimal, R. C., and Dhawan, B. N. Pharmacology of diferuloylmethane (curcumin), a non-steroidal anti-inflammatory agent. J. Pharm. Pharmacol., 25: 447-452, 1973.
254. Rao, T. S., Basu, N., and Siddiqui, H. H. Anti-inflammatory activity of curcumin analogues. Indian J. Med. Res., 75: 574-578, 1982.
255. Mukhopadhyay, A., Basu, N., Ghatak, N., and Gujral, P. K. Anti-inflammatory and irritant activities of curcumin analogues in rats. Agents Actions, 12: 508-515, 1982.
256. Yegnanarayan, R., Saraf, A. P., and Balwani, J. H. Comparison of anti-inflammatory activity of various extracts of Curcuma longa (Linn). Indian J. Med. Res., 64: 601-608, 1976.
257. Huang, M-T., Smart, R. C., Wong, C-Q., and Conney, A. H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-I3-acetate. Cancer Res., 48: 5941-5946, 1988.
258. Huang, M-T., Wang, Z. Y., Georgiadis, C. A., Laskin, J. D., and Conney, A. H. Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7, 12-dimethylbenz[a]anthracene. Carcinogenesis (Lond.), 13: 2183-2186, 1992.
259. Huang, M-T., Lysz, T., Ferraro, T., and Conney, A. H. Inhibitory effects of curcumin on tumor promotion and arachidonic acid metabolism in mouse epidermis. In: L. W. Wattenberg, M. Lipkin, C. W. Boone, and G. J. Kelloff (eds.), Cancer Chemoprevention, pp. 375-391. Boca Raton, FL: CRC Press, 1992.
260. Lu, Y-P., Chang, R. L., Huang, M. T., and Conney, A. H. Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis. Carcinogenesis (Lond.), 14: 293-297, 1993.
261. Huang, M-T., Ma, W., Yen, P., Xie, J-G., Han, J., Frenkel, K., Grunberger, D., and Conney, A. H. Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis (Lond.), 18: 83-88, 1997.
262. Weiss, L. C. Report on chlorogenic acid in coffee. J. Assoc. Official Agricul. Chem., 40: 350-354, 1957.
263. Huang, M-T., Ma, W., Lu, Y-P., Chang, R. L., Fisher, C., Manchand, P. S., Newmark, H. L., and Conney, A. H. Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis (Lond.), 16: 2493-2497, 1995.
264. Huang, M-T., Ma. W., Yen, P., Xie, J-G., Han, J., Frenkel, K., Grunberger, D., and Conney, A. H. Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. Carcinogenesis (Lond.), 17: 761-765, 1996.
265. Sreejayan, and Rao, M. N. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol., 46: 1013-1016, 1994.
266. Osawa, T., Ramarathnam, N., Kawakishi, S., and Namiki, M. Antioxidative defense systems generated by phenolic plant constituents. In: M-T. Huang, C-T. Ho, and C. Y. Lee (eds.), Phenolic Compounds in Food and Their Effects on Health II. Antioxidants and Cancer Prevention, Vol. Series 507, pp. 122-134, American Chemical Society Symposium, 1992.
267. Osawa, T., Sugiyama, Y., Inayoshi, M., and Kawakishi, S. Antioxidative activity of tetrahydrocurcuminoids. Biosci. Biotechnol. Biochem., 59: 1609-1612, 1995.
268. Sugiyama, Y., Kawakishi, S., and Osawa, T. Involvement of the β-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin. Biochem. Pharmacol., 52: 519-525, 1996.
269. Huang, M-T., Deschner, E. E., Newmark, H. L., Wang, Z-Y., Ferraro, T. A., and Conney, A. H. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett., 64: 117-121, 1992.
270. Huang, M-T., Lou, Y-R., Ma, W., Newmark, H. L., Reuhl, K. R., and Conney, A. H. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res., 54: 5841-5847, 1994.
271. Tanaka, T., Makita, H., Ohnishi, M., Hirose, Y., Wang, A., Mori, H., Satoh, K., Hara, A., and Ogawa, H. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of β-carotene. Cancer Res., 54: 4653-4659, 1994.
272. Rao, C. V., Rivenson, A., Simi, B., and Reddy, B. S. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res., 55: 259-266, 1995.
273. Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V., and Reddy, B. S. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res., 59: 597-601, 1999.
274. Ushida, J., Sugie, S., Kawabata, K., Pham, Q. V., Tanaka, T., Fujii, K., Takeuchi, H., Ito, Y., and Mori, H. Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Jpn. J. Cancer Res., 91: 893-898, 2000.
275. Ikezaki, S., Nishikawa, A., Furukawa, F., Kudo, K., Nakamura, H., Tamura, K., and Mori, H. Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine and sodium chloride in rats. Anticancer Res., 21: 3407-3411, 2001.
276. Mahmoud, N. N., Carothers, A. M., Grunberger, D., Bilinski, R. T., Churchill, M. R., Martucci, C., Newmark, H. L., and Bertagnolli, M. M. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis (Lond.), 21: 921-927, 2000.
277. Perkins, S., Verschoyle, R. D., Hill, K., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P., and Gescher, A. J. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol. Biomark. Prev., 11: 535-540, 2002.
278. Samaha, H. S., Kelloff, G. J., Steele, V., Rao, C. V., and Reddy, B. S. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res., 57: 1301-1305, 1997.
279. Li, N., Chen, X., Liao, J., Yang, G., Wang, S., Josephson, Y., Han, C., Chen, J., Huang, M-T., and Yang, C. S. Inhibition of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis (Lond.), 23: 1307-1313, 2002.
280. Krishnaswamy, K., Goud, V. K., Sesikeran, B., Mukundan, M. A., and Krishna, T. P. Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin. Nutr. Cancer, 30: 163-166, 1998.
281. Limtrakul, P., Lipigomgoson, S., Namwong, O., Apisariyakul, A., and Dunn, F. W. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett., 116: 197-203, 1997.
282. Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., Hsieh, C. Y., and Cheng, A. L. Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis (Lond.), 21: 331-335, 2000.
283. Inano, H., Onoda, M., Inafuku, N., Kubota, M., Kamada, Y., Osawa, T., Kobayashi, H., and Wakabayashi, K. Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis (Lond.), 21: 1835-1841, 2000.
284. Inano, H., and Onoda, M. Prevention of radiation-mammary tumors. Int. J. Radiat. Oncol. Biol. Phys., 52: 212-223, 2002.
285. Inano, H., and Onoda, M. Radioprotective action of curcumin extracted from Curcuma longa Linn: inhibitory effect on formation of urinary 8-hydroxy-2′-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. Int. J. Radiat. Oncol. Biol. Phys., 53: 735-743, 2002.
286. Inano, H., Onoda, M., Inafuku, N., Kubota, M., Kamada, Y., Osawa, T., Kobayashi, H., and Wakabayashi, K. Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. Carcinogenesis (Lond.), 20: 1011-1018, 1999.
287. Huang, M-T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., and Conney, A. H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res., 51: 813-819, 1991.
288. Zhang, F., Altorki, N. K., Mestre, J. R., Subbaramaiah, K., and Dannenberg, A. J. Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol estertreated human gastrointestinal epithelial cells. Carcinogenesis (Lond.), 20: 445-451, 1999.
289. Plummer, S. M., Holloway, K. A., Manson, M. M., Munks, R. J., Kaptein, A., Farrow, S., and Howells, L. Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex. Oncogene, 18: 6013-6020, 1999.
290. Suh, N., Luyengi, L., Fong, H. H. S., Kinghorn, A. D., and Pezzuto, J. M. Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res., 15: 233-239, 1995.
291. 3-induced differentiation in human promyelocytic leukemia HL-60 cells. Oncol. Res., 9: 19-29, 1997.
292. 3. Oncol. Res., 9: 31-39, 1997.
293. 3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr. Cancer, 33: 105-112, 1999.
294. Sohn, O. S., Surace, A., Fiala, E. S., Richie, J. P., Jr., Colosimo, S., Zang, E., and Weisburger, J. H. Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat. Xenobiotica, 24: 119-127, 1994.
295. Bu-Abbas, A., Clifford, M. N., Walker, R., and Ioannides, C. Selective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green tea. Carcinogenesis (Lond.), 15: 2575-2579, 1994.
296. Chen, L., Bondoc, F. Y., Lee, M. J., Hussin, A. H., Thomas, P. E., and Yang, C. S. Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats. Drug Metab. Dispos., 24: 529-533, 1996.
297. Khan, S. G., Katiyar, S. K., Agarwal, R., and Mukhtar, H. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res., 52: 4050-4052, 1992.
298. Tassaneeyakul, W., Birkett, D. J., McManus, M. E., Veronese, M. E., Andersson, T., Tukey, R. H., and Miners, J. O. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem. Pharmacol., 47: 1767-1776, 1994.
299. Colton, T., Gosselin, R. E., and Smith, R. P. The tolerance of coffee drinkers to caffeine. Clin. Pharmacol. Ther., 9: 31-39, 1967.
300. Robertson, D., Wade, D., Workman, R., Woosley, R. L., and Oates, J. A. Tolerance to the humoral and hemodynamic effects of caffeine in man. J. Clin. Investig., 67: 1111-1117, 1981.
301. Curatolo, P. W., and Robertson, D. The health consequences of caffeine. Ann. Intern. Med., 98: 641-653, 1983.
302. Caraco, Y., Zylber-Katz, E., Granit, L., and Levy, M. Does restriction of caffeine intake affect mixed function oxidase activity and caffeine metabolism? Biopharm. Drug Dispos., 11: 639-643, 1990.
303. Sayer, J. M., Yagi, H., Wood, A. W., Conney, A. H., and Jerina, D. M. Extremely facile reaction between the ultimate carcinogen benzo[a]pyrene-7, 8-diol-9, 10-epoxide and ellagic acid. J. Am. Chem. Soc., 104: 5562-5564, 1982.
304. Chang, R. L., Huang, M-T., Wood, A. W., Wong, C-Q., Newmark, H. L., Yagi, H., Sayer, J. M., Jerina. D. M., and Conney, A. H. Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7β, 8α-dihydroxy-9α, 10α-epoxy-7, 8, 9, 10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse. Carcinogenesis (Lond.), 6: 1127-1133, 1985.
305. Khan, W. A., Wang, Z. Y., Athar, M., Bickers, D. R., and Mukhtar, H. Inhibition of the skin tumorigenicity of (+/-)-7β, 8α -dihydroxy-9α, 10α-epoxy-7, 8, 9, 10-tetrahydrobenzo[a]pyrene by tannic acid, green tea polyphenols and quercetin in Sencar mice. Cancer Lett., 42: 7-12, 1988.
306. Jain, A. K., Shimoi, K., Nakamura, Y., Kada, T., Hara, Y., and Tomita, I. Crude tea extracts decrease the mutagenic activity of N-methyl-N′ -nitro-N-nitrosoguanidine in vitro and in intragastric tract of rats. Mutat. Res., 210: 1-8, 1989.
307. Yoshizawa, S., Horiuchi, T., Fujiki, H., Yoshida, T., Okuda, T., and Sugimura, T. Antitumor promoting activity of (-)-epigallocatechin gallate, the main constituent of "tannin" in green tea. Phytother. Res., 1: 44-47, 1987.
308. Fujita, Y., Yamane, Y., Tanaka, T., Kuwata, K., Okuzumi, J., Takahashi, T., Fujiki, H., and Okuda, T. Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N′-nitro-N-nitrosoguanidine in mouse duodenum. Jpn. J. Cancer Res., 80: 503-505, 1989.
309. Yang, C. S., and Wang, Z. Y. Tea and cancer. J. Natl. Cancer Inst., 85: 1038-1049, 1993.
310. Katiyar, S. K., and Mukhtar, H. Tea in chemoprevention of cancer: epidemiologic and experimental studies (review). Int. J. Oncol., 8: 221-238, 1996.
311. Yang, C. S., Maliakal, P., and Meng, X. Inhibition of carcinogenesis by tea. Annu. Rev. Pharmacol. Toxicol., 42: 25-54, 2002.
312. Higdon. J. V., and Frei, B. Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr., 43: 89-143, 2003.
313. Nishida, H., Omori, M., Fukutomi, Y., Ninomiya, M., Nishiwaki, S., Suganuma, M., Moriwaki, H., and Muto, Y. Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/HeNCrj mice and human hepatoma-derived PLC/PRF/5 cells. Jpn. J. Cancer Res., 85: 221-225, 1994.
314. Gupta, S., Hastak, K., Ahmad, N., Lewin, J. S., and Mukhtar, H. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc. Natl. Acad. Sci. USA, 98: 10350-10355, 2001.
315. Wang, Z. Y., Agarwal, R., Bickers, D. R., and Mukhtar, H. Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis (Lond.), 12: 1527-1530, 1991.
316. Wang, Z-Y., Huang, M-T., Ferraro, T., Wong, C-Q., Lou, Y-R., Reuhl, K., latropoulos, M., Yang, C. S., and Conney. A. H. Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res., 52: 1162-1170, 1992.
317. Wang, Z-Y., Huang, M-T., Lou, Y-R., Xie, J-G., Reuhl, K. R., Newmark, H. L., Ho, C-T., Yang, C. S., and Conney, A. H. Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7, 12-dimethylbenz[a] anthracene-initiated SKH-1 mice. Cancer Res., 54: 3428-3435, 1994.
318. Huang, M-T., Xie, J-G., Wang, Z-Y., Ho, C-T., Lou, Y-R., Wang, C-X., Hard, G. C., and Conney, A. H. Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea. Cancer Res., 57: 2623-2629, 1997.
319. Lu, Y-P., Lou, Y-R., Li, X-H., Xie, J-G., Brash, D., Huang, M-T., and Conney, A. H. Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21 (WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. Cancer Res., 60: 4785-4791, 2000.
320. Lu, Y-P., Lou, Y-R., Li, X. H., Xie, J-G., Lin, Y., Weichung, J. S., and Conney, A. H. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in mouse skin. Oncol. Res., 13: 61-70, 2002.
321. Brash, D. E., Ziegler, A., Jonason, A. S., Simon, J. A., Kunala, S., and Leffell, D. J. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J. Investig. Dermatol. Symp. Proc., 1: 136-142, 1996.
322. Lou, Y-R., Lu, Y-P., Xie, J-G., Huang, M-T., and Conney, A. H. Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light. Nutr. Cancer. 33: 146-153, 1999.
323. Lu, Y-P., Lou, Y-R., Lin, Y., Shih, W. J., Huang, M-T., Yang, C. S., and Conney, A. H. Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. Cancer Res., 61: 5002-5009, 2001.
324. Lu, Y-P., Lou, Y-R., Xie, J-G., Peng, Q-Y., Liao, J., Yang, C. S., Huang, M-T., and Conney, A. H. Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc. Natl. Acad. Sci. USA, 99: 12455-12460, 2002.
325. Chen, Z. P., Schell. J. B., Ho, C. T., and Chen, K. Y. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Lett., 129: 173-179, 1998.
326. Lin, J. K., Liang, Y. C., and Lin-Shiau, S. Y. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem. Pharmacol., 58: 911-915, 1999.
327. Ahmad, N., Cheng, P., and Mukhtar, H. Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem. Biophys. Res. Commun., 275: 328-334, 2000.
328. Fujiki, H., Suganuma, M., Okabe, S., Sueoka, N., Komori, A., Sueoka, E., Kozu, T., Tada, Y., Suga, K., Imai, K., and Nakachi, K. Cancer inhibition by green tea. Mutat. Res., 402: 307-310, 1998.
329. Tan, X., Hu, D., Li, S., Han, Y., Zhang, Y., and Zhou, D. Differences of four catechins in cell cycle arrest and induction of apoptosis in LoVo cells. Cancer Lett., 158: 1-6, 2000.
330. Hayakawa, S., Saeki, K., Sazuka, M., Suzuki, Y., Shoji, Y., Ohta, T., Kaji, K., Yuo, A., and Isemura, M. Apoptosis induction by epigallocatechin gallate involves its binding to Fas. Biochem. Biophys. Res. Commun., 285: 1102-1106, 2001.
331. Schlegel, R., and Pardee, A. B. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (Wash. DC), 232: 1264-1266, 1986.
332. Yao, S. L., Akhtar, A. J., McKenna, K. A., Bedi, G. C., Sidransky, D., Mabry, M., Ravi, R., Collector, M. I., Jones, R. J., Sharkis, S. J., Fuchs, E. J., and Bedi, A. Selective radiosensitization of p53-deficient cells by caffein-mediated activation of p34cdc2 kinase. Nat. Med., 2: 1140-1143, 1996.
333. 1 checkpoint-deficient and G1 checkpoint-competent cells. Cancer Res., 55: 1639-1642, 1995.
334. 2 delay. Cancer Res., 55: 1643-1648, 1995.
335. Musk, S. R., and Steel, G. G. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. Int. J. Radiat. Biol., 57: 1105-1112, 1990.
336. Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M., and Abraham, R. T. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res., 59: 4375-4382, 1999.
337. Higuchi, K., Mitsuhashi, N., Saitoh, J., Maebayashi, K., Sakurai, H., Akimoto, T., and Niibe, H. Caffeine enhanced radiosansitivity of rat tumor cells with a mutant-type p53 by inducing apoptosis in a p53-independent manner. Cancer Lett., 152: 157-162, 2000.
338. 1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl. Acad. Sci. USA, 98: 9092-9097, 2001.
339. Nghiem, P., Park, P. K., Kim Ys, Y. S., Desai, B. N., and Schreiber, S. L. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J. Biol. Chem., 277: 4428-4434, 2002.
340. Wang, Z-Y., Huang, M-T., Ho, C-T., Chang, R., Ma, W., Ferraro, T., Reuhl, K. R., Yang, C. S., and Conney, A. H. Inhibitory effect of green tea on the growth of established skin papillomas in mice. Cancer Res., 52: 6657-6665, 1992.
341. Lu, Y-P., Lou, Y-R., Xie, J-G., Yen, P., Huang, M-T., and Conney, A. H. Inhibitory effect of black tea on the growth of established skin tumors in mice: effects on tumor size, apoptosis, mitosis and bromodeoxyuridine incorporation into DNA. Carcinogenesis (Lond.), 18: 2163-2169, 1997.
342. Liao, S., Umekita, Y., Guo, J., Kokontis, J. M., and Hiipakka, R. A. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett., 96: 239-243, 1995.
343. Tsubono, Y., Nishino, Y., Komatsu, S., Hsieh, C. C., Kanemura, S., Tsuji, I., Nakatsuka, H., Fukao, A., Satoh, H., and Hisamichi, S. Green tea and the risk of gastric cancer in Japan. N. Engl. J. Med., 344: 632-636, 2001.
344. Parsons, W. D., and Neims, A. H. Effect of smoking on caffeine clearance. Clin. Pharmacol. Ther., 24: 40-45, 1978.
345. Goodman, G. E., Schaffer, S., Omenn, G. S., Chen, C., and King, I. The association between lung and prostate cancer risk, and serum micronutrients: Results and lessons learned from β-carotene and retinol efficacy trial. Cancer Epidemiol. Biomark. Prev., 12: 518-526, 2003.
346. Wang, Z. Y., Chen, L., Lee, M. J., and Yang, C. S. Tea and cancer prevention. In: J. W. Finley, D. Armstrong, S. F. Robinson, and S. Nagy (eds.), Hypernutritious Food, pp. 239-260. New Orleans: American Chemical Society Symposium, 1996.
347. Gao, Y. T., McLaughlin, J. K., Blot, W. J., Ji, B. T., Dai, Q., and Fraumeni, J. F., Jr. Reduced risk of esophageal cancer associated with green tea consumption. J. Natl. Cancer Inst., 86: 855-858, 1994.
348. Sun, C. L., Yuan, J. M., Lee, M. J., Yang, C. S., Gao, Y. T., Ross, R. K., and Yu, M. C. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. Carcinogenesis (Lond.), 23: 1497-1503, 2002.
349. Rothwell, K. Dose-related inhibition of chemical carcinogenesis in mouse skin by caffeine. Nature (Lond.), 252: 69-70, 1974.
350. Nomura, T. Diminution of tumorigenesis initiated by 4-nitroquinoline-1-oxide by post-treatment with caffeine in mice. Nature (Lond.), 260: 547-549, 1976.
351. Zajdela, F., and Latarjet, R. Ultraviolet light induction of skin carcinoma in the mouse; influence of cAMP modifying agents. Bull. Cancer (Paris)., 65: 305-313, 1978.
352. Theiss, J. C., and Shimkin, M. B. Inhibiting effect of caffeine on spontaneous and urethan-induced lung tumors in strain A mice. Cancer Res., 38: 1757-1761, 1978.
353. Nomura, T. Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine. Cancer Res., 40: 1332-1340, 1980.
354. Perchellet, J. P., and Boutwell, R. K. Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tatradecanoylphorbol-13-acetate. Cancer Res., 41: 3927-3935, 1981.
355. Nomura, T. Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice. Cancer Res., 43: 1342-1346, 1983.
356. VanderPloeg, L. C., and Welsch, C. W. Inhibition by caffeine of ovarian hormone-induced mammary gland tumorigenesis in female GR mice. Cancer Lett., 56: 245-250, 1991.
357. Hagiwara, A., Boonyaphiphat, P., Tanaka, H., Kawabe, M., Tamano, S., Kaneko, H., Matsui, M., Hirose, M., Ito, N., and Shirai, T. Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants α-tocopherol and n-tritriacontane-16, 18-dione, on 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344 rats. Jpn. J. Cancer Res., 90: 399-405, 1999.
358. Hiroshino, H., and Tanooka, H. Caffeine enhances skin tumor induction in mice. Toxicol. Lett., 4: 83-85, 1979.
359. Minton, J. P., Abou-Issa, H., Foecking, M. K., and Sriram, M. G. Caffeine and unsaturated fat diet significantly promotes DMBA-induced breast cancer in rats. Cancer (Phila.), 51: 1249-1253, 1983.
360. Welsch, C. W., Scieszka, K. M., Senn, E. R., and DeHoog, J. V. Caffeine (1, 3, 7-trimethylxanthine), a temperature promoter of DMBA-induced rat mammary gland carcinogenesis. Int. J. Cancer, 32: 479-484, 1983.
361. Nagasawa, H., and Konishi, R. Stimulation by caffeine of spontaneous mammary tumorigenesis in mice. Eur. J. Cancer Clin. Oncol., 24: 803-805, 1988.
362. Welsch, C. W., DeHoog, J. V., and O'Connor, D. H. Influence of caffeine consumption on carcinomatous and normal mammary gland development in mice. Cancer Res., 48: 2078-2082, 1988.
363. Knekt, P. Role of vitamin E in the prophylaxis of cancer. Ann. Med., 23: 3-12, 1991.
364. Knekt, P., Aromaa, A., Maatela, J., Aaran, R. K., Nikkari, T., Hakama, M., Hakulinen, T., Peto, R., and Teppo, L. Vitamin E and cancer prevention. Am. J. Clin. Nutr., 53: 283S-286S, 1991.
365. Gridley, G., McLaughlin, J. K., Block, G., Blot, W. J., Gluch, M., and Fraumeni, J. F., Jr. Vitamin supplement use and reduced risk of oral and pharyngeal cancer. Am. J. Epidemiol., 135: 1083-1092, 1992.
366. Blot, W. J., Li, J. Y., Taylor, P. R., Guo, W., Dawsey, S., Wang, G. Q., Yang, C. S., Zheng, S. F., Gail, M., and Li, G. Y. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl. Cancer Inst., 85: 1483-1492, 1993.
367. Willett, W. Diet nutrition and the prevention of cancer. In: M. E. Shils, J. A. Olson, M. Shike, and A. C. Ross (eds.), Modern Nutrition in Health and Disease, Ninth Edition, pp. 1243-1253. Baltimore, MD: Williams and Wilkins, 1998.
368. Odukoya, O., Hawach, F., and Shklar, G. Retardation of experimental oral cancer by topical vitamin E. Nutr. Cancer. 6: 98-104, 1984.
369. Slaga, T. J., and Bracken, W. M. The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase. Cancer Res., 37: 1631-1635, 1977.
370. Perchellet, J. P., Owen, M. D., Posey, T. D., Orten, D. K., and Schneider, B. A. Inhibitory effects of glutathione level-raising agents and D-α-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis (Lond.), 6: 567-573, 1985.
371. Gensler, H. L., and Magdaleno, M. Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation. Nutr. Cancer, 15: 97-106, 1991.
372. Gensler, H. L., Aickin, M., Peng, Y. M., and Xu, M. Importance of the form of topical vitamin E for prevention of photocarcinogenesis. Nutr. Cancer, 26: 183-191, 1996.
373. McIntosh, G. H. The influence of dietary vitamin E and calcium status on intestinal tumors in rats. Nutr. Cancer, 17: 47-55, 1992.
374. Mitchel, R. E., and McCann, R. Vitamin E is a complete tumor promoter in mouse skin. Carcinogenesis (Lond.), 14: 659-662, 1993.
375. Kline, K., and Sanders, B. G. Modulation of immune suppression and enhanced tumorigenesis in retrovirus tumor challenged chickens treated with vitamin E. In Vivo, 3: 161-166, 1989.
376. Nitta, Y., Kamiya, K., Tanimoto, M., Sadamoto, S., Niwa, O., and Yokoro, K. Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats. Jpn. J. Cancer Res., 82: 511-517, 1991.
377. Verma, A. K., Shapas, B. G., Rice, H. M., and Boutwell, R. K. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion. Cancer Res., 39: 419-425, 1979.
378. 3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin. Biochem. Biophys. Res. Commun., 116: 605-611, 1983.
379. Conney, A. H., Lou, Y-R., Xie, J-G., Osawa, T., Newmark, H. L., Liu, Y., Chang, R. L., and Huang, M-T. Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea. Proc. Soc. Exp. Biol. Med., 216: 234-245, 1997.
380. Verma, A. K., Conrad, E. A., and Boutwell, R. K. Differential effects of retinoic acid and 7, 8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen. Cancer Res., 42: 3519-3525, 1982.
381. 3 on the formation of skin tumors in mice treated chronically with 7, 12-dimethylbenz[a]anthracene. Biochem. Biophys. Res. Commun., 130: 924-931, 1985.
382. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med., 330: 1029-1035, 1994.
383. Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., Bamhart, S., and Hammar, S. Effects of a combination of β carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med., 334: 1150-1155, 1996.
384. Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., Willett, W., and Peto, R. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med., 334: 1145-1149, 1996.
385. Neuhouser, M. L., Patterson, R. E., Thornquist, M. D., Omenn, G. S., King, I. B., and Goodman, G. E. Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of β-carotene and retinol efficacy trial (CARET). Cancer Epidemiol. Biomark. Prev., 12: 350-358, 2003.
386. Baron, J. A., Cole, B. F., Mott, L., Haile, R., Grau, M., Church, T. R., Beck, G. J., and Greenberg, E. R. Neoplastic and antineoplastic effects of β-carotene on colorectal adenoma recurrence: results of a randomized trial. J. Natl. Cancer Inst., 95: 717-722, 2003.