The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers

Toxicology in Vitro

Volumn 25, Issue 4, 2011, Pages 785-795

  Anwar Mohamed, Anwar ^a   Degenhardt, Owen S ^a   El Gendy, Mohamed A M ^a   Seubert, John M ^a   Kleeberger, Steven R ^b   El Kadi, Ayman O S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cytochrome P450; Nrf2; Phase I metabolizing enzymes; Phase II metabolizing enzymes

Indexed keywords

CARRIER PROTEIN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1; CYTOCHROME P450 2B10; DRUG METABOLIZING ENZYME; GLUTATHIONE TRANSFERASE; LIVER PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; NUCLEAR RECEPTOR COACTIVATOR 2; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; PREGNANE X RECEPTOR; PROTEIN NCOR1; PROTEIN NCOR2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; REPRESSOR PROTEIN; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AHR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CATALYSIS; CONTROLLED STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALS; BIOLOGICAL TRANSPORT; CYTOCHROME P-450 ENZYME SYSTEM; ENZYMES; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; NUCLEAR RECEPTOR CO-REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 2; RNA, MESSENGER;

MUS;

EID: 79955466298     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.01.014     Document Type: Article

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