-
1
-
-
34548448413
-
Two phases of palmitate-induced insulin resistance in skeletal muscle: Impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity
-
Alkhateeb H, Chabowski A, Glatz JF, Luiken JF, Bonen A. Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity. Am J Physiol Endocrinol Metab 293: E783-E793, 2007.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Alkhateeb, H.1
Chabowski, A.2
Glatz, J.F.3
Luiken, J.F.4
Bonen, A.5
-
2
-
-
77955648969
-
Pathway-based identification of biomarkers for targeted therapeutics: Personalized oncology with PI3K pathway inhibitors
-
Andersen JN, Sathyanarayanan S, Di BA, Chi A, Zhang T, Chen AH, Dolinski B, Kraus M, Roberts B, Arthur W, Klinghoffer RA, Gargano D, Li L, Feldman I, Lynch B, Rush J, Hendrickson RC, Blume-Jensen P, Paweletz CP. Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Sci Transl Med 2: 43ra55, 2010.
-
(2010)
Sci Transl Med
, vol.2
-
-
Andersen, J.N.1
Sathyanarayanan, S.2
Di, B.A.3
Chi, A.4
Zhang, T.5
Chen, A.H.6
Dolinski, B.7
Kraus, M.8
Roberts, B.9
Arthur, W.10
Klinghoffer, R.A.11
Gargano, D.12
Li, L.13
Feldman, I.14
Lynch, B.15
Rush, J.16
Hendrickson, R.C.17
Blume-Jensen, P.18
Paweletz, C.P.19
-
3
-
-
4344574540
-
Large-scale characterization of HeLa cell nuclear phosphoproteins
-
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci USA 101: 12130-12135, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12130-12135
-
-
Beausoleil, S.A.1
Jedrychowski, M.2
Schwartz, D.3
Elias, J.E.4
Villen, J.5
Li, J.6
Cohn, M.A.7
Cantley, L.C.8
Gygi, S.P.9
-
4
-
-
77957596001
-
Discovery of pyrrolopyrimidine inhibitors of Akt
-
Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ. Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg Med Chem Lett 20: 5607-5612, 2010.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 5607-5612
-
-
Blake, J.F.1
Kallan, N.C.2
Xiao, D.3
Xu, R.4
Bencsik, J.R.5
Skelton, N.J.6
Spencer, K.L.7
Mitchell, I.S.8
Woessner, R.D.9
Gloor, S.L.10
Risom, T.11
Gross, S.D.12
Martinson, M.13
Morales, T.H.14
Vigers, G.P.15
Brandhuber, B.J.16
-
5
-
-
77954830905
-
cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4
-
Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP. cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24: 1453-1468, 2010.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1453-1468
-
-
Blancquaert, S.1
Wang, L.2
Paternot, S.3
Coulonval, K.4
Dumont, J.E.5
Harris, T.E.6
Roger, P.P.7
-
6
-
-
77949390747
-
BacMam-enabled LanthaScreen cellular assays for PI3K/Akt pathway compound profiling in disease-relevant cell backgrounds
-
Carlson CB, Mashock MJ, Bi K. BacMam-enabled LanthaScreen cellular assays for PI3K/Akt pathway compound profiling in disease-relevant cell backgrounds. J Biomol Screen 15: 327-334, 2010.
-
(2010)
J Biomol Screen
, vol.15
, pp. 327-334
-
-
Carlson, C.B.1
Mashock, M.J.2
Bi, K.3
-
7
-
-
0036713098
-
Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc
-
Chern JJ, Choi KW. Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129: 4005-4013, 2002.
-
(2002)
Development
, vol.129
, pp. 4005-4013
-
-
Chern, J.J.1
Choi, K.W.2
-
8
-
-
79955864040
-
High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy
-
Das F, Dey N, Venkatesan B, Kasinath BS, Ghosh-Choudhury N, Choudhury GG. High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy. Cell Signal 23: 1311-1319, 2011.
-
(2011)
Cell Signal
, vol.23
, pp. 1311-1319
-
-
Das, F.1
Dey, N.2
Venkatesan, B.3
Kasinath, B.S.4
Ghosh-Choudhury, N.5
Choudhury, G.G.6
-
9
-
-
79959597793
-
Phos-phoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1)
-
Demirkan G, Yu K, Boylan JM, Salomon AR, Gruppuso PA. Phos-phoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1). PLoS One 6: e21729, 2011.
-
(2011)
PLoS One
, vol.6
-
-
Demirkan, G.1
Yu, K.2
Boylan, J.M.3
Salomon, A.R.4
Gruppuso, P.A.5
-
10
-
-
79960418116
-
MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes
-
Dey N, Das F, Mariappan MM, Mandal CC, Ghosh-Choudhury N, Kasinath BS, Choudhury GG. MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. J Biol Chem 286: 25586-25603, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 25586-25603
-
-
Dey, N.1
Das, F.2
Mariappan, M.M.3
Mandal, C.C.4
Ghosh-Choudhury, N.5
Kasinath, B.S.6
Choudhury, G.G.7
-
11
-
-
77956528177
-
PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy
-
Dey N, Ghosh-Choudhury N, Das F, Li X, Venkatesan B, Barnes JL, Kasinath BS, Ghosh CG. PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy. J Cell Physiol 225: 27-41, 2010.
-
(2010)
J Cell Physiol
, vol.225
, pp. 27-41
-
-
Dey, N.1
Ghosh-Choudhury, N.2
Das, F.3
Li, X.4
Venkatesan, B.5
Barnes, J.L.6
Kasinath, B.S.7
Ghosh, C.G.8
-
12
-
-
79960349522
-
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression
-
Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol Cell Biol 31: 2787-2801, 2011.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2787-2801
-
-
Ekim, B.1
Magnuson, B.2
Acosta-Jaquez, H.A.3
Keller, J.A.4
Feener, E.P.5
Fingar, D.C.6
-
13
-
-
41649101570
-
The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
-
Fonseca BD, Lee VH, Proud CG. The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. Biochem J 411: 141-149, 2008.
-
(2008)
Biochem J
, vol.411
, pp. 141-149
-
-
Fonseca, B.D.1
Lee, V.H.2
Proud, C.G.3
-
14
-
-
34548359244
-
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
-
Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem 282: 24514-24524, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 24514-24524
-
-
Fonseca, B.D.1
Smith, E.M.2
Lee, V.H.3
Mackintosh, C.4
Proud, C.G.5
-
15
-
-
62149090949
-
BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma
-
Gaitonde S, De SK, Tcherpakov M, Dewing A, Yuan H, Riel-Mehan M, Krajewski S, Robertson G, Pellecchia M, Ronai Z. BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma. Pigment Cell Melanoma Res 22: 187-195, 2009.
-
(2009)
Pigment Cell Melanoma Res
, vol.22
, pp. 187-195
-
-
Gaitonde, S.1
De, S.K.2
Tcherpakov, M.3
Dewing, A.4
Yuan, H.5
Riel-Mehan, M.6
Krajewski, S.7
Robertson, G.8
Pellecchia, M.9
Ronai, Z.10
-
16
-
-
77957823928
-
Activation of mTOR and RhoA is a major mechanism by which Ceramide 1-phosphate stimulates macrophage proliferation
-
Gangoiti P, Arana L, Ouro A, Granado MH, Trueba M, Gómez-Muñoz A. Activation of mTOR and RhoA is a major mechanism by which Ceramide 1-phosphate stimulates macrophage proliferation. Cell Signal 23: 27-34, 2011.
-
(2011)
Cell Signal
, vol.23
, pp. 27-34
-
-
Gangoiti, P.1
Arana, L.2
Ouro, A.3
Granado, M.H.4
Trueba, M.5
Gómez-Muñoz, A.6
-
17
-
-
49849098119
-
Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies
-
Garcia JA, Danielpour D. Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies. Mol Cancer Ther 7: 1347-1354, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1347-1354
-
-
Garcia, J.A.1
Danielpour, D.2
-
18
-
-
0036905341
-
Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells
-
Harthill JE, Pozuelo RM, Milne FC, MacKintosh C. Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells. Biochem J 368: 565-572, 2002.
-
(2002)
Biochem J
, vol.368
, pp. 565-572
-
-
Harthill, J.E.1
Pozuelo, R.M.2
Milne, F.C.3
Mackintosh, C.4
-
19
-
-
77951728579
-
Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction
-
Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH. Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. J Cell Biochem 109: 1172-1184, 2010.
-
(2010)
J Cell Biochem
, vol.109
, pp. 1172-1184
-
-
Hong-Brown, L.Q.1
Brown, C.R.2
Kazi, A.A.3
Huber, D.S.4
Pruznak, A.M.5
Lang, C.H.6
-
20
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332: 1317-1322, 2011.
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
Peterson, T.R.7
Choi, Y.8
Gray, N.S.9
Yaffe, M.B.10
Marto, J.A.11
Sabatini, D.M.12
-
21
-
-
26044474979
-
Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis
-
Huang B, Porter G. Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis. Acta Pharmacol Sin 26: 1253-1258, 2005.
-
(2005)
Acta Pharmacol Sin
, vol.26
, pp. 1253-1258
-
-
Huang, B.1
Porter, G.2
-
22
-
-
37549054706
-
Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients
-
Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM, Meinders AE. Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia 51: 309-319, 2008.
-
(2008)
Diabetologia
, vol.51
, pp. 309-319
-
-
Jazet, I.M.1
Schaart, G.2
Gastaldelli, A.3
Ferrannini, E.4
Hesselink, M.K.5
Schrauwen, P.6
Romijn, J.A.7
Maassen, J.A.8
Pijl, H.9
Ouwens, D.M.10
Meinders, A.E.11
-
23
-
-
61349084198
-
Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas
-
Johnson MD, O'Connell M, Vito F, Bakos RS. Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas. J Neurooncol 92: 129-136, 2009.
-
(2009)
J Neurooncol
, vol.92
, pp. 129-136
-
-
Johnson, M.D.1
O'Connell, M.2
Vito, F.3
Bakos, R.S.4
-
24
-
-
77952018605
-
Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway
-
Johnson MD, O'Connell MJ, Pilcher W, Reeder JE. Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway. J Neurosurg 112: 934-939, 2010.
-
(2010)
J Neurosurg
, vol.112
, pp. 934-939
-
-
Johnson, M.D.1
O'Connell, M.J.2
Pilcher, W.3
Reeder, J.E.4
-
25
-
-
77956626055
-
PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts
-
Kazi AA, Lang CH. PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts. Mol Med 16: 359-371, 2010.
-
(2010)
Mol Med
, vol.16
, pp. 359-371
-
-
Kazi, A.A.1
Lang, C.H.2
-
26
-
-
79959409830
-
Amino acid signaling in TOR activation
-
Kim J, Guan KL. Amino acid signaling in TOR activation. Annu Rev Biochem 80: 1001-1032, 2011.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 1001-1032
-
-
Kim, J.1
Guan, K.L.2
-
27
-
-
80155141166
-
PIM1-activated PRAS40 regulates radioresis-tance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases
-
Kim W, Youn H, Seong KM, Yang HJ, Yun YJ, Kwon T, Kim YH, Lee JY, Jin YW, Youn B. PIM1-activated PRAS40 regulates radioresis-tance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases. Radiat Res 176: 539-552, 2011.
-
(2011)
Radiat Res
, vol.176
, pp. 539-552
-
-
Kim, W.1
Youn, H.2
Seong, K.M.3
Yang, H.J.4
Yun, Y.J.5
Kwon, T.6
Kim, Y.H.7
Lee, J.Y.8
Jin, Y.W.9
Youn, B.10
-
28
-
-
0037855834
-
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
-
Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem 278: 10189-10194, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 10189-10194
-
-
Kovacina, K.S.1
Park, G.Y.2
Bae, S.S.3
Guzzetta, A.W.4
Schaefer, E.5
Birnbaum, M.J.6
Roth, R.A.7
-
29
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr Biol 19: R1046-R1052, 2009.
-
(2009)
Curr Biol
, vol.19
-
-
Laplante, M.1
Sabatini, D.M.2
-
31
-
-
57349116906
-
Rapamycin does not improve insulin sensitivity despite elevated mamma-lian target of rapamycin complex 1 activity in muscles of ob/ob mice
-
Miller AM, Brestoff JR, Phelps CB, Berk EZ, Reynolds TH, 4th. Rapamycin does not improve insulin sensitivity despite elevated mamma-lian target of rapamycin complex 1 activity in muscles of ob/ob mice. Am J Physiol Regul Integr Comp Physiol 295: R1431-R1438, 2008.
-
(2008)
Am J Physiol Regul Integr Comp Physiol
, vol.295
-
-
Miller, A.M.1
Brestoff, J.R.2
Phelps, C.B.3
Berk, E.Z.4
Reynolds, T.H.5
-
32
-
-
33845513785
-
Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats
-
Nascimento EB, Fodor M, van der Zon GC, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, Diamant M, Ouwens DM. Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 55: 3221-3228, 2006.
-
(2006)
Diabetes
, vol.55
, pp. 3221-3228
-
-
Nascimento, E.B.1
Fodor, M.2
van der Zon, G.C.3
Jazet, I.M.4
Meinders, A.E.5
Voshol, P.J.6
Vlasblom, R.7
Baan, B.8
Eckel, J.9
Maassen, J.A.10
Diamant, M.11
Ouwens, D.M.12
-
33
-
-
70449397351
-
PRAS40: Target or modulator of mTORC1 signalling and insulin action?
-
Nascimento EB, Ouwens DM. PRAS40: target or modulator of mTORC1 signalling and insulin action? Arch Physiol Biochem 115: 163-175, 2009.
-
(2009)
Arch Physiol Biochem
, vol.115
, pp. 163-175
-
-
Nascimento, E.B.1
Ouwens, D.M.2
-
34
-
-
77949912176
-
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1
-
Nascimento EB, Snel M, Guigas B, van der Zon GC, Kriek J, Maassen JA, Jazet IM, Diamant M, Ouwens DM. Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cell Signal 22: 961-967, 2010.
-
(2010)
Cell Signal
, vol.22
, pp. 961-967
-
-
Nascimento, E.B.1
Snel, M.2
Guigas, B.3
van der Zon, G.C.4
Kriek, J.5
Maassen, J.A.6
Jazet, I.M.7
Diamant, M.8
Ouwens, D.M.9
-
35
-
-
34547133519
-
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
-
Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 282: 20329-20339, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 20329-20339
-
-
Oshiro, N.1
Takahashi, R.2
Yoshino, K.3
Tanimura, K.4
Nakashima, A.5
Eguchi, S.6
Miyamoto, T.7
Hara, K.8
Takehana, K.9
Avruch, J.10
Kikkawa, U.11
Yonezawa, K.12
-
36
-
-
34547699873
-
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification
-
Ouwens DM, Diamant M, Fodor M, Habets DD, Pelsers MM, El Hasnaoui M, Dang ZC, van den Brom CE, Vlasblom R, Rietdijk A, Boer C, Coort SL, Glatz JF, Luiken JJ. Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia 50: 1938-1948, 2007.
-
(2007)
Diabetologia
, vol.50
, pp. 1938-1948
-
-
Ouwens, D.M.1
Diamant, M.2
Fodor, M.3
Habets, D.D.4
Pelsers, M.M.5
El Hasnaoui, M.6
Dang, Z.C.7
van den Brom, C.E.8
Vlasblom, R.9
Rietdijk, A.10
Boer, C.11
Coort, S.L.12
Glatz, J.F.13
Luiken, J.J.14
-
37
-
-
84855970149
-
Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila
-
Pallares-Cartes C, Cakan-Akdogan G, Teleman AA. Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila. Dev Cell 22: 172-182, 2012.
-
(2012)
Dev Cell
, vol.22
, pp. 172-182
-
-
Pallares-Cartes, C.1
Cakan-Akdogan, G.2
Teleman, A.A.3
-
38
-
-
80055073635
-
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamy-cin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling
-
Rapley J, Oshiro N, Ortiz-Vega S, Avruch J. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamy-cin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J Biol Chem 286: 38043-38053, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 38043-38053
-
-
Rapley, J.1
Oshiro, N.2
Ortiz-Vega, S.3
Avruch, J.4
-
39
-
-
42049115641
-
Characterization of an Akt kinase inhibitor with potent pharmacody-namic and antitumor activity
-
Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, McConnell RT, Gilmer TM, Zhang SY, Robell K, Ka-hana JA, Geske RS, Kleymenova EV, Choudhry AE, Lai Z, Leber JD, Minthorn EA, Strum SL, Wood ER, Huang PS, Copeland RA, Kumar R. Characterization of an Akt kinase inhibitor with potent pharmacody-namic and antitumor activity. Cancer Res 68: 2366-2374, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 2366-2374
-
-
Rhodes, N.1
Heerding, D.A.2
Duckett, D.R.3
Eberwein, D.J.4
Knick, V.B.5
Lansing, T.J.6
McConnell, R.T.7
Gilmer, T.M.8
Zhang, S.Y.9
Robell, K.10
Ka-Hana, J.A.11
Geske, R.S.12
Kleymenova, E.V.13
Choudhry, A.E.14
Lai, Z.15
Leber, J.D.16
Minthorn, E.A.17
Strum, S.L.18
Wood, E.R.19
Huang, P.S.20
Copeland, R.A.21
Kumar, R.22
more..
-
40
-
-
33644858950
-
Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia
-
Saito A, Hayashi T, Okuno S, Nishi T, Chan PH. Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Stroke 37: 513-517, 2006.
-
(2006)
Stroke
, vol.37
, pp. 513-517
-
-
Saito, A.1
Hayashi, T.2
Okuno, S.3
Nishi, T.4
Chan, P.H.5
-
41
-
-
1242274413
-
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: Relationships with nerve growth factor
-
Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. J Neurosci 24: 1584-1593, 2004.
-
(2004)
J Neurosci
, vol.24
, pp. 1584-1593
-
-
Saito, A.1
Narasimhan, P.2
Hayashi, T.3
Okuno, S.4
Ferrand-Drake, M.5
Chan, P.H.6
-
42
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25: 903-915, 2007.
-
(2007)
Mol Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
43
-
-
77949853349
-
Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation
-
Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. Am J Physiol Endo-crinol Metab 298: E761-E769, 2010.
-
(2010)
Am J Physiol Endo-crinol Metab
, vol.298
-
-
Sanchez Canedo, C.1
Demeulder, B.2
Ginion, A.3
Bayascas, J.R.4
Balligand, J.L.5
Alessi, D.R.6
Vanoverschelde, J.L.7
Beauloye, C.8
Hue, L.9
Bertrand, L.10
-
44
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
45
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40: 310-322, 2010.
-
(2010)
Mol Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
46
-
-
33846084612
-
Lobe and Serrate are required for cell survival during early eye development in Drosophila
-
Singh A, Shi X, Choi KW. Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development 133: 4771-4781, 2006.
-
(2006)
Development
, vol.133
, pp. 4771-4781
-
-
Singh, A.1
Shi, X.2
Choi, K.W.3
-
47
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96, 2006.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
48
-
-
0036181011
-
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif
-
Tee AR, Proud CG. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol Cell Biol 22: 1674-1683, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1674-1683
-
-
Tee, A.R.1
Proud, C.G.2
-
49
-
-
43249124698
-
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
-
Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jeno P, Arrieu-merlou C, Hall MN. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One 2: e1217, 2007.
-
(2007)
PLoS One
, vol.2
-
-
Thedieck, K.1
Polak, P.2
Kim, M.L.3
Molle, K.D.4
Cohen, A.5
Jeno, P.6
Arrieu-Merlou, C.7
Hall, M.N.8
-
50
-
-
62849111751
-
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin
-
Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol 29: 1411-1420, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1411-1420
-
-
Toschi, A.1
Lee, E.2
Xu, L.3
Garcia, A.4
Gadir, N.5
Foster, D.A.6
-
51
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9: 316-323, 2007.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 316-323
-
-
Vander Haar, E.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
52
-
-
80755190061
-
Proline-rich Akt substrate of 40kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway
-
Wang H, Zhang Q, Wen Q, Zheng Y, Philip L, Jiang H, Lin J, Zheng W. Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway. Cell Signal 24: 17-24, 2012.
-
(2012)
Cell Signal
, vol.24
, pp. 17-24
-
-
Wang, H.1
Zhang, Q.2
Wen, Q.3
Zheng, Y.4
Philip, L.5
Jiang, H.6
Lin, J.7
Zheng, W.8
-
53
-
-
47049127002
-
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamy-cin complex 1 (mTORC1)-mediated phosphorylation
-
Wang L, Harris TE, Lawrence JC Jr. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamy-cin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 283: 15619-15627, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 15619-15627
-
-
Wang, L.1
Harris, T.E.2
Lawrence, J.C.3
-
54
-
-
34547099855
-
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
-
Wang L, Harris TE, Roth RA, Lawrence JC Jr. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282: 20036-20044, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 20036-20044
-
-
Wang, L.1
Harris, T.E.2
Roth, R.A.3
Lawrence, J.C.4
-
55
-
-
70349478708
-
Reduction of Lobe leads to TORC1 hypoactiva-tion that induces ectopic Jak/STAT signaling to impair Drosophila eye development
-
Wang YH, Huang ML. Reduction of Lobe leads to TORC1 hypoactiva-tion that induces ectopic Jak/STAT signaling to impair Drosophila eye development. Mech Dev 126: 781-790, 2009.
-
(2009)
Mech Dev
, vol.126
, pp. 781-790
-
-
Wang, Y.H.1
Huang, M.L.2
-
56
-
-
79951815611
-
Preclinical pharmacology, antitu-mor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930
-
Yap TA, Walton MI, Hunter LJ, Valenti M, de Haven BA, Eve PD, Ruddle R, Heaton SP, Henley A, Pickard L, Vijayaraghavan G, Caldwell JJ, Thompson NT, Aherne W, Raynaud FI, Eccles SA, Workman P, Collins I, Garrett MD. Preclinical pharmacology, antitu-mor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther 10: 360-371, 2011.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 360-371
-
-
Yap, T.A.1
Walton, M.I.2
Hunter, L.J.3
Valenti, M.4
de Haven, B.A.5
Eve, P.D.6
Ruddle, R.7
Heaton, S.P.8
Henley, A.9
Pickard, L.10
Vijayaraghavan, G.11
Caldwell, J.J.12
Thompson, N.T.13
Aherne, W.14
Raynaud, F.I.15
Eccles, S.A.16
Workman, P.17
Collins, I.18
Garrett, M.D.19
-
57
-
-
77953091045
-
Structure of the human mTOR complex I and its implications for rapamycin inhibition
-
Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell 38: 768-774, 2010.
-
(2010)
Mol Cell
, vol.38
, pp. 768-774
-
-
Yip, C.K.1
Murata, K.2
Walz, T.3
Sabatini, D.M.4
Kang, S.A.5
-
58
-
-
37549001405
-
Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury
-
Yu F, Narasimhan P, Saito A, Liu J, Chan PH. Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury. J Cereb Blood Flow Metab 28: 44-52, 2008.
-
(2008)
J Cereb Blood Flow Metab
, vol.28
, pp. 44-52
-
-
Yu, F.1
Narasimhan, P.2
Saito, A.3
Liu, J.4
Chan, P.H.5
-
59
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villen J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332: 1322-1326, 2011.
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
Villen, J.6
Kubica, N.7
Hoffman, G.R.8
Cantley, L.C.9
Gygi, S.P.10
Blenis, J.11
-
60
-
-
68149158207
-
PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells
-
Zhang F, Beharry ZM, Harris TE, Lilly MB, Smith CD, Mahajan S, Kraft AS. PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells. Cancer Biol Ther 8: 846-853, 2009.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 846-853
-
-
Zhang, F.1
Beharry, Z.M.2
Harris, T.E.3
Lilly, M.B.4
Smith, C.D.5
Mahajan, S.6
Kraft, A.S.7
-
61
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35, 2011.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|