Discovery of pyrrolopyrimidine inhibitors of Akt

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5607-5612

  Blake, James F ^a   Kallan, Nicholas C ^a   Xiao, Dengming ^a   Xu, Rui ^a   Bencsik, Josef R ^a   Skelton, Nicholas J ^b   Spencer, Keith L ^a   Mitchell, Ian S ^a   Woessner, Richard D ^a   Gloor, Susan L ^a   Risom, Tyler ^a   Gross, Stefan D ^a   Martinson, Matthew ^a   Morales, Tony H ^a   Vigers, Guy P A ^a   Brandhuber, Barbara J ^a  

^a ARRAY BIOPHARMA INC   (United States)

^b GENENTECH INC   (United States)

Author keywords

Akt kinase inhibitors

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PYRROLOPYRIMIDINE DERIVATIVE;

ARTICLE; CELL STRAIN LNCAP; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; TUMOR XENOGRAFT;

ANIMALS; BINDING SITES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; PHOSPHOPROTEINS; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77957596001     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.053     Document Type: Article

References (18)

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