Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway

Journal of Neurosurgery

Volumn 112, Issue 5, 2010, Pages 934-939

  Johnson, Mahlon D ^a   O'Connell, Mary J ^a   Pilcher, Webster ^a   Reeder, Jay E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Acidic fibroblast growth factor; Akt; Fibroblast growth factor receptor; Fibroblast growth factor 1; Meningioma; Mitogen activated protein kinase; STAT3

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; EXON; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MENINGIOMA; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL PROLIFERATION; FEMALE; HUMANS; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; POINT MUTATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; WORLD HEALTH ORGANIZATION;

EID: 77952018605     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2009.7.JNS09726     Document Type: Article

References (36)

1. Adams EF, Schrell UMH, Thieruf P, White MC, Fahlbusch R: Autocrine control of human meningioma proliferation: secretion of platelet-derived growth factor-like molecules. Int J Cancer 49:398-402, 1991
2. Chesi M, Nardini E, Brents LA, Schröck E, Reid T, Kuehl WM, et al: Frequent translocation t(4;14) (p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 16:260-264, 1997 (Pubitemid 27280209)
3. Crowell JA, Steele VE, Fay JR: Targeting the Akt protein kinase for cancer chemoprevention. Mol Cancer Ther 6:2139-2418, 2007
4. Dickson C, Spencer-Dene B, Fantl V: Tyrosine kinase signaling in breast cancer: fibroblast growth factors and their receptors. Breast Cancer Res 2:191-196, 2000 (Pubitemid 32223584)
5. Eswarakumar VP, Lax I, Schlessinger J: Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16:139-149, 2005 (Pubitemid 40616112)
6. Ford-Perriss M, Abud H, Murphy M: Fibroblast growth factors in the developing central nervous system. Clin Exp Pharmacol Physiol 28:493-503, 2001 (Pubitemid 32588423)
7. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G: Structural characteristics and biological functions of fibroblast growth factor. Endocr Rev 8:95-114, 1987 (Pubitemid 18012921)
8. Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ: Transformation and STAT activation by derivatives of FGFR1, FGFR3 and FGFR4. Oncogene 19:3309-3320, 2000
9. Jang JH, Shin KH, Park JG: Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with gastric and colorectal cancers. Cancer Res 61:3541-3543, 2001
10. Johnson M, Toms S: Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy? J Neuropathol Exp Neurol 64:1029-1036, 2005 (Pubitemid 43755396)
11. Johnson MD, Horiba M, Arteaga C: The epidermal growth factor receptor is associated with phospholipase C γ in meningiomas. Hum Pathol 25:146-153, 1994 (Pubitemid 24079634)
12. Johnson MD, Okedli E, Woodard A, Toms SA, Allen GS: Evidence for phosphatidylinositol 3-kinase Akt-p70S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in human meningioma cells. J Neurosurg 97:668-675, 2002 (Pubitemid 34994385)
13. Johnson MD, Woodard A, Kim P, Frexes-Steed M: Evidence for mitogen-associated protein kinase activation and transduction of mitogenic signals by platelet-derived growth factor in human meningioma cells. J Neurosurg 94:293-300, 2001 (Pubitemid 32799692)
14. Jones NR, Rossi ML, Gregoriou M, Hughes JT: Epidermal growth factor receptor expression in 72 meningiomas. Cancer 66:152-155, 1990 (Pubitemid 20197100)
15. Kwabi-Addo B, Ozen M, Ittmann M: The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer 11:709-724, 2004 (Pubitemid 40065546)
16. L'Hôte CG, Knowles MA: Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp Cell Res 304:417-431, 2004
17. Maxwell M, Galanopoulos T, Hedley-Whyte ET, Black PM, Antoniades HN: Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products. Int J Cancer 46:16-21, 1990 (Pubitemid 20225781)
18. McKay MM, Morrison DK: Integrating signals from RTKs to ERK/MAPK. Oncogene 26:3113-3121, 2007
19. Meloche S, Pouyssegur J: The ERK 1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26:3227-3239, 2007 (Pubitemid 46763017)
20. Munro NP, Knowles MA: Fibroblast growth factors and their receptors in transitional carcinoma. J Urol 169:675-682, 2003 (Pubitemid 36133021)
21. Onose H, Emoto N, Sugihara H, Shimizu K, Wakabayashi I: Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. Eur J Endocrinol 140:169-173, 1999 (Pubitemid 29090447)
22. Paulus W, Grothe C, Sensenbrenner M, Janet T, Baur I, Graf M, et al: Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors. Acta Neuropathol 79:418-423, 1990 (Pubitemid 20048450)
23. Perry A, Louis DN, Scheithauer BW, Budka H, von Deimling A: Meningiomas, in Louis DN, Ohgaki H, Wiestler OD, et al (eds): Tumours of the Nervous System. Geneva: WHO Press, 2007, pp 164-172
24. Shamah SM, Alberta JA, Giannobile WV, Guha A, Kwon YK, Carroll RS: Detection of activated platelet-derived growth factor receptors in human meningioma. Cancer Res 57:4141-4147, 1997 (Pubitemid 27427709)
25. Sibley K, Stern P, Knowles MA: Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. Oncogene 20:4416-4418, 2001 (Pubitemid 32726885)
26. Smith JS, Lal A, Harmon-Smith M, Bollen AW, McDermott MW: Association between absence of epidermal growth factor receptor immunoreactivity and poor prognosis in patients with atypical meningiomas. J Neurosurg 106:1034-1040, 2007 (Pubitemid 46871117)
27. Takahashi JA, Mori HA, Fukumoto M, Igrashi K, Jayne M, Oda Y, et al: Gene expression of fibroblast growth factor in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues. Proc Natl Acad Sci U S A 87:5710-5714, 1990 (Pubitemid 20240357)
28. Takahashi JA, Suzui H, Yasuda Y, Ito N, Ohta M, Jayne M, et al: Gene expression of fibroblast growth factor receptors in tissues of human gliomas and meningiomas. Biochem Biophys Res Commun 177:1-7, 1991
29. Thisse B, Thisse C: Functions and regulations of fibroblastic growth factor signaling during embryonic development. Dev Biol 287:390-402, 2005 (Pubitemid 41636772)
30. Tomlinson DC, L'Hôte CG, Kennedy W, Pitt E, Knowles MA: Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines. Cancer Res 65:10441-10449, 2005 (Pubitemid 41743738)
31. Ueba T, Takahashi JA, Fukumoto M, Ohta M, Ito N, Oda Y, et al: Expression of fibroblast growth factor receptor-1 in human and meningioma tissues. Neurosurgery 34:221-225, 1994 (Pubitemid 24044098)
32. Vivanco I, Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501, 2002 (Pubitemid 37328931)
33. Wang JL, Nister M, Hermansson M, Westermark B, Ponten J: Expression of PDGF β-receptors in human meningioma cells. Int J Cancer 46:772-778, 1990
34. Weisman AS, Raguet SS, Kelly PA: Characterization of the epidermal growth factor receptor in human meningioma. Cancer Res 47:2172-2176, 1987 (Pubitemid 17074628)
35. Yi W, Chen J, Golwa FH, Xye D: Basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas. J Huazhong Univ Sci Technolog Med Sci 25:75-77, 2005 (Pubitemid 40045091)
36. Yoshimura N, Sano H, Hashiramoto A, Yamada R, Nakajima H, Kondo M, et al: The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer. Clin Immunol Immunopathol 89:28-34, 1998 (Pubitemid 28457883)