메뉴 건너뛰기




Volumn 225, Issue 1, 2010, Pages 27-41

PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INITIATION FACTOR 4E BINDING PROTEIN 1; MULTIPROTEIN COMPLEX; PROLINE RICH AKT SUBSTRATE OF 40 KDA PROTEIN; PROLINE RICH PROTEIN; S6 KINASE; TORC1 PROTEIN; UNCLASSIFIED DRUG;

EID: 77956528177     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22186     Document Type: Article
Times cited : (44)

References (87)
  • 2
    • 0033057938 scopus 로고    scopus 로고
    • Expression of embryonic fibronectin isoform EIIIA parallels alpha-smooth muscle actin in maturing and diseased kidney
    • Barnes VL, Musa J, Mitchell RJ, Barnes JL. 1999. Expression of embryonic fibronectin isoform EIIIA parallels alpha-smooth muscle actin in maturing and diseased kidney. J Histochem Cytochem 47:787-798.
    • (1999) J Histochem Cytochem , vol.47 , pp. 787-798
    • Barnes, V.L.1    Musa, J.2    Mitchell, R.J.3    Barnes, J.L.4
  • 3
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96:4240-4245.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 4
    • 0033850165 scopus 로고    scopus 로고
    • The need for early predictors of diabetic nephropathy risk: Is albumin excretion rate sufficient?
    • Caramori ML, Fioretto P, Mauer M. 2000. The need for early predictors of diabetic nephropathy risk: Is albumin excretion rate sufficient? Diabetes 49:1399-1408.
    • (2000) Diabetes , vol.49 , pp. 1399-1408
    • Caramori, M.L.1    Fioretto, P.2    Mauer, M.3
  • 5
    • 23944491271 scopus 로고    scopus 로고
    • Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
    • Chen JK, Chen J, Neilson EG, Harris RC. 2005. Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol 16:1384-1391.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1384-1391
    • Chen, J.K.1    Chen, J.2    Neilson, E.G.3    Harris, R.C.4
  • 6
    • 0036713098 scopus 로고    scopus 로고
    • Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc
    • Chern JJ, Choi KW. 2002. Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129:4005-4013.
    • (2002) Development , vol.129 , pp. 4005-4013
    • Chern, J.J.1    Choi, K.W.2
  • 7
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • Chiang GG, Abraham RT. 2005. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 280:25485-25490.
    • (2005) J Biol Chem , vol.280 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 8
    • 0038482156 scopus 로고    scopus 로고
    • Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
    • Choi KM, McMahon LP, Lawrence JC, Jr. 2003. Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. J Biol Chem 278:19667-19673.
    • (2003) J Biol Chem , vol.278 , pp. 19667-19673
    • Choi, K.M.1    McMahon, L.P.2    Lawrence Jr., J.C.3
  • 9
    • 0035929657 scopus 로고    scopus 로고
    • Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: Regulation of c-fos and p27(kip1) gene expression
    • Choudhury GG. 2001. Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: Regulation of c-fos and p27(kip1) gene expression. J Biol Chem 276:35636-35643.
    • (2001) J Biol Chem , vol.276 , pp. 35636-35643
    • Choudhury, G.G.1
  • 10
    • 0025741580 scopus 로고
    • A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor
    • Choudhury GG, Wang LM, Pierce J, Harvey SA, Sakaguchi AY. 1991. A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor. J Biol Chem 266:8068-8072. (Pubitemid 21906476)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.13 , pp. 8068-8072
    • Choudhury, G.G.1    Wang, L.-M.2    Pierce, J.3    Harvey, S.A.4    Sakaguchi, A.Y.5
  • 12
    • 0343200750 scopus 로고    scopus 로고
    • Association and direct activation of signal transducer and activator of transcription 1alpha by platelet-derived growth factor receptor
    • Choudhury GG, Ghosh-Choudhury N, Abboud HE. 1998. Association and direct activation of signal transducer and activator of transcription 1alpha by platelet-derived growth factor receptor. J Clin Invest 101:2751-2760.
    • (1998) J Clin Invest , vol.101 , pp. 2751-2760
    • Choudhury, G.G.1    Ghosh-Choudhury, N.2    Abboud, H.E.3
  • 13
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully M, You H, Levine AJ, Mak TW. 2006. Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192. (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 16
    • 37349112714 scopus 로고    scopus 로고
    • Akt kinase targets association of CBP with SMAD 3 to regulate TGFbeta-induced expression of plasminogen activator inhibitor-1
    • Das F, Ghosh-Choudhury N, Venkatesan B, Li X, Mahimainathan L, Choudhury GG. 2008b. Akt kinase targets association of CBP with SMAD 3 to regulate TGFbeta-induced expression of plasminogen activator inhibitor-1. J Cell Physiol 214:513-527.
    • (2008) J Cell Physiol , vol.214 , pp. 513-527
    • Das, F.1    Ghosh-Choudhury, N.2    Venkatesan, B.3    Li, X.4    Mahimainathan, L.5    Choudhury, G.G.6
  • 17
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • DOI 10.1038/sj.onc.1207542
    • Fingar DC, Blenis J. 2004. Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171. (Pubitemid 38638827)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 18
    • 34548359244 scopus 로고    scopus 로고
    • PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    • Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG. 2007. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem 282:24514-24524.
    • (2007) J Biol Chem , vol.282 , pp. 24514-24524
    • Fonseca, B.D.1    Smith, E.M.2    Lee, V.H.3    MacKintosh, C.4    Proud, C.G.5
  • 19
    • 41649101570 scopus 로고    scopus 로고
    • The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
    • Fonseca BD, Lee VH, Proud CG. 2008. The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. Biochem J 411:141-149.
    • (2008) Biochem J , vol.411 , pp. 141-149
    • Fonseca, B.D.1    Lee, V.H.2    Proud, C.G.3
  • 22
    • 0037290638 scopus 로고    scopus 로고
    • PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells
    • Ghosh Choudhury G, Lenin M, Calhaun C, Zhang JH, Abboud HE. 2003. PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells. Cell Signal 15:161-170.
    • (2003) Cell Signal , vol.15 , pp. 161-170
    • Ghosh Choudhury, G.1    Lenin, M.2    Calhaun, C.3    Zhang, J.H.4    Abboud, H.E.5
  • 23
    • 0037031854 scopus 로고    scopus 로고
    • Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
    • Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG. 2002. Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription. J Biol Chem 277:33361-33368.
    • (2002) J Biol Chem , vol.277 , pp. 33361-33368
    • Ghosh-Choudhury, N.1    Abboud, S.L.2    Nishimura, R.3    Celeste, A.4    Mahimainathan, L.5    Choudhury, G.G.6
  • 24
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. 2007. Defining the role of mTOR in cancer. Cancer Cell 12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 25
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
    • Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11:859-871.
    • (2006) Dev Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5    Moffat, J.6    Brown, M.7    Fitzgerald, K.J.8    Sabatini, D.M.9
  • 26
    • 0028932953 scopus 로고
    • Progression of renal disease and renal hypertrophy
    • Hostetter TH. 1995. Progression of renal disease and renal hypertrophy. Annu Rev Physiol 57:263-278.
    • (1995) Annu Rev Physiol , vol.57 , pp. 263-278
    • Hostetter, T.H.1
  • 27
    • 0037349373 scopus 로고    scopus 로고
    • Hyperfiltration and glomerulosclerosis
    • Hostetter TH. 2003. Hyperfiltration and glomerulosclerosis. Semin Nephrol 23:194-199.
    • (2003) Semin Nephrol , vol.23 , pp. 194-199
    • Hostetter, T.H.1
  • 28
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
    • Huang J, Manning BD. 2008. The TSC1-TSC2 complex: A molecular switchboard controlling cell growth. Biochem J 412:179-190.
    • (2008) Biochem J , vol.412 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 29
    • 26044474979 scopus 로고    scopus 로고
    • Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis
    • DOI 10.1111/j.1745-7254.2005.00184.x
    • Huang B, Porter G. 2005. Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis. Acta Pharmacol Sin 26:1253-1258. (Pubitemid 41406643)
    • (2005) Acta Pharmacologica Sinica , vol.26 , Issue.10 , pp. 1253-1258
    • Huang, B.1    Porter, G.2
  • 30
    • 0033623783 scopus 로고    scopus 로고
    • G1 kinases and transforming growth factor-beta signaling are associated with a growth pattern switch in diabetes-induced renal growth
    • Huang HC, Preisig PA. 2000. G1 kinases and transforming growth factor-beta signaling are associated with a growth pattern switch in diabetes-induced renal growth. Kidney Int 58:162-172.
    • (2000) Kidney Int , vol.58 , pp. 162-172
    • Huang, H.C.1    Preisig, P.A.2
  • 31
    • 55249083264 scopus 로고    scopus 로고
    • Role of TSC-mTOR pathway in diabetic nephropathy
    • Inoki K. 2008. Role of TSC-mTOR pathway in diabetic nephropathy. Diabetes Res Clin Pract 82:S59-S62.
    • (2008) Diabetes Res Clin Pract , vol.82
    • Inoki, K.1
  • 32
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. 2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 33
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127:125-137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huang, Q.7    Qin, J.8    Su, B.9
  • 38
    • 0034680848 scopus 로고    scopus 로고
    • Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes
    • Kong M, Mounier C, Wu J, Posner BI. 2000. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. J Biol Chem 275:36035-36042.
    • (2000) J Biol Chem , vol.275 , pp. 36035-36042
    • Kong, M.1    Mounier, C.2    Wu, J.3    Posner, B.I.4
  • 42
    • 0034109107 scopus 로고    scopus 로고
    • Molecular mechanism of diabetic nephropathy
    • Lehmann R, Schleicher ED. 2000. Molecular mechanism of diabetic nephropathy. Clin Chim Acta 297:135-144.
    • (2000) Clin Chim Acta , vol.297 , pp. 135-144
    • Lehmann, R.1    Schleicher, E.D.2
  • 45
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma XM, Blenis J. 2009. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10:307-318.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 46
    • 2442498583 scopus 로고    scopus 로고
    • Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase
    • Mahimainathan L, Choudhury GG. 2004. Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. J Biol Chem 279:15258-15268.
    • (2004) J Biol Chem , vol.279 , pp. 15258-15268
    • Mahimainathan, L.1    Choudhury, G.G.2
  • 47
    • 20844449577 scopus 로고    scopus 로고
    • EGF stimulates mesangial cell mitogenesis via PI3-kinase-mediated MAPK-dependent and AKT kinase-independent manner: Involvement of c-fos and p27Kip1
    • Mahimainathan L, Ghosh-Choudhury N, Venkatesan BA, Danda RS, Choudhury GG. 2005. EGF stimulates mesangial cell mitogenesis via PI3-kinase-mediated MAPK-dependent and AKT kinase-independent manner: Involvement of c-fos and p27Kip1. Am J Physiol Renal Physiol 289:F72-F82.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Mahimainathan, L.1    Ghosh-Choudhury, N.2    Venkatesan, B.A.3    Danda, R.S.4    Choudhury, G.G.5
  • 48
    • 33747043113 scopus 로고    scopus 로고
    • Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN
    • Mahimainathan L, Das F, Venkatesan B, Choudhury GG. 2006. Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Diabetes 55:2115-2125.
    • (2006) Diabetes , vol.55 , pp. 2115-2125
    • Mahimainathan, L.1    Das, F.2    Venkatesan, B.3    Choudhury, G.G.4
  • 50
    • 70350332198 scopus 로고    scopus 로고
    • Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation
    • Mandal CC, Ghosh Choudhury G, Ghosh-Choudhury N. 2009. Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation. Endocrinology 150:4989-4998.
    • (2009) Endocrinology , vol.150 , pp. 4989-4998
    • Mandal, C.C.1    Ghosh Choudhury, G.2    Ghosh-Choudhury, N.3
  • 53
    • 0037507252 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    • Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K. 2003. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem 278:15461-15464.
    • (2003) J Biol Chem , vol.278 , pp. 15461-15464
    • Nojima, H.1    Tokunaga, C.2    Eguchi, S.3    Oshiro, N.4    Hidayat, S.5    Yoshino, K.6    Hara, K.7    Tanaka, N.8    Avruch, J.9    Yonezawa, K.10
  • 54
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    • DOI 10.1101/gad.845700
    • Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E. 2000. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 14:2689-2694. (Pubitemid 32531195)
    • (2000) Genes and Development , vol.14 , Issue.21 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 60
    • 1242274413 scopus 로고    scopus 로고
    • Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: Relationships with nerve growth factor
    • Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH. 2004. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: Relationships with nerve growth factor. J Neurosci 24:1584-1593.
    • (2004) J Neurosci , vol.24 , pp. 1584-1593
    • Saito, A.1    Narasimhan, P.2    Hayashi, T.3    Okuno, S.4    Ferrand-Drake, M.5    Chan, P.H.6
  • 64
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 66
    • 34547686666 scopus 로고    scopus 로고
    • Kidney growth, hypertrophy and the unifying mechanism of diabetic complications
    • DOI 10.1007/s00726-007-0529-9, Special Issue: Polyamines and their Analogs in Cancer and other Diseases
    • Satriano J. 2007. Kidney growth, hypertrophy and the unifying mechanism of diabetic complications. Amino Acids 33:331-339. (Pubitemid 47222975)
    • (2007) Amino Acids , vol.33 , Issue.2 , pp. 331-339
    • Satriano, J.1
  • 67
    • 0037117409 scopus 로고    scopus 로고
    • Identification of a conserved motif required for mTOR signaling
    • Schalm SS, Blenis J. 2002. Identification of a conserved motif required for mTOR signaling. Curr Biol 12:632-639.
    • (2002) Curr Biol , vol.12 , pp. 632-639
    • Schalm, S.S.1    Blenis, J.2
  • 68
    • 0037718389 scopus 로고    scopus 로고
    • TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    • Schalm SS, Fingar DC, Sabatini DM, Blenis J. 2003. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol 13:797-806.
    • (2003) Curr Biol , vol.13 , pp. 797-806
    • Schalm, S.S.1    Fingar, D.C.2    Sabatini, D.M.3    Blenis, J.4
  • 70
    • 33748950810 scopus 로고    scopus 로고
    • Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
    • DOI 10.1016/j.devcel.2006.08.013, PII S1534580706003935
    • Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11:583-589. (Pubitemid 44430900)
    • (2006) Developmental Cell , vol.11 , Issue.4 , pp. 583-589
    • Shiota, C.1    Woo, J.-T.2    Lindner, J.3    Shelton, K.D.4    Magnuson, M.A.5
  • 71
    • 0023801863 scopus 로고
    • Mesangial cells express PDGF mRNAs and proliferate in response to PDGF
    • Shultz PJ, DiCorleto PE, Silver BJ, Abboud HE. 1988. Mesangial cells express PDGF mRNAs and proliferate in response to PDGF. Am J Physiol 255:F674-F684.
    • (1988) Am J Physiol , vol.255
    • Shultz, P.J.1    DiCorleto, P.E.2    Silver, B.J.3    Abboud, H.E.4
  • 72
    • 26444600338 scopus 로고    scopus 로고
    • Genetic interaction of Lobe with its modifiers in dorsoventral patterning and growth of the Drosophila eye
    • Singh A, Chan J, Chern JJ, Choi KW. 2005. Genetic interaction of Lobe with its modifiers in dorsoventral patterning and growth of the Drosophila eye. Genetics 171:169-183.
    • (2005) Genetics , vol.171 , pp. 169-183
    • Singh, A.1    Chan, J.2    Chern, J.J.3    Choi, K.W.4
  • 73
    • 0033833810 scopus 로고    scopus 로고
    • Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro
    • Takahashi T, Hara K, Inoue H, Kawa Y, Tokunaga C, Hidayat S, Yoshino K, Kuroda Y, Yonezawa K. 2000. Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro. Genes Cells 5:765-775.
    • (2000) Genes Cells , vol.5 , pp. 765-775
    • Takahashi, T.1    Hara, K.2    Inoue, H.3    Kawa, Y.4    Tokunaga, C.5    Hidayat, S.6    Yoshino, K.7    Kuroda, Y.8    Yonezawa, K.9
  • 76
    • 29044441590 scopus 로고    scopus 로고
    • PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression
    • Venkatesan BA, Mahimainathan L, Ghosh-Choudhury N, Gorin Y, Bhandari B, Valente AJ, Abboud HE, Choudhury GG. 2006. PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression. Cell Signal 18:508-518.
    • (2006) Cell Signal , vol.18 , pp. 508-518
    • Venkatesan, B.A.1    Mahimainathan, L.2    Ghosh-Choudhury, N.3    Gorin, Y.4    Bhandari, B.5    Valente, A.J.6    Abboud, H.E.7    Choudhury, G.G.8
  • 77
    • 34147208714 scopus 로고    scopus 로고
    • Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells
    • DOI 10.1002/jcp.20953
    • Venkatesan B, Mahimainathan L, Das F, Ghosh-Choudhury N, Ghosh Choudhury G. 2007. Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells. J Cell Physiol 211:457-467. (Pubitemid 46580099)
    • (2007) Journal of Cellular Physiology , vol.211 , Issue.2 , pp. 457-467
    • Venkatesan, B.1    Mahimainathan, L.2    Das, F.3    Ghosh-Choudhury, N.4    Choudhury, G.G.5
  • 79
    • 70349478708 scopus 로고    scopus 로고
    • Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development
    • Wang YH, Huang ML. 2009. Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development. Mech Dev 126:781-790.
    • (2009) Mech Dev , vol.126 , pp. 781-790
    • Wang, Y.H.1    Huang, M.L.2
  • 80
    • 34547099855 scopus 로고    scopus 로고
    • PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    • Wang L, Harris TE, Roth RA, Lawrence JC, Jr. 2007. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282:20036-20044.
    • (2007) J Biol Chem , vol.282 , pp. 20036-20044
    • Wang, L.1    Harris, T.E.2    Roth, R.A.3    Lawrence Jr., J.C.4
  • 81
    • 47049127002 scopus 로고    scopus 로고
    • Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
    • Wang L, Harris TE, Lawrence JC, Jr. 2008. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 283:15619-15627.
    • (2008) J Biol Chem , vol.283 , pp. 15619-15627
    • Wang, L.1    Harris, T.E.2    Lawrence Jr., J.C.3
  • 82
    • 0032815449 scopus 로고    scopus 로고
    • Molecular mechanisms of diabetic renal hypertrophy
    • DOI 10.1046/j.1523-1755.1999.00590.x
    • Wolf G, Ziyadeh FN. 1999. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 56:393-405. (Pubitemid 29353136)
    • (1999) Kidney International , vol.56 , Issue.2 , pp. 393-405
    • Wolf, G.1    Ziyadeh, F.N.2
  • 84
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. 2006. TOR signaling in growth and metabolism. Cell 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 87
    • 38949151661 scopus 로고    scopus 로고
    • Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy
    • Ziyadeh FN, Wolf G. 2008. Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr Diabetes Rev 4:39-45.
    • (2008) Curr Diabetes Rev , vol.4 , pp. 39-45
    • Ziyadeh, F.N.1    Wolf, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.