Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: Implications for neuroprotection and lifespan extension

Human Molecular Genetics

Volumn 21, Issue 13, 2012, Pages 2973-2990

  Mao, Peizhong ^a   Manczak, Maria ^a   Calkins, Marcus J ^a   Truong, Quang ^a   Reddy, Tejaswini P ^a   Reddy, Arubala P ^a   Shirendeb, Ulziibat ^a   Lo, Herng Hsiang ^b   Rabinovitch, Peter S ^c   Hemachandra Reddy, P ^a,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CATALASE; MEMBRANE METALLOENDOPEPTIDASE; MITOCHONDRIA TARGETED ANTIOXIDANT CATALASE; PREALBUMIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DNA DAMAGE; ENZYME RELEASE; GENE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIFE EXTENSION; MALE; MITOCHONDRION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; CATALASE; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DNA DAMAGE; FEMALE; INSULYSIN; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NEPRILYSIN; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PREALBUMIN; RANDOM ALLOCATION; RNA, MESSENGER; SYNAPTOPHYSIN;

MUS; MUS MUSCULUS;

EID: 84862325005     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds128     Document Type: Article

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