Dietary conjugated linoleic acid and hepatic steatosis: Species-specific effects on liver and adipose lipid metabolism and gene expression

Journal of Nutrition and Metabolism

Volumn 2012, Issue , 2012, Pages

  Vyas, Diwakar ^a   Kadegowda, Anil Kumar G ^b   Erdman, Richard A ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b CLEMSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; MUS; RATTUS;

EID: 84861749135     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2012/932928     Document Type: Review

References (147)

1. Salas-Salvadó J., Márquez-Sandoval F., Bulló M., Conjugated Linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Critical Reviews in Food Science and Nutrition 2006 46 6 479 488 2-s2.0-33746853449 10.1080/10408390600723953 (Pubitemid 44180328)
2. Flegal K. M., Carroll M. D., Ogden C. L., Curtin L. R., Prevalence and trends in obesity among US adults, 1999-2008. Journal of the American Medical Association 2010 303 3 235 241 2-s2.0-74549140993 10.1001/jama.2009.2014
3. Ogden C. L., Carroll M. D., Curtin L. R., Lamb M. M., Flegal K. M., Prevalence of high body mass index in US children and adolescents, 2007-2008. Journal of the American Medical Association 2010 303 3 242 249 2-s2.0-74549159752 10.1001/jama.2009.2012
4. Zivkovic A. M., German J. B., Sanyal A. J., Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. American Journal of Clinical Nutrition 2007 86 2 285 300 2-s2.0-34547882082 (Pubitemid 47256910)
5. Fabbrini E., Sullivan S., Klein S., Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010 51 2 679 689 2-s2.0-75449094816 10.1002/hep.23280
6. McCullough A. J., The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clinics in Liver Disease 2004 8 3 521 533 2-s2.0-4344628555 10.1016/j.cld.2004.04.004 (Pubitemid 39141140)
7. Reddy J. K., Rao M. S., Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. American Journal of Physiology 2006 290 5 G852 G858 2-s2.0-33645828659 10.1152/ajpgi.00521.2005
8. Diraison F., Moulin P. H., Beylot M., Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes and Metabolism 2003 29 5 478 485 2-s2.0-0344874201 (Pubitemid 37474259)
9. Ronis M. J., Chen Y., Jo C. H., Simpson P., Badger T. M., Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development. Journal of Nutrition 2004 134 12 3270 3276 2-s2.0-10044248605 (Pubitemid 39602997)
10. Charlton M., Sreekumar R., Rasmussen D., Lindor K., Nair K. S., Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 2002 35 4 898 904 2-s2.0-0036207720 10.1053/jhep.2002.32527 (Pubitemid 34258385)
11. Huang H. L., Lin W. Y., Lee L. T., Wang H. H., Lee W. J., Huang K. C., Metabolic syndrome is related to nonalcoholic steatohepatitis in severely obese subjects. Obesity Surgery 2007 17 11 1457 1463 2-s2.0-39749173966 10.1007/s11695-008-9423-0
12. Li Z. Z., Berk M., McIntyre T. M., Feldstein A. E., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-Coa desaturase. Journal of Biological Chemistry 2009 284 9 5637 5644 2-s2.0-65549136260 10.1074/jbc.M807616200
13. Day C. P., James O. F. W., Steatohepatitis: a tale of two 'Hits'. Gastroenterology 1998 114 4 I 842 845 2-s2.0-0031947715 10.1016/S0016-5085(98) 70599-2 (Pubitemid 28160420)
14. Park Y., Pariza M. W., Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Research International 2007 40 3 311 323 2-s2.0-33846307827 10.1016/j.foodres.2006.11.002 (Pubitemid 46124004)
15. Pariza M. W., Park Y., Cook M. E., The biologically active isomers of conjugated linoleic acid. Progress in Lipid Research 2001 40 4 283 298 2-s2.0-0034964992 10.1016/S0163-7827(01)00008-X (Pubitemid 32547235)
16. Eulitz K., Yurawecz M. P., Sehat N., Fritsche J., Roach J. A. G., Mossoba M. M., Kramer J. K. G., Adlof R. O., Ku Y., Preparation, separation, and confirmation of the eight geometrical cis/trans conjugated linoleic acid isomers 8, 10- through 11, 13-18:2. Lipids 1999 34 8 873 877 2-s2.0-0032860332 10.1007/s11745-999-0435-z (Pubitemid 29439838)
17. Sehat N., Rickert R., Mossoba M. M., Kramer J. K. G., Yurawecz M. P., Roach J. A. G., Adlof R. O., Morehouse K. M., Fritsche J., Eulitz K. D., Steinhart H., Ku Y., Improved separation of conjugated fatty acid methyl esters by silver ion-high-performance liquid chromatography. Lipids 1999 34 4 407 413 2-s2.0-0032897569 10.1007/s11745-999-0379-3 (Pubitemid 29230281)
18. Parodi P. W., Conjugated octadecadienoic acids of milk-fat. Journal of Dairy Science 1977 60 10 1550 1553
19. Chin S. F., Liu W., Storkson J. M., Ha Y. L., Pariza M. W., Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. Journal of Food Composition and Analysis 1992 5 3 185 197 2-s2.0-5644284678
20. Lee K. N., Kritchevsky D., Parizaa M. W., Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994 108 1 19 25 2-s2.0-0028361814 10.1016/0021-9150(94)90034-5 (Pubitemid 24216366)
21. Miller C. C., Park Y., Pariza M. W., Cook M. E., Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochemical and Biophysical Research Communications 1994 198 3 1107 1112 2-s2.0-0028234838 10.1006/bbrc.1994.1157 (Pubitemid 24172811)
22. Park Y., Albright K. J., Liu W., Storkson J. M., Cook M. E., Pariza M. W., Effect of conjugated linoleic acid on body composition in mice. Lipids 1997 32 8 853 858 2-s2.0-0030791050 10.1007/s11745-997-0109-x (Pubitemid 27360392)
23. Ip C., Dong Y., Ip M. M., Banni S., Carta G., Angioni E., Murru E., Spada S., Melis M. P., Saebo A., Conjugated linoleic acid isomers and mammary cancer prevention. Nutrition and Cancer 2002 43 1 52 58 2-s2.0-0036439367 (Pubitemid 35387256)
24. Belury M. A., Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. Journal of Nutrition 2002 132 10 2995 2998 2-s2.0-0036792212
25. Park Y., Storkson J. M., Albright K. J., Liu W., Pariza M. W., Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 1999 34 3 235 241 2-s2.0-0032955643 (Pubitemid 29169626)
26. Larsen T. M., Toubro S., Astrup A., Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. Journal of Lipid Research 2003 44 12 2234 2241 2-s2.0-0347093594 10.1194/jlr.R300011-JLR200 (Pubitemid 38082481)
27. Ide T., Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Diabetes 2005 54 2 412 423 2-s2.0-12744262842 10.2337/diabetes.54.2.412
28. Andreoli M. F., Gonzalez M. A., Martinelli M. I., Mocchiutti N. O., Bernal C. A., Effects of dietary conjugated linoleic acid at high-fat levels on triacylglycerol regulation in mice. Nutrition 2009 25 4 445 452 2-s2.0-60749104695 10.1016/j.nut.2008.10.015
29. Kadegowda A. K. G., Connor E. E., Teter B. B., Sampugna J., Delmonte P., Piperova L. S., Erdman R. A., Dietary trans fatty acid isomers differ in their effects on mammary lipid metabolism as well as lipogenic gene expression in lactating mice. Journal of Nutrition 2010 140 5 919 924 2-s2.0-77951470401 10.3945/jn.109.110890
30. Clément L., Poirier H., Niot I., Bocher V., Guerre-Millo M., Krief S., Staels B., Besnard P., Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. Journal of Lipid Research 2002 43 9 1400 1409 2-s2.0-0036739536 10.1194/jlr.M20008-JLR200
31. Degrace P., Demizieux L., Gresti J., Chardigny J. M., Sébédio J. L., Clouet P., Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans-10,cis-12-linoleic acid. FEBS Letters 2003 546 2-3 335 339 2-s2.0-0037494961 10.1016/S0014-5793(03)00610-0 (Pubitemid 36782435)
32. Rasooly R., Kelley D. S., Greg J., Mackey B. E., Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver. British Journal of Nutrition 2007 97 1 58 66 2-s2.0-33847092559 10.1017/S0007114507257745 (Pubitemid 46662059)
33. Jourdan T., Djaouti L., Demizieux L., Gresti J., Vergès B., Degrace P., Liver carbohydrate and lipid metabolism of insulin-deficient mice is altered by trans-10, cis-12 conjugated linoleic acid. Journal of Nutrition 2009 139 10 1901 1907 2-s2.0-70349333716 10.3945/jn.109.111062
34. Takahashi Y., Kushiro M., Shinohara K., Ide T., Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. Biochimica et Biophysica Acta 2003 1631 3 265 273 2-s2.0-0037426318 10.1016/S1388-1981(03)00038-6 (Pubitemid 36369362)
35. Liu L. F., Purushotham A., Wendel A. A., Belury M. A., Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice. American Journal of Physiology 2007 292 6 G1671 G1682 2-s2.0-34447499065 10.1152/ajpgi.00523.2006 (Pubitemid 47080594)
36. Degrace P., Demizieux L., Gresti J., Chardigny J. M., Sébédio J. L., Clouet P., Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-Isomer of Linoleic Acid. Journal of Nutrition 2004 134 4 861 867 2-s2.0-1842530442 (Pubitemid 38456255)
37. Belury M. A., Kempa-Steczko A., Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 1997 32 2 199 204 2-s2.0-0031056451 10.1007/s11745-997-0025-0 (Pubitemid 27093193)
38. Kelley D. S., Vemuri M., Adkins Y., Gill S. H. S., Fedor D., Mackey B. E., Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice. British Journal of Nutrition 2009 101 5 701 708 2-s2.0-61949365751 10.1017/S0007114508027451
39. Poirier H., Rouault C., Clément L., Niot I., Monnot M. C., Guerre-Millo M., Besnard P., Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Diabetologia 2005 48 6 1059 1065 2-s2.0-21344469235 10.1007/s00125-005-1765-8 (Pubitemid 40909639)
40. Tsuboyama-Kasaoka N., Takahashi M., Tanemura K., Kim H. J., Tange T., Okuyama H., Kasai M., Ikemoto S., Ezaki O., Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 2000 49 9 1534 1542 2-s2.0-0033861304
41. Poirier H., Shapiro J. S., Kim R. J., Lazar M. A., Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 2006 55 6 1634 1641 2-s2.0-33748291462 10.2337/db06-0036 (Pubitemid 44324115)
42. Halade G. V., Rahman M. M., Fernandes G., Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice. Journal of Nutritional Biochemistry 2010 21 4 332 337 2-s2.0-77649275653 10.1016/j.jnutbio.2009.01.006
43. Halade G. V., Rahman M. M., Fernandes G., Effect of CLA isomers and their mixture on aging C57Bl/6J mice. European Journal of Nutrition 2009 48 7 409 418 2-s2.0-70349604821 10.1007/s00394-009-0029-7
44. Nakanishi T., Oikawa D., Koutoku T., Hirakawa H., Kido Y., Tachibana T., Furuse M., γ -linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. Nutrition 2004 20 4 390 393 2-s2.0-1642390777 10.1016/j.nut.2003.12.014 (Pubitemid 38388515)
45. Yanagita T., Wang Y. M., Nagao K., Ujino Y., Inoue N., Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. Journal of Agricultural and Food Chemistry 2005 53 24 9629 9633 2-s2.0-28944450727 10.1021/jf052203i (Pubitemid 41784175)
46. Park Y., Albright K. J., Storkson J. M., Liu W., Cook M. E., Pariza M. W., Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 1999 34 3 243 248 2-s2.0-0032899791 (Pubitemid 29169627)
47. DeLany J. P., West D. B., Changes in body composition with conjugated linoleic acid. Journal of the American College of Nutrition 2000 19 4 487S 493S 2-s2.0-0033869287 (Pubitemid 30629155)
48. Foote M. R., Giesy S. L., Bernal-Santos G., Bauman D. E., Boisclair Y. R., t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism. American Journal of Physiology 2010 299 6 R1521 R1528 2-s2.0-78649841510 10.1152/ajpregu.00445.2010
49. Purushotham A., Shrode G. E., Wendel A. A., Liu L. F., Belury M. A., Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats. Journal of Nutritional Biochemistry 2007 18 10 676 684 2-s2.0-34548527932 10.1016/j.jnutbio.2006.10.008 (Pubitemid 47385159)
50. Moya-Camarena S. Y., Vanden Heuvel J. P., Belury M. A., Conjugated linoleic acid activates peroxisome proliferator-activated receptor α and β subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochimica et Biophysica Acta 1999 1436 3 331 342 2-s2.0-0033521702 10.1016/S0005-2760(98)00121-0 (Pubitemid 29242914)
51. Choi J. S., Jung M. H., Park H. S., Song J., Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 2004 20 11-12 1008 1017 2-s2.0-9244258577 10.1016/j.nut.2004.08.009 (Pubitemid 39550782)
52. Tsuzuki T., Igarashi M., Miyazawa T., Conjugated Eicosapentaenoic acid (EPA) inhibits transplanted tumor growth via membrane lipid peroxidation in nude mice. Journal of Nutrition 2004 134 5 1162 1166 2-s2.0-2442508116 (Pubitemid 38619957)
53. Andreoli M. F., Scalerandi M. V., Borel I. M., Bernal C. A., Effects of CLA at different dietary fat levels on the nutritional status of rats during protein repletion. Nutrition 2007 23 11-12 827 835 2-s2.0-34948828074 10.1016/j.nut.2007.08.003 (Pubitemid 47532394)
54. Miranda J., Churruca I., Fernández-Quintela A., Rodríguez V. M., MacArulla M. T., Simón E., Portillo M. P., Weak effect of trans-10, cis-12-conjugated linoleic acid on body fat accumulation in adult hamsters. British Journal of Nutrition 2009 102 11 1583 1589 2-s2.0-73649138568 10.1017/S0007114509990912
55. Zabala A., Churruca I., Fernández-Quintela A., Rodríguez V. M., Macarulla M. T., Martínez J. A., Portillo M. P., Trans-10,cis-12 conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet. British Journal of Nutrition 2006 95 6 1112 1119 2-s2.0-33745614287 10.1079/BJN20061774 (Pubitemid 43985990)
56. Macarulla M. T., Fernández-Quintela A., Zabala A., Navarro V., Echevarría E., Churruca I., Rodríguez V. M., Portillo M. P., Effects of conjugated linoleic acid on liver composition and fatty acid oxidation are isomer-dependent in hamster. Nutrition 2005 21 4 512 519 2-s2.0-16244406209 10.1016/j.nut.2004.07.011 (Pubitemid 40462473)
57. Navarro V., Portillo M. P., Margotat A., Landrier J. F., MacArulla M. T., Lairon D., Martin J. C., A multi-gene analysis strategy identifies metabolic pathways targeted by trans-10, cis-12-conjugated linoleic acid in the liver of hamsters. British Journal of Nutrition 2009 102 4 537 545 2-s2.0-70149099512 10.1017/S0007114509231734
58. Bissonauth V., Chouinard Y., Marin J., Leblanc N., Richard D., Jacques H., The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. Journal of Nutritional Biochemistry 2006 17 9 597 603 2-s2.0-33747010328 10.1016/j.jnutbio.2005.10.010 (Pubitemid 44205439)
59. Lasa A., Simón E., Churruca I., Fernández-Quintela A., Macarulla M. T., Martínez J. A., Portillo M. P., Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. Nutrition 2011 27 1 116 121 2-s2.0-78649951758 10.1016/j.nut.2010.01.003
60. Simón E., MacArulla M. T., Churruca I., Fernández-Quintela A., Portillo M. P., trans-10,cis-12 Conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters. Journal of Nutritional Biochemistry 2006 17 2 126 131 2-s2.0-30544452455 10.1016/j.jnutbio.2005.06.001 (Pubitemid 43082147)
61. Tarling E. J., Ryan K. J. P., Bennett A. J., Salter A. M., Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets. British Journal of Nutrition 2009 101 11 1630 1638 2-s2.0-67649435599 10.1017/S0007114508118785
62. De Deckere E. A. M., Van Amelsvoort J. M. M., McNeill G. P., Jones P., Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. British Journal of Nutrition 1999 82 4 309 317 2-s2.0-0032877218 (Pubitemid 29481517)
63. Thom E., Wadstein J., Gudmundsen O., Conjugated linoleic acid reduces body fat in healthy exercising humans. Journal of International Medical Research 2001 29 5 392 396 2-s2.0-0035155823 (Pubitemid 33061658)
64. Zambell K. L., Keim N. L., Van Loan M. D., Gale B., Benito P., Kelley D. S., Nelson G. J., Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids 2000 35 7 777 782 2-s2.0-0033868038 (Pubitemid 30624543)
65. Petridou A., Mougios V., Sagredos A., Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Lipids 2003 38 8 805 811 2-s2.0-0141816548 10.1007/s11745-003-1129-2 (Pubitemid 37193740)
66. Malpuech-Brugère C., Verboeket-Van De Venne W. P. H. G., Mensink R. P., Arnal M. A., Mario B., Brandolini M., Saebo A., Lassel T. S., Chardigny J. M., Sébédio J. L., Beaufrère B., Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Research 2004 12 4 591 598 2-s2.0-3042769523 (Pubitemid 41132501)
67. Berven G., Bye A., Hals O., Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. European Journal of Lipid Science and Technology 2000 102 7 455 462 2-s2.0-18844456572
68. Risérus U., Vessby B., Arner P., Zethelius B., Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 2004 47 6 1016 1019 2-s2.0-17144434666 (Pubitemid 38918160)
69. Riserus U., Arner P., Brismar K., Treatment with dietary trans10cis12 conjugated linoleic add causes isomerm-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002 25 9 1516 1521 (Pubitemid 41071104)
70. Basu S., Risérus U., Turpeinen A., Vessby B., Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clinical Science 2000 99 6 511 516 2-s2.0-0034541559 10.1042/CS20000116 (Pubitemid 32014557)
71. Benito P., Nelson G. J., Kelley D. S., Bartolini G., Schmidt P. C., Simon V., The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids 2001 36 3 229 236 2-s2.0-0035070333 (Pubitemid 32290917)
72. Mougios V., Matsakas A., Petridou A., Ring S., Sagredos A., Melissopoulou A., Tsigilis N., Nikolaidis M., Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. Journal of Nutritional Biochemistry 2001 12 10 585 594 2-s2.0-0034816005 10.1016/S0955-2863(01)00177-2 (Pubitemid 32930054)
73. Kreider R. B., Ferreira M. P., Greenwood M., Wilson M., Almada A. L., Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. Journal of Strength and Conditioning Research 2002 16 3 325 334 2-s2.0-0036693309 10.1519/1533-4287(2002)016<0325:EOCLAS>2.0.CO;2
74. Kamphuis M. M. J. W., Lejeune M. P. G. M., Saris W. H. M., Westerterp-Plantenga M. S., Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. European Journal of Clinical Nutrition 2003 57 10 1268 1274 2-s2.0-0141960047 10.1038/sj.ejcn.1601684 (Pubitemid 37259393)
75. Moloney F., Yeow T. P., Mullen A., Nolan J. J., Roche H. M., Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. American Journal of Clinical Nutrition 2004 80 4 887 895 2-s2.0-5144228885 (Pubitemid 41202087)
76. Whigham L. D., O'Shea M., Mohede I. C. M., Walaski H. P., Atkinson R. L., Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food and Chemical Toxicology 2004 42 10 1701 1709 2-s2.0-4043068489 10.1016/j.fct.2004.06.008 (Pubitemid 39078517)
77. Gaullier J. M., Halse J., Høye K., Kristiansen K., Fagertun H., Vik H., Gudmundsen O., Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. Journal of Nutrition 2005 135 4 778 784 2-s2.0-16244396154 (Pubitemid 40464104)
78. Gaullier J. M., Halse J., Høye K., Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans (vol 79, pg 1118, 2004). American Journal of Clinical Nutrition 2005 81 2 538 2-s2.0-30444459795 (Pubitemid 43073367)
79. Taylor J. S. W., Williams S. R. P., Rhys R., James P., Frenneaux M. P., Conjugated linoleic acid impairs endothelial function. Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 2 307 312 2-s2.0-33644871365 10.1161/01.ATV.0000199679.40501.ac (Pubitemid 43732192)
80. Thrush A. B., athrush@uoguelph.ca Chabowski A., Heigenhauser G. J., McBride B. W., Or-Rashid M., Dyck D. J., Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans. Applied Physiology, Nutrition and Metabolism 2007 32 3 372 382 10.1139/H06-116
81. Racine N. M., Watras A. C., Carrel A. L., Allen D. B., McVean J. J., Clark R. R., O'Brien A. R., O'Shea M., Scott C. E., Schoeller D. A., Effect of conjugated linoleic acid on body fat accretion in overweight or obese children. American Journal of Clinical Nutrition 2010 91 5 1157 1164 2-s2.0-77951952762 10.3945/ajcn.2009.28404
82. Gudbrandsen O. A., Rodríguez E., Wergedahl H., Mørk S., Reseland J. E., Skorve J., Palou A., Berge R. K., Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats. British Journal of Nutrition 2009 102 6 803 815 2-s2.0-70449726656 10.1017/S0007114509297200
83. Whigham L. D., Watras A. C., Schoeller D. A., Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. American Journal of Clinical Nutrition 2007 85 5 1203 1211 2-s2.0-34248370966 (Pubitemid 46740460)
84. Bhattacharya A., Banu J., Rahman M., Causey J., Fernandes G., Biological effects of conjugated linoleic acids in health and disease. Journal of Nutritional Biochemistry 2006 17 12 789 810 2-s2.0-33750935990 10.1016/j.jnutbio.2006.02.009 (Pubitemid 44738517)
85. Blankson H., Stakkestad J. A., Fagertun H., Thom E., Wadstein J., Gudmundsen O., Conjugated linoleic acid reduces body fat mass in overweight and obese humans. Journal of Nutrition 2000 130 12 2943 2948 2-s2.0-0034535725 (Pubitemid 32005322)
86. Cooper M. H., Miller J. R., Mitchell P. L., Currie D. L., McLeod R. S., Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE-/- mice fed a high-cholesterol diet. Atherosclerosis 2008 200 2 294 302 2-s2.0-52149083045 10.1016/j.atherosclerosis.2007.12.040
87. Gentile C. L., Pagliassotti M. J., The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease. Current Opinion in Investigational Drugs 2008 9 10 1084 1088 2-s2.0-53049097438
88. Diraison F., Beylot M., Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification. American Journal of Physiology 1998 274 2 E321 E327 2-s2.0-0031887281
89. Donnelly K. L., Smith C. I., Schwarzenberg S. J., Jessurun J., Boldt M. D., Parks E. J., Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. Journal of Clinical Investigation 2005 115 5 1343 1351 2-s2.0-18244382304 10.1172/JCI200523621 (Pubitemid 40629054)
90. Boelsterli U. A., Bedoucha M., Toxicological consequences of altered peroxisome proliferator-activated receptor γ (PPAR γ) expression in the liver: insights from models of obesity and type 2 diabetes. Biochemical Pharmacology 2002 63 1 1 10 2-s2.0-0036145372 10.1016/S0006-2952(01)00817-6 (Pubitemid 34075287)
91. Tontonoz P., Hu E., Spiegelman B. M., Stimulation of adipogenesis in fibroblasts by PPAR γ 2, a lipid-activated transcription factor. Cell 1994 79 7 1147 1156 2-s2.0-0028641559
92. Zhang Y. L., Hernandez-Ono A., Siri P., Weisberg S., Conlon D., Graham M. J., Crooke R. M., Huang L. S., Ginsberg H. N., Aberrant hepatic expression of PPAR γ 2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. Journal of Biological Chemistry 2006 281 49 37603 37615 2-s2.0-33845984572 10.1074/jbc.M604709200 (Pubitemid 46042063)
93. Gavrilova O., Haluzik M., Matsusue K., Cutson J. J., Johnson L., Dietz K. R., Nicol C. J., Vinson C., Gonzalez F. J., Reitman M. L., Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. Journal of Biological Chemistry 2003 278 36 34268 34276 2-s2.0-0141446024 10.1074/jbc.M300043200 (Pubitemid 37553270)
94. Denechaud P. D., Bossard P., Lobaccaro J. M., LXR stimulates ChREBP expression but glucose is required its post-traductional activation. Diabetes 2007 56 A39
95. Guillén N., Navarro M. A., Arnal C., Noone E., Arbonés-Mainar J. M., Acín S., Surra J. C., Muniesa P., Roche H. M., Osada J. S., Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiological Genomics 2009 37 3 187 198 2-s2.0-66349126363 10.1152/physiolgenomics.90339.2008
96. Lin X., Loor J. J., Herbein J. H., Trans10,cis12-18:2 is a more potent inhibitor of de novo fatty acid synthesis and desaturation than cis9,trans11-18:2 in the mammary gland of lactating mice. Journal of Nutrition 2004 134 6 1362 1368 2-s2.0-2642541013 (Pubitemid 38720707)
97. Stringer D. M., Zahradka P., DeClercq V. C., Ryz N. R., Diakiw R., Burr L. L., Xie X., Taylor C. G., Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. Biochimica et Biophysica Acta 2010 1801 12 1375 1385 2-s2.0-77957943331 10.1016/j.bbalip.2010.08.011
98. Musso G., Gambino R., Pacini G., De Michieli F., Cassader M., Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. American Journal of Clinical Nutrition 2009 89 2 558 567 2-s2.0-59649114145 10.3945/ajcn.2008.26720
99. Doege H., Baillie R. A., Ortegon A. M., Tsang B., Wu Q., Punreddy S., Hirsch D., Watson N., Gimeno R. E., Stahl A., Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology 2006 130 4 1245 1258 2-s2.0-33645994508 10.1053/j.gastro.2006.02.006
100. Zhou S. L., Ge F. X., Hu C. G., Increased insulin- and leptin-regulated hepatocellular fatty acid uptake plays a major role in the pathogenesis of hepatic steatosis in mouse models with intact leptin signaling, but not in those lacking leptin (ob/ob) or the leptin receptor (db/db). Hepatology 2008 48 4 1161
101. Belury M. A., Moya-Camarena S. Y., Lu M., Shi L., Leesnitzer L. M., Blanchard S. G., Conjugated linoleic acid is an activator and ligand for peroxisome proliferator-activated receptor-gamma (PPAR γ). Nutrition Research 2002 22 7 817 824 2-s2.0-0036314760 10.1016/S0271-5317(02)00393-7 (Pubitemid 34755661)
102. Degrace P., Moindrot B., Mohamed I., Gresti J., Du Z. Y., Chardigny J. M., Sébédio J. L., Clouet P., Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR -/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. Journal of Lipid Research 2006 47 12 2647 2655 2-s2.0-33845593356 10.1194/jlr.M600140-JLR200 (Pubitemid 44936078)
103. Nagayoshi A., Matsuki N., Saito H., Tsukamoto K., Kaneko K., Wakashima M., Kinoshita M., Yamanaka M., Teramoto T., Defect in assembly process of very-low-density lipoprotein in suncus liver: an animal model of fatty liver. Journal of Biochemistry 1995 117 4 787 793 2-s2.0-0028914293
104. Lin Y., Schuurbiers E., Van Der Veen S., De Deckere E. A. M., Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. Biochimica et Biophysica Acta 2001 1533 1 38 46 2-s2.0-0035968447 10.1016/S1388-1981(01)00137-8 (Pubitemid 32763264)
105. Reddy J. K., Hashimoto T., Peroxisomal β -oxidation and peroxisome proliferator-Activated receptor α: an adaptive metabolic system. Annual Review of Nutrition 2001 21 193 230 2-s2.0-0034939632 10.1146/annurev.nutr.21.1. 193 (Pubitemid 32695270)
106. Javadi M., Beynen A. C., Hovenier R., Lankhorst AE. Æ., Lemmens A. G., Terpstra A. H. M., Geelen M. J. H., Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. Journal of Nutritional Biochemistry 2004 15 11 680 687 2-s2.0-10044279280 10.1016/j.jnutbio.2004.06.005 (Pubitemid 39611366)
107. Chardigny J. M., Hasselwander O., Genty M., Kraemer K., Ptock A., Sébédio J. L., Effect of conjugated FA on feed intake, body composition, and liver FA in mice. Lipids 2003 38 9 895 902 2-s2.0-0141987909 10.1007/s11745-003-1142-5 (Pubitemid 37255275)
108. Kelley D. S., Bartolini G. L., Warren J. M., Simon V. A., Mackey B. E., Erickson K. L., Contrasting effects of t10,c12- and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids. Lipids 2004 39 2 135 141 2-s2.0-1842682842 (Pubitemid 38480943)
109. Kelley D. S., Bartolini G. L., Newman J. W., Vemuri M., Mackey B. E., Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid. Prostaglandins Leukotrienes and Essential Fatty Acids 2006 74 5 331 338 2-s2.0-33646558956 10.1016/j.plefa.2006.02.008
110. Martins S. V., Lopes P. A., Alves S. P., Alfaia C. M., Nascimento M., Castro M. F., Bessa R. J.B., Prates J. A.M., japrates@fmv.utl.pt Dietary conjugated linoleic acid isomers change the unsaturation degree of hepatic fatty acids in neutral lipids but not in polar lipids. Nutrition Research 2011 31 3 246 254 10.1016/j.nutres.2010.11.001
111. Sébédio J. L., Angioni E., Chardigny J. M., Grégoire S., Juanéda P., Berdeaux O., The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16:2 and 18:3 conjugated fatty acids in rats. Lipids 2001 36 6 575 582 2-s2.0-0034899952 (Pubitemid 32703294)
112. Puri P., Baillie R. A., Wiest M. M., Mirshahi F., Choudhury J., Cheung O., Sargeant C., Contos M. J., Sanyal A. J., A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007 46 4 1081 1090 2-s2.0-36349024819 10.1002/hep.21763 (Pubitemid 350144772)
113. Wang D., Wei Y., Pagliassotti M. J., Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 2006 147 2 943 951 2-s2.0-30944451788 10.1210/en.2005-0570 (Pubitemid 43113013)
114. Eder K., Slomma N., Becker K., Trans-10,cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and α -linolenic acids in HepG2 cells. Journal of Nutrition 2002 132 6 1115 1121 2-s2.0-0036277054 (Pubitemid 34606437)
115. Lin X., Bo J., Oliver S. A. M., Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs. The Journal of Nutritional Biochemistry. In press
116. Sugano M., Tsujita A., Yamasaki M., Noguchi M., Yamada K., Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids 1998 33 5 521 527 2-s2.0-0031799341 10.1007/s11745-998-0236-4 (Pubitemid 28261956)
117. Lukivskaya O. Y., Maskevich A. A., Buko V. U., Effect of ursodeoxycholic acid on prostaglandin metabolism and microsomal membranes in alcoholic fatty liver. Alcohol 2001 25 2 99 105 2-s2.0-0035679490 10.1016/S0741-8329(01)00171-9 (Pubitemid 34016035)
118. El-Badry A. M., Graf R., Clavien P. A., Omega 3-Omega 6: what is right for the liver? Journal of Hepatology 2007 47 5 718 725 2-s2.0-34848880484 10.1016/j.jhep.2007.08.005 (Pubitemid 47503438)
119. Li Y., Watkins B. A., Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 1998 33 4 417 425 2-s2.0-0031976761 10.1007/s11745-998- 0223-9 (Pubitemid 28217388)
120. Eder K., Slomma N., Becker K., Brandsch C., Effect of linseed oil supplementation on concentrations of (n-3) polyunsaturated fatty acids in liver phospholipids of rats fed diets containing either an oil rich in conjugated linoleic acids, sunflower oil or high-oleic acid sunflower oil. Journal of Animal Physiology and Animal Nutrition 2005 89 1-2 45 54 2-s2.0-13944264008 10.1111/j.1439-0396.2004.00510.x (Pubitemid 40263190)
121. Banni S., Petroni A., Blasevich M., Carta G., Cordeddu L., Murru E., Melis M. P., Mahon A., Belury M. A., Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFA. Lipids 2004 39 11 1143 1146 2-s2.0-12344254779 10.1007/s11745-004-1341-0 (Pubitemid 40129057)
122. Brown J. M., McIntosh M. K., Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. Journal of Nutrition 2003 133 10 3041 3046 2-s2.0-0141752753 (Pubitemid 37222212)
123. Kang K., Miyazaki M., Ntambi J. M., Pariza M. W., Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. Biochemical and Biophysical Research Communications 2004 315 3 532 537 2-s2.0-1242340451 10.1016/j.bbrc.2004.01.087 (Pubitemid 38229376)
124. Park Y., Storkson J. M., Ntambi J. M., Cook M. E., Sih C. J., Pariza M. W., Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis- 12 conjugated linoleic acid and its derivatives. Biochimica et Biophysica Acta 2000 1486 2-3 285 292 2-s2.0-0034686661 10.1016/S1388-1981(00)00074-3 (Pubitemid 30618868)
125. Ntambi J. M., Miyazaki M., Stoehr J. P., Lan H., Kendziorski C. M., Yandell B. S., Song Y., Cohen P., Friedman J. M., Attie A. D., Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proceedings of the National Academy of Sciences of the United States of America 2002 99 17 11482 11486 2-s2.0-0037143752 10.1073/pnas.132384699 (Pubitemid 34920951)
126. MacDonald M. L. E., Singaraja R. R., Bissada N., Ruddle P., Watts R., Karasinska J. M., Gibson W. T., Fievet C., Vance J. E., Staels B., Hayden M. R., Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. Journal of Lipid Research 2008 49 1 217 229 2-s2.0-38049169032 10.1194/jlr.M700478-JLR200
127. Miyazaki M., Flowers M. T., Sampath H., Chu K., Otzelberger C., Liu X., Ntambi J. M., Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metabolism 2007 6 6 484 496 2-s2.0-36448991861 10.1016/j.cmet.2007.10.014 (Pubitemid 350163054)
128. Gutiérrez-Juárez R., Pocai A., Mulas C., Ono H., Bhanot S., Monia B. P., Rossetti L., Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. Journal of Clinical Investigation 2006 116 6 1686 1695 2-s2.0-33745212925 10.1172/JCI26991
129. Jiang G., Li Z., Liu F., Ellsworth K., Dallas-Yang Q., Wu M., Ronan J., Esau C., Murphy C., Szalkowski D., Bergeron R., Doebber T., Zhang B. B., Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. Journal of Clinical Investigation 2005 115 4 1030 1038 2-s2.0-20144388684 10.1172/JCI200523962 (Pubitemid 40489408)
130. Flowers M. T., Ntambi J. M., Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Current Opinion in Lipidology 2008 19 3 248 256 2-s2.0-43249127067 10.1097/MOL.0b013e3282f9b54d (Pubitemid 351653562)
131. House R. L., Cassady J. P., Eisen E. J., Eling T. E., Collins J. B., Grissom S. F., Odle J., Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiological Genomics 2005 21 351 361 2-s2.0-21244497638 10.1152/physiolgenomics.00244.2004 (Pubitemid 40898495)
132. Reynolds C. M., Roche H. M., Conjugated linoleic acid and inflammatory cell signalling. Prostaglandins Leukotrienes and Essential Fatty Acids 2010 82 4-6 199 204 2-s2.0-77951975492 10.1016/j.plefa.2010.02.021
133. Senn J. J., Klover P. J., Nowak I. A., Zimmers T. A., Koniaris L. G., Furlanetto R. W., Mooney R. A., Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. Journal of Biological Chemistry 2003 278 16 13740 13746 2-s2.0-0037853260 10.1074/jbc.M210689200 (Pubitemid 36799910)
134. Kern P. A., Di Gregorio G. B., Lu T., Rassouli N., Ranganathan G., Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor- α expression. Diabetes 2003 52 7 1779 1785 2-s2.0-0037677604 (Pubitemid 36792470)
135. Tsuboyama-Kasaoka N., Miyazaki H., Kasaoka S., Ezaki O., Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice. Journal of Nutrition 2003 133 6 1793 1799 2-s2.0-0037977719 (Pubitemid 36666515)
136. Nagao K., Inoue N., Ujino Y., Higa K., Shirouchi B., Wang Y. M., Yanagita T., Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model mice. Lipids in Health and Disease 2008 7, article 8 2-s2.0-41549125848 10.1186/1476-511X-7-8 (Pubitemid 351473768)
137. Stout M., Li L., Belury M., Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C ε in mice. Molecular Nutrition and Food Research 2011 55 7 1010 1017 10.1002/mnfr.201000413
138. LaRosa P. C., Riethoven J. J. M., Chen H., Xia Y., Zhou Y., Chen M., Miner J., Fromm M. E., Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. Physiological Genomics 2007 31 3 544 553 2-s2.0-36249023729 10.1152/physiolgenomics.00156.2007 (Pubitemid 350127793)
139. Poirier H., Niot I., Clément L., Guerre-Millo M., Besnard P., Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse. Biochimie 2005 87 1 73 79 2-s2.0-14544287769 10.1016/j.biochi.2004. 11.006 (Pubitemid 40298768)
140. Oikawa D., Tsuyama S., Akimoto Y., Mizobe Y., Furuse M., Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice. British Journal of Nutrition 2009 101 10 1558 1563 2-s2.0-67649443913 10.1017/S0007114508091253
141. Ferramosca A., Savy V., Conte L., Zara V., Dietary combination of conjugated linoleic acid (CLA) and pine nut oil prevents CLA-induced fatty liver in mice. Journal of Agricultural and Food Chemistry 2008 56 17 8148 8158 2-s2.0-52649106460 10.1021/jf8010728
142. Vemuri M., Kelley D. S., Bartolini G., Decosahexaenoic acid (DHA) but not eicosapentaenoic acid (EPA) reverses trans-10, cis-12-conjugated linoleic acid (t10, c12-CLA) induced insulin resistance in mice. Faseb Journal 2007 21 5 A113
143. Roche H. M., Noone E., Sewter C., McBennett S. M., Savage D., Gibney M. J., O'Rahilly S., Vidal-Puig A. J., Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXR α Diabetes 2002 51 7 2037 2044 2-s2.0-0036300023 (Pubitemid 34729006)
144. Mater M. K., Thelen A. P., Jump D. B., Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression. Journal of Lipid Research 1999 40 6 1045 1052 2-s2.0-0032587414 (Pubitemid 29287875)
145. Choi Y., Kim Y. C., Han Y. B., Park Y., Pariza M. W., Ntambi J. M., The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 Adipocytes. Journal of Nutrition 2000 130 8 1920 1924 2-s2.0-0033929212 (Pubitemid 30497521)
146. Choi J. S., Koh I. U., Jung M. H., Song J., Effects of three different conjugated linoleic acid preparations on insulin signalling, fat oxidation and mitochondrial function in rats fed a high-fat diet. British Journal of Nutrition 2007 98 2 264 275 2-s2.0-34447632832 10.1017/S000711450770497X (Pubitemid 47091367)
147. De Roos B., Rucklidge G., Reid M., Ross K., Duncan G., Navarro M. A., Arbones-Mainar J. M., Guzman-Garcia M. A., Osada J., Browne J., Loscher C. E., Roche H. M., Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. FASEB Journal 2005 19 12 1746 1748 2-s2.0-26444496110 10.1096/fj.05-3953fje (Pubitemid 41429550)