Dietary conjugated linoleic acid isomers change the unsaturation degree of hepatic fatty acids in neutral lipids but not in polar lipids

Nutrition Research

Volumn 31, Issue 3, 2011, Pages 246-254

  Martins, Susana V ^a   Lopes, Paula A ^a   Alves, Susana P ^b,c   Alfaia, Cristina M ^a   Nascimento, Mafalda ^a   Castro, Matilde F ^d   Bessa, Rui J B ^a,b   Prates, José António Mestre ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b INRB   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Conjugated linoleic acid; Fatty acids; Liver; Neutral lipids; Polar lipids; Rat; Unsaturation degree

Indexed keywords

ARACHIDONIC ACID; CONJUGATED LINOLEIC ACID; FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FATTY ACID ANALYSIS; FOOD COMPOSITION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID COMPOSITION; LIPID LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WISTAR RAT;

ANIMALS; ARACHIDONIC ACID; DIET; DIETARY FATS, UNSATURATED; DIETARY SUPPLEMENTS; ISOMERISM; LINOLEIC ACID; LINOLEIC ACIDS, CONJUGATED; LIVER; MALE; PHOSPHOLIPIDS; RATS; RATS, WISTAR;

RATTUS;

EID: 79953748144     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2010.11.001     Document Type: Article

References (40)

1. Kelley D.S., Bartolini G.L., Warren J.M., Simon V.A., Mackey B.E., Erickson K.L. Contrasting effects of t10,c12- and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids. Lipids 2004, 39:135-141.
2. Park Y., Albright K.J., Storkson J.M., Liu W., Pariza M.W. Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model. J Food Sci 2007, 72:S612-S617.
3. Griinari J.M., Bauman D.E. Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. Advances in conjugated linoleic acid research 1999, Vol. 1:180-200. AOCS Press, Champaign (Ill), USA. M.P. Yurawecz, M.M. Mossoba, J.K.G. Kramer, M.W. Pariza, G.J. Nelson (Eds.).
4. Corl B.A., Baumgard L.H., Dwyer D.A., Griinari J.M., Phillips B.S., Bauman D.E. The role of delta9-desaturase in the production of cis-9,trans-11 CLA. J Nutr Biochem 2001, 12:622-630.
5. Santora J.E., Palmquist D.L., Roehrig K.L. Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J Nutr 2000, 130:208-215.
6. Lock A.L., Corl B.A., Barbano D.M., Bauman D.E., Ip C. The anticarcinogenic effects of trans-11 18:1 is dependent on its conversion to cis-9,trans-11 CLA by delta9-desaturase in rats. J Nutr 2004, 134:2698-2704.
7. Glaser K.R., Wenk C., Scheeder M.R.L. Effects of feeding pigs increasing levels of C18:1 trans fatty acids on fatty acid composition of backfat and intramuscular fat as well as backfat firmness. Animal Nutr 2002, 56:117-130.
8. Turpeinen A.M., Mutanen M., Aro A., Salminen I., Basu S., Palmquist D.L., et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. Am J Clin Nutr 2002, 76:504-510.
9. Herbel B.K., McGuire M.K., McGuire M.A., Shultz T.D. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr 1998, 67:332-337.
10. Wahle K.W.J., James W.P.T. Isomeric fatty acids and human health. Eur J Clin Nutr 1993, 47:828-839.
11. Sugano M., Tsujita A., Yamasaki A., Yamada K., Ikeda I., Kritchevsky D. Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. J Nutr Biochem 1997, 8:38-43.
12. Kramer J.K.G., Sehat N., dugan M.E.R., Mossoba M.M., Yurawecz M.P., Roach J.A.G., et al. Distributions of conjugated linoleic acid (CLA) isomers in tissue lipids classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver ion-high-performance liquid chromatograph. Lipids 1998, 33:549-558.
13. Banni S., Carta G., Angioni E., Murru E., Scanu P., Melis M.P., et al. Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J Lipid Res 2001, 42:1056-1061.
14. Spector A.A., Yorek M.A. Membrane lipid-composition and cellular function. J Lipid Res 1985, 26:1015-1035.
15. Schimtz G., Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008, 47:147-155.
16. Lands W.E., Morris A., Libelt B. Quantitative effects of dietary polyunsaturated fats on the composition of fatty-acids in rat-tissues. Lipids 1990, 25:505-516.
17. Soveral G., Martins A.P., Martins S.V., Lopes P.A., Alfaia C.M., Prates J.A.M., et al. Effect of dietary conjugated linoleic acid isomers on water and glycerol permeability of kidney membranes. Biochem Biophys Res Comm 2009, 383:108-112.
18. Lopes P.A., Martins S.V., Pinho M.S., Alfaia C.M., Fontes C.M., Rodrigues P.O., et al. Diet supplementation with the cis-9, trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. Nutr Res 2008, 28:480-486.
19. Fritsche J., Fritsche S., Solomon M.B., Mossoba M.M., Yurawecz M.P., Morehouse K., et al. Quantitative determination of conjugated linoleic acid isomers in beef fat. Eur J Lipid Sci Technol 2000, 102:667-672.
20. Juaneda P., Rocquelin G. Rapid and convenient separation of phospholipids and non phosphorus lipids from rat heart using silica cartridges. Lipids 1985, 20:40-41.
21. Raes K., De Smet S., Demeyer D. Effect of double-muscling in Belgian Blue young bulls on the intramuscular fatty acid composition with emphasis on conjugated linoleic acid and polyunsaturated fatty acids. Animal Sci 2001, 73:253-260.
22. Rego O., Rosa H., Regalo S., Alves S., Alfaia C., Prates J., et al. Seasonal changes of CLA isomers and other fatty acids of milk fat from grazing dairy herds in the Azores. J Sci Food Agric 2008, 88:1855-1859.
23. Alfaia C., Ribeiro V., Lourenço M., Quaresma M., Martins S., Portugal A., et al. Fatty acid composition, conjugated linoleic acid isomers and cholesterol in beef from crossbred bullocks intensively produced and from Alentejana purebred bullocks reared according to Carnalentejana-PDO specifications. Meat Sci 2006, 72:425-436.
24. SAS Institute SAS/STAT user's guide. Version 9.1 2004, SAS Institute, Cary (NC).
25. Banni S., Petroni A., Blasevich M., Carta G., Cordeddu L., Murru E., et al. Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFA. Lipids 2004, 39:1143-1146.
26. Sébédio J.L., Chardigny J.M., Berdeaux O. Metabolism of conjugated linoleic acids. Advances in conjugated linoleic acid research 2003, Vol. 2:259-266. AOCS Press, Champaign (Ill), USA. J.L. Sébédio, W.W. Christie, R. Adlof (Eds.).
27. Sébédio J.L., Angioni E., Chardigny J.M., Grégoire S., Juanéda P., Berdeaux O. The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16:2 and 18:3 conjugated linoleic acids in rat. Lipids 2001, 36:575-582.
28. Ha Y.L., Storkson J., Pariza M.W. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res 1990, 50:1097-1101.
29. Ip C., Chin S.F., Scimeca J.A., Pariza M.W. Mammary cancer prevention of conjugated dienoic derivative of linoleic acid. Cancer Res 1991, 51:6118-6124.
30. Sinensky M. Homeoviscous adaptation-a homeostatic. process that regulates the viscosity of membrane lipids in Escherichia coli. Proc Nat Acad Sci U S A 1974, 71:522-525.
31. Scislowsky V., Durand D., Gruffat-Mouty D., Motta C., Bauchart D. Linoleate supplementation in steers modifies lipid composition of plasma lipoproteins but does not alter their fluidity. Br J Nutr 2004, 91:575-584.
32. Jerónimo E., Alves S.P., Prates J.A.M., Santos-Silva J., Bessa R.J.B. Effect of dietary replacement of sunflower oil with linseed oil on intramuscular fatty acids of lamb meat. Meat Sci 2009, 83:499-505.
33. Belury M.A., Kempa-Steczko A. Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 1997, 32:199-204.
34. Hillgartner F.B., Salati L.M., Goodridge A.G. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Phys Rev 1995, 75:47-76.
35. Choi Y., Park Y., Pariza M.W., Ntambi J.M. Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem Bioph Res Co 2001, 284:689-693.
36. Smith S.B., Hively T.S., Cortese G.M., Han J.J., Chung K.Y., Castaneda P., et al. Conjugated linoleic acid depresses the Δ9 desaturase index and stearoyl coenzyme A desaturase enzyme activity in porcine subcutaneous adipose tissue. J Anim Sci 2002, 80:2110-2115.
37. Chardigny J.M., Hasselwander O., Genty M., Kramer K., Ptock A., Sébédio J.L. Effect of conjugated FA on feed intake, body composition, and liver FA in mice. Lipids 2003, 38:895-902.
38. Hargrave K.M., Meyer B.J., Li C., Azain M.J., Baile C.A., Miner J.L. Influence of dietary conjugated linoleic acid and fat source on body fat and apoptosis in mice. Obesity Res 2004, 12:1435-1444.
39. Tsuzuki T., Ikeda I. Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid. Biosci Biotechnol Biochem 2007, 71:2034-2040.
40. Yang L., Yeung S.Y.V., Huang Y., Wang H.Q., Chen Z.Y. Preferential incorporation of trans,trans-conjugated linoleic acid isomers into the liver of suckling rats. Br J Nutr 2002, 87:253-260.