Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE-/- mice fed a high-cholesterol diet

Atherosclerosis

Volumn 200, Issue 2, 2008, Pages 294-302

  Cooper, Margaret H ^a   Miller, Jessica R ^a   Mitchell, Patricia L ^a   Currie, Deborah L ^a   McLeod, Roger S ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Adiponectin; ApoE mice; Atherosclerosis; Conjugated linoleic acid; Liver steatosis

Indexed keywords

ADIPONECTIN; APOLIPOPROTEIN E; CHOLESTEROL; CONJUGATED LINOLEIC ACID; GLUCOSE; INSULIN; LIPOPROTEIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA ROOT; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET SUPPLEMENTATION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID LIVER LEVEL; LIPID METABOLISM; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; DIET; INSULIN; LINOLEIC ACIDS, CONJUGATED; LIPID METABOLISM; LIPIDS; LIPOPROTEINS; LIVER; MICE; TRIGLYCERIDES;

EID: 52149083045     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.12.040     Document Type: Article

References (49)

1. Pariza M.W., Ashoor S.H., Chu F.S., and Lund D.B. Effects of temperature and time on mutagen formation in pan-fried hamburger. Cancer Lett 7 (1979) 63-69
2. Ha Y.L., Grimm N.K., and Pariza M.W. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis 8 (1987) 1881-1887
3. Park Y., Albright K.J., Liu W., et al. Effect of conjugated linoleic acid on body composition in mice. Lipids 32 (1997) 853-858
4. Mosley E.E., Shafii D.B., Moate P.J., and McGuire M.A. cis-9,trans-11 conjugated linoleic acid is synthesized directly from vaccenic acid in lactating dairy cattle. J Nutr 136 (2006) 570-575
5. Roche H.M., Noone E., Sewter C., et al. Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes 51 (2002) 2037-2044
6. Tricon S., Burdge G.C., Kew S., et al. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr 80 (2004) 614-620
7. Macarulla M.T., Fernandez-Quintela A., Zabala A., et al. Effects of conjugated linoleic acid on liver composition and fatty acid oxidation are isomer-dependent in hamster. Nutrition 21 (2005) 512-519
8. Pariza M.W. The biological activities of conjugated linoleic acid. In: Yurawecz M.P., Mossoba M.M., Kramer J.K., Pariza M.W., and Nelson G.J. (Eds). Advances in conjugated linoleic acid research vol. 1 (1999), AOCS Press, Champaign, IL 12-20
9. Belury M.A. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr 22 (2002) 505-531
10. McLeod R.S., LeBlanc A.M., Langille M.A., Mitchell P.L., and Currie D.L. Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism. Am J Clin Nutr 79 (2004) 1169S-1174S
11. Murray C.J., and Lopez A.D. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349 (1997) 1269-1276
12. Steinberg D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 8 (2002) 1211-1217
13. Williams K.J., and Tabas I. The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol 15 (1995) 551-561
14. Rajala M.W., Scherer P.E., and Minireview:. The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144 (2003) 3765-3773
15. Lau D.C., Dhillon B., Yan H., Szmitko P.E., and Verma S. Adipokines: molecular links between obesity and atheroslcerosis. Am J Physiol Heart Circ Physiol 288 (2005) H2031-H2041
16. Shimada K., Miyazaki T., and Daida H. Adiponectin and atherosclerotic disease. Clin Chim Acta 344 (2004) 1-12
17. Hug C., and Lodish H.F. The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol 5 (2005) 129-134
18. Trujillo M.E., and Scherer P.E. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 257 (2005) 167-175
19. Kritchevsky D., Tepper S.A., Wright S., et al. Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids 39 (2004) 611-616
20. Wilson T.A., Nicolosi R.J., Chrysam M., and Kritchevsky D. Conjugated linoleic acid reduces early aortic atherosclerosis greater than linoleic acid in hypercholesterolemic hamsters. Nutr Res 20 (2000) 1795-1805
21. Mitchell P.L., Langille M.A., Currie D.L., and McLeod R.S. Effect of conjugated linoleic acid isomers on lipoproteins and atherosclerosis in the Syrian Golden hamster. Biochim Biophys Acta 1734 (2005) 269-276
22. Toomey S., Harhen B., Roche H.M., Fitzgerald D., and Belton O. Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis 187 (2006) 40-49
23. Kritchevsky D., Tepper S.A., Wright S., and Czarnecki S.K. Influence of graded levels of conjugated linoleic acid (CLA) on experimental atherosclerosis in rabbits. Nutr Res 22 (2002) 1275-1279
24. Yurawecz M.P., Kramer J.K., and Ku Y. Methylation procedures for conjugated linoleic acid. In: Yurawecz M.P., Mossoba M.M., Kramer J.K., Pariza M.W., and Nelson G.J. (Eds). Advances in conjugated linoleic acid research vol. 1 (1999), AOCS Press, Champaign, IL 64-82
25. Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226 (1957) 497-509
26. Toomey S., Roche H., Fitzgerald D., and Belton O. Regression of pre-established atherosclerosis in the apoE-/- mouse by conjugated linoleic acid. Biochem Soc Trans 31 (2003) 1075-1079
27. Arbones-Mainar J.M., Navarro M.A., Guzman M.A., et al. Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice. Atherosclerosis 189 (2006) 318-327
28. Clement L., Poirier H., Niot I., et al. Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 43 (2002) 1400-1409
29. Poirier H., Niot I., Clement L., Guerre-Millo M., and Besnard P. Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse. Biochimie 87 (2005) 73-79
30. Poirier H., Rouault C., Clement L., et al. Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Diabetologia 48 (2005) 1059-1065
31. Valeille K., Gripois D., Blouquit M.F., et al. Lipid atherogenic risk markers can be more favourably influenced by the cis-9,trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters. Br J Nutr 91 (2004) 191-199
32. Nestel P., Fujii A., and Allen T. The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice. Atherosclerosis 189 (2006) 282-287
33. Wilson T.A., Nicolosi R.J., Saati A., Kotyla T., and Kritchevsky D. Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters. Lipids 41 (2006) 41-48
34. Arbones-Mainar J.M., Navarro M.A., Acin S., et al. trans-10,cis-12- and cis-9,trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice. J Nutr 136 (2006) 353-359
35. Moya-Camarena S.Y., and Belury M.A. Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid. Nutr Rev 57 (1999) 336-340
36. Acin S., Navarro M.A., Carnicer R., et al. Dietary cholesterol suppresses the ability of olive oil to delay the development of atherosclerotic lesions in apolipoprotein E knockout mice. Atherosclerosis 182 (2005) 17-28
37. Sato M., Shibata K., Nomura R., et al. Linoleic acid-rich fats reduce atherosclerosis development beyond its oxidative and inflammatory stress-increasing effect in apolipoprotein E-deficient mice in comparison with saturated fatty acid-rich fats. Br J Nutr 94 (2005) 896-901
38. Tsuboyama-Kasaoka N., Miyazaki H., Kasaoka S., and Ezaki O. Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice. J Nutr 133 (2003) 1793-1799
39. Degrace P., Demizieux L., Gresti J., et al. Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6J mice fed trans-10,cis-12-linoleic acid. FEBS Lett 546 (2003) 335-339
40. Javadi M., Beynen A.C., Hovenier R., et al. Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. J Nutr Biochem 15 (2004) 680-687
41. Tsuboyama-Kasaoka N., Takahashi M., Tanemura K., et al. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49 (2000) 1534-1542
42. Brown J.M., Boysen M.S., Chung S., et al. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J Biol Chem 279 (2004) 26735-26747
43. Chung S., Brown J.M., Provo J.N., Hopkins R., and McIntosh M.K. Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J Biol Chem 280 (2005) 38445-38456
44. de Roos B., Rucklidge G., Reid M., et al. Divergent mechanisms of cis9,trans1- and trans10,cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. FASEB J 19 (2005) 1746-1748
45. Hotta K., Funahashi T., Bodkin N.L., et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50 (2001) 1126-1133
46. Yamauchi T., Kamon J., Waki H., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7 (2001) 941-946
47. Warren J.M., Simon V.A., Bartolini G., et al. trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes. Lipids 38 (2003) 497-504
48. Purushotham A., Wendel A.A., Liu L.F., and Belury M.A. Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in mice. J Lipid Res 48 (2007) 444-452
49. Moya-Camarena S.Y., Vanden Heuvel J.P., Blanchard S.G., Leesnitzer L.A., and Belury M.A. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res 40 (1999) 1426-1433