메뉴 건너뛰기




Volumn 299, Issue 6, 2010, Pages

t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism

Author keywords

Ductal growth; Fatty liver; Lipogenic gene expression; Mammary fat pad

Indexed keywords

10,12 CONJUGATED LINOLEIC ACID; CONJUGATED LINOLEIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 5; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG;

EID: 78649841510     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00445.2010     Document Type: Article
Times cited : (24)

References (43)
  • 1
    • 38949142642 scopus 로고    scopus 로고
    • Regulation of fat synthesis by conjugated linoleic acid: Lactation and the ruminant model
    • Bauman DE, Perfield JW, 2nd Harvatine KJ, Baumgard LH. Regulation of fat synthesis by conjugated linoleic acid: lactation and the ruminant model. J Nutr 138: 403-409, 2008.
    • (2008) J Nutr , vol.138 , pp. 403-409
    • Bauman, D.E.1    Perfield II, J.W.2    Harvatine, K.J.3    Baumgard, L.H.4
  • 3
  • 4
    • 2942755860 scopus 로고    scopus 로고
    • Conjugated linoleic acid induces human adipocyte delipidation: Autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines
    • Brown JM, Boysen MS, Chung S, Fabiyi O, Morrison RF, Mandrup S, McIntosh MK. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J Biol Chem 279: 26735-26747, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 26735-26747
    • Brown, J.M.1    Boysen, M.S.2    Chung, S.3    Fabiyi, O.4    Morrison, R.F.5    Mandrup, S.6    McIntosh, M.K.7
  • 5
    • 33644680390 scopus 로고    scopus 로고
    • Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production
    • Chung S, Brown JM, Provo JN, Hopkins R, McIntosh MK. Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. J Biol Chem 280: 38445-38456, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 38445-38456
    • Chung, S.1    Brown, J.M.2    Provo, J.N.3    Hopkins, R.4    McIntosh, M.K.5
  • 6
    • 34248353890 scopus 로고    scopus 로고
    • Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development
    • Ciarloni L, Mallepell S, Brisken C. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci USA 104: 5455-5460, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5455-5460
    • Ciarloni, L.1    Mallepell, S.2    Brisken, C.3
  • 8
    • 0036211231 scopus 로고    scopus 로고
    • Adipose tissue: A vital in vivo role in mammary gland development but not differentiation
    • Couldrey C, Moitra J, Vinson C, Anver M, Nagashima K, Green J. Adipose tissue: a vital in vivo role in mammary gland development but not differentiation. Dev Dyn 223: 459-468, 2002.
    • (2002) Dev Dyn , vol.223 , pp. 459-468
    • Couldrey, C.1    Moitra, J.2    Vinson, C.3    Anver, M.4    Nagashima, K.5    Green, J.6
  • 10
    • 61349178831 scopus 로고    scopus 로고
    • The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse
    • Fernandez-Valdivia R, Mukherjee A, Ying Y, Li J, Paquet M, De- Mayo FJ, Lydon JP. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol 328: 127-139, 2009.
    • (2009) Dev Biol , vol.328 , pp. 127-139
    • Fernandez-Valdivia, R.1    Mukherjee, A.2    Ying, Y.3    Li, J.4    Paquet, M.5    De- Mayo, F.J.6    Lydon, J.P.7
  • 11
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509, 1957.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 12
    • 0015591066 scopus 로고
    • Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method
    • Foster LB, Dunn RT. Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chem 19: 338-340, 1973.
    • (1973) Clin Chem , vol.19 , pp. 338-340
    • Foster, L.B.1    Dunn, R.T.2
  • 13
    • 70449726656 scopus 로고    scopus 로고
    • Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats
    • Gudbrandsen OA, Rodriguez E, Wergedahl H, Mork S, Reseland JE, Skorve J, Palou A, Berge RK. Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats. Br J Nutr 102: 803-815, 2009.
    • (2009) Br J Nutr , vol.102 , pp. 803-815
    • Gudbrandsen, O.A.1    Rodriguez, E.2    Wergedahl, H.3    Mork, S.4    Reseland, J.E.5    Skorve, J.6    Palou, A.7    Berge, R.K.8
  • 14
    • 33749471630 scopus 로고    scopus 로고
    • SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA
    • Harvatine KJ, Bauman DE. SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA. J Nutr 136: 2468-2474, 2006.
    • (2006) J Nutr , vol.136 , pp. 2468-2474
    • Harvatine, K.J.1    Bauman, D.E.2
  • 15
    • 78649806083 scopus 로고    scopus 로고
    • Trans-10, cis-12 conjugated linoleic acid (CLA) induces a dose-dependent reduction in milk fat synthesis in C57BL6J mice
    • Harvatine KJ, Robblee MM, Boisclair YR, Bauman DE. Trans-10, cis-12 conjugated linoleic acid (CLA) induces a dose-dependent reduction in milk fat synthesis in C57BL6J mice. J Dairy Sci 91 E-Suppl 1: 567, 2008.
    • (2008) J Dairy Sci , vol.91 , Issue.E-SUPPL 1 , pp. 567
    • Harvatine, K.J.1    Robblee, M.M.2    Boisclair, Y.R.3    Bauman, D.E.4
  • 17
    • 21244497638 scopus 로고    scopus 로고
    • Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice
    • DOI 10.1152/physiolgenomics.00244.2004
    • House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol Genomics 21: 351-361, 2005. (Pubitemid 40898495)
    • (2005) Physiological Genomics , vol.21 , pp. 351-361
    • House, R.L.1    Cassady, J.P.2    Eisen, E.J.3    Eling, T.E.4    Collins, J.B.5    Grissom, S.F.6    Odle, J.7
  • 18
    • 22744451979 scopus 로고    scopus 로고
    • Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue
    • House RL, Cassady JP, Eisen EJ, McIntosh MK, Odle J. Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue. Obes Rev 6: 247-258, 2005.
    • (2005) Obes Rev , vol.6 , pp. 247-258
    • House, R.L.1    Cassady, J.P.2    Eisen, E.J.3    McIntosh, M.K.4    Odle, J.5
  • 20
    • 0141490789 scopus 로고    scopus 로고
    • Prevention of mammary cancer with conjugated linoleic acid: Role of the stroma and the epithelium
    • Ip MM, Masso-Welch PA, Ip C. Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium. J Mammary Gland Biol Neoplasia 8: 103-118, 2003.
    • (2003) J Mammary Gland Biol Neoplasia , vol.8 , pp. 103-118
    • Ip, M.M.1    Masso-Welch, P.A.2    Ip, C.3
  • 21
    • 34047155557 scopus 로고    scopus 로고
    • The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium
    • Ip MM, McGee SO, Masso-Welch PA, Ip C, Meng X, Ou L, Shoemaker SF. The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium. Carcinogenesis 28: 1269-1276, 2007.
    • (2007) Carcinogenesis , vol.28 , pp. 1269-1276
    • Ip, M.M.1    McGee, S.O.2    Masso-Welch, P.A.3    Ip, C.4    Meng, X.5    Ou, L.6    Shoemaker, S.F.7
  • 23
    • 57149143868 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions
    • Kleinberg DL, Wood TL, Furth PA, Lee AV. Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr Rev 30: 51-74, 2009.
    • (2009) Endocr Rev , vol.30 , pp. 51-74
    • Kleinberg, D.L.1    Wood, T.L.2    Furth, P.A.3    Lee, A.V.4
  • 24
    • 33947405131 scopus 로고    scopus 로고
    • Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: A microarray and histological analysis
    • LaRosa PC, Miner J, Xia Y, Zhou Y, Kachman S, Fromm ME. Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. Physiol Genomics 27: 282-294, 2006.
    • (2006) Physiol Genomics , vol.27 , pp. 282-294
    • LaRosa, P.C.1    Miner, J.2    Xia, Y.3    Zhou, Y.4    Kachman, S.5    Fromm, M.E.6
  • 25
    • 12544254217 scopus 로고    scopus 로고
    • Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health
    • Lock AL, Bauman DE. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids 39: 1197-1206, 2004.
    • (2004) Lipids , vol.39 , pp. 1197-1206
    • Lock, A.L.1    Bauman, D.E.2
  • 26
    • 33144474647 scopus 로고    scopus 로고
    • Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
    • Mallepell S, Krust A, Chambon P, Brisken C. Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci USA 103: 2196-2201, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2196-2201
    • Mallepell, S.1    Krust, A.2    Chambon, P.3    Brisken, C.4
  • 27
    • 47249098385 scopus 로고    scopus 로고
    • t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways
    • Meng X, Shoemaker SF, McGee SO, Ip MM. t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways. Carcinogenesis 29: 1013-1021, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 1013-1021
    • Meng, X.1    Shoemaker, S.F.2    McGee, S.O.3    Ip, M.M.4
  • 28
    • 33847399236 scopus 로고    scopus 로고
    • Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue
    • Moloney F, Toomey S, Noone E, Nugent A, Allan B, Loscher CE, Roche HM. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56: 574-582, 2007.
    • (2007) Diabetes , vol.56 , pp. 574-582
    • Moloney, F.1    Toomey, S.2    Noone, E.3    Nugent, A.4    Allan, B.5    Loscher, C.E.6    Roche, H.M.7
  • 29
    • 34249809738 scopus 로고    scopus 로고
    • Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene
    • DOI 10.1210/en.2006-0041
    • Ning Y, Hoang B, Schuller AG, Cominski TP, Hsu MS, Wood TL, Pintar JE. Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene. Endocrinology 148: 2138-2147, 2007. (Pubitemid 46997078)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2138-2147
    • Ning, Y.1    Hoang, B.2    Schuller, A.G.P.3    Cominski, T.P.4    Hsu, M.-S.5    Wood, T.L.6    Pintar, J.E.7
  • 30
    • 0034964992 scopus 로고    scopus 로고
    • The biologically active isomers of conjugated linoleic acid
    • Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40: 283-298, 2001.
    • (2001) Prog Lipid Res , vol.40 , pp. 283-298
    • Pariza, M.W.1    Park, Y.2    Cook, M.E.3
  • 31
    • 77649296864 scopus 로고    scopus 로고
    • Moderate doses of conjugated linoleic acid reduce fat gain, maintain insulin sensitivity without impairing inflammatory adipose tissue status in mice fed a high-fat diet
    • Parra P, Palou A, Serra F. Moderate doses of conjugated linoleic acid reduce fat gain, maintain insulin sensitivity without impairing inflammatory adipose tissue status in mice fed a high-fat diet. Nutr Metab (Lond) 7: 5, 2010.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 5
    • Parra, P.1    Palou, A.2    Serra, F.3
  • 32
    • 73949094337 scopus 로고    scopus 로고
    • Moderate doses of conjugated linoleic acid isomers mix contribute to lowering body fat content maintaining insulin sensitivity and a noninflammatory pattern in adipose tissue in mice
    • Parra P, Serra F, Palou A. Moderate doses of conjugated linoleic acid isomers mix contribute to lowering body fat content maintaining insulin sensitivity and a noninflammatory pattern in adipose tissue in mice. J Nutr Biochem 21: 107-115, 2010.
    • (2010) J Nutr Biochem , vol.21 , pp. 107-115
    • Parra, P.1    Serra, F.2    Palou, A.3
  • 33
    • 33748291462 scopus 로고    scopus 로고
    • Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue
    • Poirier H, Shapiro JS, Kim RJ, Lazar MA. Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 55: 1634-1641, 2006.
    • (2006) Diabetes , vol.55 , pp. 1634-1641
    • Poirier, H.1    Shapiro, J.S.2    Kim, R.J.3    Lazar, M.A.4
  • 35
    • 3042596853 scopus 로고    scopus 로고
    • Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I
    • Richards RG, Klotz DM, Walker MP, Diaugustine RP. Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology 145: 3106-3110, 2004.
    • (2004) Endocrinology , vol.145 , pp. 3106-3110
    • Richards, R.G.1    Klotz, D.M.2    Walker, M.P.3    Diaugustine, R.P.4
  • 37
    • 0034989437 scopus 로고    scopus 로고
    • Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats
    • Sisk MB, Hausman DB, Martin RJ, Azain MJ. Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J Nutr 131: 1668-1674, 2001.
    • (2001) J Nutr , vol.131 , pp. 1668-1674
    • Sisk, M.B.1    Hausman, D.B.2    Martin, R.J.3    Azain, M.J.4
  • 38
    • 69849084075 scopus 로고    scopus 로고
    • Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis
    • Sternlicht MD. Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res 8: 201, 2006.
    • (2006) Breast Cancer Res , vol.8 , pp. 201
    • Sternlicht, M.D.1
  • 39
    • 77954915663 scopus 로고    scopus 로고
    • Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3
    • Thorn SR, Giesy SL, Myers MG Jr, Boisclair YR. Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3. Signal Endocrinol 151: 3985-3995, 2010.
    • (2010) Signal Endocrinol , vol.151 , pp. 39853995
    • Thorn, S.R.1    Giesy, S.L.2    Myers Jr., M.G.3    Boisclair, Y.R.4
  • 40
    • 0036798203 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice
    • Tonner E, Barber MC, Allan GJ, Beattie J, Webster J, Whitelaw CB, Flint DJ. Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice. Development 129: 4547-4557, 2002.
    • (2002) Development , vol.129 , pp. 4547-4557
    • Tonner, E.1    Barber, M.C.2    Allan, G.J.3    Beattie, J.4    Webster, J.5    Whitelaw, C.B.6    Flint, D.J.7
  • 41
    • 0034744035 scopus 로고    scopus 로고
    • TNFα induces NF-κB/p50 in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells
    • Varela LM, Stangle-Castor NC, Shoemaker SF, Shea-Eaton WK, Ip MM. TNFα induces NF-κB/p50 in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells. J Cell Physiol 188: 120-131, 2001.
    • (2001) J Cell Physiol , vol.188 , pp. 120-131
    • Varela, L.M.1    Stangle-Castor, N.C.2    Shoemaker, S.F.3    Shea-Eaton, W.K.4    Ip, M.M.5
  • 42
    • 0031791258 scopus 로고    scopus 로고
    • Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development
    • Walden PD, Ruan W, Feldman M, Kleinberg DL. Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development. Endocrinology 139: 659-662, 1998.
    • (1998) Endocrinology , vol.139 , pp. 659-662
    • Walden, P.D.1    Ruan, W.2    Feldman, M.3    Kleinberg, D.L.4
  • 43
    • 33845910163 scopus 로고    scopus 로고
    • NFκB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: Implications for NF-κB2/p52 and RelB
    • Zhang J, Warren MA, Shoemaker SF, Ip MM. NFκB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NF-κB2/p52 and RelB. Endocrinology 148: 268-278, 2007.
    • (2007) Endocrinology , vol.148 , pp. 268-278
    • Zhang, J.1    Warren, M.A.2    Shoemaker, S.F.3    Ip, M.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.