Weak effect of trans-10, cis-12-conjugated linoleic acid on body fat accumulation in adult hamsters

British Journal of Nutrition

Volumn 102, Issue 11, 2009, Pages 1583-1589

  Miranda, Jonatan ^a   Churruca, Itziar ^a   Fernández Quintela, Alfredo ^a   Rodríguez, Victor Manuel ^a   MacArulla, María Teresa ^a   Simón, Edurne ^a   Portillo, María Puy ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Adipose tissue; Adult hamsters; Conjugated linoleic acid

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CONJUGATED LINOLEIC ACID; FATTY ACID SYNTHASE; LIPOPROTEIN LIPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCOUPLING PROTEIN 1;

ADULT ANIMAL; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS FAT; LIPID DIET; LIPID STORAGE; LIPID TRANSPORT; LIPOGENESIS; MALE; NONHUMAN; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; SYRIAN HAMSTER; THERMOGENESIS;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; BODY WEIGHT; CRICETINAE; EATING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ION CHANNELS; LINOLEIC ACIDS, CONJUGATED; LIPOGENESIS; MALE; MESOCRICETUS; MITOCHONDRIAL PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; TRANSCRIPTION FACTORS;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 73649138568     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509990912     Document Type: Article

References (49)

1. Wang YW & Jones PJ (2004) Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J Obes Relat Metab Disord 28, 941-955.
2. Bhattacharya A, Banu J, Rahman M, et al. (2006) Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 17, 789-810.
3. Park Y & Pariza MW (2007) Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Res Int 40, 311-323.
4. Larsen TM, Toubro S & Astrup A (2003) Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. J Lipid Res 44, 2234-2241.
5. Terpstra AH (2004) Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Am J Clin Nutr 79, 352-361.
6. Salas-Salvado J, Marquez-Sandoval F & Bullo M (2006) Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr 46, 479-488.
7. Navarro V, Fernández-Quintela A, Churruca I, et al. (2006) The body fat-lowering effect of conjugated linoleic acid: a comparison between animal and human studies. J Physiol Biochem 62, 137-147.
8. Mirand PP, Arnal-Bagnard MA, Mosoni L, et al. (2004) Cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers do not modify body composition in adult sedentary or exercised rats. J Nutr 134, 2263-2269.
9. Faulconnier Y, Arnal MA, Patureau Mirand P, et al. (2004) Isomers of conjugated linoleic acid decrease plasma lipids and stimulate adipose tissue lipogenesis without changing adipose weight in post-prandial adult sedentary or trained Wistar rats. J Nutr Biochem 15, 741-748.
10. Park Y, Albright K, Storkson J, et al. (1999) Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34, 243-248. (Pubitemid 29169627)
11. Miner JL, Cederberg CA, Nielsen MK, et al. (2001) Conjugated linoleic acid (CLA), body fat, and apoptosis. Obes Res 9, 129-134.
12. Navarro V, Miranda J, Churruca I, et al. (2006) Effects of trans-10,cis-12 conjugated linoleic acid on body fat and serum lipids in young and adult hamsters. J Physiol Biochem 62, 81-87.
13. Eckel R (1989) Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. N Engl J Med 320, 1060-1068.
14. Kersten S (2002) Peroxisome proliferator activated receptors and obesity. Eur J Pharmacol 440, 223-234.
15. Khan S & Vanden Heuvel J (2003) Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14, 554-567.
16. Pai J, Guryev O, Brown M, et al. (1998) Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J Biol Chem 273, 26138-26148.
17. Shimano H (2001) Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40, 439-452.
18. Horton J (2002) Sterol regulatory element-binding proteins (SREBPs): transcriptional activators of lipid synthesis. Biochem Soc Trans 30, 1091-1095.
19. Himms-Hagen J (1985) Brown adipose tissue metabolism and thermogenesis. Annu Rev Nutr 5, 69-94.
20. Reeves P, Nielsen F & Fahey GJ (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951.
21. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
22. Zabala A, Churruca I, Fernandez-Quintela A, et al. (2006) Trans-10,cis-12 conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet. Br J Nutr 95, 1112-1119.
23. Lynen F (1969) Yeast fatty acid synthase. Methods Enzymol 14, 14-17.
24. Livak K & Schmittgen T (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 22DDCT method. Methods 25, 402-408.
25. Miranda J, Fernández-Quintela A, Churruca I, et al. (2009) Hepatomegaly induced by trans-10,cis-12 conjugated linoleic acid in adult hamsters fed an atherogenic diet is not associated with steatosis. J Am Coll Nutr 28, 43-49.
26. Kelley DS & Erickson KL (2003) Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks. Lipids 38, 377-386.
27. Kim MR, Park Y, Albright KJ, et al. (2002) Differential responses of hamsters and rats fed high-fat or low-fat diets supplemented with conjugated linoleic acid. Nutr Res 22, 715-722.
28. Pariza MW (2004) Perspective on the safety and effectiveness of conjugated linoleic acid. Am J Clin Nutr 79, 1132S-1136S.
29. Wahle K, Heys S & Rotondo D (2004) Conjugated linoleic acids: are they beneficial or detrimental to health? Prog Lipid Res 43, 553-587.
30. Navarro V, Zabala A, Macarulla MT, et al. (2003) Effects of conjugated linoleic acid on body fat accumulation and serum lipids in hamsters fed an atherogenic diet. J Physiol Biochem 59, 193-199.
31. Park Y, Albright K, Liu W, et al. (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32, 853-858. (Pubitemid 27360392)
32. Park Y, Storkson J, Albright K, et al. (1999) Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34, 235-241. (Pubitemid 29169626)
33. Park Y & Pariza M (2001) The effects of dietary conjugated nonadecadienoic acid on body composition in mice. Biochim Biophys Acta 1533, 171-174.
34. Park Y, Storkson J, Liu W, et al. (2004) Structure-activity relationship of conjugated linoleic acid and its cognates in inhibiting heparin-releasable lipoprotein lipase and glycerol release from fully differentiated 3T3-L1 adipocytes. J Nutr Biochem 15, 561-568.
35. Lin Y, Kreeft A, Schuurbiers J, et al. (2001) Different effects of conjugated linoleic acid isomers on lipoprotein lipase activity in 3T3-L1 adipocytes. J Nutr Biochem 12, 183-189.
36. Xu X, Storkson J, Kim S, et al. (2003) Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. J Nutr 133, 663-667.
37. West D, Blohm F, Truett A, et al. (2000) Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J Nutr 130, 2471-2477.
38. Kang K, Miyazaki M, Ntambi J, et al. (2004) Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase 1 expression and enzyme activity. Biochem Biophys Res Commun 315, 532-537.
39. Azain MJ, Hausman DB, Sisk MB, et al. (2000) Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr 130, 1548-1554.
40. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, et al. (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49, 1534-1542.
41. Clement L, Poirier H, Niot I, et al. (2002) Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 43, 1400-1409.
42. Pariza M, Park Y & Cook M (2001) The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40, 283-298.
43. Roche H, Noone E & Gibney A (2001) Conjugated linoleic acid: a novel therapeutic nutrient? Nutr Res Rev 14, 173-188.
44. Ryder J, Portocarrero C, Song X, et al. (2001) Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 50, 1149-1157.
45. Ealey KN, El-Sohemy A & Archer MC (2002) Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats. Lipids 37, 853-861.
46. Roche H, Noone E, Sewter C, et al. (2002) Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRa. Diabetes 51, 2037-2044.
47. Rodríguez E, Ribot J & Palou A (2002) Trans-10, cis-12, but not cis-9, trans-11 CLA isomer, inhibits brown adipocyte thermogenic capacity. Am J Physiol Regul Integr Comp Physiol 282, R1789-R1797.
48. Takahashi Y, Kushiro M, Shinohara K, et al. (2002) Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. Comp Biochem Physiol B Biochem Mol Biol 133, 395-404.
49. Choi JS, Jung MH, Park HS, et al. (2004) Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 20, 1008-1017.