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Volumn 33, Issue 6, 2012, Pages 281-288

Determining germinal centre B cell fate

Author keywords

Affinity maturation; Antibodies; Cytokines; Humoral immunity; Memory

Indexed keywords

CYTOKINE; INTERLEUKIN 21; INTERLEUKIN 4;

EID: 84861688429     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2012.04.003     Document Type: Review
Times cited : (70)

References (139)
  • 1
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
    • Jacob J., et al. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 1991, 173:1165-1175.
    • (1991) J. Exp. Med. , vol.173 , pp. 1165-1175
    • Jacob, J.1
  • 2
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu Y.J., et al. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 1991, 21:2951-2962.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2951-2962
    • Liu, Y.J.1
  • 3
    • 23844445862 scopus 로고    scopus 로고
    • Two waves of memory B-cell generation in the primary immune response
    • Inamine A., et al. Two waves of memory B-cell generation in the primary immune response. Int. Immunol. 2005, 17:581-589.
    • (2005) Int. Immunol. , vol.17 , pp. 581-589
    • Inamine, A.1
  • 4
    • 0022975140 scopus 로고
    • Distinct short-lived and long-lived antibody-producing cell populations
    • Ho F., et al. Distinct short-lived and long-lived antibody-producing cell populations. Eur. J. Immunol. 1986, 16:1297-1301.
    • (1986) Eur. J. Immunol. , vol.16 , pp. 1297-1301
    • Ho, F.1
  • 5
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • Jacob J., Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 1992, 176:679-687.
    • (1992) J. Exp. Med. , vol.176 , pp. 679-687
    • Jacob, J.1    Kelsoe, G.2
  • 6
    • 0026497315 scopus 로고
    • Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific, IgG1+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP
    • Lalor P.A., et al. Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific, IgG1+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immunol. 1992, 22:3001-3011.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 3001-3011
    • Lalor, P.A.1
  • 7
    • 0027265278 scopus 로고
    • Antigen-driven B cell differentiation in vivo
    • McHeyzer-Williams M.G., et al. Antigen-driven B cell differentiation in vivo. J. Exp. Med. 1993, 178:295-307.
    • (1993) J. Exp. Med. , vol.178 , pp. 295-307
    • McHeyzer-Williams, M.G.1
  • 8
    • 33645856486 scopus 로고    scopus 로고
    • Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
    • Paus D., et al. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 2006, 203:1081-1091.
    • (2006) J. Exp. Med. , vol.203 , pp. 1081-1091
    • Paus, D.1
  • 9
    • 0036073140 scopus 로고    scopus 로고
    • Role of BCR affinity in T cell dependent antibody responses in vivo
    • Shih T.A., et al. Role of BCR affinity in T cell dependent antibody responses in vivo. Nat. Immunol. 2002, 3:570-575.
    • (2002) Nat. Immunol. , vol.3 , pp. 570-575
    • Shih, T.A.1
  • 10
    • 70349249529 scopus 로고    scopus 로고
    • Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts
    • Chan T.D., et al. Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts. J. Immunol. 2009, 183:3139-3149.
    • (2009) J. Immunol. , vol.183 , pp. 3139-3149
    • Chan, T.D.1
  • 11
    • 73349126428 scopus 로고    scopus 로고
    • Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
    • Anderson S.M., et al. Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J. Immunol. 2009, 183:7314-7325.
    • (2009) J. Immunol. , vol.183 , pp. 7314-7325
    • Anderson, S.M.1
  • 12
    • 77955898582 scopus 로고    scopus 로고
    • T cells and follicular dendritic cells in germinal center B-cell formation and selection
    • Vinuesa C.G., et al. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol. Rev. 2010, 237:72-89.
    • (2010) Immunol. Rev. , vol.237 , pp. 72-89
    • Vinuesa, C.G.1
  • 13
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal centre formation
    • Qi H., et al. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 2008, 455:764-769.
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1
  • 14
    • 76949091588 scopus 로고    scopus 로고
    • Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    • Cannons J.L., et al. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity 2010, 32:253-265.
    • (2010) Immunity , vol.32 , pp. 253-265
    • Cannons, J.L.1
  • 15
    • 63449096041 scopus 로고    scopus 로고
    • Follicular helper T cells are required for systemic autoimmunity
    • Linterman M.A., et al. Follicular helper T cells are required for systemic autoimmunity. J. Exp. Med. 2009, 206:561-576.
    • (2009) J. Exp. Med. , vol.206 , pp. 561-576
    • Linterman, M.A.1
  • 16
    • 77954913409 scopus 로고    scopus 로고
    • Control systems and decision making for antibody production
    • Goodnow C.C., et al. Control systems and decision making for antibody production. Nat. Immunol. 2010, 11:681-688.
    • (2010) Nat. Immunol. , vol.11 , pp. 681-688
    • Goodnow, C.C.1
  • 17
    • 77954150116 scopus 로고    scopus 로고
    • Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses
    • Pereira J.P., et al. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int. Immunol. 2010, 22:413-419.
    • (2010) Int. Immunol. , vol.22 , pp. 413-419
    • Pereira, J.P.1
  • 18
    • 68649108084 scopus 로고    scopus 로고
    • Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses
    • Gatto D., et al. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 2009, 31:259-269.
    • (2009) Immunity , vol.31 , pp. 259-269
    • Gatto, D.1
  • 19
    • 69349087555 scopus 로고    scopus 로고
    • EBI2 mediates B cell segregation between the outer and centre follicle
    • Pereira J.P., et al. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 2009, 460:1122-1126.
    • (2009) Nature , vol.460 , pp. 1122-1126
    • Pereira, J.P.1
  • 20
    • 33745182931 scopus 로고    scopus 로고
    • Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    • Klein U., et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 2006, 7:773-782.
    • (2006) Nat. Immunol. , vol.7 , pp. 773-782
    • Klein, U.1
  • 21
    • 33747133955 scopus 로고    scopus 로고
    • Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
    • Sciammas R., et al. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006, 25:225-236.
    • (2006) Immunity , vol.25 , pp. 225-236
    • Sciammas, R.1
  • 22
    • 31344450346 scopus 로고    scopus 로고
    • Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    • Lee C.H., et al. Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. J. Exp. Med. 2006, 203:63-72.
    • (2006) J. Exp. Med. , vol.203 , pp. 63-72
    • Lee, C.H.1
  • 23
    • 0033680860 scopus 로고    scopus 로고
    • BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
    • Shaffer A.L., et al. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000, 13:199-212.
    • (2000) Immunity , vol.13 , pp. 199-212
    • Shaffer, A.L.1
  • 24
    • 0034684672 scopus 로고    scopus 로고
    • Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6
    • Reljic R., et al. Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6. J. Exp. Med. 2000, 192:1841-1848.
    • (2000) J. Exp. Med. , vol.192 , pp. 1841-1848
    • Reljic, R.1
  • 26
    • 18444395232 scopus 로고    scopus 로고
    • Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    • Shaffer A.L., et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002, 17:51-62.
    • (2002) Immunity , vol.17 , pp. 51-62
    • Shaffer, A.L.1
  • 27
    • 79956079578 scopus 로고    scopus 로고
    • Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
    • Nutt S.L., Tarlinton D.M. Germinal center B and follicular helper T cells: siblings, cousins or just good friends?. Nat. Immunol. 2011, 12:472-477.
    • (2011) Nat. Immunol. , vol.12 , pp. 472-477
    • Nutt, S.L.1    Tarlinton, D.M.2
  • 30
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent A.L., et al. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997, 276:589-592.
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1
  • 31
    • 0030763072 scopus 로고    scopus 로고
    • Disruption of the Bcl6 gene results in an impaired germinal center formation
    • Fukuda T., et al. Disruption of the Bcl6 gene results in an impaired germinal center formation. J. Exp. Med. 1997, 186:439-448.
    • (1997) J. Exp. Med. , vol.186 , pp. 439-448
    • Fukuda, T.1
  • 32
    • 17144439800 scopus 로고    scopus 로고
    • The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    • Ye B.H., et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 1997, 16:161-170.
    • (1997) Nat. Genet. , vol.16 , pp. 161-170
    • Ye, B.H.1
  • 33
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D., et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009, 31:457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 34
    • 0018836189 scopus 로고
    • Peanut lectin binding properties of germinal centres of mouse lymphoid tissue
    • Rose M.L., et al. Peanut lectin binding properties of germinal centres of mouse lymphoid tissue. Nature 1980, 284:364-366.
    • (1980) Nature , vol.284 , pp. 364-366
    • Rose, M.L.1
  • 35
    • 0027324869 scopus 로고
    • Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells
    • Laszlo G., et al. Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells. J. Immunol. 1993, 150:5252-5262.
    • (1993) J. Immunol. , vol.150 , pp. 5252-5262
    • Laszlo, G.1
  • 36
    • 0029936947 scopus 로고    scopus 로고
    • Induction of long-lived germinal centers associated with persisting antigen after viral infection
    • Bachmann M.F., et al. Induction of long-lived germinal centers associated with persisting antigen after viral infection. J. Exp. Med. 1996, 183:2259-2269.
    • (1996) J. Exp. Med. , vol.183 , pp. 2259-2269
    • Bachmann, M.F.1
  • 37
    • 0032536872 scopus 로고    scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection
    • Takahashi Y., et al. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 1998, 187:885-895.
    • (1998) J. Exp. Med. , vol.187 , pp. 885-895
    • Takahashi, Y.1
  • 38
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen C.D., et al. Germinal-center organization and cellular dynamics. Immunity 2007, 27:190-202.
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1
  • 39
    • 31344479725 scopus 로고    scopus 로고
    • CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers
    • Huntington N.D., et al. CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat. Immunol. 2006, 7:190-198.
    • (2006) Nat. Immunol. , vol.7 , pp. 190-198
    • Huntington, N.D.1
  • 40
    • 0030683640 scopus 로고    scopus 로고
    • Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B
    • Su G.H., et al. Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. EMBO J. 1997, 16:7118-7129.
    • (1997) EMBO J. , vol.16 , pp. 7118-7129
    • Su, G.H.1
  • 41
    • 13844296663 scopus 로고    scopus 로고
    • Immunological synapses are versatile structures enabling selective T cell polarization
    • Depoil D., et al. Immunological synapses are versatile structures enabling selective T cell polarization. Immunity 2005, 22:185-194.
    • (2005) Immunity , vol.22 , pp. 185-194
    • Depoil, D.1
  • 42
    • 0035942781 scopus 로고    scopus 로고
    • B cells acquire antigen from target cells after synapse formation
    • Batista F.D., et al. B cells acquire antigen from target cells after synapse formation. Nature 2001, 411:489-494.
    • (2001) Nature , vol.411 , pp. 489-494
    • Batista, F.D.1
  • 43
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen C.D., et al. Imaging of germinal center selection events during affinity maturation. Science 2007, 315:528-531.
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1
  • 44
    • 0031154831 scopus 로고    scopus 로고
    • Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts
    • Oprea M., Perelson A.S. Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts. J. Immunol. 1997, 158:5155-5162.
    • (1997) J. Immunol. , vol.158 , pp. 5155-5162
    • Oprea, M.1    Perelson, A.S.2
  • 45
    • 0034614899 scopus 로고    scopus 로고
    • Germinal centers without T cells
    • de Vinuesa C.G., et al. Germinal centers without T cells. J. Exp. Med. 2000, 191:485-494.
    • (2000) J. Exp. Med. , vol.191 , pp. 485-494
    • de Vinuesa, C.G.1
  • 46
    • 33746217902 scopus 로고    scopus 로고
    • The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand
    • Gaspal F.M., et al. The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. Eur. J. Immunol. 2006, 36:1665-1673.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1665-1673
    • Gaspal, F.M.1
  • 47
    • 0035399920 scopus 로고    scopus 로고
    • Cutting edge: germinal centers can be induced in the absence of T cells
    • Lentz V.M., Manser T. Cutting edge: germinal centers can be induced in the absence of T cells. J. Immunol. 2001, 167:15-20.
    • (2001) J. Immunol. , vol.167 , pp. 15-20
    • Lentz, V.M.1    Manser, T.2
  • 48
    • 83755184217 scopus 로고    scopus 로고
    • Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice
    • Wittenbrink N., et al. Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice. J. Immunol. 2011, 187:6185-6196.
    • (2011) J. Immunol. , vol.187 , pp. 6185-6196
    • Wittenbrink, N.1
  • 49
    • 33846400415 scopus 로고    scopus 로고
    • The germinal center response is impaired in the absence of T cell-expressed CXCR5
    • Arnold C.N., et al. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur. J. Immunol. 2007, 37:100-109.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 100-109
    • Arnold, C.N.1
  • 50
    • 0029870826 scopus 로고    scopus 로고
    • Differences in the germinal centres of palatine tonsils and lymph nodes
    • Brachtel E.F., et al. Differences in the germinal centres of palatine tonsils and lymph nodes. Scand. J. Immunol. 1996, 43:239-247.
    • (1996) Scand. J. Immunol. , vol.43 , pp. 239-247
    • Brachtel, E.F.1
  • 51
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes N.M., et al. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 2007, 179:5099-5108.
    • (2007) J. Immunol. , vol.179 , pp. 5099-5108
    • Haynes, N.M.1
  • 52
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D., et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 2000, 192:1545-1552.
    • (2000) J. Exp. Med. , vol.192 , pp. 1545-1552
    • Breitfeld, D.1
  • 53
    • 0035908122 scopus 로고    scopus 로고
    • Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
    • Kim C.H., et al. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J. Exp. Med. 2001, 193:1373-1381.
    • (2001) J. Exp. Med. , vol.193 , pp. 1373-1381
    • Kim, C.H.1
  • 54
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P., et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 2000, 192:1553-1562.
    • (2000) J. Exp. Med. , vol.192 , pp. 1553-1562
    • Schaerli, P.1
  • 55
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu D., Vinuesa C.G. The elusive identity of T follicular helper cells. Trends Immunol. 2010, 31:377-383.
    • (2010) Trends Immunol. , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 56
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 2011, 29:621-663.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 57
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T., et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 2004, 173:68-78.
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1
  • 58
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston R.J., et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009, 325:1006-1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 59
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva R.I., et al. Bcl6 mediates the development of T follicular helper cells. Science 2009, 325:1001-1005.
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 60
    • 0025764757 scopus 로고
    • Interleukin-4: a prototypic immunoregulatory lymphokine
    • Paul W.E. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 1991, 77:1859-1870.
    • (1991) Blood , vol.77 , pp. 1859-1870
    • Paul, W.E.1
  • 61
    • 0025004188 scopus 로고
    • IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production
    • Ben-Sasson S.Z., et al. IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. J. Immunol. 1990, 145:1127-1136.
    • (1990) J. Immunol. , vol.145 , pp. 1127-1136
    • Ben-Sasson, S.Z.1
  • 62
    • 0020081969 scopus 로고
    • Identification of a T cell-derived b cell growth factor distinct from interleukin 2
    • Howard M., et al. Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J. Exp. Med. 1982, 155:914-923.
    • (1982) J. Exp. Med. , vol.155 , pp. 914-923
    • Howard, M.1
  • 63
    • 65549114338 scopus 로고    scopus 로고
    • IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • King I.L., Mohrs M. IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 2009, 206:1001-1007.
    • (2009) J. Exp. Med. , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 64
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt R.L., et al. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 2009, 10:385-393.
    • (2009) Nat. Immunol. , vol.10 , pp. 385-393
    • Reinhardt, R.L.1
  • 65
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    • Yusuf I., et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J. Immunol. 2010, 185:190-202.
    • (2010) J. Immunol. , vol.185 , pp. 190-202
    • Yusuf, I.1
  • 66
    • 0025216937 scopus 로고
    • Lymphokine control of in vivo immunoglobulin isotype selection
    • Finkelman F.D., et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 1990, 8:303-333.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 303-333
    • Finkelman, F.D.1
  • 67
    • 0027452977 scopus 로고
    • Disruption of the murine IL-4 gene blocks Th2 cytokine responses
    • Kopf M., et al. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993, 362:245-248.
    • (1993) Nature , vol.362 , pp. 245-248
    • Kopf, M.1
  • 68
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R., et al. Generation and analysis of interleukin-4 deficient mice. Science 1991, 254:707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1
  • 69
    • 1642275659 scopus 로고    scopus 로고
    • Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells
    • Cunningham A.F., et al. Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells. Eur. J. Immunol. 2004, 34:686-694.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 686-694
    • Cunningham, A.F.1
  • 70
    • 0024442594 scopus 로고
    • Regulation of IgG1 and IgE synthesis by interleukin 4 in mouse B cells
    • Moon H.B., et al. Regulation of IgG1 and IgE synthesis by interleukin 4 in mouse B cells. Scand J. Immunol. 1989, 30:355-361.
    • (1989) Scand J. Immunol. , vol.30 , pp. 355-361
    • Moon, H.B.1
  • 71
    • 0023933655 scopus 로고
    • Differential regulation of IgG1 and IgE synthesis by interleukin 4
    • Snapper C.M., et al. Differential regulation of IgG1 and IgE synthesis by interleukin 4. J. Exp. Med. 1988, 167:183-196.
    • (1988) J. Exp. Med. , vol.167 , pp. 183-196
    • Snapper, C.M.1
  • 72
    • 0023219492 scopus 로고
    • B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide
    • Snapper C.M., Paul W.E. B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide. J. Immunol. 1987, 139:10-17.
    • (1987) J. Immunol. , vol.139 , pp. 10-17
    • Snapper, C.M.1    Paul, W.E.2
  • 73
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan M.H., et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996, 4:313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1
  • 74
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K., et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996, 380:630-633.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1
  • 75
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda K., et al. Essential role of Stat6 in IL-4 signalling. Nature 1996, 380:627-630.
    • (1996) Nature , vol.380 , pp. 627-630
    • Takeda, K.1
  • 76
    • 33847367120 scopus 로고    scopus 로고
    • IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
    • Coquet J.M., et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol. 2007, 178:2827-2834.
    • (2007) J. Immunol. , vol.178 , pp. 2827-2834
    • Coquet, J.M.1
  • 77
    • 33845903869 scopus 로고    scopus 로고
    • IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses
    • Harada M., et al. IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses. J. Exp. Med. 2006, 203:2929-2937.
    • (2006) J. Exp. Med. , vol.203 , pp. 2929-2937
    • Harada, M.1
  • 78
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J., et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000, 408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1
  • 79
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard W.J., Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 2005, 5:688-698.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 80
    • 33749531054 scopus 로고    scopus 로고
    • Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
    • Good K.L., et al. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J. Immunol. 2006, 177:5236-5247.
    • (2006) J. Immunol. , vol.177 , pp. 5236-5247
    • Good, K.L.1
  • 81
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H., et al. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J. Immunol. 2004, 173:657-665.
    • (2004) J. Immunol. , vol.173 , pp. 657-665
    • Jin, H.1
  • 82
    • 33845447720 scopus 로고    scopus 로고
    • Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21
    • Jin H., Malek T.R. Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21. J. Leukoc. Biol. 2006, 80:1416-1423.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 1416-1423
    • Jin, H.1    Malek, T.R.2
  • 83
    • 0037093258 scopus 로고    scopus 로고
    • Interleukin-21 is a growth and survival factor for human myeloma cells
    • Brenne A.T., et al. Interleukin-21 is a growth and survival factor for human myeloma cells. Blood 2002, 99:3756-3762.
    • (2002) Blood , vol.99 , pp. 3756-3762
    • Brenne, A.T.1
  • 84
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K., et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002, 298:1630-1634.
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1
  • 85
    • 47249097068 scopus 로고    scopus 로고
    • The role of IL-21 in regulating B-cell function in health and disease
    • Ettinger R., et al. The role of IL-21 in regulating B-cell function in health and disease. Immunol. Rev. 2008, 223:60-86.
    • (2008) Immunol. Rev. , vol.223 , pp. 60-86
    • Ettinger, R.1
  • 86
    • 0037446642 scopus 로고    scopus 로고
    • IL-21 induces the apoptosis of resting and activated primary B cells
    • Mehta D.S., et al. IL-21 induces the apoptosis of resting and activated primary B cells. J. Immunol. 2003, 170:4111-4118.
    • (2003) J. Immunol. , vol.170 , pp. 4111-4118
    • Mehta, D.S.1
  • 87
    • 6344269331 scopus 로고    scopus 로고
    • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    • Ozaki K., et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 2004, 173:5361-5371.
    • (2004) J. Immunol. , vol.173 , pp. 5361-5371
    • Ozaki, K.1
  • 88
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    • Avery D.T., et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J. Exp. Med. 2010, 207:155-171.
    • (2010) J. Exp. Med. , vol.207 , pp. 155-171
    • Avery, D.T.1
  • 89
    • 71749089605 scopus 로고    scopus 로고
    • Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
    • Kwon H., et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 2009, 31:941-952.
    • (2009) Immunity , vol.31 , pp. 941-952
    • Kwon, H.1
  • 90
    • 33745273911 scopus 로고    scopus 로고
    • JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells
    • Arguni E., et al. JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells. Int. Immunol. 2006, 18:1079-1089.
    • (2006) Int. Immunol. , vol.18 , pp. 1079-1089
    • Arguni, E.1
  • 91
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva R.I., et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008, 29:138-149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1
  • 92
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A., et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008, 29:127-137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1
  • 93
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T., et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007, 448:484-487.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1
  • 94
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007, 8:967-974.
    • (2007) Nat. Immunol. , vol.8 , pp. 967-974
    • Zhou, L.1
  • 95
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R., et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007, 448:480-483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1
  • 96
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu H.C., et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 2008, 9:166-175.
    • (2008) Nat. Immunol. , vol.9 , pp. 166-175
    • Hsu, H.C.1
  • 97
    • 77954500603 scopus 로고    scopus 로고
    • Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner
    • Bessa J., et al. Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner. J. Immunol. 2010, 184:4615-4619.
    • (2010) J. Immunol. , vol.184 , pp. 4615-4619
    • Bessa, J.1
  • 98
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D., et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J. Exp. Med. 2010, 207:365-378.
    • (2010) J. Exp. Med. , vol.207 , pp. 365-378
    • Zotos, D.1
  • 99
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman M.A., et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 2010, 207:353-363.
    • (2010) J. Exp. Med. , vol.207 , pp. 353-363
    • Linterman, M.A.1
  • 100
    • 77958138084 scopus 로고    scopus 로고
    • T follicular helper cells during immunity and tolerance
    • Linterman M.A., Vinuesa C.G. T follicular helper cells during immunity and tolerance. Prog. Mol. Biol. Transl. Sci. 2010, 92:207-248.
    • (2010) Prog. Mol. Biol. Transl. Sci. , vol.92 , pp. 207-248
    • Linterman, M.A.1    Vinuesa, C.G.2
  • 101
    • 0030925491 scopus 로고    scopus 로고
    • The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
    • Smith K.G., et al. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J. 1997, 16:2996-3006.
    • (1997) EMBO J. , vol.16 , pp. 2996-3006
    • Smith, K.G.1
  • 102
    • 0034614896 scopus 로고    scopus 로고
    • Bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
    • Smith K.G., et al. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J. Exp. Med. 2000, 191:475-484.
    • (2000) J. Exp. Med. , vol.191 , pp. 475-484
    • Smith, K.G.1
  • 103
    • 33750502877 scopus 로고    scopus 로고
    • High affinity germinal center B cells are actively selected into the plasma cell compartment
    • Phan T.G., et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 2006, 203:2419-2424.
    • (2006) J. Exp. Med. , vol.203 , pp. 2419-2424
    • Phan, T.G.1
  • 104
    • 34548237299 scopus 로고    scopus 로고
    • A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma
    • Saito M., et al. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 2007, 12:280-292.
    • (2007) Cancer Cell , vol.12 , pp. 280-292
    • Saito, M.1
  • 105
    • 34247387876 scopus 로고    scopus 로고
    • Repression of BCL-6 is required for the formation of human memory B cells in vitro
    • Kuo T.C., et al. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J. Exp. Med. 2007, 204:819-830.
    • (2007) J. Exp. Med. , vol.204 , pp. 819-830
    • Kuo, T.C.1
  • 106
    • 0029052398 scopus 로고
    • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    • Han S., et al. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 1995, 155:556-567.
    • (1995) J. Immunol. , vol.155 , pp. 556-567
    • Han, S.1
  • 107
    • 33344470255 scopus 로고    scopus 로고
    • T-independent type II immune responses generate memory B cells
    • Obukhanych T.V., Nussenzweig M.C. T-independent type II immune responses generate memory B cells. J. Exp. Med. 2006, 203:305-310.
    • (2006) J. Exp. Med. , vol.203 , pp. 305-310
    • Obukhanych, T.V.1    Nussenzweig, M.C.2
  • 108
    • 0023686940 scopus 로고
    • B cell memory to thymus-independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction
    • Zhang J., et al. B cell memory to thymus-independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction. Eur. J. Immunol. 1988, 18:1417-1424.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 1417-1424
    • Zhang, J.1
  • 109
    • 0036754646 scopus 로고    scopus 로고
    • Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells
    • Toyama H., et al. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 2002, 17:329-339.
    • (2002) Immunity , vol.17 , pp. 329-339
    • Toyama, H.1
  • 110
    • 14044275745 scopus 로고    scopus 로고
    • Cutting edge: back to " one-way" germinal centers
    • Meyer-Hermann M.E., Maini P.K. Cutting edge: back to " one-way" germinal centers. J. Immunol. 2005, 174:2489-2493.
    • (2005) J. Immunol. , vol.174 , pp. 2489-2493
    • Meyer-Hermann, M.E.1    Maini, P.K.2
  • 111
    • 34248585765 scopus 로고    scopus 로고
    • Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
    • Hauser A.E., et al. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 2007, 26:655-667.
    • (2007) Immunity , vol.26 , pp. 655-667
    • Hauser, A.E.1
  • 112
    • 34250877785 scopus 로고    scopus 로고
    • In vivo imaging studies shed light on germinal-centre development
    • Hauser A.E., et al. In vivo imaging studies shed light on germinal-centre development. Nat. Rev. Immunol. 2007, 7:499-504.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 499-504
    • Hauser, A.E.1
  • 113
    • 0025863323 scopus 로고
    • The heterogeneity of follicular reactions
    • MacLennan I.C., et al. The heterogeneity of follicular reactions. Res. Immunol. 1991, 142:253-257.
    • (1991) Res. Immunol. , vol.142 , pp. 253-257
    • MacLennan, I.C.1
  • 114
    • 43949172221 scopus 로고
    • Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation
    • Kepler T.B., Perelson A.S. Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunol. Today 1993, 14:412-415.
    • (1993) Immunol. Today , vol.14 , pp. 412-415
    • Kepler, T.B.1    Perelson, A.S.2
  • 115
    • 4644219817 scopus 로고    scopus 로고
    • Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    • Allen C.D., et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat. Immunol. 2004, 5:943-952.
    • (2004) Nat. Immunol. , vol.5 , pp. 943-952
    • Allen, C.D.1
  • 116
    • 33847206141 scopus 로고    scopus 로고
    • In vivo imaging of germinal centres reveals a dynamic open structure
    • Schwickert T.A., et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 2007, 446:83-87.
    • (2007) Nature , vol.446 , pp. 83-87
    • Schwickert, T.A.1
  • 117
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora G.D., et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 2010, 143:592-605.
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1
  • 118
    • 0035752146 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases
    • Leonard W.J. Cytokines and immunodeficiency diseases. Nat. Rev. Immunol. 2001, 1:200-208.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 200-208
    • Leonard, W.J.1
  • 119
    • 0034633734 scopus 로고    scopus 로고
    • Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
    • Ozaki K., et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:11439-11444.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 11439-11444
    • Ozaki, K.1
  • 120
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: from interferons to cytokines
    • Schindler C., et al. JAK-STAT signaling: from interferons to cytokines. J. Biol. Chem. 2007, 282:20059-20063.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20059-20063
    • Schindler, C.1
  • 121
    • 0027972046 scopus 로고
    • An interleukin-4-induced transcription factor: IL-4 Stat
    • Hou J., et al. An interleukin-4-induced transcription factor: IL-4 Stat. Science 1994, 265:1701-1706.
    • (1994) Science , vol.265 , pp. 1701-1706
    • Hou, J.1
  • 122
    • 0027688778 scopus 로고
    • Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4
    • Kotanides H., Reich N.C. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 1993, 262:1265-1267.
    • (1993) Science , vol.262 , pp. 1265-1267
    • Kotanides, H.1    Reich, N.C.2
  • 123
    • 0032553318 scopus 로고    scopus 로고
    • The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain
    • Lischke A., et al. The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain. J. Biol. Chem. 1998, 273:31222-31229.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31222-31229
    • Lischke, A.1
  • 124
    • 0028262965 scopus 로고
    • STF-IL-4: a novel IL-4-induced signal transducing factor
    • Schindler C., et al. STF-IL-4: a novel IL-4-induced signal transducing factor. EMBO J. 1994, 13:1350-1356.
    • (1994) EMBO J. , vol.13 , pp. 1350-1356
    • Schindler, C.1
  • 125
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H., et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol. 2001, 167:1-5.
    • (2001) J. Immunol. , vol.167 , pp. 1-5
    • Asao, H.1
  • 126
    • 17644425689 scopus 로고    scopus 로고
    • The B7 family revisited
    • Greenwald R.J., et al. The B7 family revisited. Annu. Rev. Immunol. 2005, 23:515-548.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 515-548
    • Greenwald, R.J.1
  • 127
    • 0027281691 scopus 로고
    • Differential T cell costimulatory requirements in CD28-deficient mice
    • Shahinian A., et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993, 261:609-612.
    • (1993) Science , vol.261 , pp. 609-612
    • Shahinian, A.1
  • 128
    • 0029989758 scopus 로고    scopus 로고
    • CD28 is required for germinal center formation
    • Ferguson S.E., et al. CD28 is required for germinal center formation. J. Immunol. 1996, 156:4576-4581.
    • (1996) J. Immunol. , vol.156 , pp. 4576-4581
    • Ferguson, S.E.1
  • 129
    • 0142219442 scopus 로고    scopus 로고
    • Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
    • Shapiro-Shelef M., et al. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 2003, 19:607-620.
    • (2003) Immunity , vol.19 , pp. 607-620
    • Shapiro-Shelef, M.1
  • 130
    • 20444501371 scopus 로고    scopus 로고
    • CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers
    • Wang Y., Carter R.H. CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers. Immunity 2005, 22:749-761.
    • (2005) Immunity , vol.22 , pp. 749-761
    • Wang, Y.1    Carter, R.H.2
  • 131
    • 0028486131 scopus 로고
    • Mice deficient for the CD40 ligand
    • Xu J., et al. Mice deficient for the CD40 ligand. Immunity 1994, 1:423-431.
    • (1994) Immunity , vol.1 , pp. 423-431
    • Xu, J.1
  • 132
    • 0028447437 scopus 로고
    • The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation
    • Kawabe T., et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994, 1:167-178.
    • (1994) Immunity , vol.1 , pp. 167-178
    • Kawabe, T.1
  • 133
    • 0034691531 scopus 로고    scopus 로고
    • A chemokine-driven positive feedback loop organizes lymphoid follicles
    • Ansel K.M., et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000, 406:309-314.
    • (2000) Nature , vol.406 , pp. 309-314
    • Ansel, K.M.1
  • 134
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • Cyster J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 2005, 23:127-159.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 135
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T-cell activation and function
    • Dong C., et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001, 409:97-101.
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1
  • 136
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40-mediated antibody class switching
    • McAdam A.J., et al. ICOS is critical for CD40-mediated antibody class switching. Nature 2001, 409:102-105.
    • (2001) Nature , vol.409 , pp. 102-105
    • McAdam, A.J.1
  • 137
    • 0035804269 scopus 로고    scopus 로고
    • ICOS is essential for effective T-helper-cell responses
    • Tafuri A., et al. ICOS is essential for effective T-helper-cell responses. Nature 2001, 409:105-109.
    • (2001) Nature , vol.409 , pp. 105-109
    • Tafuri, A.1
  • 138
    • 15444346834 scopus 로고    scopus 로고
    • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
    • Mittrucker H.W., et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997, 275:540-543.
    • (1997) Science , vol.275 , pp. 540-543
    • Mittrucker, H.W.1
  • 139
    • 0026091380 scopus 로고
    • Mice lacking MHC class II molecules
    • Cosgrove D., et al. Mice lacking MHC class II molecules. Cell 1991, 66:1051-1066.
    • (1991) Cell , vol.66 , pp. 1051-1066
    • Cosgrove, D.1


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