Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6

Journal of Experimental Medicine

Volumn 192, Issue 12, 2000, Pages 1841-1847

  Reljic, Rajko ^a   Wagner, Simon D ^a,b   Peakman, Luke J ^a   Fearon, Douglas T ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

BTB POZ protein; Germinal center; Interleukins; Plasma cell; Retrovirus

Indexed keywords

CYTOKINE; PROTEIN BCL 6;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMOSOME TRANSLOCATION; CLONAL ANERGY; GERMINAL CENTER; IMMUNE RESPONSE; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL SURVIVAL; CYTOKINES; DNA-BINDING PROTEINS; FLOW CYTOMETRY; MICE; PLASMA CELLS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; REPRESSOR PROTEINS; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034684672     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.12.1841     Document Type: Article

References (30)

1. Maturation of the immune response in germinal centers
2. Intraclonal generation of antibody mutants in germinal centres
3. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas
4. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
5. The LAZ3/BCL-6 oncogene encodes a sequence-specific transcriptional inhibitor: A novel function for the BTB/POZ domain as an autonomous repressing domain
6. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
7. Transcriptional repression by the proto-oncogene BCL-6
8. The POZ domain: A conserved protein-protein interaction motif
9. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
10. Disruption of the BCL-6 gene results in an impaired germinal center formation
11. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
12. BCL-6 regulates chemokine gene transcription in macrophages
13. BCL-6 represses genes that function in lymphocyte differentiation, inflammation and cell cycle control
14. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
15. Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development
16. Identification and characterization of a novel repressor of β-interferon gene expression
17. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor
18. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line
19. Production of high-titer helper-free retroviruses by transient transfection
20. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
21. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization
22. Interleukin-2 (IL-2) regulates the accessibility of the IL-2-responsive enhancer in the IL-2 receptor α gene to transcription factors
23. The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro
24. Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells
25. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of iepsilon transcription and immunoglobulin E switching
26. PMA/ionomycin induces Ig κ 3′ enhancer activity which is in part mediated by a unique NFAT transcription complex
27. A model system for peptide hormone action in differentiation: Interleukin 2 induces a B lymphoma to transcribe the J chain gene
28. B cell response pathways regulated by 1L-5 and IL-2. Secretory μH chain-mRNA and J chain mRNA expression are separately controlled events
29. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation
30. Jaks and STATs: Biological implications