P38α and p38 mediate oncogenic ras-induced senescence through differential mechanisms

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11237-11246

  Kwong, Jinny ^a   Hong, Lixin ^b   Liao, Rong ^a   Deng, Qingdong ^a   Han, Jiahuai ^b   Sun, Peiqing ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER DEVELOPMENT; DEFENSE MECHANISM; ESSENTIAL COMPONENT; HAIRPIN RNA; HUMAN FIBROBLAST; IN-CELL; IN-VIVO; ISOFORMS; MOLECULAR MECHANISM; P38 MAPK; SENESCENCE INDUCTION; SIGNALING PATHWAYS; TRANSCRIPTIONAL ACTIVITY;

CELL CULTURE; NUCLEIC ACIDS; ONCOGENIC VIRUSES; RNA;

TUMORS;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN P53; RAS PROTEIN; SHORT HAIRPIN RNA; SYNAPTOPHYSIN; ISOPROTEIN; SERINE; TP53 PROTEIN, HUMAN;

ARTICLE; CELL AGING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENE SILENCING; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; PHOSPHORYLATION;

CELL AGING; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFLAMMATION; MITOGEN-ACTIVATED PROTEIN KINASE 12; MITOGEN-ACTIVATED PROTEIN KINASE 14; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN ISOFORMS; RAS PROTEINS; SERINE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 66449084405     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808327200     Document Type: Article

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