메뉴 건너뛰기




Volumn 8, Issue 6, 2012, Pages 342-351

Importance of oestrogen receptors to preserve functional β-cell mass in diabetes

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; CONJUGATED ESTROGEN; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; G PROTEIN COUPLED RECEPTOR; GESTAGEN; GLUCOSE; LIPID; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 84861335162     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2011.242     Document Type: Review
Times cited : (196)

References (131)
  • 1
    • 0035856952 scopus 로고    scopus 로고
    • β-cell death during progression to diabetes
    • Mathis, D., Vence, L. & Benoist, C. β-cell death during progression to diabetes. Nature 414, 792-798 (2001).
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 2
    • 0029821899 scopus 로고    scopus 로고
    • Vulnerability of islets in the immediate posttransplantation period: Dynamic changes in structure and function
    • Davalli, A. M. et al. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 45, 1161-1167 (1996). (Pubitemid 26296313)
    • (1996) Diabetes , vol.45 , Issue.9 , pp. 1161-1167
    • Davalli, A.M.1    Scaglia, L.2    Zangen, D.H.3    Hollister, J.4    Bonner-Weir, S.5    Weir, G.C.6
  • 4
    • 33745863033 scopus 로고    scopus 로고
    • Islet β cell failure in type 2 diabetes
    • DOI 10.1172/JCI29103
    • Prentki, M. & Nolan, C. J. Islet β cell failure in type 2 diabetes. J. Clin. Invest. 116, 1802-1812 (2006). (Pubitemid 44033300)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 5
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and β-cell dysfunction
    • DOI 10.1210/er.2007-0023
    • Poitout, V. & Robertson, R. P. Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr. Rev. 29, 351-366 (2008). (Pubitemid 351679704)
    • (2008) Endocrine Reviews , vol.29 , Issue.3 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 6
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • DOI 10.1210/er.2007-0015
    • Eizirik, D. L., Cardozo, A. K. & Cnop, M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 29, 42-61 (2008). (Pubitemid 351252746)
    • (2008) Endocrine Reviews , vol.29 , Issue.1 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 7
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • DOI 10.1172/JCI27987
    • Deroo, B. J. & Korach, K. S. Estrogen receptors and human disease. J. Clin. Invest. 116, 561-570 (2006). (Pubitemid 43326860)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 8
    • 77149165088 scopus 로고    scopus 로고
    • Minireview estrogenic protection of β-cell failure in metabolic diseases
    • Liu, S. & Mauvais-Jarvis, F. Minireview: estrogenic protection of β-cell failure in metabolic diseases. Endocrinology 151, 859-864 (2010).
    • (2010) Endocrinology , vol.151 , pp. 859-864
    • Liu, S.1    Mauvais-Jarvis, F.2
  • 9
    • 78650521925 scopus 로고    scopus 로고
    • Estrogen and androgen receptors: Regulators of fuel homeostasis and emerging targets for diabetes and obesity
    • Mauvais-Jarvis, F. Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity. Trends Endocrinol. Metab. 22, 24-33 (2011).
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 24-33
    • Mauvais-Jarvis, F.1
  • 10
    • 0013962479 scopus 로고
    • Some effects of oral contraceptives on carbohydrate metabolism
    • Wynn, V. & Doar, J. W. Some effects of oral contraceptives on carbohydrate metabolism. Lancet 2, 715-719 (1966).
    • (1966) Lancet , vol.2 , pp. 715-719
    • Wynn, V.1    Doar, J.W.2
  • 11
    • 0036185539 scopus 로고    scopus 로고
    • Sex steroids and insulin resistance
    • DOI 10.1042/CS20010197
    • Livingstone, C. & Collison, M. Sex steroids and insulin resistance. Clin. Sci. (Lond.) 102, 151-166 (2002). (Pubitemid 34185043)
    • (2002) Clinical Science , vol.102 , Issue.2 , pp. 151-166
    • Livingstone, C.1    Collison, M.2
  • 15
    • 8544267912 scopus 로고    scopus 로고
    • Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM
    • DOI 10.1007/s001250050758
    • Brussaard, H. E., Gevers Leuven, J. A., Frölich, M., Kluft, C. & Krans, H. M. Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM. Diabetologia 40, 843-849 (1997). (Pubitemid 27306964)
    • (1997) Diabetologia , vol.40 , Issue.7 , pp. 843-849
    • Brussaard, H.E.1    Gevers Leuven, J.A.2    Frolich, M.3    Kluft, C.4    Krans, H.M.J.5
  • 17
    • 0035142209 scopus 로고    scopus 로고
    • Conjugated equine estrogen-improves glycemic control and blood lipoproteins in postmenopausal women with type 2 diabetes
    • DOI 10.1210/jc.86.1.48
    • Friday, K. E., Dong, C. & Fontenot, R. U. Conjugated equine estrogen improves glycemic control and blood lipoproteins in postmenopausal women with type 2 diabetes. J. Clin. Endocrinol. Metab. 86, 48-52 (2001). (Pubitemid 32109774)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.1 , pp. 48-52
    • Friday, K.E.1    Dong, C.2    Fontenot, R.U.3
  • 18
    • 0036780352 scopus 로고    scopus 로고
    • Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: Results from the Third National Health and Nutrition Examination Survey (NHANES III)
    • DOI 10.2337/diacare.25.10.1675
    • Crespo, C. J., Smit, E., Snelling, A., Sempos, C. T. & Andersen, R. E. Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care 25, 1675-1680 (2002). (Pubitemid 41071069)
    • (2002) Diabetes Care , vol.25 , Issue.10 , pp. 1675-1680
    • Crespo, C.J.1    Smit, E.2    Snelling, A.3    Sempos, C.T.4    Andersen, R.E.5
  • 19
    • 0036669003 scopus 로고    scopus 로고
    • Effects of postmenopausal hormone replacement therapy on insulin resistance
    • DOI 10.1385/ENDO:18:3:211
    • Saglam, K., Polat, Z., Yilmaz, M. I., Gulec, M. & Akinci, S. B. Effects of postmenopausal hormone replacement therapy on insulin resistance. Endocrine 18, 211-214 (2002). (Pubitemid 35239782)
    • (2002) Endocrine , vol.18 , Issue.3 , pp. 211-214
    • Saglam, K.1    Polat, Z.2    Yilmaz, M.I.3    Gulec, M.4    Akinci, S.B.5
  • 21
    • 0035048787 scopus 로고    scopus 로고
    • The effects of transdermal estradiol in combination with oral norethisterone on lipoproteins, coagulation, and endothelial markers in postmenopausal women with type 2 diabetes: A randomized, placebo-controlled study
    • DOI 10.1210/jc.86.3.1140
    • Perera, M. et al. The effects of transdermal estradiol in combination with oral norethisterone on lipoproteins, coagulation, and endothelial markers in postmenopausal women with type 2 diabetes: a randomized, placebo-controlled study. J. Clin. Endocrinol. Metab. 86, 1140-1143 (2001). (Pubitemid 32322994)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.3 , pp. 1140-1143
    • Perera, M.1    Sattar, N.2    Petrie, J.R.3    Hillier, C.4    Small, M.5    Connell, J.M.C.6    Lowe, G.D.O.7    Lumsden, M.-A.8
  • 22
    • 0026771186 scopus 로고
    • Effects of low doses of transdermal 17β-estradiol on carbohydrate metabolism in postmenopausal women
    • Cagnacci, A. et al. Effects of low doses of transdermal 17β-estradiol on carbohydrate metabolism in postmenopausal women. J. Clin. Endocrinol. Metab. 74, 1396-1400 (1992).
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 1396-1400
    • Cagnacci, A.1
  • 24
    • 0035122028 scopus 로고    scopus 로고
    • Diabetes and gender
    • DOI 10.1007/s001250051573
    • Gale, E. A. & Gillespie, K. M. Diabetes and gender. Diabetologia 44, 3-15 (2001). (Pubitemid 32141879)
    • (2001) Diabetologia , vol.44 , Issue.1 , pp. 3-15
    • Gale, E.A.M.1    Gillespie, K.M.2
  • 25
    • 27744532581 scopus 로고    scopus 로고
    • Oestrogens and insulin secretion
    • DOI 10.1007/s00125-005-1930-0
    • Godsland, I. F. Oestrogens and insulin secretion. Diabetologia 48, 2213-2220 (2005). (Pubitemid 41618909)
    • (2005) Diabetologia , vol.48 , Issue.11 , pp. 2213-2220
    • Godsland, I.F.1
  • 26
    • 77955286961 scopus 로고    scopus 로고
    • Androgen excess produces systemic oxidative stress and predisposes to β-cell failure in female mice
    • Liu, S., Navarro, G. & Mauvais-Jarvis, F. Androgen excess produces systemic oxidative stress and predisposes to β-cell failure in female mice. PLoS ONE 5, e11302 (2010).
    • (2010) PLoS ONE , vol.5
    • Liu, S.1    Navarro, G.2    Mauvais-Jarvis, F.3
  • 27
    • 0026536483 scopus 로고
    • Androgen treatment prevents diabetes in nonobese diabetic mice
    • Fox, H. S. Androgen treatment prevents diabetes in nonobese diabetic mice. J. Exp. Med. 175, 1409-1412 (1992).
    • (1992) J. Exp. Med. , vol.175 , pp. 1409-1412
    • Fox, H.S.1
  • 28
    • 0029151431 scopus 로고
    • Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2
    • Pearce, R. B., Formby, B., Healy, K. & Peterson, C. M. Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2. Autoimmunity 20, 247-258 (1995).
    • (1995) Autoimmunity , vol.20 , pp. 247-258
    • Pearce, R.B.1    Formby, B.2    Healy, K.3    Peterson, C.M.4
  • 30
    • 0037094032 scopus 로고    scopus 로고
    • Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • Bao, M., Yang, Y., Jun, H. S. & Yoon, J. W. Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Immunol. 168, 5369-5375 (2002). (Pubitemid 34496006)
    • (2002) Journal of Immunology , vol.168 , Issue.10 , pp. 5369-5375
    • Bao, M.1    Yang, Y.2    Jun, H.-S.3    Yoon, J.-W.4
  • 31
    • 0021812151 scopus 로고
    • Insulinotropic effect of ovarian steroid hormones in streptozotocin diabetic female mice
    • Puah, J. A. & Bailey, C. J. Insulinotropic effect of ovarian steroid hormones in streptozotocin diabetic female mice. Horm. Metab. Res. 17, 216-218 (1985). (Pubitemid 15062950)
    • (1985) Hormone and Metabolic Research , vol.17 , Issue.4 , pp. 216-218
    • Puah, J.A.1    Bailey, C.J.2
  • 33
    • 0019951922 scopus 로고
    • Induction of insulin-dependent diabetes by streptozotocin. Inhibition by estrogens and potentiation by androgens
    • Paik, S. G., Michelis, M. A., Kim, Y. T. & Shin, S. Induction of insulin-dependent diabetes by streptozotocin. Inhibition by estrogens and potentiation by androgens. Diabetes 31, 724-729 (1982). (Pubitemid 12095170)
    • (1982) Diabetes , vol.31 , Issue.8 , pp. 724-729
    • Paik, S.G.1    Michelis, M.A.2    Kim, Y.T.3    Shin, S.4
  • 34
    • 70349649964 scopus 로고    scopus 로고
    • Importance of extranuclear estrogen receptor-α and membrane G protein-coupled estrogen receptor in pancreatic islet survival
    • Liu, S. et al. Importance of extranuclear estrogen receptor-α and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes 58, 2292-2302 (2009).
    • (2009) Diabetes , vol.58 , pp. 2292-2302
    • Liu, S.1
  • 35
    • 0019292063 scopus 로고
    • Androgen sensitization of streptozotocin-induced diabetes in mice
    • Maclaren, N. K., Neufeld, M., McLaughlin, J. V. & Taylor, G. Androgen sensitization of streptozotocin-induced diabetes in mice. Diabetes 29, 710-716 (1980). (Pubitemid 11026643)
    • (1980) Diabetes , vol.29 , Issue.9 , pp. 710-716
    • Maclaren, N.K.1    Neufeld, M.2    McLaughlin, J.V.3    Taylor, G.4
  • 36
    • 0024428356 scopus 로고
    • Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus
    • DOI 10.1016/0014-4827(89)90407-2
    • Betsholtz, C. et al. Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus. Exp. Cell Res. 183, 484-493 (1989). (Pubitemid 19218505)
    • (1989) Experimental Cell Research , vol.183 , Issue.2 , pp. 484-493
    • Betsholtz, C.1    Svensson, V.2    Rorsman, F.3    Engstrom, U.4    Westermark, G.T.5    Wilander, E.6    Johnson, K.7    Westermark, P.8
  • 37
    • 0024400674 scopus 로고
    • Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species
    • DOI 10.1016/0014-5793(89)81467-X
    • Betsholtz, C. et al. Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. FEBS Lett. 251, 261-264 (1989). (Pubitemid 19181881)
    • (1989) FEBS Letters , vol.251 , Issue.1-2 , pp. 261-264
    • Betsholtz, C.1    Christmansson, L.2    Engstrom, U.3    Rorsman, F.4    Svensson, V.5    Johnson, K.H.6    Westermark, P.7
  • 38
    • 0025881320 scopus 로고
    • Sequences of islet amyloid polypeptide precursors of an Old World monkey, the pig-tailed macaque (Macaca nemestrina), and the dog (Canis familiaris)
    • Ohagi, S., Nishi, M., Bell, G. I., Ensinck, J. W. & Steiner, D. F. Sequences of islet amyloid polypeptide precursors of an Old World monkey, the pig-tailed macaque (Macaca nemestrina), and the dog (Canis familiaris). Diabetologia 34, 555-558 (1991).
    • (1991) Diabetologia , vol.34 , pp. 555-558
    • Ohagi, S.1    Nishi, M.2    Bell, G.I.3    Ensinck, J.W.4    Steiner, D.F.5
  • 41
    • 0033793584 scopus 로고    scopus 로고
    • Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes
    • Kahn, S. E. et al. Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes. Diabetologia 43, 1309-1312 (2000).
    • (2000) Diabetologia , vol.43 , pp. 1309-1312
    • Kahn, S.E.1
  • 42
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
    • Lee, Y. et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc. Natl Acad. Sci. USA 91, 10878-10882 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 10878-10882
    • Lee, Y.1
  • 43
    • 79960977229 scopus 로고    scopus 로고
    • Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
    • Tiano, J. P. et al. Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J. Clin. Invest. 121, 3331-3342 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 3331-3342
    • Tiano, J.P.1
  • 45
    • 12944327383 scopus 로고    scopus 로고
    • Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: Relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia
    • DOI 10.1007/s00441-004-1019-y
    • Garris, D. R. & Garris, B. L. Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia. Cell Tissue Res. 319, 231-242 (2005). (Pubitemid 40174517)
    • (2005) Cell and Tissue Research , vol.319 , Issue.2 , pp. 231-242
    • Garris, D.R.1    Garris, B.L.2
  • 46
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka, M., Kayo, T., Ikeda, T. & Koizumi, A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894 (1997). (Pubitemid 27188269)
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 49
    • 33845310353 scopus 로고    scopus 로고
    • Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice
    • DOI 10.1016/j.bbrc.2006.11.076, PII S0006291X06025551
    • Toyoshima, M. et al. Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice. Biochem. Biophys. Res. Commun. 352, 703-708 (2007). (Pubitemid 44880311)
    • (2007) Biochemical and Biophysical Research Communications , vol.352 , Issue.3 , pp. 703-708
    • Toyoshima, M.1    Asakawa, A.2    Fujimiya, M.3    Inoue, K.4    Inoue, S.5    Kinboshi, M.6    Koizumi, A.7
  • 50
    • 43149124387 scopus 로고    scopus 로고
    • Ablation of estrogen receptor α(ERα) prevents upregulation of POMC by leptin and insulin
    • Hirosawa, M. et al. Ablation of estrogen receptor α (ERα) prevents upregulation of POMC by leptin and insulin. Biochem. Biophys. Res. Commun. 371, 320-323 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 320-323
    • Hirosawa, M.1
  • 51
    • 0028112936 scopus 로고
    • OLETF (Otsuka Long-Evans Tokushima Fatty) rat: A new NIDDM rat strain
    • Kawano, K., Hirashima, T., Mori, S. & Natori, T. OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain. Diabetes Res. Clin. Pract. 24 (Suppl.), S317-S320 (1994).
    • (1994) Diabetes Res. Clin. Pract. , vol.24 , Issue.SUPPL.
    • Kawano, K.1    Hirashima, T.2    Mori, S.3    Natori, T.4
  • 52
    • 0026722931 scopus 로고
    • Spontaneous long-term hyperglycemic rat with diabetic complications Otsuka Long-Evans Tokushima Fatty (OLETF) strain
    • Kawano, K. et al. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41, 1422-1428 (1992).
    • (1992) Diabetes , vol.41 , pp. 1422-1428
    • Kawano, K.1
  • 53
    • 0029148479 scopus 로고
    • An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor
    • Funakoshi, A. et al. An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. Biochem. Biophys. Res. Commun. 210, 787-796 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.210 , pp. 787-796
    • Funakoshi, A.1
  • 54
    • 0027934601 scopus 로고
    • Sexual difference in the incidence of diabetes mellitus in Otsuka-Long- Evans-Tokushima-Fatty Rats: Effects of castration and sex hormone replacement on its incidence
    • DOI 10.1016/0026-0495(94)90213-5
    • Shi, K., Mizuno, A., Sano, T., Ishida, K. & Shima, K. Sexual difference in the incidence of diabetes mellitus in Otsuka-Long-Evans-Tokushima- Fatty rats: effects of castration and sex hormone replacement on its incidence. Metabolism 43, 1214-1220 (1994). (Pubitemid 24307933)
    • (1994) Metabolism: Clinical and Experimental , vol.43 , Issue.10 , pp. 1214-1220
    • Shi, K.1    Mizuno, A.2    Sano, T.3    Ishida, K.4    Shima, K.5
  • 56
    • 0025239429 scopus 로고
    • Diabetes induced in male transgenic mice by expression of human H-ras oncoprotein in pancreatic β cells
    • Efrat, S., Fleischer, N. & Hanahan, D. Diabetes induced in male transgenic mice by expression of human H-ras oncoprotein in pancreatic β cells. Mol. Cell Biol. 10, 1779-1783 (1990).
    • (1990) Mol. Cell Biol. , vol.10 , pp. 1779-1783
    • Efrat, S.1    Fleischer, N.2    Hanahan, D.3
  • 57
    • 0026016699 scopus 로고
    • Sexual dimorphism of pancreatic β-cell degeneration in transgenic mice expressing an insulin-ras hybrid gene
    • Efrat, S. Sexual dimorphism of pancreatic β-cell degeneration in transgenic mice expressing an insulin-ras hybrid gene. Endocrinology 128, 897-901 (1991).
    • (1991) Endocrinology , vol.128 , pp. 897-901
    • Efrat, S.1
  • 59
    • 0034699544 scopus 로고    scopus 로고
    • IRS-2 pathways integrate female reproduction and energy homeostasis
    • Burks, D. J. et al. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407, 377-382 (2000).
    • (2000) Nature , vol.407 , pp. 377-382
    • Burks, D.J.1
  • 62
    • 0027504201 scopus 로고
    • Effects of steroid and lactogenic hormones on islets of Langerhans: A new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy
    • DOI 10.1210/en.133.5.2227
    • Sorenson, R. L., Brelje, T. C. & Roth, C. Effects of steroid and lactogenic hormones on islets of Langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy. Endocrinology 133, 2227-2234 (1993). (Pubitemid 23324731)
    • (1993) Endocrinology , vol.133 , Issue.5 , pp. 2227-2234
    • Sorenson, R.L.1    Brelje, T.C.2    Roth, C.3
  • 63
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma β TC-1 cells
    • Fehmann, H. C. & Habener, J. F. Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma β TC-1 cells. Endocrinology 130, 159-166 (1992).
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 64
    • 0027473729 scopus 로고
    • Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)
    • DOI 10.1038/361362a0
    • Holz, G. G. 4th, Kühtreiber, W. M. & Habener, J. F. Pancreatic β-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 361, 362-365 (1993). (Pubitemid 23041630)
    • (1993) Nature , vol.361 , Issue.6410 , pp. 362-365
    • Holz IV, G.G.1    Kuhtreiber, W.M.2    Habener, J.F.3
  • 67
    • 77958568034 scopus 로고    scopus 로고
    • Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic β cell apoptosis and increases insulin gene expression and secretion
    • Wijesekara, N. et al. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic β cell apoptosis and increases insulin gene expression and secretion. J. Biol. Chem. 285, 33623-33631 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 33623-33631
    • Wijesekara, N.1
  • 68
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • Holland, W. L. et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat. Med. 17, 55-63 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 55-63
    • Holland, W.L.1
  • 71
    • 0034633656 scopus 로고    scopus 로고
    • Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β
    • Nadal, A. et al. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β. Proc. Natl Acad. Sci. USA 97, 11603-11608 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11603-11608
    • Nadal, A.1
  • 72
    • 0036188982 scopus 로고    scopus 로고
    • A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas
    • DOI 10.1210/me.16.3.497
    • Ropero, A. B., Soria, B. & Nadal, A. A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas. Mol. Endocrinol. 16, 497-505 (2002). (Pubitemid 34214569)
    • (2002) Molecular Endocrinology , vol.16 , Issue.3 , pp. 497-505
    • Ropero, A.B.1    Soria, B.2    Nadal, A.3
  • 73
    • 0036777477 scopus 로고    scopus 로고
    • Low doses of the endocrine disruptor bisphenol-A and the native hormone 17β-estradiol rapidly activate transcription factor CREB
    • Quesada, I. et al. Low doses of the endocrine disruptor bisphenol-A and the native hormone 17β-estradiol rapidly activate transcription factor CREB. FASEB J. 16, 1671-1673 (2002).
    • (2002) FASEB J. , vol.16 , pp. 1671-1673
    • Quesada, I.1
  • 74
    • 0037110453 scopus 로고    scopus 로고
    • 17β-estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: Molecular mechanisms and islet functionality
    • Contreras, J. L. et al. 17β-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality. Transplantation 74, 1252-1259 (2002). (Pubitemid 35402594)
    • (2002) Transplantation , vol.74 , Issue.9 , pp. 1252-1259
    • Contreras, J.L.1    Smyth, C.A.2    Bilbao, G.3    Young, C.J.4    Thompson, J.A.5    Eckhoff, D.E.6
  • 75
    • 77950407928 scopus 로고    scopus 로고
    • Involvement of estrogen receptor variant ER-α36, not GPR30, in nongenomic estrogen signaling
    • Kang, L. et al. Involvement of estrogen receptor variant ER-α36, not GPR30, in nongenomic estrogen signaling. Mol. Endocrinol. 24, 709-721 (2010).
    • (2010) Mol. Endocrinol. , vol.24 , pp. 709-721
    • Kang, L.1
  • 76
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • DOI 10.1126/science.1106943
    • Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B. & Prossnitz, E. R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307, 1625-1630 (2005). (Pubitemid 40354745)
    • (2005) Science , vol.307 , Issue.5715 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 80
    • 33846813959 scopus 로고    scopus 로고
    • The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitro
    • DOI 10.1016/j.bone.2006.10.014, PII S8756328206007927
    • Mann, V., Huber, C., Kogianni, G., Collins, F. & Noble, B. The antioxidant effect of estrogen and selective estrogen receptor modulators in the inhibition of osteocyte apoptosis in vitro. Bone 40, 674-684 (2007). (Pubitemid 46201947)
    • (2007) Bone , vol.40 , Issue.3 , pp. 674-684
    • Mann, V.1    Huber, C.2    Kogianni, G.3    Collins, F.4    Noble, B.5
  • 81
    • 77956999983 scopus 로고    scopus 로고
    • Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms
    • Yue, W. et al. Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms. Int. J. Cancer 127, 1748-1757 (2010).
    • (2010) Int. J. Cancer , vol.127 , pp. 1748-1757
    • Yue, W.1
  • 82
    • 0042328118 scopus 로고    scopus 로고
    • Suppression of the c-Jun N-terminal kinase pathway by 17β-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction
    • DOI 10.1067/msy.2003.219
    • Eckhoff, D. E. et al. Suppression of the c-Jun N-terminal kinase pathway by 17β-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction. Surgery 134, 169-179 (2003). (Pubitemid 37070336)
    • (2003) Surgery , vol.134 , Issue.2 , pp. 169-179
    • Eckhoff, D.E.1    Smyth, C.A.2    Eckstein, C.3    Bilbao, G.4    Young, C.J.5    Thompson, J.A.6    Contreras, J.L.7
  • 83
    • 77149168602 scopus 로고    scopus 로고
    • Nongenomic estrogen actions protect pancreatic islet survival
    • Liu, S. & Mauvais-Jarvis, F. Rapid, nongenomic estrogen actions protect pancreatic islet survival. Islets 1, 273-275 (2009).
    • (2009) Islets , vol.1 , pp. 273-275
    • Liu, S.1    Rapid, M.F.2
  • 84
    • 77949566651 scopus 로고    scopus 로고
    • Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice
    • Balhuizen, A., Kumar, R., Amisten, S., Lundquist, I. & Salehi, A. Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice. Mol. Cell Endocrinol. 320, 16-24 (2010).
    • (2010) Mol. Cell Endocrinol. , vol.320 , pp. 16-24
    • Balhuizen, A.1    Kumar, R.2    Amisten, S.3    Lundquist, I.4    Salehi, A.5
  • 85
    • 79959457594 scopus 로고    scopus 로고
    • Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G.-1 on human pancreatic islets
    • Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I. & Salehi, A. Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G.-1 on human pancreatic islets. Endocrinology 152, 2568-2579 (2011).
    • (2011) Endocrinology , vol.152 , pp. 2568-2579
    • Kumar, R.1    Balhuizen, A.2    Amisten, S.3    Lundquist, I.4    Salehi, A.5
  • 86
    • 84995910795 scopus 로고
    • Correlations between the chemical structure and the pharmacological actions of the steroids
    • Selye, H. Correlations between the chemical structure and the pharmacological actions of the steroids. Endocrinology 30, 437-453 (1942).
    • (1942) Endocrinology , vol.30 , pp. 437-453
    • Selye, H.1
  • 87
    • 0014140501 scopus 로고
    • Adenosine 3',5'-monophosphate in rat uterus: Acute elevation by estrogen
    • Szego, C. M. & Davis, J. S. Adenosine 3',5'-monophosphate in rat uterus: acute elevation by estrogen. Proc. Natl Acad. Sci. USA 58, 1711-1718 (1967).
    • (1967) Proc. Natl Acad. Sci. USA , vol.58 , pp. 1711-1718
    • Szego, C.M.1    Davis, J.S.2
  • 88
    • 0001464486 scopus 로고
    • Basic guides to the mechanism of estrogen action
    • Jensen, E. & Jacobson, H. Basic guides to the mechanism of estrogen action. Recent Prog. Horm. Res. 18, 387-414 (1962).
    • (1962) Recent Prog. Horm. Res. , vol.18 , pp. 387-414
    • Jensen, E.1    Jacobson, H.2
  • 90
    • 79954426590 scopus 로고    scopus 로고
    • Genistein reduces hyperglycemia and islet cell loss in a high-dosage manner in rats with alloxan-induced pancreatic damage
    • Yang, W., Wang, S., Li, L., Liang, Z. & Wang, L. Genistein reduces hyperglycemia and islet cell loss in a high-dosage manner in rats with alloxan-induced pancreatic damage. Pancreas 40, 396-402 (2011).
    • (2011) Pancreas , vol.40 , pp. 396-402
    • Yang, W.1    Wang, S.2    Li, L.3    Liang, Z.4    Wang, L.5
  • 91
    • 33646366423 scopus 로고    scopus 로고
    • Virtual and biomolecular screening converge on a selective agonist for GPR30
    • Bologa, C. G. et al. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat. Chem. Biol. 2, 207-212 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 207-212
    • Bologa, C.G.1
  • 92
    • 79959781820 scopus 로고    scopus 로고
    • The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis
    • Baquie, M. et al. The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis. Hum. Mol. Genet. 20, 2823-2833 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 2823-2833
    • Baquie, M.1
  • 93
    • 0012475174 scopus 로고
    • Improvement in experimental diabetes following the administration of ammniotin
    • Barnes, B. O., Regan, J. F. & Nelson, W. O. Improvement in experimental diabetes following the administration of ammniotin. JAMA 101, 926-927 (1933).
    • (1933) JAMA , vol.101 , pp. 926-927
    • Barnes, B.O.1    Regan, J.F.2    Nelson, W.O.3
  • 94
    • 84995865448 scopus 로고
    • The effect of oestrogenic hormone on experimental pancreatic diabetes in the monkey
    • Nelson, W. O. & Overholser, M. D. The effect of oestrogenic hormone on experimental pancreatic diabetes in the monkey. Endocrinology 20, 473-480 (1936).
    • (1936) Endocrinology , vol.20 , pp. 473-480
    • Nelson, W.O.1    Overholser, M.D.2
  • 95
    • 0343824798 scopus 로고
    • eds Leibel, B. S. & Wrenshall, G. A. Excerpta Medica Foundation
    • Rodriguez, R. R. in On the Nature and Treatment of Diabetes (eds Leibel, B. S. & Wrenshall, G. A.) 288-307 (Excerpta Medica Foundation, 1965).
    • (1965) On the Nature and Treatment of Diabetes , pp. 288-307
    • Rodriguez, R.R.1
  • 96
    • 0015056190 scopus 로고
    • Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion
    • Costrini, N. V. & Kalkhoff, R. K. Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion. J. Clin. Invest. 50, 992-999 (1971).
    • (1971) J. Clin. Invest. , vol.50 , pp. 992-999
    • Costrini, N.V.1    Kalkhoff, R.K.2
  • 97
    • 26844582510 scopus 로고    scopus 로고
    • Estrogen and exercise may enhance β-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats
    • DOI 10.1210/en.2004-1653
    • Choi, S. B., Jang, J. S. & Park, S. Estrogen and exercise may enhance β-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats. Endocrinology 146, 4786-4794 (2005). (Pubitemid 41446616)
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4786-4794
    • Soo, B.C.1    Jin, S.J.2    Park, S.3
  • 98
    • 30344444488 scopus 로고    scopus 로고
    • The estrogenic effect of bisphenol a disrupts pancreatic β-cell function in vivo and induces insulin resistance
    • DOI 10.1289/ehp.8451
    • Alonso-Magdalena, P., Morimoto, S., Ripoll, C., Fuentes, E. & Nadal, A. The estrogenic effect of bisphenol A disrupts pancreatic β-cell function in vivo and induces insulin resistance. Environ. Health Perspect. 114, 106-112 (2006). (Pubitemid 43056876)
    • (2006) Environmental Health Perspectives , vol.114 , Issue.1 , pp. 106-112
    • Alonso-Magdalena, P.1    Morimoto, S.2    Ripoll, C.3    Fuentes, E.4    Nadal, A.5
  • 99
    • 77955606282 scopus 로고    scopus 로고
    • Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis
    • Wong, W. P. et al. Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc. Natl Acad. Sci. USA 107, 13057-13062 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 13057-13062
    • Wong, W.P.1
  • 100
    • 0017018046 scopus 로고
    • Preliminary report: Effects of female sex hormones on insulin secretion by the perfused rat pancreas
    • Sutter-Dub, M. T. Preliminary report: effects of female sex hormones on insulin secretion by the perfused rat pancreas. J. Physiol. (Paris) 72, 795-800 (1976).
    • (1976) J. Physiol. (Paris) , vol.72 , pp. 795-800
    • Sutter-Dub, M.T.1
  • 101
    • 0017815602 scopus 로고
    • Effects of ovariectomy and treatment with progesterone or oestradiol-17 β on the secretion of insulin by the perfused rat pancreas
    • Senzen, S. Effects of ovariectomy and treatment with progesterone or oestradiol-17 β on the secretion of insulin by the perfused rat pancreas. J. Endocrinol. 78, 153-154 (1978).
    • (1978) J. Endocrinol. , vol.78 , pp. 153-154
    • Senzen, S.1
  • 102
    • 0018428388 scopus 로고
    • Insulin secretion from isolated pancreatic islets in the female rat. Short and long term oestradiol influence
    • Faure, A. & Sutter-Dub, M. T. Insulin secretion from isolated pancreatic islets in the female rat. Short and long term oestradiol influence. J. Physiol. (Paris) 75, 289-295 (1979). (Pubitemid 9214631)
    • (1979) Journal de Physiologie , vol.75 , Issue.3 , pp. 289-295
    • Faure, A.1    Sutter-Dub -Th., M.2
  • 103
    • 44349121098 scopus 로고    scopus 로고
    • Pancreatic insulin content regulation by the estrogen receptor ER α
    • Alonso-Magdalena, P. et al. Pancreatic insulin content regulation by the estrogen receptor ER α. PLoS ONE 3, e2069 (2008).
    • (2008) PLoS ONE , vol.3
    • Alonso-Magdalena, P.1
  • 106
    • 17844397490 scopus 로고    scopus 로고
    • Effect of 17β-estradiol on insulin secretion and cytosolic calcium in Min6 mouse insulinoma cells and human islets of Langerhans
    • DOI 10.1097/01.mpa.0000161886.17492.22
    • Al-Majed, H. T. et al. Effect of 17β-estradiol on insulin secretion and cytosolic calcium in Min6 mouse insulinoma cells and human islets of Langerhans. Pancreas 30, 307-313 (2005). (Pubitemid 40586806)
    • (2005) Pancreas , vol.30 , Issue.4 , pp. 307-313
    • Al-Majed, H.T.1    Squires, P.E.2    Persaud, S.J.3    Huang, G.-C.C.4    Amiel, S.5    Whitehouse, B.J.6    Jones, P.M.7
  • 107
    • 73249129499 scopus 로고    scopus 로고
    • Rapid regulation of K(ATP) channel activity by 17β-estradiol in pancreatic β-cells involves the estrogen receptor β and the atrial natriuretic peptide receptor
    • Soriano, S. et al. Rapid regulation of K(ATP) channel activity by 17β-estradiol in pancreatic β-cells involves the estrogen receptor β and the atrial natriuretic peptide receptor. Mol. Endocrinol. 23, 1973-1982 (2009).
    • (2009) Mol. Endocrinol. , vol.23 , pp. 1973-1982
    • Soriano, S.1
  • 108
    • 59649122739 scopus 로고    scopus 로고
    • Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice
    • Mårtensson, U. E. et al. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology 150, 687-698 (2009).
    • (2009) Endocrinology , vol.150 , pp. 687-698
    • Mårtensson, U.E.1
  • 109
    • 79960705272 scopus 로고    scopus 로고
    • Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic β-cells
    • Sharma, G. & Prossnitz, E. R. Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic β-cells. Endocrinology 152, 3030-3039 (2011).
    • (2011) Endocrinology , vol.152 , pp. 3030-3039
    • Sharma, G.1    Prossnitz, E.R.2
  • 110
    • 27744513348 scopus 로고    scopus 로고
    • Estrogen regulation of adiposity and fuel partitioning: Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways
    • DOI 10.1074/jbc.M507339200
    • D'Eon, T. M. et al. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J. Biol. Chem. 280, 35983-35991 (2005). (Pubitemid 41633867)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.43 , pp. 35983-35991
    • D'Eon, T.M.1    Souza, S.C.2    Aronovitz, M.3    Obin, M.S.4    Fried, S.K.5    Greenberg, A.S.6
  • 111
    • 33744492590 scopus 로고    scopus 로고
    • Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: A possible mechanism is through direct regulation of signal transducer and activator of transcription 3
    • DOI 10.1210/me.2006-0012
    • Gao, H. et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol. Endocrinol. 20, 1287-1299 (2006). (Pubitemid 43801232)
    • (2006) Molecular Endocrinology , vol.20 , Issue.6 , pp. 1287-1299
    • Gao, H.1    Bryzgalova, G.2    Hedman, E.3    Khan, A.4    Efendic, S.5    Gustafsson, J.-A.6    Dahlman-Wright, K.7
  • 117
    • 58149510203 scopus 로고    scopus 로고
    • Estrogen and type 1 diabetes mellitus
    • Codner, E. Estrogen and type 1 diabetes mellitus. Pediatr. Endocrinol. Rev. 6, 228-234 (2008).
    • (2008) Pediatr. Endocrinol. Rev. , vol.6 , pp. 228-234
    • Codner, E.1
  • 119
    • 0000122029 scopus 로고
    • Production or prevention of some types of experimental diabetes by oestrogens or corticosteroids
    • Houssay, B. A., Foglia, V. G. & Rodriguez, R. R. Production or prevention of some types of experimental diabetes by oestrogens or corticosteroids. Acta Endocrinol. (Copenh.) 17, 146-164 (1954).
    • (1954) Acta Endocrinol. (Copenh.) , vol.17 , pp. 146-164
    • Houssay, B.A.1    Foglia, V.G.2    Rodriguez, R.R.3
  • 120
    • 0016303838 scopus 로고
    • Short-term effects of oestradiol benzoate in normal, hypophysectomized and alloxan-diabetic male rats
    • Goodman, M. N. & Hazelwood, R. L. Short-term effects of oestradiol benzoate in normal, hypophysectomized and alloxan-diabetic male rats. J. Endocrinol. 62, 439-449 (1974).
    • (1974) J. Endocrinol. , vol.62 , pp. 439-449
    • Goodman, M.N.1    Hazelwood, R.L.2
  • 121
    • 77957881119 scopus 로고    scopus 로고
    • Beneficial effect of 17β-estradiol on hyperglycemia and islet β-cell functions in a streptozotocin-induced diabetic rat model
    • Yamabe, N., Kang, K. S. & Zhu, B. T. Beneficial effect of 17β-estradiol on hyperglycemia and islet β-cell functions in a streptozotocin-induced diabetic rat model. Toxicol. Appl. Pharmacol. 249, 76-85 (2010).
    • (2010) Toxicol. Appl. Pharmacol. , vol.249 , pp. 76-85
    • Yamabe, N.1    Kang, K.S.2    Zhu, B.T.3
  • 122
    • 77955294454 scopus 로고    scopus 로고
    • Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor α
    • Ren, Z., Zou, C., Ji, H. & Zhang, Y. A. Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor α. Cell Biol. Int. 34, 523-530 (2010).
    • (2010) Cell Biol. Int. , vol.34 , pp. 523-530
    • Ren, Z.1    Zou, C.2    Ji, H.3    Zhang, Y.A.4
  • 124
    • 18144421167 scopus 로고    scopus 로고
    • Endometrial cancer and hormone-replacement therapy in the Million Women Study
    • Beral, V., Bull, D. & Reeves, G. Endometrial cancer and hormone-replacement therapy in the Million Women Study. Lancet 365, 1543-1551 (2005).
    • (2005) Lancet , vol.365 , pp. 1543-1551
    • Beral, V.1    Bull, D.2    Reeves, G.3
  • 125
    • 56549102911 scopus 로고    scopus 로고
    • The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention
    • Kharode, Y., Bodine, P. V., Miller, C. P., Lyttle, C. R. & Komm, B. S. The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention. Endocrinology 149, 6084-6091 (2008).
    • (2008) Endocrinology , vol.149 , pp. 6084-6091
    • Kharode, Y.1    Bodine, P.V.2    Miller, C.P.3    Lyttle, C.R.4    Komm, B.S.5
  • 126
    • 57849153536 scopus 로고    scopus 로고
    • A new approach to menopausal therapy: The tissue selective estrogen complex
    • Komm, B. S. A new approach to menopausal therapy: the tissue selective estrogen complex. Reprod. Sci. 15, 984-992 (2008).
    • (2008) Reprod. Sci. , vol.15 , pp. 984-992
    • Komm, B.S.1
  • 129
    • 72149133431 scopus 로고    scopus 로고
    • Plasma membrane estrogen receptors
    • Levin, E. R. Plasma membrane estrogen receptors. Trends Endocrinol. Metab. 20, 477-482 (2009).
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 477-482
    • Levin, E.R.1
  • 131
    • 0024552738 scopus 로고
    • The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia
    • Leiter, E. H., Chapman, H. D. & Coleman, D. L. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology 124, 912-922 (1989). (Pubitemid 19057087)
    • (1989) Endocrinology , vol.124 , Issue.2 , pp. 912-922
    • Leiter, E.H.1    Chapman, H.D.2    Coleman, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.