Ablation of estrogen receptor alpha (ERα) prevents upregulation of POMC by leptin and insulin

Biochemical and Biophysical Research Communications

Volumn 371, Issue 2, 2008, Pages 320-323

  Hirosawa, Michi ^a   Minata, Mutsuko ^a   Harada, Kouji H ^a   Hitomi, Toshiaki ^a   Krust, Andree ^b   Koizumi, Akio ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CNRS   (France)

Author keywords

Diabetes; Dimorphisms; Estrogen receptor alpha; Hyperphagia

Indexed keywords

ESTROGEN RECEPTOR ALPHA; INSULIN; LEPTIN; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FOOD INTAKE; HYPERINSULINEMIA; HYPOINSULINEMIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION; GENE EXPRESSION REGULATION; HYPERPHAGIA; HYPOTHALAMUS; INSULIN; LEPTIN; MICE; MICE, KNOCKOUT; PRO-OPIOMELANOCORTIN; UP-REGULATION;

MUS;

EID: 43149124387     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.073     Document Type: Article

References (21)

1. Schlundt D.G., Rea M.R., Kline S.S., and Pichert J.W. Situational obstacles to dietary adherence for adults with diabetes. J. Am. Diet. Assoc. 94 (1994) 874-876 879; quiz 877-878
2. Yoshioka M., Kayo T., Ikeda T., and Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46 (1997) 887-894
3. Wang J., Takeuchi T., Tanaka S., Kubo S.K., Kayo T., Lu D., Takata K., Koizumi A., and Izumi T. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J. Clin. Invest. 103 (1999) 27-37
4. Kayo T., and Koizumi A. Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period. J. Clin. Invest. 101 (1998) 2112-2118
5. Asakawa A., Toyoshima M., Inoue K., and Koizumi A. Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system. Int. J. Mol. Med. 19 (2007) 649-652
6. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
7. Lonnqvist F., Arner P., Nordfors L., and Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat. Med. 1 (1995) 950-953
8. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1 (1995) 1155-1161
9. Leibowitz S.F., and Wortley K.E. Hypothalamic control of energy balance: different peptides, different functions. Peptides 25 (2004) 473-504
10. Havel P.J., Hahn T.M., Sindelar D.K., Baskin D.G., Dallman M.F., Weigle D.S., and Schwartz M.W. Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 49 (2000) 244-252
11. Plum L., Belgardt B.F., and Bruning J.C. Central insulin action in energy and glucose homeostasis. J. Clin. Invest. 116 (2006) 1761-1766
12. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., and Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 (2001) 480-484
13. Thornton J.E., Cheung C.C., Clifton D.K., and Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138 (1997) 5063-5066
14. Toyoshima M., Asakawa A., Fujimiya M., Inoue K., Inoue S., Kinboshi M., and Koizumi A. Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice. Biochem. Biophys. Res. Commun. 352 (2007) 703-708
15. Jeong S., Han M., Lee H., Kim M., Kim J., Nicol C.J., Kim B.H., Choi J.H., Nam K.H., Oh G.T., and Yoon M. Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice. Metabolism 53 (2004) 1284-1289
16. Geary N., Asarian L., Korach K.S., Pfaff D.W., and Ogawa S. Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice. Endocrinology 142 (2001) 4751-4757
17. Meli R., Pacilio M., Raso G.M., Esposito E., Coppola A., Nasti A., Di Carlo C., Nappi C., and Di Carlo R. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology 145 (2004) 3115-3121
18. Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., and Cooke P.S. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. USA 97 (2000) 12729-12734
19. Dupont S., Krust A., Gansmuller A., Dierich A., Chambon P., and Mark M. Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127 (2000) 4277-4291
20. Kitamura T., Feng Y., Kitamura Y.I., Chua Jr. S.C., Xu A.W., Barsh G.S., Rossetti L., and Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat. Med. 12 (2006) 534-540
21. Catalano S., Mauro L., Marsico S., Giordano C., Rizza P., Rago V., Montanaro D., Maggiolini M., Panno M.L., and Ando S. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J. Biol. Chem. 279 (2004) 19908-19915