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Volumn 114, Issue 1, 2006, Pages 106-112

The estrogenic effect of bisphenol a disrupts pancreatic β-cell function in vivo and induces insulin resistance

Author keywords

Bisphenol A; Diabetes; Endocrine disruptors; Estradiol; Estrogen receptor; Insulin; Islet of Langerhans; Nongenomic; Xenoestrogens

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ESTRADIOL; ESTROGEN DERIVATIVE; ESTROGEN RECEPTOR; GLUCOSE; INSULIN;

EID: 30344444488     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8451     Document Type: Article
Times cited : (540)

References (57)
  • 1
    • 15044364584 scopus 로고    scopus 로고
    • Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors
    • Adachi T, Yasuda K, Mori C, Yoshinaga M, Aoki N, Tsujimoto G, et al. 2005. Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors. Food Chem Toxicol 43:713-719.
    • (2005) Food Chem Toxicol , vol.43 , pp. 713-719
    • Adachi, T.1    Yasuda, K.2    Mori, C.3    Yoshinaga, M.4    Aoki, N.5    Tsujimoto, G.6
  • 2
    • 23844476055 scopus 로고    scopus 로고
    • 2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans
    • doi:10.1289/ehp.8002 [Online 18 May 2005]
    • 2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. Environ Health Perspect 113:969-977; doi:10.1289/ehp.8002 [Online 18 May 2005].
    • (2005) Environ Health Perspect , vol.113 , pp. 969-977
    • Alonso-Magdalena, P.1    Laribi, O.2    Ropero, A.B.3    Fuentes, E.4    Ripoll, C.5    Soria, B.6
  • 5
    • 30344444118 scopus 로고    scopus 로고
    • Bisphenol A Global Industry Group. Arlington VA:Bisphenol A Global Industry Group of the American Plastics Council. Available: [accessed 31 August 2005]
    • Bisphenol A Global Industry Group. 2005. Bisphenol A Homepage. Arlington VA:Bisphenol A Global Industry Group of the American Plastics Council. Available: http://www.bisphenol-a.org/ [accessed 31 August 2005].
    • (2005) Bisphenol A Homepage
  • 7
    • 18844480439 scopus 로고    scopus 로고
    • Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance
    • Charollais A, Gjinovci A, Huarte J, Bauquis J, Nadal A, Martin F, et al. 2000. Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance. J Clin Invest 106:235-243.
    • (2000) J Clin Invest , vol.106 , pp. 235-243
    • Charollais, A.1    Gjinovci, A.2    Huarte, J.3    Bauquis, J.4    Nadal, A.5    Martin, F.6
  • 9
    • 0027428381 scopus 로고
    • Developmental effects of endocrine-disrupting chemicals in wildlife and humans
    • Colborn T, vom Saal FS, Soto AM. 1993. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101:378-384.
    • (1993) Environ Health Perspect , vol.101 , pp. 378-384
    • Colborn, T.1    vom Saal, F.S.2    Soto, A.M.3
  • 10
    • 0037110453 scopus 로고    scopus 로고
    • 17β-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: Molecular mechanisms and islet functionality
    • Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, Eckhoff DE. 2002. 17β-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality. Transplantation 74:1252-1259.
    • (2002) Transplantation , vol.74 , pp. 1252-1259
    • Contreras, J.L.1    Smyth, C.A.2    Bilbao, G.3    Young, C.J.4    Thompson, J.A.5    Eckhoff, D.E.6
  • 11
    • 0015056190 scopus 로고
    • Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion
    • Costrini NV, Kalkhoff RK. 1971. Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion. J Clin Invest 50:992-999
    • (1971) J Clin Invest , vol.50 , pp. 992-999
    • Costrini, N.V.1    Kalkhoff, R.K.2
  • 12
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • DeFronzo RA. 1997. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 5:178-269.
    • (1997) Diabetes Rev , vol.5 , pp. 178-269
    • DeFronzo, R.A.1
  • 13
    • 0026021161 scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannini E. 1991. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-94.
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • DeFronzo, R.A.1    Ferrannini, E.2
  • 14
    • 0028147131 scopus 로고
    • Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man
    • Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. 1994. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 37:1025-1035.
    • (1994) Diabetologia , vol.37 , pp. 1025-1035
    • Del Prato, S.1    Leonetti, F.2    Simonson, D.C.3    Sheehan, P.4    Matsuda, M.5    DeFronzo, R.A.6
  • 15
    • 0034063375 scopus 로고    scopus 로고
    • Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes
    • Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrin M, et al. 2000. Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. J Clin Invest 105:731-740.
    • (2000) J Clin Invest , vol.105 , pp. 731-740
    • Devedjian, J.C.1    George, M.2    Casellas, A.3    Pujol, A.4    Visa, J.5    Pelegrin, M.6
  • 16
    • 51149188436 scopus 로고
    • Synthetic oestrogenic agents without the phenantrene nucleus
    • Dodds EC, Lawson W. 1936. Synthetic oestrogenic agents without the phenantrene nucleus. Nature 137:996.
    • (1936) Nature , vol.137 , pp. 996
    • Dodds, E.C.1    Lawson, W.2
  • 17
    • 30344454514 scopus 로고    scopus 로고
    • ECSCF. Opinion of the Scientific Committee on Food on Bisphenol A. SCF/CS/PM/3936 Final. Brussels:European Commission Scientific Committee on Food. Available: [accessed 31 August 2005]
    • ECSCF. 2002. Opinion of the Scientific Committee on Food on Bisphenol A. SCF/CS/PM/3936 Final. Brussels:European Commission Scientific Committee on Food. Available: http://europa.eu.int/comm/food/fs/sc/scf/out128_en.pdf [accessed 31 August 2005].
    • (2002)
  • 18
    • 0021876555 scopus 로고
    • Insulin secretion and biosynthesis after oestradiol treatment
    • Faure A, Haouari M, Sutter BC. 1985. Insulin secretion and biosynthesis after oestradiol treatment. Horm Metab Res 17:378.
    • (1985) Horm Metab Res , vol.17 , pp. 378
    • Faure, A.1    Haouari, M.2    Sutter, B.C.3
  • 19
    • 0036303832 scopus 로고    scopus 로고
    • Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide
    • Geisler JG, Zawalich W, Zawalich K, Lakey JR, Stukenbrok H, Milici AJ, et al. 2002. Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide. Diabetes 51:2158-2169.
    • (2002) Diabetes , vol.51 , pp. 2158-2169
    • Geisler, J.G.1    Zawalich, W.2    Zawalich, K.3    Lakey, J.R.4    Stukenbrok, H.5    Milici, A.J.6
  • 20
    • 0347030129 scopus 로고    scopus 로고
    • Endocrine disruptors and the obesity epidemic
    • Heindel JJ. 2003. Endocrine disruptors and the obesity epidemic. Toxicol Sci 76:247-249.
    • (2003) Toxicol Sci , vol.76 , pp. 247-249
    • Heindel, J.J.1
  • 22
    • 0020628007 scopus 로고
    • Alterations of maternal metabolism in normal and diabetic pregnancies: Differences in insulin-dependent, non-insulin-dependent, and gestational diabetes
    • Hollingsworth DR. 1983. Alterations of maternal metabolism in normal and diabetic pregnancies: differences in insulin-dependent, non-insulin-dependent, and gestational diabetes. Am J Obstet Gynecol 146:417-429.
    • (1983) Am J Obstet Gynecol , vol.146 , pp. 417-429
    • Hollingsworth, D.R.1
  • 25
    • 0036851180 scopus 로고    scopus 로고
    • Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure
    • Ikezuki Y, Tsutsumi O, Takai Y, Kamei Y, Taketani Y. 2002. Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Hum Reprod 17:2839-2841.
    • (2002) Hum Reprod , vol.17 , pp. 2839-2841
    • Ikezuki, Y.1    Tsutsumi, O.2    Takai, Y.3    Kamei, Y.4    Taketani, Y.5
  • 26
  • 27
    • 0036185539 scopus 로고    scopus 로고
    • Sex esteroids and insulin resistance
    • Livingstone C, Collison M. 2002. Sex esteroids and insulin resistance. Clin Sci 102:151-166.
    • (2002) Clin Sci , vol.102 , pp. 151-166
    • Livingstone, C.1    Collison, M.2
  • 29
    • 3142550827 scopus 로고    scopus 로고
    • Antidiabetic actions of estrogen: Insights from humans and genetic mouse models
    • Louet JF, LeMay C, Mauvais-Jarvis F. 2004. Antidiabetic actions of estrogen: insights from humans and genetic mouse models. Curr Atheroscler Rep 6:180-185.
    • (2004) Curr Atheroscler Rep , vol.6 , pp. 180-185
    • Louet, J.F.1    LeMay, C.2    Mauvais-Jarvis, F.3
  • 30
    • 0024457316 scopus 로고
    • Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene
    • Marban SL, DeLoia JA, Gearhart JD. 1989. Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene. Dev Genet 10:356-364.
    • (1989) Dev Genet , vol.10 , pp. 356-364
    • Marban, S.L.1    DeLoia, J.A.2    Gearhart, J.D.3
  • 31
    • 0036244748 scopus 로고    scopus 로고
    • Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes
    • Masuno H, Kidani T, Sekiya K, Sakayama K, Shiosaka T, Yamamoto H. 2002. Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes. J Lipid Res 43:676-684.
    • (2002) J Lipid Res , vol.43 , pp. 676-684
    • Masuno, H.1    Kidani, T.2    Sekiya, K.3    Sakayama, K.4    Shiosaka, T.5    Yamamoto, H.6
  • 32
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • McGurry JD. 1992. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-770.
    • (1992) Science , vol.258 , pp. 766-770
    • McGurry, J.D.1
  • 33
    • 0034989592 scopus 로고    scopus 로고
    • Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals
    • McLachlan JA. 2001. Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 22:319-341.
    • (2001) Endocr Rev , vol.22 , pp. 319-341
    • McLachlan, J.A.1
  • 34
    • 20844456812 scopus 로고    scopus 로고
    • The environmental estrogen bisphenol A inhibits estrogen-induced hippocampal synaptogenesis
    • doi:10.1289/ehp.7633 [Online 24 February 2005]
    • McLusky NJ, Hajszan T, Leranth C. 2005. The environmental estrogen bisphenol A inhibits estrogen-induced hippocampal synaptogenesis. Environ Health Perspect 113:675-679; doi:10.1289/ehp.7633 [Online 24 February 2005].
    • (2005) Environ Health Perspect , vol.113 , pp. 675-679
    • McLusky, N.J.1    Hajszan, T.2    Leranth, C.3
  • 36
    • 0035051359 scopus 로고    scopus 로고
    • Testosterone effect on insulin content, messenger ribonucleic acid levels, promoter activity, and secretion in the rat
    • Morimoto S, Fernandez-Mejia C, Romero-Navarro G, Morales-Peza N, Diaz-Sanchez V. 2001. Testosterone effect on insulin content, messenger ribonucleic acid levels, promoter activity, and secretion in the rat. Endocrinology 142:1442-1447.
    • (2001) Endocrinology , vol.142 , pp. 1442-1447
    • Morimoto, S.1    Fernandez-Mejia, C.2    Romero-Navarro, G.3    Morales-Peza, N.4    Diaz-Sanchez, V.5
  • 37
    • 15044353993 scopus 로고    scopus 로고
    • Disentangling the molecular mechanism of action of natural and environmental estrogens
    • Nadal A, Alonso-Magdalena P, Ripoll C, Fuentes E. 2005. Disentangling the molecular mechanism of action of natural and environmental estrogens. Pflugers Arch 449:335-343.
    • (2005) Pflugers Arch , vol.449 , pp. 335-343
    • Nadal, A.1    Alonso-Magdalena, P.2    Ripoll, C.3    Fuentes, E.4
  • 38
    • 3543043163 scopus 로고    scopus 로고
    • Estrogen and xenoestrogen actions on endocrine pancreas: From ion channel modulation to activation of nuclear function
    • Nadal A, Ropero AB, Fuentes E, Soria B, Ripoll C. 2004. Estrogen and xenoestrogen actions on endocrine pancreas: from ion channel modulation to activation of nuclear function. Steroids 69:531-536.
    • (2004) Steroids , vol.69 , pp. 531-536
    • Nadal, A.1    Ropero, A.B.2    Fuentes, E.3    Soria, B.4    Ripoll, C.5
  • 39
    • 0034633656 scopus 로고    scopus 로고
    • Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta
    • Nadal A, Ropero AB, Laribi O, Maillet M, Fuentes E, Soria B. 2000. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta. Proc Natl Acad Sci USA 97:11603-11608.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11603-11608
    • Nadal, A.1    Ropero, A.B.2    Laribi, O.3    Maillet, M.4    Fuentes, E.5    Soria, B.6
  • 40
    • 0031720257 scopus 로고    scopus 로고
    • Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor
    • Nadal A, Rovira JM, Laribi O, Leon-Quinto T, Andreu E, Ripoll C, et al. 1998. Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. FASEB J 12:1341-1348.
    • (1998) FASEB J , vol.12 , pp. 1341-1348
    • Nadal, A.1    Rovira, J.M.2    Laribi, O.3    Leon-Quinto, T.4    Andreu, E.5    Ripoll, C.6
  • 41
    • 4143083825 scopus 로고    scopus 로고
    • Lessons learned from perinatal exposure to diethylstilbestrol
    • 199
    • Newbold RR. 2004. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol 199:142-150.
    • (2004) Toxicol Appl Pharmacol , pp. 142-150
    • Newbold, R.R.1
  • 42
    • 0042318549 scopus 로고    scopus 로고
    • An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat
    • Perez-Martin M, Azcoitia I, Trejo JL, Sierra A, Garcia-Segura LM. 2003. An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. European J Neurosci 18:923-930.
    • (2003) European J Neurosci , vol.18 , pp. 923-930
    • Perez-Martin, M.1    Azcoitia, I.2    Trejo, J.L.3    Sierra, A.4    Garcia-Segura, L.M.5
  • 43
    • 0026601859 scopus 로고
    • Patients with insulinoma show insulin resistance in the absence of arterial hypertension
    • Pontiroli AE, Alberetto M, Pozza G. 1992. Patients with insulinoma show insulin resistance in the absence of arterial hypertension. Diabetologia 35:294-295.
    • (1992) Diabetologia , vol.35 , pp. 294-295
    • Pontiroli, A.E.1    Alberetto, M.2    Pozza, G.3
  • 44
    • 0036777477 scopus 로고    scopus 로고
    • Low doses of the endocrine disruptor bisphenol-A and the native hormone 17beta-estradiol rapidly activate transcription factor CREB
    • Quesada I, Fuentes E, Viso-Leon MC, Soria B, Ripoll C, Nadal A. 2002. Low doses of the endocrine disruptor bisphenol-A and the native hormone 17beta-estradiol rapidly activate transcription factor CREB. FASEB J 16:1671-1673.
    • (2002) FASEB J , vol.16 , pp. 1671-1673
    • Quesada, I.1    Fuentes, E.2    Viso-Leon, M.C.3    Soria, B.4    Ripoll, C.5    Nadal, A.6
  • 45
    • 0036737834 scopus 로고    scopus 로고
    • Linking dioxins to diabetes: Epidemiology and biologic plausibility
    • Remillard RBJ, Bunce NJ. 2002. Linking dioxins to diabetes: epidemiology and biologic plausibility. Environ Health Perspect 110:853-858.
    • (2002) Environ Health Perspect , vol.110 , pp. 853-858
    • Remillard, R.B.J.1    Bunce, N.J.2
  • 46
    • 0036188982 scopus 로고    scopus 로고
    • A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas
    • Ropero AB, Soria B, Nadal A. 2002. A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas. Mol Endocrinol 16:497-505.
    • (2002) Mol Endocrinol , vol.16 , pp. 497-505
    • Ropero, A.B.1    Soria, B.2    Nadal, A.3
  • 49
    • 0029856092 scopus 로고    scopus 로고
    • Comparison of insulin sensitivity in patients with insulinoma and obese type 2 diabetes mellitus
    • Skrha J, Sindelka G, Haas T, Hilgertova J, Justova V. 1996. Comparison of insulin sensitivity in patients with insulinoma and obese type 2 diabetes mellitus. Horm Metab Res 28:595-598.
    • (1996) Horm Metab Res , vol.28 , pp. 595-598
    • Skrha, J.1    Sindelka, G.2    Haas, T.3    Hilgertova, J.4    Justova, V.5
  • 50
    • 0035943610 scopus 로고    scopus 로고
    • Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones
    • Song M, Helguera G, Eghbali M, Zhu N, Zarei MM, Olcese R, et al. 2001. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones. J Biol Chem 276:31883-31890.
    • (2001) J Biol Chem , vol.276 , pp. 31883-31890
    • Song, M.1    Helguera, G.2    Eghbali, M.3    Zhu, N.4    Zarei, M.M.5    Olcese, R.6
  • 51
    • 21544445248 scopus 로고    scopus 로고
    • Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel drosophila G-protein-coupled receptor
    • Srivastava DP, Yu EJ, Kennedy K, Chatwin H, Reale V, Hamon M, et al. 2005. Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel drosophila G-protein-coupled receptor. J Neurosci 25:6145-6155.
    • (2005) J Neurosci , vol.25 , pp. 6145-6155
    • Srivastava, D.P.1    Yu, E.J.2    Kennedy, K.3    Chatwin, H.4    Reale, V.5    Hamon, M.6
  • 52
    • 0036148978 scopus 로고    scopus 로고
    • Rapid non-genomic and genomic responses to progestogens, estrogens, and glucocorticoids in the endocrine pancreatic B cell, the adipocyte and other cell types
    • Sutter-Dub MT. 2002. Rapid non-genomic and genomic responses to progestogens, estrogens, and glucocorticoids in the endocrine pancreatic B cell, the adipocyte and other cell types. Steroids 67:77-93.
    • (2002) Steroids , vol.67 , pp. 77-93
    • Sutter-Dub, M.T.1
  • 53
    • 0031973887 scopus 로고    scopus 로고
    • A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior
    • vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, et al. 1998. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior. Toxicol Ind Health 14:239-260.
    • (1998) Toxicol Ind Health , vol.14 , pp. 239-260
    • vom Saal, F.S.1    Cooke, P.S.2    Buchanan, D.L.3    Palanza, P.4    Thayer, K.A.5    Nagel, S.C.6
  • 54
    • 23844545162 scopus 로고    scopus 로고
    • An extensive new literature concerning low-dose effects of bisphenol-A shows the need for a new risk assessment
    • doi:10.1289/ehp.7713 [Online 13 April 2005]
    • vom Saal FS, Hughes C. 2005. An extensive new literature concerning low-dose effects of bisphenol-A shows the need for a new risk assessment. Environ Health Perspect 113:926-933; doi:10.1289/ehp.7713 [Online 13 April 2005]
    • (2005) Environ Health Perspect , vol.113 , pp. 926-933
    • vom Saal, F.S.1    Hughes, C.2
  • 55
    • 30344463657 scopus 로고    scopus 로고
    • World Health Organization. Welcome to the Diabetes Program. Available: [accessed 23 November 2005]
    • World Health Organization. 2005. Welcome to the Diabetes Program. Available: http://www.who.int/diabetes/en/ [accessed 23 November 2005].
    • (2005)
  • 56
    • 17744396647 scopus 로고    scopus 로고
    • 2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells
    • doi:10.1289/ehp.7505 [Online 14 January 2005]
    • 2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells. Environ Health Perspect 113:431-439; doi:10.1289/ehp.7505 [Online 14 January 2005].
    • (2005) Environ Health Perspect , vol.113 , pp. 431-439
    • Wozniak, A.L.1    Bulayeva, N.N.2    Watson, C.S.3
  • 57
    • 0345073634 scopus 로고    scopus 로고
    • Biotransformations of bisphenol A in a mammalian model: Answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice
    • Zalko D, Soto AM, Dolo L, Dorio C, Rathahao E, Debrauwer L, et al. 2003. Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice. Environ Health Perspect 111:309-319.
    • (2003) Environ Health Perspect , vol.111 , pp. 309-319
    • Zalko, D.1    Soto, A.M.2    Dolo, L.3    Dorio, C.4    Rathahao, E.5    Debrauwer, L.6


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