Orchiectomy and response to testosterone in the development of obesity in young Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats

International Journal of Obesity

Volumn 22, Issue 4, 1998, Pages 318-324

  Shimizu, H ^a   Ohtani, K I ^a   Uehara, Y ^a   Abe, Y ^a   Takahashi, H ^a   Tsuchiya, T ^a   Sato, N ^a   Ibuki, Y ^a   Mori, M ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Leptin; Obesity; Orchiectomy; Otsuka Long Evans Tokushima fatty (OLETF) rats; Testosterone

Indexed keywords

LEPTIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; GENE EXPRESSION; HORMONE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORCHIECTOMY; PRIORITY JOURNAL; RAT; TESTOSTERONE BLOOD LEVEL; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

ANIMALIA; UNIDENTIFIED AGENTS;

EID: 0031883353     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800586     Document Type: Article

References (25)

1. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. Spontaneous long-term hyperglycemia rats with diabetic complications: Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 1992; 41: 1422-1428.
2. Ishida K, Mizuno A, Min Z, Sano T, Shima K. Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion? Metabolism 1995; 44: 940-945.
3. Okauchi N, Mizuno A, Yoshimoto S, Zhu M, Sano T, Shima K. Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Diab Res Clin Pract 1995; 27: 97-106.
4. Shima K, Shi K, Sano T, Iwami T, Mizumo A, Noma Y. Is exercise training effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Metabolism 1993; 42: 971-977.
5. Shoupe D, Lobo RA. The influence of androgens on insulin resistance. Fertil Steril 1984; 41: 385-388.
6. Rincon J, Holmang A, Wahlström EO, Lonnroth P, Björntorp P, Zielrath JR, Wallberg-Henriksson H. Mechanism behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment. Diabetes 1996; 45: 615-621.
7. Russell JC, Amy RM, Graham S, Wenzel LM, Dolphin PJ. Effect of castration on hyperlipidemic, insulin resistant JCR: LA-corpulent rats. Atherosclerosis 1993; 100: 113-122.
8. Shi K, Mizuno A, Sano T, Ishida K, Shima K. Sexual difference in the incidence of diabetes mellitus in Otsuka-Long-Evans-Tokushima-Fatty rats: effects of castration and sex hormone replacement on its incidence. Metabolism 1994; 43: 1214-1220.
9. Ikeda H, Shino A, Mastuo T, Iwatsuka H, Suzuoki Z. A new genetically obese- hyperglycemic rat (Wistar Fatty). Diabetes 1981; 30: 1045-1050.
10. Clark JB, Palmer CJ, Shaw WN. The diabetic Zucker Fatty rat. Proc Soc Exp Biol Med 1983; 173: 68-75.
11. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
12. Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu S-M, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat Fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-996.
13. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF. Leptin receptor missense mutation in the Fatty Zucker rat. Nature Gen 1996; 13: 18-19.
14. Havel PJ, Kasim-Karakas S, Dubuc GR, Mueller W, Phinney SD. Gender differences in plasma leptin concentrations. Nature Med 1996; 2: 949-950.
15. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996; 81: 3424-3427.
16. Shimizu H, Shimomura Y, Nakanishi Y, Futawatari T, Ohtani K, Sato N, Mori M. Estrogen increases in vivo leptin production in rats and human subjects. J Endocr 1997; 154: 285-292.
17. Krotkiewski M, Björntorp P. The effect of progesterone and of insulin administration on regional adipose tissue cellularity in the rat. Acta Physiol Scand 1976; 96: 122-127.
18. Morin LP, Cummings LA. Splitting of wheelrunning rhythms by castrated or steroid treated male and female hamsters. Physiol Behav 1982; 29: 665-675.
19. Sivitz WI, Bailey HL, Donohoue P. Rat adipose ob mRNA levels in states of altered circulating glucose and insulin. Biochem Biophys Res Commun 1996; 220: 520-525.
20. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995; 1: 1155-1161.
21. Shimizu H, Uehara Y, Mori M. Probucol attenuates reduction of serum immunoreactive insulin levels by interleukin in adrenalectomized rats. Pharmacology 1992; 44: 344-348.
22. Bjömtorp P. Insulin resistance: the consequence of a neuroendocrine disturbance? Int J Obes 19 (Suppl 1): S6-S10.
23. Shimizu H, Ohshima K, Bray GA, Peterson M, Swerdloff RS. Adrenalectomy and castration in the genetically obese (OB/ OB) mouse. Obes Res 1993; 1: 377-383.
24. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes 1996; 45: 1446-1450.
25. Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nature Gen 1996; 14: 130-131.