Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes

Diabetologia

Volumn 43, Issue 10, 2000, Pages 1309-1312

  Kahn, S E ^a   Andrikopoulos, S ^a   Verchere, C B ^a   Wang, F ^a   Hull, R L ^a   Vidal, J ^a  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

Alzheimer's disease; Amylin; Diabetes; Glucose tolerance; Islet amyloid; Islet amyloid polypeptide; Oestrogen; Oophorectomy

Indexed keywords

AMYLIN; ESTROGEN; GLUCOSE; INSULIN; TESTOSTERONE;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; ESTROGEN THERAPY; FEMALE; GLUCOSE TOLERANCE TEST; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OVARIECTOMY; PANCREAS ISLET CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMYLOID; ANIMAL; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; OVARIECTOMY; OVARY; PANCREAS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033793584     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051527     Document Type: Article

References (10)

1. Islet amyloid: A long-recognized but underappreciated pathological feature of type 2 diabetes
2. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islets
3. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
4. Islet amyloid polypeptide in diabetic and non-diabetic Pima Indians
5. Islet amyloid formation associated with hyperglycaemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide
6. Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide
7. Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: Pathogenesis of diabetes in a mouse model
8. A prospective study of postmenopausal oestrogen therapy and subsequent incidence of non-insulin-dependent diabetes mellitus
9. Two novel immortal pancreatic β-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid
10. Diet of second-generation Japanese-American men with and without non-insulin-dependent diabetes