DNA-destabilizing agents as an alternative approach for targeting DNA: Mechanisms of action and cellular consequences

Journal of Nucleic Acids

Volumn 2010, Issue , 2010, Pages

  Lenglet, Gaëlle ^a   David Cordonnier, Marie Hélène ^a  

^a JEAN PIERRE AUBERT RESEARCH CENTER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

7,8,9,10 TETRAHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; ACRIDINE ORANGE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BENZO[E]PYRENE; CATECHOL 4 HYDROXYEQUILENIN O QUINONE; CIS 1,2 DIACETOXY 6 METHOXY 3,3,14 TRIMETHYL 1,2,3 14 TETRAHYDRO 7H BENZO[B]PYRANO [3,2 H]ACRIDIN 7 ONE; CISPLATIN; DOXORUBICIN; ELLIPTICINE; HIGH MOBILITY GROUP A PROTEIN; MITOMYCIN C; OXALIPLATIN; PLATINUM COMPLEX; PSORALEN DERIVATIVE; RUTHENIUM COMPLEX; S 23906; S 28053; S 28687; S 29385; SINGLE STRANDED DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CYTOTOXICITY; DNA ALKYLATION; DNA BINDING; DNA DENATURATION; DNA HELIX; DNA REPAIR; DNA REPLICATION; DNA SEQUENCE; DNA STRAND; DNA STRUCTURE; DNA TRANSCRIPTION; DRUG STRUCTURE; ENTHALPY; ENTROPY; GENE TARGETING; PRIORITY JOURNAL; REVIEW;

EID: 84861047804     PISSN: 20900201     EISSN: 2090021X     Source Type: Journal    
DOI: 10.4061/2010/290935     Document Type: Review

References (183)

1. Gilman A., Philips F. S., The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides. Science 1946 103 2675 409 436 2-s2.0-0001060019
2. Watson J. D., Crick F. H. C., Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid. Nature 1953 171 4356 737 738 2-s2.0-0038497542 10.1038/171737a0
3. Waring M. J., DNA modification and cancer. Annual Review of Biochemistry 1981 50 159 192 2-s2.0-0019364861
4. Teicher B. A., Cancer Therapeutics: Experimental and Clinical Agents (Cancer Drug Discovery and Development) [Hardcover] 1996 1st Clifton, NJ, USA Humana Press
5. Braa M. F., Cacho M., Gradillas A., de Pascual-Teresa B., Ramos A., Intercalators as anticancer drugs. Current Pharmaceutical Design 2001 7 17 1745 1780 2-s2.0-0034782523 10.2174/1381612013397113 (Pubitemid 32998336)
6. Kostova I., Platinum complexes as anticancer agents. Recent Patents on Anti-Cancer Drug Discovery 2006 1 1 1 22 2-s2.0-33847112134 10.2174/ 157489206775246458
7. Kostova I., Ruthenium complexes as anticancer agents. Current Medicinal Chemistry 2006 13 9 1085 1107 2-s2.0-33645998774 10.2174/092986706776360941
8. Dornberger U., Leijon M., Fritzsche H., High base pair opening rates in tracts of GC base pairs. The Journal of Biological Chemistry 1999 274 11 6957 6962 2-s2.0-0033548682 10.1074/jbc.274.11.6957 (Pubitemid 29140503)
9. Bode J., Winkelmann S., Götze S., Spiker S., Tsutsui K., Bi C., A.K. P., Benham C., Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy. Journal of Molecular Biology 2006 358 2 597 613 2-s2.0-33646507893 10.1016/j.jmb.2005.11.073
10. Schneider T. D., Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation. Nucleic Acids Research 2001 29 23 4881 4891 2-s2.0-0035584142 (Pubitemid 33133560)
11. Choi C. H., Kalosakas G., Rasmussen K. O., Hiromura M., Bishop A. R., Usheva A., DNA dynamically directs its own transcription initiation. Nucleic Acids Research 2004 32 4 1584 1590 2-s2.0-2342498193 10.1093/nar/gkh335 (Pubitemid 38854755)
12. Gniazdowski M., Denny W. A., Nelson S. M., Czyz M., Effects of anticancer drugs on transcription factor-DNA interactions. Expert Opinion on Therapeutic Targets 2005 9 3 471 489 2-s2.0-21244481362 10.1517/14728222.9.3.471 (Pubitemid 40883148)
13. Calladine C. R., Drew H.R., Understanding DNA: The Molecule and How It Works 1997 2nd San Diego, Calif, USA Academic Press
14. Putnam B. F., Van Zandt L. L., Prohofsky E. W., Mei W. N., Resonant and localized breathing modes in terminal regions of the DNA double helix. Biophysical Journal 1981 35 2 271 287 2-s2.0-0019489734 (Pubitemid 11040658)
15. Harvey S. C., DNA structural dynamics: iongitudinal breathing as a possible mechanism for the BZ transition. Nucleic Acids Research 1983 11 14 4867 4878 2-s2.0-0021112288
16. Kearns D. R., NMR studies of conformational states and dynamics of DNA. CRC Critical Reviews in Biochemistry 1984 15 3 237 290 2-s2.0-0021313920
17. Breslauer K. J., Frank R., Blocker H., Marky L. A., Predicting DNA duplex stability from the base sequence. Proceedings of the National Academy of Sciences of the United States of America 1986 83 11 3746 3750 2-s2.0-0001550068 (Pubitemid 16062362)
18. Beger R., Feng Y., Prohofsky E. W., Vibrational fluctuations of hydrogen bonds in a DNA double helix with alternating TA type inserts. Biophysical Journal 1990 58 2 437 445 2-s2.0-0025102186 (Pubitemid 20249671)
19. Benham C. J., Energetics of the strand separation transition in superhelical DNA. Journal of Molecular Biology 1992 225 3 835 847 2-s2.0-0026708149 10.1016/0022-2836(92)90404-8
20. Benham C. J., Sites of predicted stress-induced DNA duplex destabilization occur preferentially at regulatory loci. Proceedings of the National Academy of Sciences of the United States of America 1993 90 7 2999 3003 2-s2.0-0027400474 (Pubitemid 23113545)
21. Benham C. J., Duplex destabilization in superhelical DNA is predicted to occur at specific transcriptional regulatory regions. Journal of Molecular Biology 1996 255 3 425 434 2-s2.0-0029965473 10.1006/jmbi.1996.0035 (Pubitemid 26105566)
22. Chen Y. Z., Prohofsky E. W., Sequence and temperature dependence of the interbase hydrogen-bond breathing modes in B-DNA polymers: comparison with low-frequency Raman peaks and their role in helix melting. Biopolymers 1995 35 6 573 582 2-s2.0-0028998993
23. Pedersen A. G., Baldi P., Chauvin Y., Brunak S., The biology of eukaryotic promoter prediction - a review. Computers and Chemistry 1999 23 3-4 191 207 2-s2.0-0033563512 (Pubitemid 129752332)
24. Lankaš F., Šponer J., Hobza P., Langowski J., Sequence-dependent elastic properties of DNA. Journal of Molecular Biology 2000 299 3 695 709 2-s2.0-0034625311 10.1006/jmbi.2000.3781
25. Wärmländer S., Sponer J. E., Sponer J., Leijoni M., The influence of the thymine C5 methyl group on spontaneous base pair breathing in DNA. The Journal of Biological Chemistry 2002 277 32 28491 28497 2-s2.0-0037047422 10.1074/jbc.M202989200 (Pubitemid 41079274)
26. Krueger A., Protozanova E., Frank-Kamenetskii M. D., Sequence-dependent basepair opening in DNA double helix. Biophysical Journal 2006 90 9 3091 3099 2-s2.0-32644444430 10.1529/biophysj.105.078774
27. Ambjörnsson T., Banik S. K., Krichevsky O., Metzler R., Sequence sensitivity of breathing dynamics in heteropolymer DNA. Physical Review Letters 2006 97 12 4 2-s2.0-33748969504 10.1103/PhysRevLett.97.128105 128105 (Pubitemid 44440766)
28. Ambjörnsson T., Banik S. K., Krichevsky O., Metzler R., Breathing dynamics in heteropolymer DNA. Biophysical Journal 2007 92 8 2674 2684 2-s2.0-34147109694 10.1529/biophysj.106.095935 (Pubitemid 46557843)
29. Minetti C. A. S.A., Remeta D. P., Dickstein R., Breslauer K. J., kjbdna@rci.rutgers.edu Energetic signatures of single base bulges: thermodynamic consequences and biological implications. Nucleic Acids Research 2010 38 1 97 116 2-s2.0-75649100485 10.1093/nar/gkp1036
30. Li Y.-J., Fu X.-H., Liu D.-P., Liang C.-C., Opening the chromatin for transcription. International Journal of Biochemistry and Cell Biology 2004 36 8 1411 1423 2-s2.0-2442463500 10.1016/j.biocel.2003.11.003 (Pubitemid 38625822)
31. Betterton M. D., Jülicher F., Opening of nucleic-acid double strands by helicases: active versus passive opening. Physical Review E 2005 71 1 11 2-s2.0-41349092240 10.1103/PhysRevE.71.011904 011904 (Pubitemid 40619965)
32. Schuck S., Stenlund A., ATP-dependent minor groove recognition of TA base pairs is required for template melting by the E1 initiator protein. Journal of Virology 2007 81 7 3293 3302 2-s2.0-33947226399 10.1128/JVI.02432-06 (Pubitemid 46456638)
33. Sanders C. M., A DNA-binding activity in BPV initiator protein E1 required for melting duplex ori DNA but not processive helicase activity initiated on partially single-stranded DNA. Nucleic Acids Research 2008 36 6 1891 1899 2-s2.0-41849092361 10.1093/nar/gkn041 (Pubitemid 351494233)
34. Jelen F., Palecek E., Nucleotide sequence-dependent opening of double-stranded DNA at an electrically charged surface. General Physiology and Biophysics 1985 4 2 219 237 2-s2.0-0022040577
35. Eckdahl T. T., Anderson J. N., Conserved DNA structures in origins of replication. Nucleic Acids Research 1990 18 6 1609 1612 2-s2.0-0025308614
36. Essevaz-Roulet B., Bockelmann U., Heslot F., Mechanical separation of the complementary strands of DNA. Proceedings of the National Academy of Sciences of the United States of America 1997 94 22 11935 11940 2-s2.0-0030699999 10.1073/pnas.94.22.11935 (Pubitemid 27467820)
37. Lohman T. M., Bjornson K. P., Mechanisms of helicase-catalyzed DNA unwinding. Annual Review of Biochemistry 1996 65 169 214 2-s2.0-0029893874 (Pubitemid 26250608)
38. Gyimesi M., Sarlós K., Kovács M., Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA. Nucleic Acids Research 2010 10.1093/nar/gkq145
39. Wold M. S., Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annual Review of Biochemistry 1997 66 61 92 2-s2.0-0030908093 10.1146/annurev.biochem.66.1.61 (Pubitemid 27274652)
40. Waga S., Stillman B., The DNA replication fork in eukaryotic cells. Annual Review of Biochemistry 1998 67 721 751 2-s2.0-0031663505 10.1146/annurev.biochem.67.1.721 (Pubitemid 28411143)
41. Maillard O., Solyom S., Naegeli H., An aromatic sensor with aversion to damaged strands confers versatility to DNA repair. PLoS Biology 2007 5 4, article e79 2-s2.0-35148856703 10.1371/journal.pbio.0050079 (Pubitemid 46631850)
42. Herrick G., Alberts B., Nucleic acid helix coil transitions mediated by helix unwinding proteins from calf thymus. The Journal of Biological Chemistry 1976 251 7 2133 2141 2-s2.0-0017229241
43. Planck S. R., Wilson S. H., Studies on the structure of mouse helix-destabilizing protein-1. DNA binding and controlled proteolysis with trypsin. The Journal of Biological Chemistry 1980 255 23 11547 11556 2-s2.0-0019321944
44. Karpel R. L., Burchard A. C., A basic isozyme of yeast glyceraldehyde-3-phosphate dehydrogenase with nucleic acid helix-destabilizing activity. Biochimica et Biophysica Acta 1981 654 2 256 267 2-s2.0-0019889692
45. Javaherian K., Sadeghi M., Liu L. F., Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. Nucleic Acids Research 1979 6 11 3569 3580 2-s2.0-0018787029
46. Butler A. P., Mardian J. K. W., Olins D. E., Nonhistone chromosomal protein HMG 1 interactions with DNA: fluorescence and thermal denaturation studies. The Journal of Biological Chemistry 1985 260 19 10613 10620 2-s2.0-0022183264 (Pubitemid 16252241)
47. David-Cordonnier M.-H., Hamdane M., Bailly C., D'Halluin J.-C., The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. Biochemistry 1998 37 17 6065 6076 2-s2.0-0032574689 10.1021/bi973030w (Pubitemid 28196763)
48. David-Cordonnier M.-H., Payet D., D'Halluin J.-C., Waring M. J., Travers A. A., Bailly C., The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA. Nucleic Acids Research 1999 27 11 2265 2270 2-s2.0-0033151841 10.1093/nar/27.11.2265 (Pubitemid 29245643)
49. Heath M. J., Derebail S. S., Gorelick R. J., DeStefano J. J., Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealing. The Journal of Biological Chemistry 2003 278 33 30755 30763 2-s2.0-0041732006 10.1074/jbc.M303819200 (Pubitemid 36994582)
50. Wang H., Yeh Y.-S., Barbara P. F., HIV-1 nucleocapsid protein bends double-stranded nucleic acids. Journal of the American Chemical Society 2009 131 42 15534 15543 2-s2.0-70350322944 10.1021/ja9070046
51. Narayanan N., Gorelick R. J., DeStefano J. J., Structure/function mapping of amino acids in the N-terminal zinc finger of the human immunodeficiency virus type 1 nucleocapsid protein: residues responsible for nucleic acid helix destabilizing activity. Biochemistry 2006 45 41 12617 12628 2-s2.0-33750046274 10.1021/bi060925c (Pubitemid 44583703)
52. Bera A., Roche A.-C., Nandi P. K., Bending and unwinding of nucleic acid by prion protein. Biochemistry 2007 46 5 1320 1328 2-s2.0-33846839458 10.1021/bi0620050 (Pubitemid 46208479)
53. Hornby D. P., Ford G. C., Protein-mediated base flipping. Current Opinion in Biotechnology 1998 9 4 354 358 2-s2.0-0032146154 10.1016/S0958-1669(98) 80007-4 (Pubitemid 28395642)
54. Cao C., Jiang Y. L., Stivers J. T., Song F., Dynamic opening of DNA during the enzymatic search for a damaged base. Nature structural & Molecular Biology 2004 11 12 1230 1236 2-s2.0-16544386633
55. Malta E., Moolenaar G. F., Goosen N., Base flipping in nucleotide excision repair. The Journal of Biological Chemistry 2006 281 4 2184 2194 2-s2.0-33644855067 10.1074/jbc.M508901200 (Pubitemid 43845809)
56. Hosfield D. J., Guan Y., Haas B. J., Cunningham R. P., Tainer J. A., Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell 1999 98 3 397 408 2-s2.0-0033529716 10.1016/S0092-8674(00)81968-6 (Pubitemid 29380574)
57. Bellamy S. R. W., Krusong K., Baldwin G. S., A rapid reaction analysis of uracil DNA glycosylase indicates an active mechanism of base flipping. Nucleic Acids Research 2007 35 5 1478 1487 2-s2.0-34247148838 10.1093/nar/gkm018 (Pubitemid 46592870)
58. Tubbs J. L., Pegg A. E., Tainer J. A., DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair 2007 6 8 1100 1115 2-s2.0-34447323281 10.1016/j.dnarep.2007.03.011 (Pubitemid 47058393)
59. Malta E., Verhagen C. P., Moolenaar G. F., Filippov D. V., Van der Marel G. A., Goosen N., Functions of base flipping in E. coli nucleotide excision repair. DNA Repair 2008 7 10 1647 1658 2-s2.0-52049089211 10.1016/j.dnarep.2008. 06.011
60. Yang C.-G., Yi C., Duguid E. M., Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature 2008 452 7190 961 965 2-s2.0-42549128712 10.1038/nature06889 (Pubitemid 351589622)
61. Jiranusornkul S., Laughton C. A., Destabilization of DNA duplexes by oxidative damage at guanine: implications for lesion recognition and repair. Journal of the Royal Society 2008 5 supplement 3 191 198 2-s2.0-58749098268 10.1098/rsif.2008.0304.focus
62. Vertino P. M., Cheng X., Blumenthal R. M., Structures and functions. S-Adenosylmethionine-dependent methyltransferases 1999 341 372
63. Sundheim O., Talstad V. A., Vågbo C. B., Slupphaug G., Krokan H. E., AlkB demethylases flip out in different ways. DNA Repair 2008 7 11 1916 1923 2-s2.0-53149136545 10.1016/j.dnarep.2008.07.015
64. Huang N., MacKerell A. D. Jr., Atomistic view of base flipping in DNA. Philosophical Transactions of the Royal Society A 2004 362 1820 1439 1460 2-s2.0-3042572329 10.1098/rsta.2004.1383 (Pubitemid 38846201)
65. Arita K., Ariyoshi M., Tochio H., Nakamura Y., Shirakawa M., Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature 2008 455 7214 818 821 2-s2.0-53649097070 10.1038/nature07249
66. Hashimoto H., Horton J. R., Zhang X., Bostick M., Jacobsen S. E., Cheng X., The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature 2008 455 7214 826 829 2-s2.0-53649089723 10.1038/nature07280
67. Mura C., McCammon J. A., Molecular dynamics of a κ B DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation. Nucleic Acids Research 2008 36 15 4941 4955 2-s2.0-50849107000 10.1093/nar/gkn473
68. Kleinwächter V., Balcarová Z., Boháek J., Thermal stability of complexes of diaminoacridines with deoxyribonucleic acids of varying base content. Biochimica et Biophysica Acta 1969 174 1 188 201 2-s2.0-0014686179
69. Kapuscinski J., Darzynkiewicz Z., Increased accessibility of bases in DNA upon binding of acridine orange. Nucleic Acids Research 1983 11 21 7555 7568 2-s2.0-0021101272
70. Kapuscinski J., Darzynkiewicz Z., Denaturation of nucleic acids induced by intercalating agents. Biochemical and biophysical properties of acridine orange-DNA complexes. Journal of Biomolecular Structure and Dynamics 1984 1 6 1485 1499 2-s2.0-0021179587 (Pubitemid 14056523)
71. Darzynkiewicz Z., Evenson D., Kapuscinski J., Melamed M. R., Denaturation of RNA and DNA in situ induced by acridine orange. Experimental Cell Research 1983 148 1 31 46 2-s2.0-0021041991 (Pubitemid 14231414)
72. Darzynkiewicz Z., Traganos F., Kapuscinski J., Melamed M. R., Denaturation and condensation of DNA in situ induced by acridine orange in relation to chromatin changes during growth and differentiation of Friend erythroleukemia cells. Cytometry 1985 6 3 195 207 2-s2.0-0021912871 (Pubitemid 15111764)
73. Canals A., Purciolas M., Aymamí J., Coll M., The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs. Acta Crystallographica Section D 2005 61 7 1009 1012 2-s2.0-24644470658 10.1107/S0907444905015404 (Pubitemid 43943165)
74. Cirilli M., Bachechi F., Ughetto G., Colonna F. P., Capobianco M. L., Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG). Journal of Molecular Biology 1993 230 3 878 889 2-s2.0-0027157444 10.1006/jmbi.1993.1208 (Pubitemid 23159933)
75. Garbett N. C., Graves D. E., Extending nature's leads: the anticancer agent ellipticine. Current Medicinal Chemistry - Anti-Cancer Agents 2004 4 2 149 172 2-s2.0-1642565147 10.2174/1568011043482070 (Pubitemid 38404690)
76. Zunino F., Gambetta R., Di Marco A., Zaccara A., Interaction of daunomycin and its derivatives with DNA. Biochimica et Biophysica Acta 1972 277 3 489 498 2-s2.0-0015506133
77. Kohn K. W., Waring M. J., Glaubiger D., Friedman C. A., Intercalative binding of ellipticine to DNA. Cancer Research 1975 35 1 71 76 2-s2.0-0016413781
78. Waring M. J., Structural requirements for the binding of ethidium to nucleic acids. Biochimica et Biophysica Acta 1966 114 2 234 244 2-s2.0-0014023905
79. Teulade-Fichou M. P., Vigneron J. P., Lehn J. M., Molecular recognition of nucleosides and nucleotides by a water soluble cyclo-bis-intercaland type receptor molecule based on acridine subunits. Supramolecular Chemistry 1995 5 139 147
80. Slama-Schwok A., Teulade-Fichou M.-P., Vigneron J.-P., Taillandier E., Lehn J.-M., Selective binding of a macrocyclic bis-acridine to DNA hairpins. Journal of the American Chemical Society 1995 117 26 6822 6830 2-s2.0-0029031077 10.1021/ja00131a003
81. Slama-Schwok A., Peronnet F., Hantz-Brachet E., Taillandier E., Teulade-Fichou M.-P., Vigneron J.-P., Best-Belpomme M., Lehn J.-M., A macrocyclic bis-acridine shifts the equilibrium from duplexes towards DNA hairpins. Nucleic Acids Research 1997 25 13 2574 2581 2-s2.0-0030802848 10.1093/nar/25.13.2574 (Pubitemid 27298151)
82. Blacker A. J., Teulade-Fichou M.-P., Vigneron J.-P., Fauquet M., Lehn J.-M., Selective photocleavage of single-stranded nucleic acids by cyclobisintercaland molecules. Bioorganic and Medicinal Chemistry Letters 1998 8 6 601 606 2-s2.0-0032539789 10.1016/S0960-894X(98)00085-7 (Pubitemid 28122360)
83. Jourdan M., García J., Lhomme J., Teulade-Fichou M.-P., Vigneron J.-P., Lehn J.-M., Threading bis-intercalation of a macrocyclic bisacridine at abasic sites in DNA: nuclear magnetic resonance and molecular modeling study. Biochemistry 1999 38 43 14205 14213 2-s2.0-0033607302 10.1021/bi991111h (Pubitemid 29513836)
84. David A., Bleimling N., Beuck C., Lehn J.-M., Weinhold E., Teulade-Fichou M.-P., DNA mismatch-specific base flipping by a bisacridine macrocycle. ChemBioChem 2003 4 12 1326 1331 2-s2.0-0346157095 10.1002/cbic.200300693 (Pubitemid 38036414)
85. Shi Y.-B., Hearst J. E., Thermostability of double-stranded deoxyribonucleic acids: effects of covalent additions of a psoralen. Biochemistry 1986 25 20 5895 5902 2-s2.0-0022970758 (Pubitemid 17204021)
86. Tomasz M., Chawla A. K., Lipman R., Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C. Biochemistry 1988 27 9 3182 3187 2-s2.0-0023899026
87. Basu A. K., Hanrahan C. J., Malia S. A., Kumar S., Bizanek R., Tomasz M., Effect of site-specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerases. Biochemistry 1993 32 18 4708 4718 2-s2.0-0027271948 10.1021/bi00069a004 (Pubitemid 23162025)
88. Warren A. J., Maccubbin A. E., Hamilton J. W., Detection of mitomycin C-DNA adducts in vivo by 32P-postlabeling: time course for formation and removal of adducts and biochemical modulation. Cancer Research 1998 58 3 453 461 2-s2.0-0032006839 (Pubitemid 28087406)
89. Kašpárková J., Nováková O., Vrána O., Farrell N., Brabec V., Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking. Biochemistry 1999 38 34 10997 11005 2-s2.0-0033600598 10.1021/bi990245s (Pubitemid 29411589)
90. Fridman A. S., Brabec V., Haroutiunian S. G., Wartell R. M., Lando D. Y., Melting of cross-linked DNA v. cross-linking effect caused by local stabilization of the double helix. Journal of Biomolecular Structure and Dynamics 2003 20 4 533 545 2-s2.0-0037319165 (Pubitemid 36206097)
91. David-Cordonnier M.-H., Laine W., Lansiaux A., Rosu F., Colson P., de Pauw E., Michel S., Tillequin F., Koch M., Hickman J. A., Pierré A., Bailly C., Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism. Molecular Cancer Therapeutics 2005 4 1 71 80 2-s2.0-13944284237 (Pubitemid 40268068)
92. Gelasco A., Lippard S. J., NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin. Biochemistry 1998 37 26 9230 9239 2-s2.0-0032580979 10.1021/bi973176v (Pubitemid 28307676)
93. Dronkert M. L. G., Kanaar R., Repair of DNA interstrand cross-links. Mutation Research 2001 486 4 217 247 2-s2.0-0035807079 10.1016/S0921-8777(01) 00092-1 (Pubitemid 32763210)
94. Schärer O. D., A molecular basis for damage recognition in eukaryotic nucleotide excision repair. ChemBioChem 2008 9 1 21 23 2-s2.0-38149019888 10.1002/cbic.200700619
95. Noll D. M., Mason T. M., Miller P. S., Formation and repair of interstrand cross-links in DNA. Chemical Reviews 2006 106 2 277 301 2-s2.0-33644623520 10.1021/cr040478b
96. Bellon S. F., Coleman J. H., Lippard S. J., DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis- diamminedichloroplatinum(II). Biochemistry 1991 30 32 8026 8035 2-s2.0-0025917146
97. Brabec V., Reedijk J., Leng M., Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding. Biochemistry 1992 31 49 12397 12402 2-s2.0-0026992557 10.1021/bi00164a014 (Pubitemid 23163115)
98. Malinge J.-M., Pérez C., Leng M., Base sequence-independent distorsions induced by interstrand cross-links in cis-diamminedichloroplatinum (II)-modified DNA. Nucleic Acids Research 1994 22 19 3834 3839 2-s2.0-0028095517 (Pubitemid 24310090)
99. Malinge J.-M., Giraud-Panis M.-J., Leng M., Interstrand cross-links of cisplatin induce striking distortions in DNA. Journal of Inorganic Biochemistry 1999 77 1-2 23 29 2-s2.0-0033368914 10.1016/S0162-0134(99)00148-8 (Pubitemid 30089077)
100. Coste F., Malinge J.-M., Serre L., Shepard W., Roth M., Leng M., Zelwer C., Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 Å resolution: hydration at the platinated site. Nucleic Acids Research 1999 27 8 1837 1846 2-s2.0-0033560940 10.1093/nar/27.8.1837 (Pubitemid 29209625)
101. Kasparkova J., Marini V., Bursova V., Brabec V., Biophysical studies on the stability of DNA intrastrand cross-links of transplatin. Biophysical Journal 2008 95 9 4361 4371 2-s2.0-58149171466 10.1529/biophysj.108.138909
102. Fridman A. S., Galyuk E. N., Vorob'ev V. I., Skvortsov A. N., Lando D. Y., lando@iboch.bas-net.by Melting of crosslinked DNA: VI. Comparison of influence of interstrand crosslinks and other chemical modifications formed by antitumor compounds on DNA stability. Journal of Biomolecular Structure and Dynamics 2008 26 2 175 185 2-s2.0-0029821230
103. Poklar N., Pilch D. S., Lippard S. J., Redding E. A., Dunham S. U., Breslauer K. J., Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. Proceedings of the National Academy of Sciences of the United States of America 1996 93 15 7606 7611 2-s2.0-0029821230 10.1073/pnas.93.15.7606 (Pubitemid 26277083)
104. Pilch D. S., Dunham S. U., Jamieson E. R., Lippard S. J., Breslauer K. J., DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA. Journal of Molecular Biology 2000 296 3 803 812 2-s2.0-0034711943 10.1006/jmbi.2000.3496
105. Malina J., Nováková O., Vojtiskova M., Natile G., Brabec V., Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog. Biophysical Journal 2007 93 11 3950 3962 2-s2.0-36849089573 10.1529/biophysj.107.116996 (Pubitemid 350223811)
106. Galyuk E. N., Fridman A. S., Vorob'ev V. I., Haroutiunian S. G., Sargsyan S. A., Hauruk M. M., Lando D. Y., Compensation of DNA stabilization and destabilization effects caused by cisplatin is partially disturbed in alkaline medium. Journal of Biomolecular Structure and Dynamics 2008 25 4 407 417 2-s2.0-38349156036
107. Brabec V., Sip M., Leng M., DNA conformational change produced by the site-specific interstrand cross- link of trans-diamminedichloroplatinum(II). Biochemistry 1993 32 43 11676 11681 2-s2.0-0027485725 10.1021/bi00094a025 (Pubitemid 23341446)
108. Teletchéa S., Komeda S., Teuben J.-M., Elizondo-Riojas M.-A., Reedijk J., Kozelka J., A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA-binding. Chemistry-A European Journal 2006 12 14 3741 3753 2-s2.0-33646531427 10.1002/chem.200500923
109. Bursova V., Kasparkova J., Hofr C., Brabec V., Effects of monofunctional adducts of platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes. Biophysical Journal 2005 88 2 1207 1214 2-s2.0-21244440964 10.1529/biophysj.104.051771 (Pubitemid 40975948)
110. Schwartz A., Marrot L., Leng M., Conformation of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II). Biochemistry 1989 28 20 7975 7979 2-s2.0-0024423977 (Pubitemid 19252876)
111. Hägerlöf M., Papsai P., Chow C. S., Elmroth S. K. C., More pronounced salt dependence and higher reactivity for platination of the hairpin r(CGCGUUGUUCGCG) compared with d(CGCGTTGTTCGCG). Journal of Biological Inorganic Chemistry 2006 11 8 974 990 2-s2.0-33751202702 10.1007/s00775-006-0157-y (Pubitemid 44786387)
112. Sava G., Pacor S., Bregant F., Ceschia V., Mestroni G., Metal complexes of ruthenium: antineoplastic properties and perspectives. Anti-Cancer Drugs 1990 1 2 99 108 2-s2.0-0025584545
113. Sava G., Pacor S., Bregant F., Ceschia V., Metal complexes of ruthenium: a potential class of selective anticancer drugs. Anticancer Research 1991 11 3 1103 1107 2-s2.0-0025835043
114. Zhang C. X., Lippard S. J., New metal complexes as potential therapeutics. Current Opinion in Chemical Biology 2003 7 4 481 489 2-s2.0-0043073120 10.1016/S1367-5931(03)00081-4 (Pubitemid 36980839)
115. Nováková O., Chen H., Vrana O., Rodger A., Sadler P. J., P.J.Sadler@ed.ac.uk Brabec V., brabec@ibp.cz DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media. Biochemistry 2003 42 39 11544 11554 2-s2.0-0036618858 10.1021/bi034933u (Pubitemid 37205749)
116. Nováková O., Nazarov A. A., Hartinger C. G., Keppler B. K., Brabec V., DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media. Biochemical Pharmacology 2009 77 3 364 374 2-s2.0-58249133731 10.1016/j.bcp.2008.10.021
117. Nováková O., Malina J., Suchankova T., Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes. Chemistry-A European Journal 2010 16 19 5744 5754 2-s2.0-0344237408 10.1002/chem.200903078
118. Spielmann H. P., Dwyer T. J., Hearst J. E., Wemmer D. E., Solution structures of psoralen monoadducted and cross-linked DNA oligomers by NMR spectroscopy and restrained molecular dynamics. Biochemistry 1995 34 40 12937 12953 2-s2.0-0028801257
119. Zhang N., Lin C., Huang X., Kolbanovskiy A., Hingerty B. E., Amin S., Broyde S., Geacintov N. E., Patel D. J., Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement. Journal of Molecular Biology 2005 346 4 951 965 2-s2.0-13444292934 10.1016/j.jmb.2004.12.027 (Pubitemid 40215522)
120. Zou Y., Van Houten B., Strand opening by the UvrA(2)B complex allows dynamic recognition of DNA damage. The EMBO Journal 1999 18 4889 4901 (Pubitemid 29415542)
121. Zou Y., Luo C., Geacintov N. E., Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair. Biochemistry 2001 40 9 2923 2931 2-s2.0-0035814936 10.1021/bi001504c (Pubitemid 32198295)
122. Cosman M., De los Santos C., Fiala R., Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA. Proceedings of the National Academy of Sciences of the United States of America 1992 89 5 1914 1918 2-s2.0-0026527186
123. Cosman M., De Los Santos C., Fiala R., Hingerty B. E., Ibanez V., Luna E., Harvey R., Geacintov N. E., Broyde S., Patel D. J., Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine. Biochemistry 1993 32 16 4145 4155 2-s2.0-0027215240 (Pubitemid 23137719)
124. Rodríguez F. A., Cai Y., Lin C., Tang Y., Kolbanovskiy A., Amin S., Patel D. J., Broyde S., Geacintov N. E., Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[ α ]pyrenyl-guanine lesions in a GG mutation hotspot context. Nucleic Acids Research 2007 35 5 1555 1568 2-s2.0-34247213435 10.1093/nar/gkm022 (Pubitemid 46603434)
125. Kropachev K., Kolbanovskii M., Cai Y., Rodríguez F., Kolbanovskii A., Liu Y., Zhang L., Amin S., Patel D., Broyde S., Geacintov N. E., The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions. Journal of Molecular Biology 2009 386 5 1193 1203 2-s2.0-60849122212 10.1016/j.jmb.2008.12.082
126. Bolton J. L., Pisha E., Zhang F., Qiu S., Role of quinoids in estrogen carcinogenesis. Chemical Research in Toxicology 1998 11 10 1113 1127 2-s2.0-0031741669 10.1021/tx9801007 (Pubitemid 28500791)
127. Bolton J. L., Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens. Toxicology 2002 177 1 55 65 2-s2.0-0036680017 10.1016/S0300-483X(02)00195-6 (Pubitemid 34786244)
128. Rossouw J. E., Anderson G. L., Prentice R. L., LaCroix A. Z., Kooperberg C., Stefanick M. L., Jackson R. D., Beresford S. A. A., Howard B. V., Johnson K. C., Kotchen J. M., Ockene J., Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. Journal of the American Medical Association 2002 288 3 321 333 2-s2.0-0037125379 (Pubitemid 34761611)
129. Zhang F., Chen Y., Pisha E., The major metabolite of equilin, 4-Hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-Hydroxyequilenin-o-quinone. Chemical Research in Toxicology 1999 12 2 204 213 2-s2.0-0032973129 10.1021/tx980217v (Pubitemid 29096070)
130. Pisha E., Lui X., Constantinou A. I., Bolton J. L., Judy.Bolton@UIC.edu Evidence that a metabolilte of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro. Chemical Research in Toxicology 2001 14 1 82 90 2-s2.0-0020471249 10.1021/tx000168y (Pubitemid 32064378)
131. Shen L., Qiu S., Chen Y., Zhang F., Van Breemen R. B., Nikolic D., Bolton J. L., Alkylation of 2'-deoxynucleosides and DNA by the premarin metabolite 4-hydroxyequilenin semiquinone radical. Chemical Research in Toxicology 1998 11 2 94 101 2-s2.0-0031931940 10.1021/tx970181r (Pubitemid 28128440)
132. Zhang F., Swanson S. M., Van Breemen R. B., Liu X., Yang Y., Gu C., Bolton J. L., Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chemical Research in Toxicology 2001 14 12 1654 1659 2-s2.0-0035659961 10.1021/tx010158c (Pubitemid 34016629)
133. Embrechts J., Lemire F., Van Dongen W., Esmans E. L., esmans@ruca.ua.ac.be Equilenin-2′-deoxynucleoside adducts: analysis with nano-liquid chromatography coupled to nano-electrospray tandem mass spectrometry. Journal of Mass Spectrometry 2001 36 3 317 328 2-s2.0-0032933110 10.1002/jms.136 (Pubitemid 32280197)
134. Kolbanovskiy A., Kuzmin V., Shastry A., Kolbanovskaya M., Chen D., Chang M., Bolton J. L., Geacintov N. E., Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin. Chemical Research in Toxicology 2005 18 11 1737 1747 2-s2.0-27644463404 10.1021/tx050190x (Pubitemid 43257756)
135. Embrechts J., Lemière F., Van Dongen W., Esmans E. L., Buytaert P., Van Marck E., Kockx M., Makar A., Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry. Journal of the American Society for Mass Spectrometry 2003 14 5 482 491 2-s2.0-0037487092 10.1016/S1044-0305(03)00130-2 (Pubitemid 36871629)
136. Ding S., Shapiro R., Geacintov N. E., Broyde S., 4-Hydroxyequilenin- adenine lesions in DNA duplexes: sereochemistry, damage site, and structure. Biochemistry 2007 46 1 182 191 2-s2.0-33846139338 10.1021/bi061652o (Pubitemid 46075022)
137. Ding S., Shapiro R., Cai Y., Geacintov N. E., Broyde S., Conformational properties of equilenin - DNA adducts: stereoisomer and base effects. Chemical Research in Toxicology 2008 21 5 1064 1073 2-s2.0-47549092381 10.1021/tx800010u
138. Ding S., Wang Y., Kolbanovskiy A., Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry. Chemical Research in Toxicology 2008 21 9 1739 1748 2-s2.0-4444383717 10.1021/tx800095f
139. Ding S., Shapiro R., Geacintov N. E., Broyde S., Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics. Biochemistry 2005 44 44 14565 14576 2-s2.0-27644502314 10.1021/bi051090t (Pubitemid 41567464)
140. Pommier Y., Kohlhagen G., Bailly C., Waring M., Mazumder A., Kohn K. W., DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the caribbean tunicate Ecteinascidia turbinata. Biochemistry 1996 35 41 13303 13309 2-s2.0-0029838307 10.1021/bi960306b (Pubitemid 26349423)
141. Tomasz M., Das A., Tang K. S., Ford M. G. J., Minnock A., Musser S. M., Waring M. J., The purine 2-amino group as the critical recognition element for sequence-specific alkylation and cross-linking of DNA by mitomycin C. Journal of the American Chemical Society 1998 120 45 11581 11593 2-s2.0-0032544947 10.1021/ja9824019 (Pubitemid 28543569)
142. Thurston D. E., Neidle S., Waring M. J., Molecular Aspects of Anticancer Drug-DNA Interactions 1999 1 London, UK Macmillan 54 87
143. Isaacs R. J., Spielmann H. P., A model for initial DNA lesion recognition by NER and MMR based on local conformational flexibility. DNA Repair 2004 3 5 455 464 2-s2.0-1842785956 10.1016/j.dnarep.2004.01.004 (Pubitemid 38482020)
144. Schärer O. D., A molecular basis for damage recognition in eukaryotic nucleotide excision repair. ChemBioChem 2008 9 1 21 23 2-s2.0-38149019888 10.1002/cbic.200700619
145. Tubbs J. L., Latypov V., Kanugula S., Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature 2009 459 7248 808 813 2-s2.0-67249113070 10.1038/nature08076
146. Brabec V., DNA Modifications by antitumor platinum and ruthenium compounds: their recognition and repair. Progress in Nucleic Acid Research and Molecular Biology 2002 71 1 68 2-s2.0-0036357321
147. Brabec V., Nováková O., DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resistance Updates 2006 9 3 111 122 2-s2.0-33747773739 10.1016/j.drup.2006.05.002 (Pubitemid 44279519)
148. Bugarcic T., Nováková O., Halámiková A., Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry 2008 51 17 5310 5319 2-s2.0-51849098200 10.1021/jm8003043
149. Reeves R., Adair J. E., Role of high mobility group (HMG) chromatin proteins in DNA repair. DNA Repair 2005 4 8 926 938 2-s2.0-21844465656 10.1016/j.dnarep.2005.04.010 (Pubitemid 40961597)
150. Privalov P. L., Dragan A. I., Crane-Robinson C., The cost of DNA bending. Trends in Biochemical Sciences 2009 34 9 464 470 2-s2.0-69749099456 10.1016/j.tibs.2009.05.005
151. Kasparkova J., Vojtiskova M., Natile G., Brabec V., Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand. Chemistry-A European Journal 2008 14 4 1330 1341 2-s2.0-38849181093 10.1002/chem.200701352 (Pubitemid 351204614)
152. Huang J.-C., Zamble D. B., Reardon J. T., Lippard S. J., Sancar A., HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proceedings of the National Academy of Sciences of the United States of America 1994 91 22 10394 10398 2-s2.0-0028117527 10.1073/pnas.91.22.10394 (Pubitemid 24329003)
153. Sharma A., Ramanjaneyulu A., Ray R., Rajeswari M. R., Involvement of high mobility group B proteins in cisplatin-induced cytotoxicity in squamous cell carcinoma of skin. DNA and Cell Biology 2009 28 7 311 318 2-s2.0-67650296980 10.1089/dna.2009.0851
154. Chow C. S., Whitehead J. P., Lippard S. J., HMG domain proteins induce sharp bends in cisplatin-modified DNA. Biochemistry 1994 33 50 15124 15130 2-s2.0-0028609494 10.1021/bi00254a023
155. Trimmer E. E., Zamble D. B., Lippard S. J., Essigmann J. M., Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities. Biochemistry 1998 37 1 352 362 2-s2.0-0032488607 10.1021/bi971675q (Pubitemid 28049139)
156. Chválová K., Sari M.-A., Bombard S., Kozelka J., LEF-1 recognition of platinated GG sequences within double-stranded DNA. Influence of flanking bases. Journal of Inorganic Biochemistry 2008 102 2 242 250 2-s2.0-38149004514 10.1016/j.jinorgbio.2007.08.006
157. Fuxreiter M., Luo N., Jedlovszky P., Simon I., Osman R., Role of base flipping in specific recognition of damaged DNA by repair enzymes. Journal of Molecular Biology 2002 323 5 823 834 2-s2.0-0036431531 10.1016/S0022-2836(02) 00999-3 (Pubitemid 35341058)
158. Yang W., Poor base stacking at DNA lesions may initiate recognition by many repair proteins. DNA Repair 2006 5 6 654 666 2-s2.0-33646768613 10.1016/j.dnarep.2006.02.004 (Pubitemid 43766519)
159. Yang W., Structure and mechanism for DNA lesion recognition. Cell Research 2008 18 1 184 197 2-s2.0-38049110204 10.1038/cr.2007.116
160. Yang C.-G., Garcia K., He C., Damage detection and base flipping in direct DNA alkylation repair. ChemBioChem 2009 10 3 417 423 2-s2.0-60349094184 10.1002/cbic.200800580
161. Duckett D. R., Drummond J. T., Murchie A. I. H., Humnan MutS α recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proceedings of the National Academy of Sciences of the United States of America 1996 93 13 6443 6447 2-s2.0-0028204781
162. Aebi S., Kurdi-Haidar B., Gordon R., Cenni B., Zheng H., Fink D., Christen R. D., Boland C. R., Koi M., Fishel R., Howell S. B., Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Research 1996 56 13 3087 3090 2-s2.0-8944230189 (Pubitemid 26199755)
163. Mello J. A., Acharya S., Fishel R., Essigmann J. M., The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chemistry and Biology 1996 3 7 579 589 2-s2.0-0030198880 10.1016/S1074-5521(96) 90149-0 (Pubitemid 26324171)
164. Fourrier L., Brooks P., Malinge J.-M., Binding discrimination of MutS to a set of lesions and compound lesions (base damage and mismatch) reveals its potential role as a cisplatin-damaged DNA sensing protein. The Journal of Biological Chemistry 2003 278 23 21267 21275 2-s2.0-0037742273 10.1074/jbc.M301390200 (Pubitemid 36806442)
165. Castellano-Castillo M., Kostrhunova H., Marini V., Kasparkova J., Sadler P. J., Malinge J.-M., Brabec V., Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. The Journal of Biological Inorganic Chemistry 2008 13 6 993 999 2-s2.0-48149087952 10.1007/s00775-008-0386-3
166. Nováková O., Kasparkova J., Bursova V., Hofr C., Vojtiskova M., Chen H., Sadler P. J., Brabec V., Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity. Chemistry and Biology 2005 12 1 121 129 2-s2.0-12344265899 10.1016/j.chembiol.2004.11.008 (Pubitemid 40118332)
167. Jia L., Kropachev K., Ding S., Van Houten B., Geacintov N. E., Broyde S., Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB. Biochemistry 2009 48 38 8948 8957 2-s2.0-70349774465 10.1021/bi9010072
168. Mocquet V., Kropachev K., Kolbanovskiy M., Kolbanovskiy A., Tapias A., Cai Y., Broyde S., Geacintov N. E., Egly J.-M., The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions. The EMBO Journal 2007 26 12 2923 2932 2-s2.0-34250795081 10.1038/sj.emboj.7601730 (Pubitemid 46975779)
169. Hartwig A., andrea.hartwig@tu-berlin.de The role of DNA repair in benzene-induced carcinogenesis. Chemico-Biological Interactions 2010 184 1-2 269 272 2-s2.0-33845436770 10.1016/j.cbi.2009.12.029
170. Janićijević A., Sugasawa K., Shimizu Y., Hanaoka F., Wijgers N., Djurica M., Hoeijmakers J. H. J., Wyman C., DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair 2003 2 3 325 336 2-s2.0-0037353459 10.1016/S1568-7864(02)00222-7 (Pubitemid 36126400)
171. Clement F. C., Camenisch U., Fei J., Kaczmarek N., Mathieu N., Naegeli H., naegelih@vetpharm.uzh.ch Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigmentosum group C protein. Mutation Research 2010 685 1-2 21 28 2-s2.0-75749154031 10.1016/j.mrfmmm.2009.08.005
172. Brown K. L., Roginskaya M., Zou Y., Altamirano A., Basu A. K., Stone M. P., michael.p.stone@vanderbilt.edu Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R -thymine glycol lesion and structure of the cis -(5R, 6S) thymine glycol epimer in the 5′ -GTgG- 3′ sequence: destabilization of two base pairs at the lesion site. Nucleic Acids Research 2009 38 2 428 440 2-s2.0-0027304370 10.1093/nar/gkp844
173. Yang J., Liu X., Niu P., Zou Y., Duan Y., Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene. Toxicology 2009 265 1-2 10 14 2-s2.0-70349982574 10.1016/j.tox.2009.09.001
174. Shinmura K., Iwaizumi M., Igarashi H., Nagura K., Yamada H., Suzuki M., Fukasawa K., Sugimura H., Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[ α ]pyrene diol epoxide (B[ α ]PDE). Journal of Pathology 2008 216 3 365 374 2-s2.0-55249086988 10.1002/path.2422
175. Lu X., Shao J., Li H., Yu Y., Early whole-genome transcriptional response induced by benzo[ α ]pyrene diol epoxide in a normal human cell line. Genomics 2009 93 4 332 342 2-s2.0-61849139048 10.1016/j.ygeno.2008.12.007
176. Lu X., Shao J., Li H., Yu Y., yingnianyu@gmail.com Temporal gene expression changes induced by a low concentration of benzo[ α ]pyrene diol epoxide in a normal human cell line. Mutation Research 2010 684 1-2 74 80 2-s2.0-41049106406 10.1016/j.mrfmmm.2009.12.002
177. Cai Y., Patel D. J., Geacintov N. E., Broyde S., Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals. Journal of Molecular Biology 2009 385 1 30 44 2-s2.0-57749188239 10.1016/j.jmb.2008.09.087
178. Chen D., Kolbanovskiy A., Shastry A., Nucleotide excision repair of DNA adducts derived from the binding of the equine estrogen metabolite 4-OHEN to dC and dA adducts in vitro. 47 Proceedings of the 97th Annual Meeting of the American Association for Cancer Research April 2006 Washington, DC, USA AACR. abstract no. #5255
179. Notch E. G., Miniutti D. M., Mayer G. D., gmayer@maine.edu 17 α -ethinylestradiol decreases expression of multiple hepatic nucleotide excision repair genes in zebrafish (Danio rerio). Aquatic Toxicology 2007 84 3 301 309 2-s2.0-0033383635 10.1016/j.aquatox.2007.06.006 (Pubitemid 47259534)
180. Notch E. G., Mayer G. D., 17 α -ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquatic Toxicology 2009 95 273 278 2-s2.0-60449109036 10.1016/j.aquatox.2009.01.001
181. Depauw S., Gaslonde T., Léonce S., Influence of the stereoisomeric position of the reactive acetate groups of the benzo[ b ]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities. Molecular Pharmacology 2009 76 6 1172 1185 2-s2.0-33646768613 10.1124/mol.109.057554
182. Rocca C. J., Poindessous V., Soares D. G., The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators. Biochemical Pharmacology 2010 80 3 335 343 2-s2.0-0032515974 10.1016/j.bcp.2010.04.012
183. Herrero A. B., Martín-Castellanos C., Marco E., Gago F., Moreno S., smo@usal.es Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Research 2006 66 16 8155 8162 2-s2.0-0034031405 10.1158/0008-5472.CAN-06-0179 (Pubitemid 44299183)