DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the caribbean tunicate Ecteinascidia turbinata

Biochemistry

Volumn 35, Issue 41, 1996, Pages 13303-13309

  Pommier, Yves ^c   Kohlhagen, Glenda ^a   Bailly, Christian ^b,d   Waring, Michael ^b   Mazumder, Abhijit ^a   Kohn, Kurt W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Institut de Recherche sur le Cancer de Lille   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE COPPER; ALKYLATING AGENT; ANTHRAMYCIN; ANTINEOPLASTIC ALKALOID; DEOXYADENOSINE; DEOXYCYTIDINE; DEOXYGUANOSINE; DEOXYINOSINE; DEOXYRIBONUCLEASE I; DNA; ECTEINASCIDIN; EXODEOXYRIBONUCLEASE III; GUANINE NUCLEOTIDE; NSC 648766; OLIGONUCLEOTIDE; THYMIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHORDATA; DNA ADDUCT; DNA ALKYLATION; DNA DENATURATION; DNA FLANKING REGION; DNA FOOTPRINTING; DNA MODIFICATION; DNA SEQUENCE; DRUG DNA INTERACTION; DRUG ISOLATION; DRUG POTENCY; PRIORITY JOURNAL;

ALKYLATION; ANIMALS; ANTHRAMYCIN; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; BINDING SITES; DIOXOLES; DNA; DNA FOOTPRINTING; GUANINE; ISOQUINOLINES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; TETRAHYDROISOQUINOLINES; UROCHORDATA;

CHORDATA; ECTEINASCIDIA TURBINATA; ESCHERICHIA COLI; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0029838307     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960306b     Document Type: Article

References (19)

1. Bailly, C., & Waring, M. J. (1995) Nucleic Acids Res. 23, 885-892.
2. Bailly, C., Møllegaard, N., Nielsen, P. E., & Waring, M. J. (1995) EMBO J. 14, 2121-2131.
3. Boger, D. L., & Johnson, D. S. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 3642-3649.
4. Fujimori, A., Harker, W. G., Kohlhagen, G., Hoki, Y., & Pommier, Y. (1995) Cancer Res. 55, 1339-1346.
5. Guan, Y., Sakai, R., Rinehart, K. L., & Wang, A. H. (1993) J. Biomol. Struct. Dyn. 10, 793-818.
6. Hay, B. A., Wassarman, D. A., & Rubin, G. M. (1995) Cell 83, 1253-1262.
7. Kohn, K. W., Glaubiger, D., & Spears, C. L. (1974) Biochim. Biophys. Acta 361, 288-302.
8. Kohn, K. W., Hartley, J. A., & Mattes, W. B. (1988) Biochem. Pharmacol 37, 1799-800.
9. Kopka, M. L., Goodsell, D. S., Baikalov, I., Grzeskowiak, K., Cascio, D., & Dickerson, R. E. (1994) Biochemistry 33, 13593-13610.
10. Lown, J. W. (1994) J. Mol. Recognit. 7, 79-88.
11. Lown, J. W., & Joshua, A. V. (1979) Biochem. Pharmacol. 28, 2017-26.
12. Pierce, J. R., Nazimiec, M., & Tang, M. S. (1993) Biochemistry 32, 7069-78.
13. Pommier, Y., Orr, A., Kohn, K. W., & Riou, J. F. (1992) Cancer Res. 52, 3125-3130.
14. Pommier, Y., Kohlhagen, G., Kohn, F., Leteurtre, F., Wani, M. C., & Wall, M. E. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 8861-8865.
15. Rinehart, K. L., Holt, T. G., Fregeau, N. L., Stroh, J. G., Keifer, P. A., Sun, F., Li, L. H., & Martin, D. G. (1990) J. Org. Chem. 55, 4512-4515.
16. Sakai, R., Rinehart, K. L., Guan, Y., & Wang, A. H.-J. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 11456-1460.
17. Sigman, D. S., Mazumder, A., & Perrin, D. M. (1993) Chem. Rev. 93, 2295-2316.
18. Suck, D. (1994) J. Mol. Recognit. 7, 65-70.
19. Tanizawa, A., Kohn, K. W., Kohlhagen, G., Leteurtre, F., & Pommier, Y. (1995) Biochemistry 43, 7200-7206.