The major metabolite of equilin, 4-Hydroxyequilin, autoxidizes to an o- quinone which isomerizes to the potent cytotoxin 4-Hydroxyequilenin-o- quinone

Chemical Research in Toxicology

Volumn 12, Issue 2, 1999, Pages 204-213

  Zhang, Fagen ^a   Chen, Yumei ^a   Pisha, Emily ^a   Shen, Li ^a   Xiong, Yansan ^a   Van Breemen, Richard B ^a   Bolton, Judy L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYEQUILENIN O QUINONE; 4 HYDROXYEQUILIN; CONJUGATED ESTROGEN; CYTOTOXIN; EQUILIN; ESTRADIOL; ESTROGEN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AUTOOXIDATION; BREAST CANCER; CANCER RISK; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA ALKYLATION; DRUG CARCINOGENICITY; ENDOMETRIUM CANCER; ESTROGEN METABOLISM; ESTROGEN THERAPY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; TOXICOKINETICS;

ANIMALS; BREAST NEOPLASMS; CYTOCHROME P-450 ENZYME SYSTEM; EQUILENIN; EQUILIN; ESTRADIOL CONGENERS; ESTRONE; FEMALE; HUMANS; MICROSOMES, LIVER; OXIDATION-REDUCTION; QUINONES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EQUIDAE; MINK CELL FOCUS-FORMING VIRUS;

EID: 0032973129     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980217v     Document Type: Article

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