The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs

Acta Crystallographica Section D: Biological Crystallography

Volumn 61, Issue 7, 2005, Pages 1009-1012

  Canals, Albert ^a   Purciolas, Mònica ^a   Aymamí, Joan ^a,b   Coll, Miquel ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; ELLIPTICINE; ELLIPTICINE DERIVATIVE; INTERCALATING AGENT;

ARTICLE; BASE PAIRING; CHEMISTRY; METHODOLOGY; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BASE PAIRING; CRYSTALLOGRAPHY, X-RAY; DNA; ELLIPTICINES; INTERCALATING AGENTS;

EID: 24644470658     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444905015404     Document Type: Article

References (18)

1. Adams, A., Guss, J. M., Collyer, C. A., Denny, W. A. & Wakelin, L. P. G. (1999). Biochemistry, 38, 9221-9233.
2. Auclair, C. (1987). Arch. Biochem. Biophys. 259, 1-14.
3. Berger, I., Kang, C., Sinha, N., Wolters, M. & Rich, A. (1996). Acta Cryst. D52, 465-468.
4. Elcock, A. H., Rodger, A. & Richards, W. G. (1996). Biopolymers, 39, 309-326.
5. Garbett, N. C. & Graves, D. E. (2004). Curr. Med. Chem. Anti-Canc. Agents, 4, 149-172.
6. Jain, S. C., Bhandary, K. K. & Sobell, H. M. (1979). J. Mol. Biol. 135, 813-840.
7. Kabsch, W. (1993). J. Appl. Cryst. 26, 795-800.
8. Kohn, K. W., Waring, M. J., Glaubiger, D. & Friedman, C. A. (1975). Cancer Res. 35, 71-76.
9. Lavery, R. & Sklenar, H. (1988). J. Biomol. Struct. Dyn. 6, 63-91.
10. Lisgarten, J. N., Coll, M., Portugal, J., Wright, C. W. & Aymamí, J. (2002). Nature Struct. Biol. 9, 57-60.
11. Murshudov, G. N., Lebedev, A., Vagin, A. A., Wilson, K. S. & Dodson, E. J. (1999). Acta Cryst. D55, 247-255.
12. Navaza, J. (1994). Acta Cryst. A50, 157-163.
13. Perrakis, A., Morris, R. & Lamzin, V. S. (1999). Nature Struct. Biol. 6, 458-463.
14. Roussel, A. & Cambilleau, C. (1989). Silicon Graphics Partners Directory, pp. 77-79. Mountain View, CA, USA: Silicon Graphics.
15. Shinomiya, M., Chu, W., Carlson, R. G., Weaver, R. F. & Takusagawa, F. (1995). Biochemistry, 34, 8481-8491.
16. Shui, X., Peek, M. E., Lipscomb, L. A., Wilkinson, A. P., Williams, L. D., Gao, M., Ogata, C., Roques, B. P. & Garbay-Jaureguiberry, C. (2000). Curr. Med. Chem. 7, 59-71.
17. Stiborová, M., Bieler, C. A., Wiessler, M. & Frei, E. (2001). Biochem. Pharmacol. 62, 1675-1648.
18. Wang, J. C. (1974). J. Mol. Biol. 89, 783-801.