메뉴 건너뛰기




Volumn 2, Issue , 2011, Pages

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks

Author keywords

[No Author keywords available]

Indexed keywords

4 [BIS(2 CHLOROETHYL)OXIDOAMINO]PHENYLALANINE; ACETYLCYSTEINE; AMIFOSTINE; BENZIMIDAZOLE DERIVATIVE; BUTYRIC ACID; CAPTOPRIL; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GAMMA HISTONE H2AX; HISTONE H2AX; MESNA; MOLECULAR MARKER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; NITROIMIDAZOLE DERIVATIVE; RADIOSENSITIZING AGENT; TEMPOL; TIRAPAZAMINE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 84861010003     PISSN: None     EISSN: 20419414     Source Type: Journal    
DOI: 10.1186/2041-9414-2-3     Document Type: Review
Times cited : (25)

References (162)
  • 1
    • 0037478635 scopus 로고    scopus 로고
    • Genomic instability and radiation
    • 10.1088/0952-4746/23/2/304, 12875549
    • Little JB. Genomic instability and radiation. J Radiol Prot 2003, 23:173-181. 10.1088/0952-4746/23/2/304, 12875549.
    • (2003) J Radiol Prot , vol.23 , pp. 173-181
    • Little, J.B.1
  • 4
    • 0035090023 scopus 로고    scopus 로고
    • General aspects of the cellular response to low- and high-LET radiation
    • 10.1007/s002590100484, 11357507
    • Pouget JP, Mather SJ. General aspects of the cellular response to low- and high-LET radiation. Eur J Nucl Med 2001, 28:541-561. 10.1007/s002590100484, 11357507.
    • (2001) Eur J Nucl Med , vol.28 , pp. 541-561
    • Pouget, J.P.1    Mather, S.J.2
  • 5
    • 4644236399 scopus 로고    scopus 로고
    • Double-strand breaks: signaling pathways and repair mechanisms
    • 10.1007/s00018-004-4174-0, 15338043
    • Karagiannis TC, El-Osta A. Double-strand breaks: signaling pathways and repair mechanisms. Cell Mol Life Sci 2004, 61:2137-2147. 10.1007/s00018-004-4174-0, 15338043.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2137-2147
    • Karagiannis, T.C.1    El-Osta, A.2
  • 6
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: signaling, repair and the cancer connection
    • 10.1038/85798, 11242102
    • Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001, 27:247. 10.1038/85798, 11242102.
    • (2001) Nat Genet , vol.27 , pp. 247
    • Khanna, K.K.1    Jackson, S.P.2
  • 8
    • 0034641963 scopus 로고    scopus 로고
    • Defying death after DNA damage
    • 10.1038/35037717, 11048728
    • Rich T, Allen RL, Wyllie AH. Defying death after DNA damage. Nature 2000, 407:777-783. 10.1038/35037717, 11048728.
    • (2000) Nature , vol.407 , pp. 777-783
    • Rich, T.1    Allen, R.L.2    Wyllie, A.H.3
  • 9
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
    • 10.1016/j.cell.2005.09.038, 16377563
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks. Cell 2005, 123:1213-1226. 10.1016/j.cell.2005.09.038, 16377563.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 10
    • 33747889217 scopus 로고    scopus 로고
    • Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
    • 10.1016/j.dnarep.2006.05.022, 16807135
    • Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair 2006, 5:1021-1029. 10.1016/j.dnarep.2006.05.022, 16807135.
    • (2006) DNA Repair , vol.5 , pp. 1021-1029
    • Sonoda, E.1    Hochegger, H.2    Saberi, A.3    Taniguchi, Y.4    Takeda, S.5
  • 11
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • 10.1038/cr.2007.111, 18157161
    • Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA double-strand break repair pathway choice. Cell Res 2008, 18:134-147. 10.1038/cr.2007.111, 18157161.
    • (2008) Cell Res , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 13
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • 360437, 1406679
    • Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 1992, 12:5041-5049. 360437, 1406679.
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 14
    • 3042805315 scopus 로고    scopus 로고
    • Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions
    • 10.1667/RR3171, 15161372
    • Karlsson K, Stenerlöw B. Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions. Radiat Res 2004, 161:517-527. 10.1667/RR3171, 15161372.
    • (2004) Radiat Res , vol.161 , pp. 517-527
    • Karlsson, K.1    Stenerlöw, B.2
  • 15
    • 33645144591 scopus 로고    scopus 로고
    • Induction and quantification of g-H2AX foci following low and high LET-irradiation
    • 10.1080/09553000600599783, 16546909
    • Leatherbarrow EL, Harper JV, Cucinotta FA, O'Neill P. Induction and quantification of g-H2AX foci following low and high LET-irradiation. Int J Radiat Biol 2006, 82:111-118. 10.1080/09553000600599783, 16546909.
    • (2006) Int J Radiat Biol , vol.82 , pp. 111-118
    • Leatherbarrow, E.L.1    Harper, J.V.2    Cucinotta, F.A.3    O'Neill, P.4
  • 16
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • 10.1074/jbc.273.10.5858, 9488723
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998, 273:5858-5868. 10.1074/jbc.273.10.5858, 9488723.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 17
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • 10.1083/jcb.146.5.905, 2169482, 10477747
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999, 146:905-916. 10.1083/jcb.146.5.905, 2169482, 10477747.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 18
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of (125) IdU-induced DNA double-strand breaks with gamma-H2AX antibody
    • 10.1667/0033-7587(2002)158[0486:QDOIID]2.0.CO;2, 12236816
    • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125) IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002, 158:486-492. 10.1667/0033-7587(2002)158[0486:QDOIID]2.0.CO;2, 12236816.
    • (2002) Radiat Res , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 19
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • 10.1073/pnas.0830918100, 154297, 12679524
    • Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 2003, 100:5057-5062. 10.1073/pnas.0830918100, 154297, 12679524.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 21
    • 34247634029 scopus 로고    scopus 로고
    • Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: Co-localization, relationship with DSB repair and clonogenic survival
    • 10.1080/09553000601170469, 17457757
    • Markova E, Schultz N, Belyaev IY. Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: Co-localization, relationship with DSB repair and clonogenic survival. Int J Radiat Biol 2007, 83:319-329. 10.1080/09553000601170469, 17457757.
    • (2007) Int J Radiat Biol , vol.83 , pp. 319-329
    • Markova, E.1    Schultz, N.2    Belyaev, I.Y.3
  • 22
    • 68449090353 scopus 로고    scopus 로고
    • Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells
    • 10.4161/cc.8.15.9311, 19633409
    • Nakamura AJ, Redon CE, Sedelnikova OA. Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells. Cell Cycle 2009, 8:2324. 10.4161/cc.8.15.9311, 19633409.
    • (2009) Cell Cycle , vol.8 , pp. 2324
    • Nakamura, A.J.1    Redon, C.E.2    Sedelnikova, O.A.3
  • 23
    • 33746721468 scopus 로고    scopus 로고
    • Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability
    • 10.1016/j.dnarep.2006.05.040, 16814620
    • Yu T, MacPhail SH, Banath JP, Klokov D, Olive PL. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. DNA Repair (Amst) 2006, 5:935-946. 10.1016/j.dnarep.2006.05.040, 16814620.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 935-946
    • Yu, T.1    MacPhail, S.H.2    Banath, J.P.3    Klokov, D.4    Olive, P.L.5
  • 24
    • 64349094838 scopus 로고    scopus 로고
    • Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells
    • 10.1016/j.yexcr.2008.12.007, 19154734
    • Banath JP, Banuelos CA, Klokov D, MacPhail SM, Lansdorp PM, Olive PL. Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells. Exp Cell Res 2009, 315:1505-1520. 10.1016/j.yexcr.2008.12.007, 19154734.
    • (2009) Exp Cell Res , vol.315 , pp. 1505-1520
    • Banath, J.P.1    Banuelos, C.A.2    Klokov, D.3    MacPhail, S.M.4    Lansdorp, P.M.5    Olive, P.L.6
  • 25
    • 77955145610 scopus 로고    scopus 로고
    • Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation
    • 10.1667/RR2071.1, 20681786
    • Anderson JA, Harper JV, Cucinotta FA, O'Neill P. Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation. Radiat Res 2010, 174:195-205. 10.1667/RR2071.1, 20681786.
    • (2010) Radiat Res , vol.174 , pp. 195-205
    • Anderson, J.A.1    Harper, J.V.2    Cucinotta, F.A.3    O'Neill, P.4
  • 27
    • 77749265017 scopus 로고    scopus 로고
    • DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle
    • 10.3109/09553000903418603, 20201648
    • Roig AI, Hight SK, Minna JD, Shay JW, Rusek A, Story MD. DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle. Int J Radiat Biol 2010, 86:194-204. 10.3109/09553000903418603, 20201648.
    • (2010) Int J Radiat Biol , vol.86 , pp. 194-204
    • Roig, A.I.1    Hight, S.K.2    Minna, J.D.3    Shay, J.W.4    Rusek, A.5    Story, M.D.6
  • 29
    • 33645144591 scopus 로고    scopus 로고
    • Induction and quantification of gamma-H2AX foci following low and high LET-irradiation
    • 10.1080/09553000600599783, 16546909
    • Leatherbarrow EL, Harper JV, Cucinotta FA, O'Neill P. Induction and quantification of gamma-H2AX foci following low and high LET-irradiation. Int J Radiat Biol 2006, 82:111-118. 10.1080/09553000600599783, 16546909.
    • (2006) Int J Radiat Biol , vol.82 , pp. 111-118
    • Leatherbarrow, E.L.1    Harper, J.V.2    Cucinotta, F.A.3    O'Neill, P.4
  • 30
    • 25444502873 scopus 로고    scopus 로고
    • Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation
    • 10.1667/RR3431.1, 16187760
    • Desai N, Davis E, O'Neill P, Durante M, Cucinotta FA, Wu H. Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation. Radiat Res 2005, 164:518-522. 10.1667/RR3431.1, 16187760.
    • (2005) Radiat Res , vol.164 , pp. 518-522
    • Desai, N.1    Davis, E.2    O'Neill, P.3    Durante, M.4    Cucinotta, F.A.5    Wu, H.6
  • 31
    • 50049123242 scopus 로고    scopus 로고
    • Tools to study DNA repair: what's in the box?
    • 10.1016/j.tig.2008.07.003, 18675488
    • Feuerhahn S, Egly JM. Tools to study DNA repair: what's in the box?. Trends Genet 2008, 24:467-474. 10.1016/j.tig.2008.07.003, 18675488.
    • (2008) Trends Genet , vol.24 , pp. 467-474
    • Feuerhahn, S.1    Egly, J.M.2
  • 32
    • 62949181960 scopus 로고    scopus 로고
    • [gamma]-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin
    • 10.1016/j.asr.2008.10.011, 2735274, 20046946
    • Redon CE, Dickey JS, Bonner WM, Sedelnikova OA. [gamma]-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin. Advances in Space Research 2009, 43:1171-1178. 10.1016/j.asr.2008.10.011, 2735274, 20046946.
    • (2009) Advances in Space Research , vol.43 , pp. 1171-1178
    • Redon, C.E.1    Dickey, J.S.2    Bonner, W.M.3    Sedelnikova, O.A.4
  • 33
    • 33845651212 scopus 로고    scopus 로고
    • Gamma H2AX in cancer cells: A potential biomarker for cancer diagnostics, prediction and recurrence
    • 10.4161/cc.5.24.3569, 17172873
    • Sedelnikova OA, Bonner WM. gamma H2AX in cancer cells: A potential biomarker for cancer diagnostics, prediction and recurrence. Cell Cycle 2006, 5:2909-2913. 10.4161/cc.5.24.3569, 17172873.
    • (2006) Cell Cycle , vol.5 , pp. 2909-2913
    • Sedelnikova, O.A.1    Bonner, W.M.2
  • 36
    • 0942278942 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX as a measure of radiosensitivity
    • Olive PL, Banath JP. Phosphorylation of histone H2AX as a measure of radiosensitivity. 2004, 331-335.
    • (2004) , pp. 331-335
    • Olive, P.L.1    Banath, J.P.2
  • 37
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle
    • 10.1128/MCB.23.16.5706-5715.2003, 166351, 12897142
    • Rothkamm K, Kruger I, Thompson LH, Lobrich M. Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle. Mol Cell Biol 2003, 23:5706-5715. 10.1128/MCB.23.16.5706-5715.2003, 166351, 12897142.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 38
    • 34250015533 scopus 로고    scopus 로고
    • Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments
    • 10.1038/sj.onc.1210174, 17213813
    • Karagiannis TC, Harikrishnan KN, El-Osta A. Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. Oncogene 2007, 26:3963-3971. 10.1038/sj.onc.1210174, 17213813.
    • (2007) Oncogene , vol.26 , pp. 3963-3971
    • Karagiannis, T.C.1    Harikrishnan, K.N.2    El-Osta, A.3
  • 39
    • 47349107760 scopus 로고    scopus 로고
    • ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
    • 10.1016/j.molcel.2008.05.017, 18657500
    • Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA. ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin. Mol Cell 2008, 31:167-177. 10.1016/j.molcel.2008.05.017, 18657500.
    • (2008) Mol Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Löbrich, M.6    Jeggo, P.A.7
  • 40
    • 42249102663 scopus 로고    scopus 로고
    • GammaH2AX foci form preferentially in euchromatin after ionising-radiation
    • 10.1371/journal.pone.0001057, 2020439, 17957241
    • Cowell IG. gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS ONE 2007, 2:e1057. 10.1371/journal.pone.0001057, 2020439, 17957241.
    • (2007) PLoS ONE , vol.2
    • Cowell, I.G.1
  • 41
    • 73849107441 scopus 로고    scopus 로고
    • Gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci
    • 10.1007/s00018-009-0181-5, 19859659
    • Vasireddy RS, Karagiannis TC, El-Osta A. gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci. Cell Mol Life Sci 2010, 67:291-294. 10.1007/s00018-009-0181-5, 19859659.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 291-294
    • Vasireddy, R.S.1    Karagiannis, T.C.2    El-Osta, A.3
  • 42
    • 34447532525 scopus 로고    scopus 로고
    • Heterochromatin is refractory to gammaH2AX modification in yeast and mammals
    • 10.1083/jcb.200612031, 2064441, 17635934
    • Kim JA, Kruhlak M, Dotiwala F, Nussenzweig A, Haber JE. Heterochromatin is refractory to gammaH2AX modification in yeast and mammals. J Cell Biol 2007, 178:209-218. 10.1083/jcb.200612031, 2064441, 17635934.
    • (2007) J Cell Biol , vol.178 , pp. 209-218
    • Kim, J.A.1    Kruhlak, M.2    Dotiwala, F.3    Nussenzweig, A.4    Haber, J.E.5
  • 44
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin Modifications and Their Function
    • 10.1016/j.cell.2007.02.005, 17320507
    • Kouzarides T. Chromatin Modifications and Their Function. Cell 2007, 128:693-705. 10.1016/j.cell.2007.02.005, 17320507.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 45
    • 0035147369 scopus 로고    scopus 로고
    • Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases
    • 10.1038/35055010, 11175742
    • Taddei A, Maison C, Roche D, Almouzni G. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. Nat Cell Biol 2001, 3:114-120. 10.1038/35055010, 11175742.
    • (2001) Nat Cell Biol , vol.3 , pp. 114-120
    • Taddei, A.1    Maison, C.2    Roche, D.3    Almouzni, G.4
  • 47
    • 0033227096 scopus 로고    scopus 로고
    • Principles of radiotherapy and radiobiology
    • 10.1016/S0749-2081(99)80054-0, 10588029
    • Dunne-Daly C. Principles of radiotherapy and radiobiology. Semin Oncol Nurs 1999, 15:250-259. 10.1016/S0749-2081(99)80054-0, 10588029.
    • (1999) Semin Oncol Nurs , vol.15 , pp. 250-259
    • Dunne-Daly, C.1
  • 48
    • 0000790595 scopus 로고
    • Protection against x-rays and therapy of radiation sickness with beta-mercaptoethylamine
    • 10.1126/science.117.3049.633, 13056641
    • Bacq Z, Dechamps G, Fischer P, Herve A, Le Bihan H, Lecomte J, Pirotte M, Rayet P. Protection against x-rays and therapy of radiation sickness with beta-mercaptoethylamine. Science 1953, 117:633-636. 10.1126/science.117.3049.633, 13056641.
    • (1953) Science , vol.117 , pp. 633-636
    • Bacq, Z.1    Dechamps, G.2    Fischer, P.3    Herve, A.4    Le Bihan, H.5    Lecomte, J.6    Pirotte, M.7    Rayet, P.8
  • 49
    • 0000416892 scopus 로고
    • Cysteine Protection against X Irradiation
    • 10.1126/science.110.2852.213, 17811258
    • Patt H, Tyree E, Straube R, Smith D. Cysteine Protection against X Irradiation. Science 1949, 110:213-214. 10.1126/science.110.2852.213, 17811258.
    • (1949) Science , vol.110 , pp. 213-214
    • Patt, H.1    Tyree, E.2    Straube, R.3    Smith, D.4
  • 50
    • 34447116285 scopus 로고    scopus 로고
    • Amifostine: The First Selective-Target and Broad-Spectrum Radioprotector
    • 10.1634/theoncologist.12-6-738, 17602063
    • Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: The First Selective-Target and Broad-Spectrum Radioprotector. Oncologist 2007, 12:738-747. 10.1634/theoncologist.12-6-738, 17602063.
    • (2007) Oncologist , vol.12 , pp. 738-747
    • Kouvaris, J.R.1    Kouloulias, V.E.2    Vlahos, L.J.3
  • 51
    • 61349198964 scopus 로고    scopus 로고
    • The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy
    • 10.1111/j.1365-2354.2008.01032.x, 19267726
    • Marcu LG. The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy. European Journal of Cancer Care 2009, 18:116-123. 10.1111/j.1365-2354.2008.01032.x, 19267726.
    • (2009) European Journal of Cancer Care , vol.18 , pp. 116-123
    • Marcu, L.G.1
  • 53
    • 1642558247 scopus 로고    scopus 로고
    • Amifostine: is there evidence of tumor protection?
    • 10.1053/j.seminoncol.2003.11.014, 14727237
    • Koukourakis M. Amifostine: is there evidence of tumor protection?. Semin Oncol 2003, 30:18-30. 10.1053/j.seminoncol.2003.11.014, 14727237.
    • (2003) Semin Oncol , vol.30 , pp. 18-30
    • Koukourakis, M.1
  • 54
    • 31844456882 scopus 로고    scopus 로고
    • Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis
    • 10.1016/j.ijrobp.2005.06.023, 16198504
    • Sasse A, Clark L, Sasse E, Clark O. Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis. Int J Radiat Oncol Biol Phys 2006, 64:784-791. 10.1016/j.ijrobp.2005.06.023, 16198504.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 784-791
    • Sasse, A.1    Clark, L.2    Sasse, E.3    Clark, O.4
  • 55
    • 0019304979 scopus 로고
    • The role of WR-2721 in radiotherapy and/or chemotherapy
    • Yuhas J, Spellman J, Culo F. The role of WR-2721 in radiotherapy and/or chemotherapy. Cancer Clin Trials 1980, 3:211-216.
    • (1980) Cancer Clin Trials , vol.3 , pp. 211-216
    • Yuhas, J.1    Spellman, J.2    Culo, F.3
  • 56
    • 0021914053 scopus 로고
    • Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721
    • 10.1080/09553008514550041, 2982751
    • Calabro-Jones P, Fahey R, Smoluk G, Ward J. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol Relat Stud Phys Chem Med 1985, 47:23-27. 10.1080/09553008514550041, 2982751.
    • (1985) Int J Radiat Biol Relat Stud Phys Chem Med , vol.47 , pp. 23-27
    • Calabro-Jones, P.1    Fahey, R.2    Smoluk, G.3    Ward, J.4
  • 57
    • 0018839016 scopus 로고
    • Active versus Passive Absorption Kinetics as the Basis for Selective Protection of Normal Tissues by S-2-(3-Aminopropylamino)-ethylphosphorothioic Acid
    • Yuhas JM. Active versus Passive Absorption Kinetics as the Basis for Selective Protection of Normal Tissues by S-2-(3-Aminopropylamino)-ethylphosphorothioic Acid. Cancer Res 1980, 40:1519-1524.
    • (1980) Cancer Res , vol.40 , pp. 1519-1524
    • Yuhas, J.M.1
  • 58
    • 0020603425 scopus 로고
    • Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implications for mechanisms of radioprotection
    • 10.1080/09553008314550611, 6303973
    • Purdie J, Inhaber E, Schneider H, Labelle J. Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implications for mechanisms of radioprotection. Int J Radiat Biol Relat Stud Phys Chem Med 1983, 43:517-527. 10.1080/09553008314550611, 6303973.
    • (1983) Int J Radiat Biol Relat Stud Phys Chem Med , vol.43 , pp. 517-527
    • Purdie, J.1    Inhaber, E.2    Schneider, H.3    Labelle, J.4
  • 59
    • 0036498533 scopus 로고    scopus 로고
    • Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer
    • 10.1016/S0360-3016(01)02683-9, 11849797
    • Antonadou D, Pepelassi M, Synodinou M, Puglisi M, Throuvalas N. Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2002, 52:739-747. 10.1016/S0360-3016(01)02683-9, 11849797.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 739-747
    • Antonadou, D.1    Pepelassi, M.2    Synodinou, M.3    Puglisi, M.4    Throuvalas, N.5
  • 61
    • 34548587650 scopus 로고    scopus 로고
    • Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs
    • 10.1667/RR0975.1, 1958995, 17723002
    • Kataoka Y, Murley JS, Baker KL, Grdina DJ. Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs. Radiat Res 2007, 168:106-114. 10.1667/RR0975.1, 1958995, 17723002.
    • (2007) Radiat Res , vol.168 , pp. 106-114
    • Kataoka, Y.1    Murley, J.S.2    Baker, K.L.3    Grdina, D.J.4
  • 62
    • 0023266266 scopus 로고
    • Modification of relaxation of lipid protons by molecular oxygen and nitroxides
    • 10.1097/00004424-198706000-00011, 3040617
    • Bennett H, Swartz H, Brown R, Koenig S. Modification of relaxation of lipid protons by molecular oxygen and nitroxides. Invest Radiol 1987, 22:502-507. 10.1097/00004424-198706000-00011, 3040617.
    • (1987) Invest Radiol , vol.22 , pp. 502-507
    • Bennett, H.1    Swartz, H.2    Brown, R.3    Koenig, S.4
  • 64
    • 0142247078 scopus 로고    scopus 로고
    • On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
    • 10.1038/sj.bjp.0705430, 1574047, 14522841
    • Muscoli C, Cuzzocrea S, Riley D, Zweier J, Thiemermann C, Wang Z, Salvemini D. On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. Br J Pharmacol 2003, 140:445-460. 10.1038/sj.bjp.0705430, 1574047, 14522841.
    • (2003) Br J Pharmacol , vol.140 , pp. 445-460
    • Muscoli, C.1    Cuzzocrea, S.2    Riley, D.3    Zweier, J.4    Thiemermann, C.5    Wang, Z.6    Salvemini, D.7
  • 65
    • 33746987545 scopus 로고    scopus 로고
    • The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells
    • 10.1186/1476-4598-5-21, 1533855, 16756681
    • Lejeune D, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Molecular Cancer 2006, 5:21. 10.1186/1476-4598-5-21, 1533855, 16756681.
    • (2006) Molecular Cancer , vol.5 , pp. 21
    • Lejeune, D.1    Hasanuzzaman, M.2    Pitcock, A.3    Francis, J.4    Sehgal, I.5
  • 67
    • 0026671446 scopus 로고
    • Nitroxide-mediated protection against X-ray- and neocarzinostatin-induced DNA damage
    • 10.1016/0891-5849(92)90142-4, 1459474
    • DeGraff W, Krishna M, Kaufman D, Mitchell J. Nitroxide-mediated protection against X-ray- and neocarzinostatin-induced DNA damage. Free Radic Biol Med 1992, 13:479-487. 10.1016/0891-5849(92)90142-4, 1459474.
    • (1992) Free Radic Biol Med , vol.13 , pp. 479-487
    • DeGraff, W.1    Krishna, M.2    Kaufman, D.3    Mitchell, J.4
  • 68
    • 0026505347 scopus 로고
    • Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens
    • 10.1002/em.2850190105, 1310080
    • DeGraff W, Krishna M, Russo A, Mitchell J. Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens. Environ Mol Mutagen 1992, 19:21-26. 10.1002/em.2850190105, 1310080.
    • (1992) Environ Mol Mutagen , vol.19 , pp. 21-26
    • DeGraff, W.1    Krishna, M.2    Russo, A.3    Mitchell, J.4
  • 69
    • 41149153264 scopus 로고    scopus 로고
    • Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications
    • Augusto O, Trindade DF, Linares E, Vaz SM. Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications. An Acad Bras Cienc 2008, 80:179-189.
    • (2008) An Acad Bras Cienc , vol.80 , pp. 179-189
    • Augusto, O.1    Trindade, D.F.2    Linares, E.3    Vaz, S.M.4
  • 70
    • 0018914018 scopus 로고
    • The hypoxic tumor cell: a target for selective cancer chemotherapy
    • 10.1016/0006-2952(80)90235-X, 6987986
    • Kennedy K, Teicher B, Rockwell S, Sartorelli A. The hypoxic tumor cell: a target for selective cancer chemotherapy. Biochem Pharmacol 1980, 29:1-8. 10.1016/0006-2952(80)90235-X, 6987986.
    • (1980) Biochem Pharmacol , vol.29 , pp. 1-8
    • Kennedy, K.1    Teicher, B.2    Rockwell, S.3    Sartorelli, A.4
  • 72
    • 70349987104 scopus 로고    scopus 로고
    • Intercellular communication of cellular stress monitored by gamma-H2AX induction
    • 10.1093/carcin/bgp192, 2757548, 19651821
    • Dickey JS, Baird BJ, Redon CE, Sokolov MV, Sedelnikova OA, Bonner WM. Intercellular communication of cellular stress monitored by gamma-H2AX induction. Carcinogenesis 2009, 30:1686-1695. 10.1093/carcin/bgp192, 2757548, 19651821.
    • (2009) Carcinogenesis , vol.30 , pp. 1686-1695
    • Dickey, J.S.1    Baird, B.J.2    Redon, C.E.3    Sokolov, M.V.4    Sedelnikova, O.A.5    Bonner, W.M.6
  • 74
    • 0023626977 scopus 로고
    • Binding of Hoechst 33258 to the minor groove of B-DNA
    • 10.1016/0022-2836(87)90123-9, 2445998
    • Pjura PE, Grzeskowiak K, Dickerson RE. Binding of Hoechst 33258 to the minor groove of B-DNA. J Mol Biol 1987, 197:257-271. 10.1016/0022-2836(87)90123-9, 2445998.
    • (1987) J Mol Biol , vol.197 , pp. 257-271
    • Pjura, P.E.1    Grzeskowiak, K.2    Dickerson, R.E.3
  • 75
    • 0026569363 scopus 로고
    • Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342
    • 556443, 1371249
    • Sriram M, van der Marel GA, Roelen HL, van Boom JH, Wang AH. Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342. EMBO J 1992, 11:225-232. 556443, 1371249.
    • (1992) EMBO J , vol.11 , pp. 225-232
    • Sriram, M.1    van der Marel, G.A.2    Roelen, H.L.3    van Boom, J.H.4    Wang, A.H.5
  • 76
    • 0035131607 scopus 로고    scopus 로고
    • In vivo radioprotection of mouse brain endothelial cells by Hoechst 33342
    • Lyubimova NV, Coultas PG, Yuen K, Martin RF. In vivo radioprotection of mouse brain endothelial cells by Hoechst 33342. Br J Radiol 2001, 74:77-82.
    • (2001) Br J Radiol , vol.74 , pp. 77-82
    • Lyubimova, N.V.1    Coultas, P.G.2    Yuen, K.3    Martin, R.F.4
  • 77
    • 0031742444 scopus 로고    scopus 로고
    • Pulse radiolysis studies indicate that electron transfer is involved in radioprotection by Hoechst 33342 and methylproamine
    • 10.1016/S0360-3016(98)00316-2, 9845105
    • Martin RF, Anderson RF. Pulse radiolysis studies indicate that electron transfer is involved in radioprotection by Hoechst 33342 and methylproamine. Int J Radiat Oncol Biol Phys 1998, 42:827-831. 10.1016/S0360-3016(98)00316-2, 9845105.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 827-831
    • Martin, R.F.1    Anderson, R.F.2
  • 79
    • 0026607267 scopus 로고
    • DNA ligands as radioprotectors: molecular studies with Hoechst 33342 and Hoechst 33258
    • 10.1080/09553009214550641, 1374112
    • Denison L, Haigh A, D'Cunha G, Martin RF. DNA ligands as radioprotectors: molecular studies with Hoechst 33342 and Hoechst 33258. Int J Radiat Biol 1992, 61:561. 10.1080/09553009214550641, 1374112.
    • (1992) Int J Radiat Biol , vol.61 , pp. 561
    • Denison, L.1    Haigh, A.2    D'Cunha, G.3    Martin, R.F.4
  • 80
    • 0026763103 scopus 로고
    • DNA ligands as radiomodifiers: studies with minor-groove binding bibenzimidazoles
    • 10.1016/0360-3016(92)90014-9, 1377193
    • Martin RF, Denison L. DNA ligands as radiomodifiers: studies with minor-groove binding bibenzimidazoles. Int J Radiat Oncol Biol Phys 1992, 23:579-584. 10.1016/0360-3016(92)90014-9, 1377193.
    • (1992) Int J Radiat Oncol Biol Phys , vol.23 , pp. 579-584
    • Martin, R.F.1    Denison, L.2
  • 81
    • 0026542588 scopus 로고
    • DNA ligands as radioprotectors: molecular studies with Hoechst 33342 and Hoechst 33258
    • 10.1080/09553009214550641, 1370318
    • Denison L, Haigh A, D'Cunha G, Martin RF. DNA ligands as radioprotectors: molecular studies with Hoechst 33342 and Hoechst 33258. Int J Radiat Biol 1992, 61:69-81. 10.1080/09553009214550641, 1370318.
    • (1992) Int J Radiat Biol , vol.61 , pp. 69-81
    • Denison, L.1    Haigh, A.2    D'Cunha, G.3    Martin, R.F.4
  • 82
    • 0024367302 scopus 로고
    • Radiation sensitivity of tumour cells stained in vitro or in vivo with the bisbenzimide fluorochrome Hoechst 33342
    • 10.1038/bjc.1989.346, 2247311, 2478182
    • Young SD, Hill RP. Radiation sensitivity of tumour cells stained in vitro or in vivo with the bisbenzimide fluorochrome Hoechst 33342. Br J Cancer 1989, 60:715-721. 10.1038/bjc.1989.346, 2247311, 2478182.
    • (1989) Br J Cancer , vol.60 , pp. 715-721
    • Young, S.D.1    Hill, R.P.2
  • 85
    • 0030713362 scopus 로고    scopus 로고
    • Anthracyclines in the treatment of cancer. An overview
    • Hortobágyi G. Anthracyclines in the treatment of cancer. An overview. Drugs 1997, 54(Suppl 4):1-7.
    • (1997) Drugs , vol.54 , Issue.SUPPL. 4 , pp. 1-7
    • Hortobágyi, G.1
  • 86
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    • 10.1016/S0006-2952(98)00307-4, 10075079
    • Gewirtz D. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 1999, 57:727-741. 10.1016/S0006-2952(98)00307-4, 10075079.
    • (1999) Biochem Pharmacol , vol.57 , pp. 727-741
    • Gewirtz, D.1
  • 87
    • 0037315233 scopus 로고    scopus 로고
    • Single-hit mechanism of tumour cell killing by radiation
    • Chapman J. Single-hit mechanism of tumour cell killing by radiation. Int J Radiat Biol 2003, 79:71-81.
    • (2003) Int J Radiat Biol , vol.79 , pp. 71-81
    • Chapman, J.1
  • 88
    • 0026714331 scopus 로고
    • The anthracyclines: will we ever find a better doxorubicin?
    • Weiss R. The anthracyclines: will we ever find a better doxorubicin?. Semin Oncol 1992, 19:670-686.
    • (1992) Semin Oncol , vol.19 , pp. 670-686
    • Weiss, R.1
  • 89
    • 34250325813 scopus 로고    scopus 로고
    • Time-targeted therapy (TTT): Proof of principle using doxorubicin and radiation in a cultured cell system
    • 10.1080/02841860601009448, 17562438
    • Zhang Y, Williams JR. Time-targeted therapy (TTT): Proof of principle using doxorubicin and radiation in a cultured cell system. Acta Oncol 2007, 46:621-627. 10.1080/02841860601009448, 17562438.
    • (2007) Acta Oncol , vol.46 , pp. 621-627
    • Zhang, Y.1    Williams, J.R.2
  • 90
    • 0022311807 scopus 로고
    • Combination of cytostatics and radiation--a new trend in the treatment of inoperable esophageal cancer
    • Kolarić K. Combination of cytostatics and radiation--a new trend in the treatment of inoperable esophageal cancer. Prog Clin Biol Res 1985, 201:259-82.
    • (1985) Prog Clin Biol Res , vol.201 , pp. 259-282
    • Kolarić, K.1
  • 91
    • 0345835371 scopus 로고    scopus 로고
    • Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks
    • Banath JP, Olive PL. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Res 2003, 63:4347-4350.
    • (2003) Cancer Res , vol.63 , pp. 4347-4350
    • Banath, J.P.1    Olive, P.L.2
  • 93
    • 77951607906 scopus 로고    scopus 로고
    • Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells
    • Shin JS, Woo SH, Lee HC, Hong SW, Yoo DH, Hong SI, Lee WJ, Lee MS, Jin YW, An S, et al. Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells. Int J Oncol 2010, 36:1445-1452.
    • (2010) Int J Oncol , vol.36 , pp. 1445-1452
    • Shin, J.S.1    Woo, S.H.2    Lee, H.C.3    Hong, S.W.4    Yoo, D.H.5    Hong, S.I.6    Lee, W.J.7    Lee, M.S.8    Jin, Y.W.9    An, S.10
  • 94
    • 77953373821 scopus 로고    scopus 로고
    • Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair
    • 10.1158/1535-7163.MCT-09-1027, 2884153, 20530711
    • Loser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther 2010, 9:1775-1787. 10.1158/1535-7163.MCT-09-1027, 2884153, 20530711.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1775-1787
    • Loser, D.A.1    Shibata, A.2    Shibata, A.K.3    Woodbine, L.J.4    Jeggo, P.A.5    Chalmers, A.J.6
  • 95
    • 77950867012 scopus 로고    scopus 로고
    • Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective
    • 10.1016/j.drup.2010.01.002, 20167530
    • Verheij M, Vens C, van Triest B. Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective. Drug Resist Updat 2010, 13:29-43. 10.1016/j.drup.2010.01.002, 20167530.
    • (2010) Drug Resist Updat , vol.13 , pp. 29-43
    • Verheij, M.1    Vens, C.2    van Triest, B.3
  • 96
    • 77957578141 scopus 로고    scopus 로고
    • Targeted therapies: PARP inhibitor olaparib is safe and effective in patients with BRCA1 and BRCA2 mutations
    • 10.1038/nrclinonc.2010.143, 20922827
    • Hutchinson L. Targeted therapies: PARP inhibitor olaparib is safe and effective in patients with BRCA1 and BRCA2 mutations. Nat Rev Clin Oncol 2010, 7:549. 10.1038/nrclinonc.2010.143, 20922827.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 549
    • Hutchinson, L.1
  • 97
    • 77956487620 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets
    • 10.1016/j.semradonc.2010.06.001, 20832020
    • Chalmers AJ, Lakshman M, Chan N, Bristow RG. Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets. Semin Radiat Oncol 2010, 20:274-281. 10.1016/j.semradonc.2010.06.001, 20832020.
    • (2010) Semin Radiat Oncol , vol.20 , pp. 274-281
    • Chalmers, A.J.1    Lakshman, M.2    Chan, N.3    Bristow, R.G.4
  • 98
    • 77956224281 scopus 로고    scopus 로고
    • Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer
    • Liang H, Tan AR. Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer. IDrugs 2010, 13:646-656.
    • (2010) IDrugs , vol.13 , pp. 646-656
    • Liang, H.1    Tan, A.R.2
  • 100
    • 77955415712 scopus 로고    scopus 로고
    • PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers
    • 10.1097/CCO.0b013e32833b5126, 20485165
    • Carden CP, Yap TA, Kaye SB. PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers. Curr Opin Oncol 2010, 22:473-480. 10.1097/CCO.0b013e32833b5126, 20485165.
    • (2010) Curr Opin Oncol , vol.22 , pp. 473-480
    • Carden, C.P.1    Yap, T.A.2    Kaye, S.B.3
  • 101
    • 35748970514 scopus 로고    scopus 로고
    • PARP inhibitor development for systemic cancer targeting
    • Zaremba T, Curtin NJ. PARP inhibitor development for systemic cancer targeting. Anticancer Agents Med Chem 2007, 7:515-523.
    • (2007) Anticancer Agents Med Chem , vol.7 , pp. 515-523
    • Zaremba, T.1    Curtin, N.J.2
  • 102
    • 77958149646 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells
    • 10.1124/mol.110.067199, 20696794
    • Mitchell C, Park M, Eulitt P, Yang C, Yacoub A, Dent P. Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells. Mol Pharmacol 2010, 78:909-917. 10.1124/mol.110.067199, 20696794.
    • (2010) Mol Pharmacol , vol.78 , pp. 909-917
    • Mitchell, C.1    Park, M.2    Eulitt, P.3    Yang, C.4    Yacoub, A.5    Dent, P.6
  • 103
    • 70349751409 scopus 로고    scopus 로고
    • BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide
    • 10.1016/j.ygyno.2009.07.009, 19699512
    • Beauchamp MC, Knafo A, Yasmeen A, Carboni JM, Gottardis MM, Pollak MN, Gotlieb WH. BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide. Gynecol Oncol 2009, 115:193-198. 10.1016/j.ygyno.2009.07.009, 19699512.
    • (2009) Gynecol Oncol , vol.115 , pp. 193-198
    • Beauchamp, M.C.1    Knafo, A.2    Yasmeen, A.3    Carboni, J.M.4    Gottardis, M.M.5    Pollak, M.N.6    Gotlieb, W.H.7
  • 104
    • 78049311247 scopus 로고    scopus 로고
    • Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation
    • 10.1158/0008-5472.CAN-10-1418, 20940411
    • Dong Y, Bey EA, Li LS, Kabbani W, Yan J, Xie XJ, Hsieh JT, Gao J, Boothman DA. Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation. Cancer Res 2010, 70:8088-8096. 10.1158/0008-5472.CAN-10-1418, 20940411.
    • (2010) Cancer Res , vol.70 , pp. 8088-8096
    • Dong, Y.1    Bey, E.A.2    Li, L.S.3    Kabbani, W.4    Yan, J.5    Xie, X.J.6    Hsieh, J.T.7    Gao, J.8    Boothman, D.A.9
  • 106
    • 0022366477 scopus 로고
    • Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate (NaB)
    • 10.2307/3576603, 4080986
    • Arundel C, Glicksman A, Leith J. Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate (NaB). Radiat Res 1985, 104:443-448. 10.2307/3576603, 4080986.
    • (1985) Radiat Res , vol.104 , pp. 443-448
    • Arundel, C.1    Glicksman, A.2    Leith, J.3
  • 107
    • 0024518889 scopus 로고
    • Chromatin decondensed by acetylation shows an elevated radiation response
    • Nackerdien Z, Michie J, Böhm L. Chromatin decondensed by acetylation shows an elevated radiation response. Radiat Res 1989 Feb;117(2):234-44 1989, 117:234-244.
    • (1989) Radiat Res 1989 Feb;117(2):234-44 , vol.117 , pp. 234-244
    • Nackerdien, Z.1    Michie, J.2    Böhm, L.3
  • 108
    • 0023924695 scopus 로고
    • Effects of sodium butyrate and 3-aminobenzamide on survival of Chinese hamster HA-1 cells after X irradiation
    • 10.2307/3577154, 3353504
    • Leith J. Effects of sodium butyrate and 3-aminobenzamide on survival of Chinese hamster HA-1 cells after X irradiation. Radiat Res 1988, 114:186-191. 10.2307/3577154, 3353504.
    • (1988) Radiat Res , vol.114 , pp. 186-191
    • Leith, J.1
  • 109
    • 67650090545 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Potential in cancer therapy
    • 10.1002/jcb.22185, 2766855, 19459166
    • Marks P, Xu W. Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem 2009, 107:600-608. 10.1002/jcb.22185, 2766855, 19459166.
    • (2009) J Cell Biochem , vol.107 , pp. 600-608
    • Marks, P.1    Xu, W.2
  • 111
    • 0036906832 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: from target to clinical trials
    • 10.1517/13543784.11.12.1695, 12457432
    • Kelly WK, O'Connor OA, Marks PA. Histone deacetylase inhibitors: from target to clinical trials. Expert Opinion on Investigational Drugs 2002, 11:1695-1713. 10.1517/13543784.11.12.1695, 12457432.
    • (2002) Expert Opinion on Investigational Drugs , vol.11 , pp. 1695-1713
    • Kelly, W.K.1    O'Connor, O.A.2    Marks, P.A.3
  • 113
    • 33745320974 scopus 로고    scopus 로고
    • Targeting histone deacetylase in cancer therapy
    • 10.1002/med.20056, 16450343
    • Lin HY, Chen CS, Lin SP, Weng JR, Chen CS. Targeting histone deacetylase in cancer therapy. Med Res Rev 2006, 26:397-413. 10.1002/med.20056, 16450343.
    • (2006) Med Res Rev , vol.26 , pp. 397-413
    • Lin, H.Y.1    Chen, C.S.2    Lin, S.P.3    Weng, J.R.4    Chen, C.S.5
  • 114
    • 0034654011 scopus 로고    scopus 로고
    • Acetylation: a regulatory modification to rival phosphorylation?
    • 10.1093/emboj/19.6.1176, 305658, 10716917
    • Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation?. EMBO J 2000, 19:1176-1179. 10.1093/emboj/19.6.1176, 305658, 10716917.
    • (2000) EMBO J , vol.19 , pp. 1176-1179
    • Kouzarides, T.1
  • 115
    • 4143128717 scopus 로고    scopus 로고
    • Acetylation of proteins as novel target for antitumor therapy: review article
    • 10.1007/s00726-004-0087-3, 15290351
    • Di Gennaro E, Bruzzese F, Caraglia M, Abruzzese A, Budillon A. Acetylation of proteins as novel target for antitumor therapy: review article. Amino Acids 2004, 26:435-441. 10.1007/s00726-004-0087-3, 15290351.
    • (2004) Amino Acids , vol.26 , pp. 435-441
    • Di Gennaro, E.1    Bruzzese, F.2    Caraglia, M.3    Abruzzese, A.4    Budillon, A.5
  • 116
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: molecular mechanisms of action
    • 10.1038/sj.onc.1210620, 17694093
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26:5541-5552. 10.1038/sj.onc.1210620, 17694093.
    • Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 117
    • 34548564426 scopus 로고    scopus 로고
    • Attenuated DNA damage repair by trichostatin A through BRCA1 suppression
    • 10.1667/RR0811.1, 17722998
    • Zhang Y, Carr T, Dimtchev A, Zaer N, Dritschilo A, Jung M. Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. Radiat Res 2007, 168:115-124. 10.1667/RR0811.1, 17722998.
    • (2007) Radiat Res , vol.168 , pp. 115-124
    • Zhang, Y.1    Carr, T.2    Dimtchev, A.3    Zaer, N.4    Dritschilo, A.5    Jung, M.6
  • 118
    • 70349671463 scopus 로고    scopus 로고
    • Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks
    • 10.1158/1078-0432.CCR-09-1039, 19789319
    • Palmieri D, Lockman PR, Thomas FC, Hua E, Herring J, Hargrave E, Johnson M, Flores N, Qian Y, Vega-Valle E, et al. Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks. Clin Cancer Res 2009, 15:6148-6157. 10.1158/1078-0432.CCR-09-1039, 19789319.
    • (2009) Clin Cancer Res , vol.15 , pp. 6148-6157
    • Palmieri, D.1    Lockman, P.R.2    Thomas, F.C.3    Hua, E.4    Herring, J.5    Hargrave, E.6    Johnson, M.7    Flores, N.8    Qian, Y.9    Vega-Valle, E.10
  • 121
    • 27644586649 scopus 로고    scopus 로고
    • Histone Deacetylase Inhibitors Radiosensitize Human Melanoma Cells by Suppressing DNA Repair Activity
    • 10.1158/1078-0432.CCR-04-2088, 16000590
    • Munshi A, Kurland JF, Nishikawa T, Tanaka T, Hobbs ML, Tucker SL, Ismail S, Stevens C, Meyn RE. Histone Deacetylase Inhibitors Radiosensitize Human Melanoma Cells by Suppressing DNA Repair Activity. Clin Cancer Res 2005, 11:4912-4922. 10.1158/1078-0432.CCR-04-2088, 16000590.
    • (2005) Clin Cancer Res , vol.11 , pp. 4912-4922
    • Munshi, A.1    Kurland, J.F.2    Nishikawa, T.3    Tanaka, T.4    Hobbs, M.L.5    Tucker, S.L.6    Ismail, S.7    Stevens, C.8    Meyn, R.E.9
  • 122
    • 34250820438 scopus 로고    scopus 로고
    • Chromatin dynamics and the preservation of genetic information
    • 10.1038/nature05980, 17581578
    • Downs JA, Nussenzweig MC, Nussenzweig A. Chromatin dynamics and the preservation of genetic information. Nature 2007, 447:951-958. 10.1038/nature05980, 17581578.
    • (2007) Nature , vol.447 , pp. 951-958
    • Downs, J.A.1    Nussenzweig, M.C.2    Nussenzweig, A.3
  • 123
    • 25144451310 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gamma H2A.X
    • Karagiannis TC, Harikrishnan KN, El-Osta A. The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gamma H2A.X. Cancer Biology & Therapy 2005, 4:787-793.
    • (2005) Cancer Biology & Therapy , vol.4 , pp. 787-793
    • Karagiannis, T.C.1    Harikrishnan, K.N.2    El-Osta, A.3
  • 124
    • 33845741562 scopus 로고    scopus 로고
    • Histone Deacetylase (HDAC) Inhibitor LBH589 Increases Duration of {gamma}-H2AX Foci and Confines HDAC4 to the Cytoplasm in Irradiated Non-Small Cell Lung Cancer
    • 10.1158/0008-5472.CAN-06-0049, 17145876
    • Geng L, Cuneo KC, Fu A, Tu T, Atadja PW, Hallahan DE. Histone Deacetylase (HDAC) Inhibitor LBH589 Increases Duration of {gamma}-H2AX Foci and Confines HDAC4 to the Cytoplasm in Irradiated Non-Small Cell Lung Cancer. Cancer Res 2006, 66:11298-11304. 10.1158/0008-5472.CAN-06-0049, 17145876.
    • (2006) Cancer Res , vol.66 , pp. 11298-11304
    • Geng, L.1    Cuneo, K.C.2    Fu, A.3    Tu, T.4    Atadja, P.W.5    Hallahan, D.E.6
  • 125
    • 69449096433 scopus 로고    scopus 로고
    • Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis
    • 10.1093/carcin/bgp079, 19351790
    • Chung YL, Lee MY, Pui NNM. Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis. Carcinogenesis 2009, 30:1387-1397. 10.1093/carcin/bgp079, 19351790.
    • (2009) Carcinogenesis , vol.30 , pp. 1387-1397
    • Chung, Y.L.1    Lee, M.Y.2    Pui, N.N.M.3
  • 126
    • 40549126605 scopus 로고    scopus 로고
    • Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments
    • 10.4161/cc.7.4.5405, 18239454
    • Harikrishnan KN, Karagiannis TC, Chow MZ, El-Osta A. Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments. Cell Cycle 2008, 7:468-476. 10.4161/cc.7.4.5405, 18239454.
    • (2008) Cell Cycle , vol.7 , pp. 468-476
    • Harikrishnan, K.N.1    Karagiannis, T.C.2    Chow, M.Z.3    El-Osta, A.4
  • 127
    • 68149170764 scopus 로고    scopus 로고
    • Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells
    • 10.1158/1535-7163.MCT-08-0544, 19270532
    • Zhang F, Zhang T, Teng Z, Zhang R, Wang J, Mei Q. Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther 2009, 8:823-831. 10.1158/1535-7163.MCT-08-0544, 19270532.
    • (2009) Cancer Biol Ther , vol.8 , pp. 823-831
    • Zhang, F.1    Zhang, T.2    Teng, Z.3    Zhang, R.4    Wang, J.5    Mei, Q.6
  • 128
    • 3042568739 scopus 로고    scopus 로고
    • Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor
    • 10.1016/j.ijrobp.2004.03.001, 15234053
    • Kim J, Shin J, Kim I. Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. Int J Radiat Oncol Biol Phys 2004, 59:1174-1180. 10.1016/j.ijrobp.2004.03.001, 15234053.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 1174-1180
    • Kim, J.1    Shin, J.2    Kim, I.3
  • 129
    • 53049089057 scopus 로고    scopus 로고
    • Postradiation Sensitization of the Histone Deacetylase Inhibitor Valproic Acid
    • 10.1158/1078-0432.CCR-08-0643, 18765532
    • Chinnaiyan P, Cerna D, Burgan WE, Beam K, Williams ES, Camphausen K, Tofilon PJ. Postradiation Sensitization of the Histone Deacetylase Inhibitor Valproic Acid. Clin Cancer Res 2008, 14:5410-5415. 10.1158/1078-0432.CCR-08-0643, 18765532.
    • (2008) Clin Cancer Res , vol.14 , pp. 5410-5415
    • Chinnaiyan, P.1    Cerna, D.2    Burgan, W.E.3    Beam, K.4    Williams, E.S.5    Camphausen, K.6    Tofilon, P.J.7
  • 130
    • 14044250159 scopus 로고    scopus 로고
    • Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid
    • 10.1002/ijc.20774, 15578701
    • Camphausen K, Cerna D, Scott T, Sproull M, Burgan W, Cerra M, Fine H, Tofilon P. Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. Int J Cancer 2005, 114:380-386. 10.1002/ijc.20774, 15578701.
    • (2005) Int J Cancer , vol.114 , pp. 380-386
    • Camphausen, K.1    Cerna, D.2    Scott, T.3    Sproull, M.4    Burgan, W.5    Cerra, M.6    Fine, H.7    Tofilon, P.8
  • 131
    • 67649342903 scopus 로고    scopus 로고
    • Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts
    • 10.1158/1535-7163.MCT-09-0038, 19509253
    • Baschnagel A, Russo A, Burgan WE, Carter D, Beam K, Palmieri D, Steeg PS, Tofilon P, Camphausen K. Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts. Mol Cancer Ther 2009, 8:1589-1595. 10.1158/1535-7163.MCT-09-0038, 19509253.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1589-1595
    • Baschnagel, A.1    Russo, A.2    Burgan, W.E.3    Carter, D.4    Beam, K.5    Palmieri, D.6    Steeg, P.S.7    Tofilon, P.8    Camphausen, K.9
  • 132
    • 59649094562 scopus 로고    scopus 로고
    • A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma
    • 10.1016/j.ijrobp.2008.10.032, 19215824
    • De Schutter H, Kimpe M, Isebaert S, Nuyts S. A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2009, 73:904-912. 10.1016/j.ijrobp.2008.10.032, 19215824.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 904-912
    • De Schutter, H.1    Kimpe, M.2    Isebaert, S.3    Nuyts, S.4
  • 133
    • 20444479514 scopus 로고    scopus 로고
    • Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid
    • 10.1038/ncponc0106, 16264908
    • Kelly W, Marks P. Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid. Nat Clin Pract Oncol 2005, 2:150-157. 10.1038/ncponc0106, 16264908.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 150-157
    • Kelly, W.1    Marks, P.2
  • 134
    • 34250015533 scopus 로고    scopus 로고
    • Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments
    • 10.1038/sj.onc.1210174, 17213813
    • Karagiannis TC, Harikrishnan KN, El-Osta A. Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. Oncogene 2007, 26:3963-3971. 10.1038/sj.onc.1210174, 17213813.
    • (2007) Oncogene , vol.26 , pp. 3963-3971
    • Karagiannis, T.C.1    Harikrishnan, K.N.2    El-Osta, A.3
  • 135
    • 0017309737 scopus 로고
    • Editorial: Hypoxic cell radiosensitizers
    • 10.1056/NEJM197606172942511, 177876
    • Belli JA, Hellman S. Editorial: Hypoxic cell radiosensitizers. N Engl J Med 1976, 294:1399-1400. 10.1056/NEJM197606172942511, 177876.
    • (1976) N Engl J Med , vol.294 , pp. 1399-1400
    • Belli, J.A.1    Hellman, S.2
  • 137
    • 67649347492 scopus 로고    scopus 로고
    • Radiosensitising agents for the radiotherapy of cancer: advances in traditional and hypoxia targeted radiosensitisers
    • 10.1517/13543770902824172, 19441939
    • Bischoff P, Altmeyer A, Dumont F. Radiosensitising agents for the radiotherapy of cancer: advances in traditional and hypoxia targeted radiosensitisers. Expert Opin Ther Pat 2009, 19:643-662. 10.1517/13543770902824172, 19441939.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 643-662
    • Bischoff, P.1    Altmeyer, A.2    Dumont, F.3
  • 138
    • 3442889371 scopus 로고    scopus 로고
    • Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide
    • 10.1158/0008-5472.CAN-04-0729, 15289343
    • Olive PL, Banath JP, Sinnott LT. Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide. Cancer Res 2004, 64:5363-5369. 10.1158/0008-5472.CAN-04-0729, 15289343.
    • (2004) Cancer Res , vol.64 , pp. 5363-5369
    • Olive, P.L.1    Banath, J.P.2    Sinnott, L.T.3
  • 139
    • 34249676952 scopus 로고    scopus 로고
    • Radiosensitization by nitric oxide at low radiation doses
    • 10.1667/RR0827.1, 17388699
    • Wardman P, Rothkamm K, Folkes LK, Woodcock M, Johnston PJ. Radiosensitization by nitric oxide at low radiation doses. Radiat Res 2007, 167:475-484. 10.1667/RR0827.1, 17388699.
    • (2007) Radiat Res , vol.167 , pp. 475-484
    • Wardman, P.1    Rothkamm, K.2    Folkes, L.K.3    Woodcock, M.4    Johnston, P.J.5
  • 140
    • 53449096820 scopus 로고    scopus 로고
    • PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells
    • 10.1002/ijc.23807, 18729192
    • Palayoor ST, Mitchell JB, Cerna D, Degraff W, John-Aryankalayil M, Coleman CN. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer 2008, 123:2430-2437. 10.1002/ijc.23807, 18729192.
    • (2008) Int J Cancer , vol.123 , pp. 2430-2437
    • Palayoor, S.T.1    Mitchell, J.B.2    Cerna, D.3    Degraff, W.4    John-Aryankalayil, M.5    Coleman, C.N.6
  • 142
    • 39149094633 scopus 로고    scopus 로고
    • Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells
    • 10.1158/0008-5472.CAN-06-4497, 18172318
    • Evans JW, Chernikova SB, Kachnic LA, Banath JP, Sordet O, Delahoussaye YM, Treszezamsky A, Chon BH, Feng Z, Gu Y, et al. Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells. Cancer Res 2008, 68:257-265. 10.1158/0008-5472.CAN-06-4497, 18172318.
    • (2008) Cancer Res , vol.68 , pp. 257-265
    • Evans, J.W.1    Chernikova, S.B.2    Kachnic, L.A.3    Banath, J.P.4    Sordet, O.5    Delahoussaye, Y.M.6    Treszezamsky, A.7    Chon, B.H.8    Feng, Z.9    Gu, Y.10
  • 144
    • 0026564841 scopus 로고
    • The kinetics of repair for sublethal radiation-induced damage in the pig epidermis: an interpretation based on a fast and a slow component of repair
    • 10.1016/0167-8140(92)90340-Z, 1546193
    • van den Aardweg G, Hopewell J. The kinetics of repair for sublethal radiation-induced damage in the pig epidermis: an interpretation based on a fast and a slow component of repair. Radiother Oncol 1992, 23:94-104. 10.1016/0167-8140(92)90340-Z, 1546193.
    • (1992) Radiother Oncol , vol.23 , pp. 94-104
    • van den Aardweg, G.1    Hopewell, J.2
  • 145
    • 0021344957 scopus 로고
    • An unexpected effect of hyperthermia on the expression of X-ray damage in mouse skin
    • 10.2307/3576200, 6695042
    • Hume S, Myers R. An unexpected effect of hyperthermia on the expression of X-ray damage in mouse skin. Radiat Res 1984, 97:186-199. 10.2307/3576200, 6695042.
    • (1984) Radiat Res , vol.97 , pp. 186-199
    • Hume, S.1    Myers, R.2
  • 146
    • 0016260227 scopus 로고
    • The kinetics of recovery in irradiated colonic mucosa of the mouse
    • 10.1002/1097-0142(197409)34:3+<896::AID-CNCR2820340717>3.0.CO;2-P, 4854926
    • Withers HR, Kathryn AM. The kinetics of recovery in irradiated colonic mucosa of the mouse. Cancer 1974, 34:896-903. 10.1002/1097-0142(197409)34:3+<896::AID-CNCR2820340717>3.0.CO;2-P, 4854926.
    • (1974) Cancer , vol.34 , pp. 896-903
    • Withers, H.R.1    Kathryn, A.M.2
  • 147
    • 69949151451 scopus 로고    scopus 로고
    • Effect of selective inhibitors of inflammation on oral mucositis: Preclinical studies
    • 10.1016/j.radonc.2009.06.006, 19576646
    • Haagen J, Krohn H, Röllig S, Schmidt M, Wolfram K, Dörr W. Effect of selective inhibitors of inflammation on oral mucositis: Preclinical studies. Radiother Oncol 2009, 92:472-476. 10.1016/j.radonc.2009.06.006, 19576646.
    • (2009) Radiother Oncol , vol.92 , pp. 472-476
    • Haagen, J.1    Krohn, H.2    Röllig, S.3    Schmidt, M.4    Wolfram, K.5    Dörr, W.6
  • 148
    • 0025342946 scopus 로고
    • Accelerated repopulation of mouse tongue epithelium during fractionated irradiations or following single doses
    • Dörr W, Kummermehr J. Accelerated repopulation of mouse tongue epithelium during fractionated irradiations or following single doses. Radiother Oncol 1990, 17:249-259.
    • (1990) Radiother Oncol , vol.17 , pp. 249-259
    • Dörr, W.1    Kummermehr, J.2
  • 149
    • 28944446549 scopus 로고    scopus 로고
    • Reduction of oral mucositis by palifermin (rHuKGF): Dose-effect of rHuKGF
    • 10.1080/09553000500196136, 16298937
    • Dorr W, Heider K, Spekl K. Reduction of oral mucositis by palifermin (rHuKGF): Dose-effect of rHuKGF. Int J Radiat Biol 2005, 81:557-565. 10.1080/09553000500196136, 16298937.
    • (2005) Int J Radiat Biol , vol.81 , pp. 557-565
    • Dorr, W.1    Heider, K.2    Spekl, K.3
  • 150
    • 77956288642 scopus 로고    scopus 로고
    • Induction of gamma-H2AX foci in human exfoliated buccal cells after in vitro exposure to ionising radiation
    • 10.3109/09553002.2010.484476, 20597838
    • Gonzalez JE, Roch-Lefevre SH, Mandina T, Garcia O, Roy L. Induction of gamma-H2AX foci in human exfoliated buccal cells after in vitro exposure to ionising radiation. Int J Radiat Biol 2010, 86:752-759. 10.3109/09553002.2010.484476, 20597838.
    • (2010) Int J Radiat Biol , vol.86 , pp. 752-759
    • Gonzalez, J.E.1    Roch-Lefevre, S.H.2    Mandina, T.3    Garcia, O.4    Roy, L.5
  • 151
    • 73349090920 scopus 로고    scopus 로고
    • Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo
    • 10.1667/RR1851.1, 20041754
    • Bhogal N, Kaspler P, Jalali F, Hyrien O, Chen R, Hill RP, Bristow RG. Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo. Radiat Res 2010, 173:1-9. 10.1667/RR1851.1, 20041754.
    • (2010) Radiat Res , vol.173 , pp. 1-9
    • Bhogal, N.1    Kaspler, P.2    Jalali, F.3    Hyrien, O.4    Chen, R.5    Hill, R.P.6    Bristow, R.G.7
  • 152
    • 4644308611 scopus 로고    scopus 로고
    • DNA double strand break quantification in skin biopsies
    • 10.1016/j.radonc.2004.07.009, 15450730
    • Qvarnstrom OF, Simonsson M, Johansson KA, Nyman J, Turesson I. DNA double strand break quantification in skin biopsies. Radiother Oncol 2004, 72:311-317. 10.1016/j.radonc.2004.07.009, 15450730.
    • (2004) Radiother Oncol , vol.72 , pp. 311-317
    • Qvarnstrom, O.F.1    Simonsson, M.2    Johansson, K.A.3    Nyman, J.4    Turesson, I.5
  • 154
    • 34548359085 scopus 로고    scopus 로고
    • Gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: Dependence on the dose-distribution, irradiated site and time from start of treatment
    • 10.1080/09553000701596118, 17729159
    • Sak A, Grehl S, Erichsen P, Engelhard M, Grannaß A, LevegrÃ1-Aprn S, Pöttgen C, Groneberg M, Stuschke M. gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: Dependence on the dose-distribution, irradiated site and time from start of treatment. Int J Radiat Biol 2007, 83:639-652. 10.1080/09553000701596118, 17729159.
    • (2007) Int J Radiat Biol , vol.83 , pp. 639-652
    • Sak, A.1    Grehl, S.2    Erichsen, P.3    Engelhard, M.4    Grannaß, A.5    LevegrÃ1-Aprn, S.6    PÃttgen, C.7    Groneberg, M.8    Stuschke, M.9
  • 155
    • 27644503129 scopus 로고    scopus 로고
    • Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus
    • 10.1158/1541-7786.MCR-05-0074, 16254189
    • Pogrlbny I, Koturbash I, Tryndyak V, Hudson D, Stevenson SML, Sedelnikova O, Bonner W, Kovalchuk O. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol Cancer Res 2005, 3:553-561. 10.1158/1541-7786.MCR-05-0074, 16254189.
    • (2005) Mol Cancer Res , vol.3 , pp. 553-561
    • Pogrlbny, I.1    Koturbash, I.2    Tryndyak, V.3    Hudson, D.4    Stevenson, S.M.L.5    Sedelnikova, O.6    Bonner, W.7    Kovalchuk, O.8
  • 156
    • 70350304614 scopus 로고    scopus 로고
    • Gamma-H2AX as protein biomarker for radiation exposure
    • Rothkamm K, Horn S. gamma-H2AX as protein biomarker for radiation exposure. Ann Ist Super Sanita 2009, 45:265-271.
    • (2009) Ann Ist Super Sanita , vol.45 , pp. 265-271
    • Rothkamm, K.1    Horn, S.2
  • 157
    • 58149510531 scopus 로고    scopus 로고
    • CellProfiler Analyst: data exploration and analysis software for complex image-based screens
    • 10.1186/1471-2105-9-482, 2614436, 19014601
    • Jones T, Kang I, Wheeler D, Lindquist R, Papallo A, Sabatini D, Golland P, Carpenter A. CellProfiler Analyst: data exploration and analysis software for complex image-based screens. BMC Bioinformatics 2008, 9:482. 10.1186/1471-2105-9-482, 2614436, 19014601.
    • (2008) BMC Bioinformatics , vol.9 , pp. 482
    • Jones, T.1    Kang, I.2    Wheeler, D.3    Lindquist, R.4    Papallo, A.5    Sabatini, D.6    Golland, P.7    Carpenter, A.8
  • 158
    • 29644443047 scopus 로고    scopus 로고
    • Computational Methods for analysis of foci: validation for radiation-induced gamma-H2AX foci in human cells
    • Böcker W, Iliakis G. Computational Methods for analysis of foci: validation for radiation-induced gamma-H2AX foci in human cells. Radiat Res 2006, 165:113-124.
    • (2006) Radiat Res , vol.165 , pp. 113-124
    • Böcker, W.1    Iliakis, G.2
  • 161
    • 21144456719 scopus 로고    scopus 로고
    • In vivo formation and repair of DNA double-strand breaks after computed tomography examinations
    • 10.1073/pnas.0501895102, 1150277, 15956203
    • Lobrich M, Rief N, Kuhne M, Heckmann M, Fleckenstein J, Rube C, Uder M. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc Natl Acad Sci USA 2005, 102:8984-8989. 10.1073/pnas.0501895102, 1150277, 15956203.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8984-8989
    • Lobrich, M.1    Rief, N.2    Kuhne, M.3    Heckmann, M.4    Fleckenstein, J.5    Rube, C.6    Uder, M.7
  • 162
    • 33845606709 scopus 로고    scopus 로고
    • Leukocyte DNA Damage after Multi†"Detector Row CT: A Quantitative Biomarker of Low-Level Radiation Exposure1
    • 10.1148/radiol.2421060171, 17185671
    • Rothkamm K, Balroop S, Shekhdar J, Fernie P, Goh V. Leukocyte DNA Damage after Multi†"Detector Row CT: A Quantitative Biomarker of Low-Level Radiation Exposure1. Radiology 2007, 242:244-251. 10.1148/radiol.2421060171, 17185671.
    • (2007) Radiology , vol.242 , pp. 244-251
    • Rothkamm, K.1    Balroop, S.2    Shekhdar, J.3    Fernie, P.4    Goh, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.