Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells

International Journal of Oncology

Volumn 36, Issue 6, 2010, Pages 1445-1452

  Shin, Jae Sik ^a,b   Woo, Sang Hyeok ^c   Lee, Hyung Chahn ^c   Hong, Seung Woo ^a   Yoo, Doo Hyun ^c   Hong, Seok Il ^c   Lee, Wang Jae ^a   Lee, Myeong Sok ^d   Jin, Young Woo ^e   An, Sungkwan ^b   Jin, Dong Hoon ^a,d   Park, In Chul ^c  

^a Seoul National University College of Medicine   (South Korea)

^b Konkuk University   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d Sookmyung Women's University   (South Korea)

^e Korea Hydro & Nuclear Power Co   (South Korea)

Author keywords

Doxorubicin; Erk1 2; Low dose of radiation; p38; Senescence

Indexed keywords

BETA GALACTOSIDASE; DOXORUBICIN; HISTONE H2AX; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53;

ARTICLE; BREAST CANCER; CELL AGING; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REPRESSION; HUMAN; HUMAN CELL; IONIZING RADIATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE;

ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL AGING; CELL LINE, TUMOR; DNA DAMAGE; DOXORUBICIN; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HISTONES; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHORYLATION; RADIATION, IONIZING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77951607906     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000630     Document Type: Article

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