Reduction of oral mucositis by palifermin (rHuKGF): Dose-effect of rHuKGF

International Journal of Radiation Biology

Volumn 81, Issue 8, 2005, Pages 557-565

  Dörr, Wolfgang ^a   Heider, Katrin ^a   Spekl, Kathrin ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Fractionated irradiation; Growth factors; Mouse model; Mucoprotection; Oral mucositis

Indexed keywords

PALIFERMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; IRRADIATION; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; ULCER;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 7; INJECTIONS, SUBCUTANEOUS; MICE; RADIATION INJURIES; STOMATITIS;

ANIMALIA;

EID: 28944446549     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000500196136     Document Type: Article

References (41)

1. Baatar D, Kawanaka H, Szabo IL, Pai R, Jones MK, Kitano S, Tarnawski AS. 2002. Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing. Gastroenterology 122:458-468.
2. Bernier J, Thames HD, Smith CD, Horiot JC. 1998. Tumor response, mucosal reactions and late effects after conventional and hyperfractionated radiotherapy. Radiother Oncol 47:137-143.
3. Brizel DM, Herman T, Goffinet D, Sailer S, Agarwala S, Schwartz G, Venkatesan V, Cripps C, Meredith RF, Logan E, Yao B. 2001. A phase I/II trial of escalating doses of recombinant human keratinocyte growth factor (rHuKGF) in head and neck cancer (HNC) patients receiving radiotherapy (RT) with concurrent chemotherapy (CCT). Int J Radiat Oncol Biol Phys 51(Suppl. 1):40 (Abstract).
4. Bourhis J, Etessami A, Wilbault P, Lusinchi A, Calais G, Lapeyre M, Pignon JP. 2004. Altered fractionated radiotherapy in the management of head and neck carcinomas: Advantages and limitations. Curr Opin Oncol 16:215-219.
5. Denham JW, Peters LJ, Johansen J, Poulsen M, Lamb DS, Hindley A, O'Brien PC, Spry NA, Penniment M, Krawitz H, Williamson S, Bear J, Tripcony L. 1999. Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer? Radiother Oncol 52:157-164.
6. Denham JW, Walker QJ, Lamb DS, Hamilton CS, O'Brien PC, Spry NA, Hindley A, Poulsen M, O'Brien M, Tripcony L. 1996. Mucosal regeneration during radiotherapy. Radiother Oncol 41:109-118.
7. Dörr W. 1997. Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions. Int J Radiat Biol 72:635-643.
8. Dörr W. 2003a. Oral mucosa: Response modification by keratinocyte growth factor. In: Nieder C, Milas L, Ang KK, editors. Biological modification of radiation response. Berlin-Heidelberg-New York: Springer. pp 113-122.
9. Dörr W. 2003b. Modulation of repopulation processes in oral mucosa: Experimental results. Int J Radiat Biol 79:531-537.
10. Dörr W, Bässler S, Reichel S, Spekl K. 2005a. Reduction of radiochemotherapy-induced early oral mucositis by recombinant human Keratinocyte Growth Factor (KGF): Experimental studies in mice. Int J Radiat Oncol Biol Phys 62:881-887.
11. Dörr W, Brankovic K, Hartmann B. 2000. Repopulation in mouse oral mucosa: Changes in the effect of dose fractionation. Int J Radiat Biol 76:383-390.
12. Dörr W, Breitner A, Kummermehr J. 1993. Capacity and kinetics of SLD repair in mouse tongue epithelium. Radiother Oncol 27:36-45.
13. Dörr W, Hendry JH. 2001. Consequential late effects in normal tissues. Radiother Oncol 61:223-231.
14. Dörr W, Emmendörfer H, Weber-Frisch M. 1996. Tissue kinetics in mouse tongue mucosa during daily fractionated radiotherapy. Cell Prolif 29:495-504.
15. Dörr W, Noack R, Spekl K, Farrell CL. 2001. Modification of oral mucositis by keratinocyte growth factor: Single radiation exposure. Int J Radiat Biol 77:341-347.
16. Dörr W, Reichel S, Spekl K. 2005b. Effects of Keratinocyte Growth Factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation. Radiother Oncol 75:99-105.
17. Dörr W, Spekl K, Farrell CL. 2002a. Amelioration of acute oral mucositis by keratinocyte growth factor: Fractionated irradiation. Int J Radiat Oncol Biol Phys 54:245-251.
18. Dörr W, Spekl K, Farrell CL. 2002b. The effect of Keratinocyte Growth Factor on healing of manifest radiation ulcers in mouse tongue epithelium. Cell Prolif 35(Suppl. 1):86-92.
19. Farrell CL, Bready JV, Rex KL, Chen JN, Dipalma CR, Whitcomb KL, Yin S, Hill DC, Wiemann B, Starnes CO, Havill AM, Lu ZN, Aukerman SL, Pierce GF, Thomason A, Potten CS, Ulich TR, Lacey DL. 1998. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 58:933-939.
20. Guttenberger R, Feng Y, Hunter N, Ang KK, Price R. 1991. Effects of TGF-α on radiation response in lip and jejunal mucosa in mice. In: Chapman JD, Dewey WC, Whitmore GF, editors. Radiation research: A twentieth-century perspective, vol. I, San Diego-New York-Boston: Academic Press. p 151 (Abstract).
21. Hille A, Rave-Fränk M, Pradier O, Damm C, Dörr W, Jäckel MC, Christiansen H, Hess CF, Schmidberger H. 2003. Effect of Keratinocyte Growth Factor on the proliferation, clonogenic capacity and colony size of human epithelial tumour cells in vitro. Int J Radiat Biol 79:119-128.
22. Köstler WJ, Hejna M, Wenzel C, Zielinski CC. 2001. Oral mucositis complicating chemotherapy and/or radiotherapy: Options for prevention and treatment. CA Cancer J Clinicians 51:290-315.
23. Liu K, Kasper M, Trott KR. 1996. Changes in keratinocyte differentiation during accelerated repopulation of the irradiated mouse epidermis. Int J Radiat Biol 69:763-769.
24. Maciejewski B, Withers HR, Taylor JM, Hliniak A. 1990. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx. Part 2. Normal tissue responses: Acute and late effects. Int J Radiat Biol Oncol Phys 18:101-111.
25. Marks JE. 1997. Mucosal protectants and their application for head and neck chemoirradiation. Curr Opin Oncol 9:267-273.
26. Nickstadt T. 2000. Capacity and kinetics of recovery from sublethal radiation damage in oral mucosa (mouse) after irradiation with 200 kV X-rays. MDS Thesis (Diss. Med. Dent.), Technical University of Dresden, 2000.
27. Ning S, Shui C, Khan WB, Benson W, Lacey DL, Knox SJ. 1998. Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo. Int J Radiat Biol Oncol Phys 40:177-187.
28. Pabst S, Spekl K, Dörr W. 2004. Changes in the effect of dose fractionation during daily fractionated irradiation: studies in mouse oral mucosa. Int J Radiat Biol Oncol Phys 58:485-492.
29. Plevova P. 1999. Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: A review. Oral Oncol 35:453-470.
30. Potten CS, Owen G, Hewitt D, Chadwick CA, Hendry H, Lord BI, Woolford LB. 1995. Stimulation and inhibition of proliferation in the small intestineal crypts of the mouse after in vivo administration of growth factors. Gut, 36:864-873.
31. Rubin JS, Bottaro DB, Chedid M, Mild T, Ron D, Cheon HG, Taylor WG, Fortney E, Sakata H, Finch PW, La Rochelle WJ. 1995. Keratinocyte growth factor. Cell Biol Int 19:399-411.
32. SAS Institute Inc. 1990. SAS/STAT Users Guide Version 6. Cary, NC: Author.
33. Sonis ST, Costa JW Jr, Evitts SM, Lindquist LE, Nicolson M. 1992. Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy. Oral Surg Oral Med Oral Pathol 74:749-755.
34. Sonis ST, Lindquist L, Van Vugt A, Stewart AA, Stam K, Qu GY, Iwata KK, Haley JD. 1994. Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3. Cancer Res 54:1135-1138.
35. Spielberger RT, Stiff P, Emmanoulides C, Yanovich S, Bensinger W, Hedrick E, Noga S, Ziegler T, Keating A, Frankel S, Gentile T, Heard R, Yao B, Elhardt D. 2001. Efficacy of recombinant human Keratinocyte Growth Factor (rHuKGF) in reducing mucositis in patients with hematologic malignancies undergoing autologous peripheral blood progenitor cell transplantation (auto-PBPCT) after radiation-based conditioning - results of a phase 2 trial. J Clin Oncol 20:7a (Abstract 25).
36. Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewalramani T, Shea T, Yanovich S, Hansen K, Noga S, McCarty J, Lemaistre CF, Sung EC, Blazar BR, Elhardt D, Chen MG, Emmanouilides C. 2004. Palifermin for oral mucositis after intensive therapy for hematologic cancers. New Engl J Med 351:2590-2598.
37. Tarnawski R, Fowler J, Skladowski K, Swiernak A, Suwinski R, Maciejewski B, Wygoda A. 2002. How fast is repopulation of tumour cells during the treatment gap? Int J Radiat Oncol Biol Phys 54:229-236.
38. Trotti A. 1998. Toxicity antagonists in head and neck cancer. Sem Radiat Oncol 8:282-291.
39. Trotti A, Klotch D, Endicott J, Ridley M, Cantor A. 1998. Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck: Long-term results of a prospective trial. Head Neck 20:119-123.
40. Van Der Schueren E, Van Den Bogaert W, Vanuytsel L, Van Limbergen E. 1990. Radiotherapy by multiple fractions per day (MFD) in head and neck cancer: Acute reactions of skin and mucosa. Int J Radiat Oncol Biol Phys 19:301-311.
41. Zaghloul MS, Doric MJ, Kallman RF. 1994. Interleukin 1 increases thymidine labeling index of normal tissues of mice but not the tumor. Int J Radiat Oncol Biol Phys 29:805-811.