Tissue-specific induction of p53 targets in vivo

Cancer Research

Volumn 62, Issue 24, 2002, Pages 7316-7327

  Fei, Peiwen ^a   Bernhard, Eric J ^a   El Deiry, Wafik S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; PROTEIN BID; PROTEIN P21; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL SPECIFICITY; CONTROLLED STUDY; DESCENDING COLON; DNA DAMAGE; ENZYME ACTIVATION; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; ILEUM; IN SITU HYBRIDIZATION; JEJUNUM; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; TISSUE SPECIFICITY; TRANSACTIVATION; TRANSVERSE COLON;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 3; CASPASES; COLON; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; GAMMA RAYS; GENE EXPRESSION REGULATION; LIVER; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; SPLEEN; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037115539     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Gottlieb, T. M. and Oren, M. p53 in growth control and neoplasia. Biochim. Biophys. Acta, 1287: 77-102, 1996.
2. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
3. Prives, C., and Hall, P. A. The p53 pathway. J. Pathol., 187: 112-126, 1999.
4. Tlsty, T. D. Functions of p53 suppress critical consequences of damage and repair in the initiation of cancers. Cancer Cell, 2-4, 2002.
5. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Wash. DC), 253: 49-53, 1991.
6. Donehower, L. A. The p53-deficient mouse: A model for basic and applied cancer studies. Semin. Cancer Biol., 7: 269-278, 1996.
7. Ko, L. J., and Prives, C. p53: Puzzle and paradigm. Genes Dev., 10: 1054-1072, 1996.
8. El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., and Volglstein, B. Definition of a consensus binding site for p53. Nat. Genet., 45-49, 1992.
9. Bourdon, J. C., Deguin-Chambon, V., Lelong, J. C., Dessen, P., May, P., Debuire, B., and May, E. Further characterisation of the p53 responsive element identification of new candidate genes for transactivation by p53. Oncogene, 14: 85-94, 1997.
10. El-Deiry, W. S. Regulation of p53 downstream genes. Semin. Cancer Biol., 8: 345-357, 1998.
11. Funk, W. D., Pak, D. T., Karas, R. H., Wright, W. E., and Shay, J. W. A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol., 12: 2866-2871, 1992.
12. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Volgelstein, B. wAF1, a potential mediator of p3 tumor suppression. Cell, 75: 817-825, 1993.
13. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71: 587-597, 1992.
14. Hermeking, H., Lengauer, C., Polyak, K., He, T. C., Zhang, L., Thiagalingam, S., Kinzler, K. W., and Vogelstein, B. 14-3-3σ is a p53-regulated inhibitor of G2/M progression. Mol. Cell, 1: 3-11, 1997.
15. 2-M cell cycle checkpoint. Proc. Natl. Acad. Sci. USA, 96: 3706-3711, 1999.
16. 2-M checkpoint. Genes Dev., 14: 1584-1588, 2000.
17. Benchimol, S. p53-dependent pathways of apoptosis. Cell Death Differ., 8: 1049-1051, 2001.
18. Owen-Schaub, L. B., Angelo, L. S., Radinsky, R., Ware, C. F., Gesner, T. G., and Bartos, D. P. Soluble Fas/APO-1 in tumor cells: A potential regulator of apoptosis? Cancer Lett., 94: 1-8, 1995.
19. Muller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., and Krammer, P. H. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med., 188: 2033-2045, 1998.
20. Wu, G. S., Burns, T. F., Mcdonald, E. R., III, Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D. D., Zhou, J. Y., Muschel, R., Hamilton, S. R., Spinner, N. B., Markowitz, S., Wu, G., and El-Deiry, W. S. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat. Genet., 17: 141-143, 1997.
21. Wu, G. S., Burns, T. F., McDonald, E. R., III, Meng, R. D., Kao, G., Muschel, R., Yen, T., and El-Deiry, W. S. Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest. Oncogene, 18: 6411-6418, 1999.
22. Attardi, L. D., Reczek, E. E., Cosmas, C., Demicco, E. G., McCurrach, M. E., Lowe, S. W., and Jacks, T. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev., 14: 704-718, 2000.
23. Lin, Y., Ma, W., and Benchimol, S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat. Genet., 26: 122-127, 2000.
24. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., and Vogelstein, B. A model for p53-induced apoptosis. Nature (Lond.), 389: 300-305, 1997.
25. Miyashita, T., Kitada, S., Krajewski, S., Horne, W. A., Delia, D., and Reed, J. C. Overexpression of the Bcl-2 protein increases the half-life of p21Bax. J. Biol. Chem., 270: 26049-26052, 1995.
26. Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., and Tanaka, N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science (Wash. DC), 288: 1053-1058, 2000.
27. Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., and Taya, Y. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell, 102: 849-862, 2000.
28. Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W., and Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell, 7: 673-682, 2001.
29. Nakano, K., and Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell, 7: 683-694, 2001.
30. Sax, J. K., Fei, P., Murphy, M. E., Bernhardt, E., Korsmeyer, S. J. and El-Deiry, W. S. Bid transcriptional regulation by p53 contributes to chemosensitivity. Nat. Cell Biol., 4: 842-849, 2002.
31. Merritt, A. J., Potten, C. S., Kemp, C. J., Hickman, J. A., Balmain, A., Lane, D. P., and Hall, P. A. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res., 54: 614-617, 1994.
32. MacCallum, D. E., Hupp, T. R., Midgley, C. A., Stuart, D., Campbell, S. J., Harper, A., Walsh, F. S., Wright, E. G., Balmain, A., Lane, D. P., and Hall, P. A. The p53 response to ionising radiation in adult and developing murine tissues. Oncogene, 13: 2575-2587, 1996.
33. Bouvard, V., Zaitchouk, T., Vacher, M., Duthu, A., Canivet, M., Choisy-Rossi, C., Nieruchalski, M., and May, E. Tissue and cell-specific expression of the p53-target genes: Bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene, 19: 649-660, 2000.
34. Burns, T. F., Bernhard, E. J., and El-Deiry, W. S. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene, 20: 4601-4612, 2001.
35. Herzog, K. H., Chong, M. J., Kapsetaki, M., Morgan, J. I., and McKinnon, P. J. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science (Wash. DC), 280: 1089-1091, 1998.
36. Komarova, E. A., Chernov, M. V., Franks, R., Wang, K., Armin, G., Zelnick, C. R., Chin, D. M., Bacus, S. S., Stark, G. R., and Gudkov, A. V. Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J., 16: 1391-1400, 1997.
37. 2-M-associated cell death after γ-irradiation. Oncogene, 14: 2759-2766, 1997.
38. Pritchard, D. M., Potten, C. S., and Hickman, J. A. The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. Cancer Res., 58: 5453-5465, 1998.
39. Pritchard, D. M., Jackman, A., Potten, C. S., and Hickman, J. A. Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity. Toxicol. Lett., 102-103: 19-27, 1998.
40. Anderson, C. N., and Tolkovsky, A. M. A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside. J. Neurosci., 19: 664-673, 1999.
41. Kadol, S., Juang, J., and Wu, T. C. In Situ Hybridization in Cancer and Normal Tissue. Totowa, NJ: Humana Press, in press, 2002.
42. El-Deiry, W. S., Tokino, T., Waldman, T., Oliner, J. D., Velculescu, V. E., Burrell, M., Hill, D. E., Healy, E., Rees, J. L., Hamilton, S. R., et al. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res., 55: 2910-2919, 1995.
43. Li, H., Zhu, H., Xu, C. J., and Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94: 491-501, 1998.
44. Hutchinson, F. Chemical changes induced in DNA by ionizing radiation. Prog. Nucleic Acid Res. Mol. Biol., 32: 115-154, 1985.
45. Ward, J. F. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability. Prog. Nucleic Acid Res. Mol. Biol., 35: 95-125, 1988.
46. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA, 89: 7491-7495, 1992.
47. 2 phase of the cell cycle. Radiat. Res., 150: S52-S59, 1998.
48. Kondo, S. Apoptotic repair of genotoxic tissue damage and the role of p53 gene. Mutat. Res., 402: 311-319, 1998.
49. Midgley, C. A., Owens, B., Briscoe, C. V., Thomas, D. B., Lane, D. P., and Hall, P. A. Coupling between γ irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J. Cell Sci., 108(Pt 5): 1843-1848, 1995.
50. Arai, T., Kida, Y., Harmon, B. V., and Gobe, G. C. Comparative alterations in p53 expression and apoptosis in the irradiated rat small and large intestine. Br. J. Cancer, 74: 406-412, 1996.
51. Soengas, M. S., Alarcon, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W., and Lowe, S. W. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (Wash. DC), 284: 156-159, 1999.
52. Knudson, C. M., Tung, K. S., Tourtellotte, W. G., Brown, G. A., and Korsmeyer, S. J. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (Wash. DC), 270: 96-99, 1995.
53. Potten, C. S., Kellett, M., Rew, D. A., and Roberts, S. A. Proliferation in human gastrointestinal epithelium using bromodeoxyuridine in vivo: Data for different sites, proximity to a tumour, and polyposis coli. Gut, 33: 524-529, 1992.
54. Merritt, A. J., Potten, C. S., Watson, A. J., Loh, D. Y., Nakayama, K., and Hickman, J. A. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J. Cell Sci., 108(Pt. 6): 2261-2271, 1995.
55. Shewach, D. S., and Lawrence, T. S. Radiosensitization of human solid tumor cell lines with gemcitabine. Semin. Oncol., 23: 65-71, 1996.
56. Oren, M., and Prives, C. p53: Upstream, downstream, and off stream. Review of the 8th p53 workshop (Dundee, July 5-9, 1996). Biochim. Biophys. Acta, 1288: R13-R19, 1996.
57. Polyak, K., Waldman, T., He, T. C., Kinzler, K. W., and Vogelstein, B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev., 10: 1945-1952, 1996.
58. 1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage. Oncogene, 16: 3461-3469, 1998.
59. MacLachlan, T. K., Takimoto, R., and El-Deiry, W. S. BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. Mol. Cell. Biol., 22: 4280-4292, 2002.
60. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
61. McCurrach, M. E., Connor, T. M., Knudson, C. M., Korsmeyer, S. J., and Lowe, S. W. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA 94: 2345-2349, 1997.
62. Alsner, J., Sorensen, S. B., and Overgaard, J. TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck. Radiother. Oncol., 59: 179-185, 2001.
63. Mohiuddin, M., Chendil, D., Dey, S., Alcock, R. A., Regine, W., and Ahmed, M. M. Influence of p53 status on radiation and 5-fluorouracil synergy in pancreatic cancer cells. Anticancer Res., 22: 825-830, 2002.
64. Smith, M. L., and Fornace, A. J., Jr. Genomic instability and the role of p53 mutations in cancer cells. Curr. Opin. Oncol., 7: 69-75, 1995.