Differentiating human stem cells into neurons and glial cells for neural repair

Frontiers in Bioscience

Volumn 17, Issue 1, 2012, Pages 65-89

  Selvaraj, Vimal ^a   Jiang, Peng ^b   Chechneva, Olga ^b   Lo, U Ging ^b   Deng, Wenbin ^b,c  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN NORTHERN CALIFORNIA   (United States)

Author keywords

Amyotrophic Lateral Sclerosis; Astrocytes; Cell Therapy; Differentiation; IPS cells; Microglia; Multiple Sclerosis; Neural Progenitors; Neurons; Oligodendrocytes; Parkinson's Disease; Review; Spinal Cord Injury; Stem cells; Stroke

Indexed keywords

ANIMALIA;

EID: 84860350412     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3916     Document Type: Article

References (286)

1. A Kriegstein and A Alvarez-Buylla: The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32, 149-84 (2009)
2. A Alvarez-Buylla, M Kohwi, TM Nguyen and FT Merkle: The heterogeneity of adult neural stem cells and the emerging complexity of their niche. Cold Spring Harb Symp Quant Biol 73, 357-65 (2008)
3. FT Merkle, AD Tramontin, JM Garcia-Verdugo and A Alvarez-Buylla: Radial glia give rise to adult neural stem cells in the subventricular zone. Proc Natl Acad Sci U S A 101, 17528-32 (2004) (Pubitemid 39657437)
4. TE Anthony, C Klein, G Fishell and N Heintz: Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41, 881-90 (2004) (Pubitemid 38429732)
5. SC Noctor, V Martinez-Cerdeno, L Ivic and AR Kriegstein: Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nat Neurosci 7, 136-44 (2004) (Pubitemid 38129789)
6. A Gritti, L Bonfanti, F Doetsch, I Caille, A Alvarez-Buylla, DA Lim, R Galli, JM Verdugo, DG Herrera and AL Vescovi: Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. J Neurosci 22, 437-45 (2002) (Pubitemid 34049081)
7. Z Liu and LJ Martin: Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human. J Comp Neurol 459, 368-91 (2003) (Pubitemid 36438286)
8. MA Hack, A Saghatelyan, A de Chevigny, A Pfeifer, R Ashery-Padan, PM Lledo and M Gotz: Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci 8, 865-72 (2005)
9. B Nait-Oumesmar, L Decker, F Lachapelle, V Avellana-Adalid, C Bachelin and AB Van Evercooren: Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination. Eur J Neurosci 11, 4357-66 (1999) (Pubitemid 30009267)
10. N Picard-Riera, L Decker, C Delarasse, K Goude, B Nait-Oumesmar, R Liblau, D Pham-Dinh and AB Evercooren: Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc Natl Acad Sci U S A 99, 13211-6 (2002)
11. B Menn, JM Garcia-Verdugo, C Yaschine, O Gonzalez-Perez, D Rowitch and A Alvarez-Buylla: Origin of oligodendrocytes in the subventricular zone of the adult brain. J Neurosci 26, 7907-18 (2006) (Pubitemid 44315160)
12. MJ Perlow, WJ Freed, BJ Hoffer, A Seiger, L Olson and RJ Wyatt: Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204, 643-7 (1979) (Pubitemid 9221523)
13. N Sunde, S Laurberg and J Zimmer: Brain grafts can restore irradiation-damaged neuronal connections in newborn rats. Nature 310, 51-3 (1984) (Pubitemid 14077859)
14. RD Lund and SD Hauschka: Transplanted neural tissue develops connections with host rat brain. Science 193, 582-4 (1976)
15. A Bjorklund and U Stenevi: Experimental reinnervation of the rat hippocampus by grafted sympathetic ganglia. I. Axonal regeneration along the hippocampal fimbria. Brain Res 138, 259-70 (1977) (Pubitemid 8233600)
16. LG Nygren, L Olson and A Seiger: Mnoaminergic reinnervation of the transected spinal cord by homologous fetal brain grafts. Brain Res 129, 227-35 (1977) (Pubitemid 8129825)
17. MM Oblinger, BH Hallas and GD Das: Neocortical transplants in the cerebellum of the rat: their afferents and efferents. Brain Res 189, 228-32 (1980) (Pubitemid 10146495)
18. F Haun and TJ Cunningham: Cortical transplants reveal CNS trophic interactions in situ. Brain Res 317, 290-4 (1984) (Pubitemid 14060857)
19. JA Thomson, J Itskovitz-Eldor, SS Shapiro, MA Waknitz, JJ Swiergiel, VS Marshall and JM Jones: Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-7 (1998) (Pubitemid 28516247)
20. GJ Spangrude, S Heimfeld and IL Weissman: Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62 (1988)
21. Y Jiang, BN Jahagirdar, RL Reinhardt, RE Schwartz, CD Keene, XR Ortiz-Gonzalez, M Reyes, T Lenvik, T Lund, M Blackstad, J Du, S Aldrich, A Lisberg, WC Low, DA Largaespada and CM Verfaillie: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41-9 (2002) (Pubitemid 34742565)
22. SH Oh, HM Hatch and BE Petersen: Hepatic oval 'stem' cell in liver regeneration. Semin Cell Dev Biol 13, 405-9 (2002) (Pubitemid 36027144)
23. FH Gage: Mammalian neural stem cells. Science 287, 1433-8 (2000) (Pubitemid 30127128)
24. S Temple: The development of neural stem cells. Nature 414, 112-7 (2001) (Pubitemid 33041635)
25. JG Toma, M Akhavan, KJ Fernandes, F Barnabe-Heider, A Sadikot, DR Kaplan and FD Miller: Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3, 778-84 (2001) (Pubitemid 32842682)
26. T Tumbar, G Guasch, V Greco, C Blanpain, WE Lowry, M Rendl and E Fuchs: Defining the epithelial stem cell niche in skin. Science 303, 359-63 (2004) (Pubitemid 38095773)
27. X Shi and DJ Garry: Muscle stem cells in development, regeneration, and disease. Genes Dev 20, 1692-708 (2006) (Pubitemid 43992877)
28. PA Zuk, M Zhu, P Ashjian, DA De Ugarte, JI Huang, H Mizuno, ZC Alfonso, JK Fraser, P Benhaim and MH Hedrick: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13, 4279-95 (2002) (Pubitemid 35471185)
29. S Conrad, M Renninger, J Hennenlotter, T Wiesner, L Just, M Bonin, W Aicher, HJ Buhring, U Mattheus, A Mack, HJ Wagner, S Minger, M Matzkies, M Reppel, J Hescheler, KD Sievert, A Stenzl and T Skutella: Generation of pluripotent stem cells from adult human testis. Nature 456, 344-9 (2008)
30. L Simon, GC Ekman, N Kostereva, Z Zhang, RA Hess, MC Hofmann and PS Cooke: Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells 27, 1666-75 (2009)
31. N Golestaneh, M Kokkinaki, D Pant, J Jiang, D DeStefano, C Fernandez-Bueno, JD Rone, BR Haddad, GI Gallicano and M Dym: Pluripotent stem cells derived from adult human testes. Stem Cells Dev 18, 1115-26 (2009)
32. D Bryder, DJ Rossi and IL Weissman: Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol 169, 338-46 (2006) (Pubitemid 44156296)
33. MF Pittenger, AM Mackay, SC Beck, RK Jaiswal, R Douglas, JD Mosca, MA Moorman, DW Simonetti, S Craig and DR Marshak: Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-7 (1999) (Pubitemid 29282067)
34. M Krampera, G Pizzolo, G Aprili and M Franchini: Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair. Bone 39, 678-83 (2006) (Pubitemid 44311724)
35. EJ Gang, D Bosnakovski, CA Figueiredo, JW Visser and RC Perlingeiro: SSEA-4 identifies mesenchymal stem cells from bone marrow. Blood 109, 1743-51 (2007) (Pubitemid 46239610)
36. HE Broxmeyer, GW Douglas, G Hangoc, S Cooper, J Bard, D English, M Arny, L Thomas and EA Boyse: Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 86, 3828-32 (1989) (Pubitemid 19141838)
37. EM Horwitz, DJ Prockop, LA Fitzpatrick, WW Koo, PL Gordon, M Neel, M Sussman, P Orchard, JC Marx, RE Pyeritz and MK Brenner: Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5, 309-13 (1999) (Pubitemid 29124367)
38. R Quarto, M Mastrogiacomo, R Cancedda, SM Kutepov, V Mukhachev, A Lavroukov, E Kon and M Marcacci: Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344, 385-6 (2001) (Pubitemid 32107654)
39. EM Horwitz, DJ Prockop, PL Gordon, WW Koo, LA Fitzpatrick, MD Neel, ME McCarville, PJ Orchard, RE Pyeritz and MK Brenner: Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 97, 1227-31 (2001) (Pubitemid 32183743)
40. K Le Blanc, C Gotherstrom, O Ringden, M Hassan, R McMahon, E Horwitz, G Anneren, O Axelsson, J Nunn, U Ewald, S Norden-Lindeberg, M Jansson, A Dalton, E Astrom and M Westgren: Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta. Transplantation 79, 1607-14 (2005) (Pubitemid 40847594)
41. TR Brazelton, FM Rossi, GI Keshet and HM Blau: From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775-9 (2000) (Pubitemid 32004810)
42. E Mezey, KJ Chandross, G Harta, RA Maki and SR McKercher: Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779-82 (2000) (Pubitemid 32004811)
43. JJ Ross and CM Verfaillie: Evaluation of neural plasticity in adult stem cells. Philos Trans R Soc Lond B Biol Sci 363, 199-205 (2008) (Pubitemid 350174573)
44. BE Reubinoff, P Itsykson, T Turetsky, MF Pera, E Reinhartz, A Itzik and T Ben-Hur: Neural progenitors from human embryonic stem cells. Nat Biotechnol 19, 1134-40 (2001) (Pubitemid 33115699)
45. V Tabar, G Panagiotakos, ED Greenberg, BK Chan, M Sadelain, PH Gutin and L Studer: Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain. Nat Biotechnol 23, 601-6 (2005) (Pubitemid 41724899)
46. P Jiang, V Selvaraj and W Deng: Differentiation of embryonic stem cells into oligodendrocyte precursors. J Vis Exp 39 (2010)
47. I Kehat, L Khimovich, O Caspi, A Gepstein, R Shofti, G Arbel, I Huber, J Satin, J Itskovitz-Eldor and L Gepstein: Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22, 1282-9 (2004) (Pubitemid 39341201)
48. JQ He, Y Ma, Y Lee, JA Thomson and TJ Kamp: Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res 93, 32-9 (2003) (Pubitemid 36859038)
49. K Chadwick, L Wang, L Li, P Menendez, B Murdoch, A Rouleau and M Bhatia: Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 102, 906-15 (2003) (Pubitemid 36917782)
50. AL Olsen, DL Stachura and MJ Weiss: Designer blood: creating hematopoietic lineages from embryonic stem cells. Blood 107, 1265-75 (2006) (Pubitemid 43242358)
51. S Sinha, BR Wamhoff, MH Hoofnagle, J Thomas, RL Neppl, T Deering, BP Helmke, DK Bowles, AV Somlyo and GK Owens: Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells. Stem Cells 24, 1678-88 (2006) (Pubitemid 44474181)
52. S Assady, G Maor, M Amit, J Itskovitz-Eldor, KL Skorecki and M Tzukerman: Insulin production by human embryonic stem cells. Diabetes 50, 1691-7 (2001) (Pubitemid 33641584)
53. KA D'Amour, AG Bang, S Eliazer, OG Kelly, AD Agulnick, NG Smart, MA Moorman, E Kroon, MK Carpenter and EE Baetge: Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24, 1392-401 (2006) (Pubitemid 44722103)
54. S Levenberg, JS Golub, M Amit, J Itskovitz-Eldor and R Langer: Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 99, 4391-6 (2002) (Pubitemid 34285995)
55. VL Bautch: Embryonic stem cell differentiation and the vascular lineage. Methods Mol Biol 185, 117-25 (2002)
56. JL Tremoleda, NR Forsyth, NS Khan, D Wojtacha, I Christodoulou, BJ Tye, SN Racey, S Collishaw, V Sottile, AJ Thomson, AH Simpson, BS Noble and J McWhir: Bone tissue formation from human embryonic stem cells in vivo. Cloning Stem Cells 10, 119-32 (2008)
57. V Sottile, A Thomson and J McWhir: In vitro osteogenic differentiation of human ES cells. Cloning Stem Cells 5, 149-55 (2003) (Pubitemid 36877165)
58. H Shirahashi, J Wu, N Yamamoto, A Catana, H Wege, B Wager, K Okita and MA Zern: Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplant 13, 197-211 (2004) (Pubitemid 38620961)
59. M Gropp, P Itsykson, O Singer, T Ben-Hur, E Reinhartz, E Galun and BE Reubinoff: Stable genetic modification of human embryonic stem cells by lentiviral vectors. Mol Ther 7, 281-7 (2003) (Pubitemid 36395364)
60. AS Daar and L Sheremeta: The science of stem cells: ethical, legal and social issues. Exp Clin Transplant 1, 139-46 (2003)
61. M Drukker, G Katz, A Urbach, M Schuldiner, G Markel, J Itskovitz-Eldor, B Reubinoff, O Mandelboim and N Benvenisty: Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U S A 99, 9864-9 (2002) (Pubitemid 34831138)
62. M Drukker and N Benvenisty: The immunogenicity of human embryonic stem-derived cells. Trends Biotechnol 22, 136-41 (2004) (Pubitemid 38230392)
63. T Fujikawa, SH Oh, L Pi, HM Hatch, T Shupe and BE Petersen: Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cellderived insulin-producing cells. Am J Pathol 166, 1781-91 (2005) (Pubitemid 40734401)
64. SA Przyborski: Differentiation of human embryonic stem cells after transplantation in immune-deficient mice. Stem Cells 23, 1242-50 (2005) (Pubitemid 41504912)
65. NS Roy, C Cleren, SK Singh, L Yang, MF Beal and SA Goldman: Functional engraftment of human ES cellderived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 12, 1259-68 (2006) (Pubitemid 44706928)
66. T Sasazuki, T Juji, Y Morishima, N Kinukawa, H Kashiwabara, H Inoko, T Yoshida, A Kimura, T Akaza, N Kamikawaji, Y Kodera and F Takaku: Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl J Med 339, 1177-85 (1998) (Pubitemid 28482126)
67. CJ Taylor, EM Bolton, S Pocock, LD Sharples, RA Pedersen and JA Bradley: Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 366, 2019-25 (2005) (Pubitemid 41773377)
68. K Takahashi and S Yamanaka: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-76 (2006) (Pubitemid 44233629)
69. K Takahashi, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda and S Yamanaka: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-72 (2007) (Pubitemid 350138099)
70. J Yu, MA Vodyanik, K Smuga-Otto, J Antosiewicz-Bourget, JL Frane, S Tian, J Nie, GA Jonsdottir, V Ruotti, R Stewart, Slukvin, II and JA Thomson: Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-20 (2007)
71. K Okita, M Nakagawa, H Hyenjong, T Ichisaka and S Yamanaka: Generation of mouse induced pluripotent stem cells without viral vectors. Science 322, 949-53 (2008)
72. M Stadtfeld, M Nagaya, J Utikal, G Weir and K Hochedlinger: Induced pluripotent stem cells generated without viral integration. Science 322, 945-9 (2008)
73. K Woltjen, IP Michael, P Mohseni, R Desai, M Mileikovsky, R Hamalainen, R Cowling, W Wang, P Liu, M Gertsenstein, K Kaji, HK Sung and A Nagy: piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458, 766-70 (2009)
74. H Zhou, S Wu, JY Joo, S Zhu, DW Han, T Lin, S Trauger, G Bien, S Yao, Y Zhu, G Siuzdak, HR Scholer, L Duan and S Ding: Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4, 381-4 (2009)
75. M Stadtfeld, E Apostolou, H Akutsu, A Fukuda, P Follett, S Natesan, T Kono, T Shioda and K Hochedlinger: Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 465, 175-81 (2010)
76. S Gajovic, L St-Onge, Y Yokota and P Gruss: Retinoic acid mediates Pax6 expression during in vitro differentiation of embryonic stem cells. Differentiation 62, 187-92 (1997)
77. Y Okada, T Shimazaki, G Sobue and H Okano: Retinoic-acid-concentration- dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells. Dev Biol 275, 124-42 (2004) (Pubitemid 39302616)
78. M Kawamorita, C Suzuki, G Saito, T Sato and K Sato: In vitro differentiation of mouse embryonic stem cells after activation by retinoic acid. Hum Cell 15, 178-82 (2002)
79. XJ Li, ZW Du, ED Zarnowska, M Pankratz, LO Hansen, RA Pearce and SC Zhang: Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 23, 215-21 (2005) (Pubitemid 40255332)
80. MF Pera, J Andrade, S Houssami, B Reubinoff, A Trounson, EG Stanley, D Ward-van Oostwaard and C Mummery: Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci 117, 1269-80 (2004) (Pubitemid 38456107)
81. SM Chambers, CA Fasano, EP Papapetrou, M Tomishima, M Sadelain and L Studer: Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 27, 275-80 (2009)
82. J Itskovitz-Eldor, M Schuldiner, D Karsenti, A Eden, O Yanuka, M Amit, H Soreq and N Benvenisty: Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med 6, 88-95 (2000)
83. S Levenberg, NF Huang, E Lavik, AB Rogers, J Itskovitz-Eldor and R Langer: Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A 100, 12741-6 (2003) (Pubitemid 37339969)
84. P Itsykson, N Ilouz, T Turetsky, RS Goldstein, MF Pera, I Fishbein, M Segal and BE Reubinoff: Derivation of neural precursors from human embryonic stem cells in the presence of noggin. Mol Cell Neurosci 30, 24-36 (2005) (Pubitemid 41133337)
85. H Baharvand, NZ Mehrjardi, M Hatami, S Kiani, M Rao and MM Haghighi: Neural differentiation from human embryonic stem cells in a defined adherent culture condition. Int J Dev Biol 51, 371-8 (2007) (Pubitemid 47320209)
86. L Gerrard, L Rodgers and W Cui: Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. Stem Cells 23, 1234-41 (2005) (Pubitemid 41504911)
87. H Kawasaki, H Suemori, K Mizuseki, K Watanabe, F Urano, H Ichinose, M Haruta, M Takahashi, K Yoshikawa, S Nishikawa, N Nakatsuji and Y Sasai: Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A 99, 1580-5 (2002) (Pubitemid 34136535)
88. H Lee, GA Shamy, Y Elkabetz, CM Schofield, NL Harrsion, G Panagiotakos, ND Socci, V Tabar and L Studer: Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 25, 1931-9 (2007) (Pubitemid 47258171)
89. CH Park, YK Minn, JY Lee, DH Choi, MY Chang, JW Shim, JY Ko, HC Koh, MJ Kang, JS Kang, DJ Rhie, YS Lee, H Son, SY Moon, KS Kim and SH Lee: In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neurons. J Neurochem 92, 1265-76 (2005) (Pubitemid 40344315)
90. AL Perrier, V Tabar, T Barberi, ME Rubio, J Bruses, N Topf, NL Harrison and L Studer: Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A 101, 12543-8 (2004) (Pubitemid 39122060)
91. M Ideguchi, TD Palmer, LD Recht and JM Weimann: Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J Neurosci 30, 894-904 (2010)
92. J Sanchez-Ramos, S Song, F Cardozo-Pelaez, C Hazzi, T Stedeford, A Willing, TB Freeman, S Saporta, W Janssen, N Patel, DR Cooper and PR Sanberg: Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 164, 247-56 (2000) (Pubitemid 32008970)
93. JR Sanchez-Ramos: Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res 69, 880-93 (2002) (Pubitemid 34984705)
94. D Woodbury, EJ Schwarz, DJ Prockop and IB Black: Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61, 364-70 (2000) (Pubitemid 30620221)
95. A Joannides, P Gaughwin, C Schwiening, H Majed, J Sterling, A Compston and S Chandran: Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells. Lancet 364, 172-8 (2004) (Pubitemid 38891689)
96. KM Safford, SD Safford, JM Gimble, AK Shetty and HE Rice: Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. Exp Neurol 187, 319-28 (2004) (Pubitemid 38610278)
97. SC Zhang, M Wernig, ID Duncan, O Brustle and JA Thomson: In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 19, 1129-33 (2001) (Pubitemid 33115698)
98. MT Pankratz, XJ Li, TM Lavaute, EA Lyons, X Chen and SC Zhang: Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells 25, 1511-20 (2007) (Pubitemid 47106020)
99. M Bibikova, E Chudin, B Wu, L Zhou, EW Garcia, Y Liu, S Shin, TW Plaia, JM Auerbach, DE Arking, R Gonzalez, J Crook, B Davidson, TC Schulz, A Robins, A Khanna, P Sartipy, J Hyllner, P Vanguri, S Savant-Bhonsale, AK Smith, A Chakravarti, A Maitra, M Rao, DL Barker, JF Loring and JB Fan: Human embryonic stem cells have a unique epigenetic signature. Genome Res 16, 1075-83 (2006) (Pubitemid 44320394)
100. L Iacovitti, AE Donaldson, CE Marshall, S Suon and M Yang: A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo. Brain Res 1127, 19-25 (2007) (Pubitemid 44856720)
101. G Lee, H Kim, Y Elkabetz, G Al Shamy, G Panagiotakos, T Barberi, V Tabar and L Studer: Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol 25, 1468-75 (2007) (Pubitemid 350233140)
102. TC Schulz, SA Noggle, GM Palmarini, DA Weiler, IG Lyons, KA Pensa, AC Meedeniya, BP Davidson, NA Lambert and BG Condie: Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture. Stem Cells 22, 1218-38 (2004) (Pubitemid 39636400)
103. JH Kim, JM Auerbach, JA Rodriguez-Gomez, I Velasco, D Gavin, N Lumelsky, SH Lee, J Nguyen, R Sanchez-Pernaute, K Bankiewicz and R McKay: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418, 50-6 (2002) (Pubitemid 34742566)
104. SH Lee, N Lumelsky, L Studer, JM Auerbach and RD McKay: Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18, 675-9 (2000) (Pubitemid 30415305)
105. PH Schwartz, DJ Brick, AE Stover, JF Loring and FJ Muller: Differentiation of neural lineage cells from human pluripotent stem cells. Methods 45, 142-58 (2008) (Pubitemid 351885361)
106. Y Elkabetz, G Panagiotakos, G Al Shamy, ND Socci, V Tabar and L Studer: Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev 22, 152-65 (2008)
107. BY Hu, ZW Du, XJ Li, M Ayala and SC Zhang: Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development 136, 1443-52 (2009)
108. TM Jessell: Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 1, 20-9 (2000)
109. Y Elkabetz and L Studer: Human ESC-derived neural rosettes and neural stem cell progression. Cold Spring Harb Symp Quant Biol 73, 377-87 (2008)
110. BY Hu, ZW Du and SC Zhang: Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc 4, 1614-22 (2009)
111. BY Hu and SC Zhang: Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc 4, 1295-304 (2009)
112. Y Yan, D Yang, ED Zarnowska, Z Du, B Werbel, C Valliere, RA Pearce, JA Thomson and SC Zhang: Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23, 781-90 (2005) (Pubitemid 40791793)
113. SC Zhang: Neural subtype specification from embryonic stem cells. Brain Pathol 16, 132-42 (2006)
114. C Guo, HY Qiu, M Shi, Y Huang, RL Johnson, M Rubinstein, SD Chen and YQ Ding: Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. J Neurosci 28, 14097-106 (2008)
115. MP Smidt, SM Smits, H Bouwmeester, FP Hamers, AJ van der Linden, AJ Hellemons, J Graw and JP Burbach: Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development 131, 1145-55 (2004) (Pubitemid 38380467)
116. JR Jorgensen, B Juliusson, KF Henriksen, C Hansen, S Knudsen, TN Petersen, N Blom, A Seiger and LU Wahlberg: Identification of novel genes regulated in the developing human ventral mesencephalon. Exp Neurol 198, 427-37 (2006)
117. AL Ferri, W Lin, YE Mavromatakis, JC Wang, H Sasaki, JA Whitsett and SL Ang: Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development 134, 2761-9 (2007) (Pubitemid 47307232)
118. SL Ang: Transcriptional control of midbrain dopaminergic neuron development. Development 133, 3499-506 (2006)
119. HH Simon, H Saueressig, W Wurst, MD Goulding and DD O'Leary: Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J Neurosci 21, 3126-34 (2001) (Pubitemid 32323494)
120. S Kaufman: Tyrosine hydroxylase. Adv Enzymol Relat Areas Mol Biol 70, 103-220 (1995) (Pubitemid 3022806)
121. W Tao and E Lai: Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron 8, 957-66 (1992)
122. W Wurst and L Bally-Cuif: Neural plate patterning: upstream and downstream of the isthmic organizer. Nat Rev Neurosci 2, 99-108 (2001) (Pubitemid 33673364)
123. CM Gall, SH Hendry, KB Seroogy, EG Jones and JW Haycock: Evidence for coexistence of GABA and dopamine in neurons of the rat olfactory bulb. J Comp Neurol 266, 307-18 (1987) (Pubitemid 18009360)
124. T Kosaka, K Kosaka, Y Hataguchi, I Nagatsu, JY Wu, OP Ottersen, J Storm-Mathisen and K Hama: Catecholaminergic neurons containing GABA-like and/or glutamic acid decarboxylase-like immunoreactivities in various brain regions of the rat. Exp Brain Res 66, 191-210 (1987) (Pubitemid 17039286)
125. M Denham and M Dottori: Signals involved in neural differentiation of human embryonic stem cells. Neurosignals 17, 234-41 (2009)
126. MS Cho, DY Hwang and DW Kim: Efficient derivation of functional dopaminergic neurons from human embryonic stem cells on a large scale. Nat Protoc 3, 1888-94 (2008)
127. E Roussa and K Krieglstein: Induction and specification of midbrain dopaminergic cells: focus on SHH, FGF8, and TGF-beta. Cell Tissue Res 318, 23-33 (2004) (Pubitemid 39362624)
128. CE Chamberlain, J Jeong, C Guo, BL Allen and AP McMahon: Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development 135, 1097-106 (2008) (Pubitemid 351578138)
129. H Nakamura, T Sato and A Suzuki-Hirano: Isthmus organizer for mesencephalon and metencephalon. Dev Growth Differ 50 Suppl 1, S113-8 (2008) (Pubitemid 351725094)
130. L Lillien and H Raphael: BMP and FGF regulate the development of EGF-responsive neural progenitor cells. Development 127, 4993-5005 (2000)
131. A Liu and AL Joyner: Early anterior/posterior patterning of the midbrain and cerebellum. Annu Rev Neurosci 24, 869-96 (2001) (Pubitemid 32695247)
132. TC Schulz, GM Palmarini, SA Noggle, DA Weiler, MM Mitalipova and BG Condie: Directed neuronal differentiation of human embryonic stem cells. BMC Neurosci 4, 27 (2003)
133. KC Sonntag, J Pruszak, T Yoshizaki, J van Arensbergen, R Sanchez-Pernaute and O Isacson: Enhanced yield of neuroepithelial precursors and midbrainlike dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells 25, 411-8 (2007) (Pubitemid 46232796)
134. M Dezawa, H Kanno, M Hoshino, H Cho, N Matsumoto, Y Itokazu, N Tajima, H Yamada, H Sawada, H Ishikawa, T Mimura, M Kitada, Y Suzuki and C Ide: Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 113, 1701-10 (2004) (Pubitemid 39071662)
135. YS Fu, YC Cheng, MY Lin, H Cheng, PM Chu, SC Chou, YH Shih, MH Ko and MS Sung: Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells 24, 115-24 (2006)
136. WD Richardson, HK Smith, T Sun, NP Pringle, A Hall and R Woodruff: Oligodendrocyte lineage and the motor neuron connection. Glia 29, 136-42 (2000) (Pubitemid 30044507)
137. KL Ligon, SP Fancy, RJ Franklin and DH Rowitch: Olig gene function in CNS development and disease. Glia 54, 1-10 (2006) (Pubitemid 43980029)
138. NP Pringle, WP Yu, S Guthrie, H Roelink, A Lumsden, AC Peterson and WD Richardson: Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol 177, 30-42 (1996) (Pubitemid 26252478)
139. UM Lim, KS Sidhu and BE Tuch: Derivation of Motor Neurons from three Clonal Human Embryonic Stem Cell Lines. Curr Neurovasc Res 3, 281-8 (2006) (Pubitemid 44706252)
140. XJ Li, BY Hu, SA Jones, YS Zhang, T Lavaute, ZW Du and SC Zhang: Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 26, 886-93 (2008)
141. S Karumbayaram, BG Novitch, M Patterson, JA Umbach, L Richter, A Lindgren, AE Conway, AT Clark, SA Goldman, K Plath, M Wiedau-Pazos, HI Kornblum and WE Lowry: Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 27, 806-11 (2009)
142. N Baumann and D Pham-Dinh: Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81, 871-927 (2001) (Pubitemid 32267079)
143. H Xue, S Wu, ST Papadeas, S Spusta, AM Swistowska, CC MacArthur, MP Mattson, NJ Maragakis, MR Capecchi, MS Rao, X Zeng and Y Liu: A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells 27, 1836-46 (2009)
144. GI Nistor, MO Totoiu, N Haque, MK Carpenter and HS Keirstead: Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 49, 385-96 (2005) (Pubitemid 40222916)
145. SM Kang, MS Cho, H Seo, CJ Yoon, SK Oh, YM Choi and DW Kim: Efficient induction of oligodendrocytes from human embryonic stem cells. Stem Cells 25, 419-24 (2007)
146. M Izrael, P Zhang, R Kaufman, V Shinder, R Ella, M Amit, J Itskovitz-Eldor, J Chebath and M Revel: Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci 34, 310-23 (2007) (Pubitemid 46330036)
147. JE Gil, DH Woo, JH Shim, SE Kim, HJ You, SH Park, SH Paek, SK Kim and JH Kim: Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. FEBS Lett 583, 561-7 (2009)
148. L Buzanska, EK Machaj, B Zablocka, Z Pojda and K Domanska-Janik: Human cord blood-derived cells attain neuronal and glial features in vitro. J Cell Sci 115, 2131-8 (2002) (Pubitemid 34746379)
149. VR Dasari, DG Spomar, CS Gondi, CA Sloffer, KL Saving, M Gujrati, JS Rao and DH Dinh: Axonal remyelination by cord blood stem cells after spinal cord injury. J Neurotrauma 24, 391-410 (2007) (Pubitemid 46492159)
150. MS Rao and M Jacobson: Astrocyte development. In: Developmental Neurobiology. Kluwer Academic/Plenum Publishers, New York (2005)
151. RP Skoff: Gliogenesis in rat optic nerve: astrocytes are generated in a single wave before oligodendrocytes. Dev Biol 139, 149-68 (1990)
152. SW Levison and JE Goldman: Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 10, 201-12 (1993) (Pubitemid 23079542)
153. NP Pringle, S Guthrie, A Lumsden and WD Richardson: Dorsal spinal cord neuroepithelium generates astrocytes but not oligodendrocytes. Neuron 20, 883-93 (1998) (Pubitemid 28247394)
154. GE Gray and JR Sanes: Migratory paths and phenotypic choices of clonally related cells in the avian optic tectum. Neuron 6, 211-25 (1991)
155. P Malatesta, E Hartfuss and M Gotz: Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development 127, 5253-63 (2000) (Pubitemid 32049182)
156. SC Noctor, AC Flint, TA Weissman, RS Dammerman and AR Kriegstein: Neurons derived from radial glial cells establish radial units in neocortex. Nature 409, 714-20 (2001) (Pubitemid 32144516)
157. F Doetsch, I Caille, DA Lim, JM Garcia-Verdugo and A Alvarez-Buylla: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-16 (1999) (Pubitemid 29278045)
158. ED Laywell, P Rakic, VG Kukekov, EC Holland and DA Steindler: Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proc Natl Acad Sci U S A 97, 13883-8 (2000)
159. F Doetsch: The glial identity of neural stem cells. Nat Neurosci 6, 1127-34 (2003) (Pubitemid 37346029)
160. A Buffo, I Rite, P Tripathi, A Lepier, D Colak, AP Horn, T Mori and M Gotz: Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci U S A 105, 3581-6 (2008) (Pubitemid 351723595)
161. AM Clement, MD Nguyen, EA Roberts, ML Garcia, S Boillee, M Rule, AP McMahon, W Doucette, D Siwek, RJ Ferrante, RH Brown, Jr., JP Julien, LS Goldstein and DW Cleveland: Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302, 113-7 (2003) (Pubitemid 37210700)
162. A Trounson: The production and directed differentiation of human embryonic stem cells. Endocr Rev 27, 208-19 (2006)
163. DS Lee, K Yu, JY Rho, E Lee, JS Han, DB Koo, YS Cho, J Kim, KK Lee and YM Han: Cyclopamine treatment of human embryonic stem cells followed by culture in human astrocyte medium promotes differentiation into nestin-and GFAP-expressing astrocytic lineage. Life Sci 80, 154-9 (2006) (Pubitemid 44853981)
164. S Wislet-Gendebien, P Leprince, G Moonen and B Rogister: Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells. J Cell Sci 116, 3295-302 (2003) (Pubitemid 37038978)
165. BH Choi: Hematogenous cells in the central nervous system of developing human embryos and fetuses. J Comp Neurol 196, 683-94 (1981) (Pubitemid 11099050)
166. P Rezaie and D Male: Colonisation of the developing human brain and spinal cord by microglia: a review. Microsc Res Tech 45, 359-82 (1999) (Pubitemid 29321051)
167. MA Eglitis and E Mezey: Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci U S A 94, 4080-5 (1997) (Pubitemid 27180502)
168. AR Simard and S Rivest: Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J 18, 998-1000 (2004) (Pubitemid 39561504)
169. WJ Streit and QS Xue: Life and death of microglia. J Neuroimmune Pharmacol 4, 371-9 (2009)
170. M Schwartz, O Butovsky, W Bruck and UK Hanisch: Microglial phenotype: is the commitment reversible? Trends Neurosci 29, 68-74 (2006) (Pubitemid 43202595)
171. TB Yu, YS Cheng, P Zhao, DW Kou, K Sun, BH Chen and AM Wang: Immune therapy with cultured microglia grafting into the injured spinal cord promoting the recovery of rat's hind limb motor function. Chin J Traumatol 12, 291-5 (2009)
172. K Takata, Y Kitamura, D Yanagisawa, S Morikawa, M Morita, T Inubushi, D Tsuchiya, S Chishiro, M Saeki, T Taniguchi, S Shimohama and I Tooyama: Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. FEBS Lett 581, 475-8 (2007) (Pubitemid 46149623)
173. D Narantuya, A Nagai, AM Sheikh, K Wakabayashi, Y Shiota, T Watanabe, J Masuda, S Kobayashi, SU Kim and S Yamaguchi: Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition. Brain Res 1316, 145-52 (2010)
174. T Tsuchiya, KC Park, S Toyonaga, SM Yamada, H Nakabayashi, E Nakai, N Ikawa, M Furuya, A Tominaga and K Shimizu: Characterization of microglia induced from mouse embryonic stem cells and their migration into the brain parenchyma. J Neuroimmunol 160, 210-8 (2005) (Pubitemid 40248611)
175. DN Angelov, S Arnhold, C Andressen, H Grabsch, M Puschmann, J Hescheler and K Addicks: Temporospatial relationships between macroglia and microglia during in vitro differentiation of murine stem cells. Dev Neurosci 20, 42-51 (1998) (Pubitemid 28132704)
176. I Napoli, K Kierdorf and H Neumann: Microglial precursors derived from mouse embryonic stem cells. Glia 57, 1660-71 (2009)
177. SL Rossi and HS Keirstead: Stem cells and spinal cord regeneration. Curr Opin Biotechnol 20, 552-62 (2009)
178. M Ronaghi, S Erceg, V Moreno-Manzano and M Stojkovic: Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells? Stem Cells 28, 93-9 (2009)
179. Q Chen, Y Long, X Yuan, L Zou, J Sun, S Chen, JR Perez-Polo and K Yang: Protective effects of bone marrow stromal cell transplantation in injured rodent brain: synthesis of neurotrophic factors. J Neurosci Res 80, 611-9 (2005) (Pubitemid 40896182)
180. Y Li and G Raisman: Sprouts from cut corticospinal axons persist in the presence of astrocytic scarring in longterm lesions of the adult rat spinal cord. Exp Neurol 134, 102-11 (1995)
181. Y Ke, L Chi, R Xu, C Luo, D Gozal and R Liu: Early response of endogenous adult neural progenitor cells to acute spinal cord injury in mice. Stem Cells 24, 1011-9 (2006) (Pubitemid 44464734)
182. AJ Mothe and CH Tator: Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat. Neuroscience 131, 177-87 (2005) (Pubitemid 40170498)
183. J Silver and JH Miller: Regeneration beyond the glial scar. Nat Rev Neurosci 5, 146-56 (2004) (Pubitemid 38160289)
184. QL Cao, RM Howard, JB Dennison and SR Whittemore: Differentiation of engrafted neuronalrestricted precursor cells is inhibited in the traumatically injured spinal cord. Exp Neurol 177, 349-59 (2002) (Pubitemid 35366125)
185. BJ Cummings, N Uchida, SJ Tamaki and AJ Anderson: Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol Res 28, 474-81 (2006) (Pubitemid 44141313)
186. BJ Cummings, N Uchida, SJ Tamaki, DL Salazar, M Hooshmand, R Summers, FH Gage and AJ Anderson: Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A 102, 14069-74 (2005) (Pubitemid 41377704)
187. M Vroemen, L Aigner, J Winkler and N Weidner: Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways. Eur J Neurosci 18, 743-51 (2003) (Pubitemid 37059685)
188. DJ Webber, EJ Bradbury, SB McMahon and SL Minger: Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med 2, 929-45 (2007)
189. CP Hofstetter, NA Holmstrom, JA Lilja, P Schweinhardt, J Hao, C Spenger, Z Wiesenfeld-Hallin, SN Kurpad, J Frisen and L Olson: Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci 8, 346-53 (2005) (Pubitemid 40300192)
190. T Mitsui, JS Shumsky, AC Lepore, M Murray and I Fischer: Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry. J Neurosci 25, 9624-36 (2005) (Pubitemid 41510903)
191. RP Bunge, MB Bunge and Rish: Electron microscopic study of demyelination in an experimentally induced lesion in adult cat spinal cord. J Biophys Biochem Cytol 7, 685-96 (1960)
192. FM Bareyre: Neuronal repair and replacement in spinal cord injury. J Neurol Sci 265, 63-72 (2008)
193. HS Keirstead, G Nistor, G Bernal, M Totoiu, F Cloutier, K Sharp and O Steward: Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 25, 4694-705 (2005) (Pubitemid 40664118)
194. YW Zhang, J Denham and RS Thies: Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors. Stem Cells Dev 15, 943-52 (2006) (Pubitemid 46147864)
195. DP Ankeny, DM McTigue and LB Jakeman: Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp Neurol 190, 17-31 (2004) (Pubitemid 39335703)
196. D Cizkova, J Rosocha, I Vanicky, S Jergova and M Cizek: Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat. Cell Mol Neurobiol 26, 1167-80 (2006) (Pubitemid 44924038)
197. S Wu, Y Suzuki, Y Ejiri, T Noda, H Bai, M Kitada, K Kataoka, M Ohta, H Chou and C Ide: Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res 72, 343-51 (2003) (Pubitemid 36504703)
198. SH Yoon, YS Shim, YH Park, JK Chung, JH Nam, MO Kim, HC Park, SR Park, BH Min, EY Kim, BH Choi, H Park and Y Ha: Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells 25, 2066-73 (2007) (Pubitemid 47258184)
199. F Callera and RX do Nascimento: Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study. Exp Hematol 34, 130-1 (2006) (Pubitemid 43184317)
200. KK Jain: Cell therapy for CNS trauma. Mol Biotechnol 42, 367-76 (2009)
201. HC Park, YS Shim, Y Ha, SH Yoon, SR Park, BH Choi and HS Park: Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocytemacrophage colony stimulating factor. Tissue Eng 11, 913-22 (2005) (Pubitemid 40960794)
202. J Goolsby, MC Marty, D Heletz, J Chiappelli, G Tashko, D Yarnell, PS Fishman, S Dhib-Jalbut, CT Bever, Jr., B Pessac and D Trisler: Hematopoietic progenitors express neural genes. Proc Natl Acad Sci U S A 100, 14926-31 (2003) (Pubitemid 37517993)
203. GJ del Zoppo, K Poeck, MS Pessin, SM Wolpert, AJ Furlan, A Ferbert, MJ Alberts, JA Zivin, L Wechsler, O Busse and et al.: Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 32, 78-86 (1992)
204. R Dubinsky and SM Lai: Mortality of stroke patients treated with thrombolysis: analysis of nationwide inpatient sample. Neurology 66, 1742-4 (2006) (Pubitemid 43964635)
205. CT Ekdahl, Z Kokaia and O Lindvall: Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience 158, 1021-9 (2009)
206. C Buhnemann, A Scholz, C Bernreuther, CY Malik, H Braun, M Schachner, KG Reymann and M Dihne: Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain 129, 3238-48 (2006) (Pubitemid 44871439)
207. T England, P Martin and PM Bath: Stem cells for enhancing recovery after stroke: a review. Int J Stroke 4, 101-10 (2009)
208. O Lindvall and Z Kokaia: Stem cells in human neurodegenerative disorders-time for clinical translation? J Clin Invest 120, 29-40 (2010)
209. V Darsalia, SJ Allison, C Cusulin, E Monni, D Kuzdas, T Kallur, O Lindvall and Z Kokaia: Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. J Cereb Blood Flow Metab (2010)
210. MM Daadi, AL Maag and GK Steinberg: Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model. PLoS One 3, e1644 (2008)
211. MM Daadi, Z Li, A Arac, BA Grueter, M Sofilos, RC Malenka, JC Wu and GK Steinberg: Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther 17, 1282-91 (2009)
212. S Kelly, TM Bliss, AK Shah, GH Sun, M Ma, WC Foo, J Masel, MA Yenari, IL Weissman, N Uchida, T Palmer and GK Steinberg: Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci U S A 101, 11839-44 (2004) (Pubitemid 39095381)
213. T Kallur, V Darsalia, O Lindvall and Z Kokaia: Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats. J Neurosci Res 84, 1630-44 (2006) (Pubitemid 44892598)
214. M Bacigaluppi, S Pluchino, L Peruzzotti Jametti, E Kilic, U Kilic, G Salani, E Brambilla, MJ West, G Comi, G Martino and DM Hermann: Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain 132, 2239-51 (2009)
215. AL Ho, S Keshavarzi and ML Levy: Exploitation of genetically modified neural stem cells for neurological disease. Adv Exp Med Biol 671, 74-92 (2010)
216. KM Harms, L Li and LA Cunningham: Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1alpha-regulated VEGF signaling. PLoS One 5, e9767 (2010)
217. K Toyama, O Honmou, K Harada, J Suzuki, K Houkin, H Hamada and JD Kocsis: Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia. Exp Neurol 216, 47-55 (2009)
218. H Ohtaki, JH Ylostalo, JE Foraker, AP Robinson, RL Reger, S Shioda and DJ Prockop: Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc Natl Acad Sci U S A 105, 14638-43 (2008)
219. YP Liu, H Seckin, Y Izci, ZW Du, YP Yan and MK Baskaya: Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 29, 780-91 (2009)
220. T Onda, O Honmou, K Harada, K Houkin, H Hamada and JD Kocsis: Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 genemodified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab 28, 329-40 (2008) (Pubitemid 351161284)
221. RH Miller, L Bai, DP Lennon and AI Caplan: The potential of mesenchymal stem cells for neural repair. Discov Med 9, 236-42 (2010)
222. F Locatelli, A Bersano, E Ballabio, S Lanfranconi, D Papadimitriou, S Strazzer, N Bresolin, GP Comi and S Corti: Stem cell therapy in stroke. Cell Mol Life Sci 66, 757-72 (2009)
223. D Kondziolka, L Wechsler, S Goldstein, C Meltzer, KR Thulborn, J Gebel, P Jannetta, S DeCesare, EM Elder, M McGrogan, MA Reitman and L Bynum: Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55, 565-9 (2000) (Pubitemid 30647258)
224. D Kondziolka, GK Steinberg, L Wechsler, CC Meltzer, E Elder, J Gebel, S Decesare, T Jovin, R Zafonte, J Lebowitz, JC Flickinger, D Tong, MP Marks, C Jamieson, D Luu, T Bell-Stephens and J Teraoka: Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg 103, 38-45 (2005) (Pubitemid 43193932)
225. OY Bang, JS Lee, PH Lee and G Lee: Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57, 874-82 (2005) (Pubitemid 40798626)
226. JS Lee, JM Hong, GJ Moon, PH Lee, YH Ahn and OY Bang: A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke. Stem Cells 28, 1099-1106 (2010)
227. SS Rabinovich, VI Seledtsov, NV Banul, OV Poveshchenko, VV Senyukov, SV Astrakov, DM Samarin and VY Taraban: Cell therapy of brain stroke. Bull Exp Biol Med 139, 126-8 (2005)
228. SI Savitz, J Dinsmore, J Wu, GV Henderson, P Stieg and LR Caplan: Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis 20, 101-7 (2005) (Pubitemid 41160209)
229. K Pollock, P Stroemer, S Patel, L Stevanato, A Hope, E Miljan, Z Dong, H Hodges, J Price and JD Sinden: A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke. Exp Neurol 199, 143-55 (2006) (Pubitemid 43959830)
230. P Limousin, P Krack, P Pollak, A Benazzouz, C Ardouin, D Hoffmann and AL Benabid: Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 339, 1105-11 (1998) (Pubitemid 28465758)
231. H Yuan, ZW Zhang, LW Liang, Q Shen, XD Wang, SM Ren, HJ Ma, SJ Jiao and P Liu: Treatment strategies for Parkinson's disease. Neurosci Bull 26, 66-76 (2010)
232. O Lindvall and A Bjorklund: Cell therapy in Parkinson's disease. NeuroRx 1, 382-93 (2004) (Pubitemid 46589366)
233. O Lindvall, S Rehncrona, P Brundin, B Gustavii, B Astedt, H Widner, T Lindholm, A Bjorklund, KL Leenders, JC Rothwell, R Frackowiak, D Marsden, B Johnels, G Steg, R Freedman, BJ Hoffer, A Seiger, M Bygdeman, I Stromberg and L Olson: Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up. Arch Neurol 46, 615-31 (1989) (Pubitemid 19150940)
234. O Lindvall, G Sawle, H Widner, JC Rothwell, A Bjorklund, D Brooks, P Brundin, R Frackowiak, CD Marsden, P Odin and et al.: Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 35, 172-80 (1994) (Pubitemid 24050152)
235. O Lindvall, H Widner, S Rehncrona, P Brundin, P Odin, B Gustavii, R Frackowiak, KL Leenders, G Sawle, JC Rothwell and et al.: Transplantation of fetal dopamine neurons in Parkinson's disease: one-year clinical and neurophysiological observations in two patients with putaminal implants. Ann Neurol 31, 155-65 (1992)
236. CR Freed, RE Breeze, NL Rosenberg, SA Schneck, E Kriek, JX Qi, T Lone, YB Zhang, JA Snyder, TH Wells and et al.: Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N Engl J Med 327, 1549-55 (1992)
237. CR Freed, NL Rosenberg, SA Schneck and RE Breeze: Improved drug responsiveness following fetal tissue implant for Parkinson's disease. Neurochem Int 20 Suppl, 321S-327S (1992)
238. TB Freeman, CW Olanow, RA Hauser, GM Nauert, DA Smith, CV Borlongan, PR Sanberg, DA Holt, JH Kordower, FJ Vingerhoets and et al.: Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol 38, 379-88 (1995)
239. JH Kordower, Y Chu, RA Hauser, TB Freeman and CW Olanow: Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14, 504-6 (2008) (Pubitemid 351655212)
240. JY Li, E Englund, JL Holton, D Soulet, P Hagell, AJ Lees, T Lashley, NP Quinn, S Rehncrona, A Bjorklund, H Widner, T Revesz, O Lindvall and P Brundin: Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 14, 501-3 (2008) (Pubitemid 351655211)
241. CR Freed, PE Greene, RE Breeze, WY Tsai, W DuMouchel, R Kao, S Dillon, H Winfield, S Culver, JQ Trojanowski, D Eidelberg and S Fahn: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344, 710-9 (2001) (Pubitemid 32204988)
242. CW Olanow, CG Goetz, JH Kordower, AJ Stoessl, V Sossi, MF Brin, KM Shannon, GM Nauert, DP Perl, J Godbold and TB Freeman: A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 54, 403-14 (2003) (Pubitemid 37072046)
243. CW Olanow, K Kieburtz and AH Schapira: Why have we failed to achieve neuroprotection in Parkinson's disease? Ann Neurol 64 Suppl 2, S101-10 (2008)
244. DR Rosen, T Siddique, D Patterson, DA Figlewicz, P Sapp, A Hentati, D Donaldson, J Goto, JP O'Regan, HX Deng and et al.: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62 (1993) (Pubitemid 23087289)
245. K Yamanaka, SJ Chun, S Boillee, N Fujimori-Tonou, H Yamashita, DH Gutmann, R Takahashi, H Misawa and DW Cleveland: Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11, 251-3 (2008) (Pubitemid 351311795)
246. JM Harper, C Krishnan, JS Darman, DM Deshpande, S Peck, I Shats, S Backovic, JD Rothstein and DA Kerr: Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc Natl Acad Sci U S A 101, 7123-8 (2004) (Pubitemid 38596453)
247. DM Deshpande, YS Kim, T Martinez, J Carmen, S Dike, I Shats, LL Rubin, J Drummond, C Krishnan, A Hoke, N Maragakis, J Shefner, JD Rothstein and DA Kerr: Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol 60, 32-44 (2006)
248. H Wichterle, I Lieberam, JA Porter and TM Jessell: Directed differentiation of embryonic stem cells into motor neurons. Cell 110, 385-97 (2002)
249. P Soundararajan, GB Miles, LL Rubin, RM Brownstone and VF Rafuse: Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J Neurosci 26, 3256-68 (2006)
250. AC Lepore, B Rauck, C Dejea, AC Pardo, MS Rao, JD Rothstein and NJ Maragakis: Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci 11, 1294-301 (2008)
251. DH Hwang, HJ Lee, IH Park, JI Seok, BG Kim, IS Joo and SU Kim: Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther 16, 1234-44 (2009)
252. DA Kerr, J Llado, MJ Shamblott, NJ Maragakis, DN Irani, TO Crawford, C Krishnan, S Dike, JD Gearhart and JD Rothstein: Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. J Neurosci 23, 5131-40 (2003) (Pubitemid 36793241)
253. SH Appel, JI Engelhardt, JS Henkel, L Siklos, DR Beers, AA Yen, EP Simpson, Y Luo, G Carrum, HE Heslop, MK Brenner and U Popat: Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology 71, 1326-34 (2008)
254. L Mazzini, K Mareschi, I Ferrero, E Vassallo, G Oliveri, N Nasuelli, GD Oggioni, L Testa and F Fagioli: Stem cell treatment in Amyotrophic Lateral Sclerosis. J Neurol Sci 265, 78-83 (2008)
255. I Ferrero, L Mazzini, D Rustichelli, M Gunetti, K Mareschi, L Testa, N Nasuelli, GD Oggioni and F Fagioli: Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients. Cell Transplant 17, 255-66 (2008) (Pubitemid 351717329)
256. A Vercelli, OM Mereuta, D Garbossa, G Muraca, K Mareschi, D Rustichelli, I Ferrero, L Mazzini, E Madon and F Fagioli: Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 31, 395-405 (2008)
257. HR Martinez, MT Gonzalez-Garza, JE Moreno-Cuevas, E Caro, E Gutierrez-Jimenez and JJ Segura: Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Cytotherapy 11, 26-34 (2009)
258. H Deda, MC Inci, AE Kurekci, A Sav, K Kayihan, E Ozgun, GE Ustunsoy and S Kocabay: Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy 11, 18-25 (2009)
259. HF McFarland and R Martin: Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 8, 913-9 (2007) (Pubitemid 47300005)
260. DM Wingerchuk: Current evidence and therapeutic strategies for multiple sclerosis. Semin Neurol 28, 56-68 (2008) (Pubitemid 351273084)
261. L Bai, DP Lennon, V Eaton, K Maier, AI Caplan, SD Miller and RH Miller: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 57, 1192-203 (2009)
262. E Zappia, S Casazza, E Pedemonte, F Benvenuto, I Bonanni, E Gerdoni, D Giunti, A Ceravolo, F Cazzanti, F Frassoni, G Mancardi and A Uccelli: Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106, 1755-61 (2005) (Pubitemid 41208591)
263. RK Burt, Y Loh, B Cohen, D Stefoski, R Balabanov, G Katsamakis, Y Oyama, EJ Russell, J Stern, P Muraro, J Rose, A Testori, J Bucha, B Jovanovic, F Milanetti, J Storek, JC Voltarelli and WH Burns: Autologous nonmyeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol 8, 244-53 (2009)
264. E Capello, L Vuolo, F Gualandi, MT Van Lint, L Roccatagliata, L Bonzano, M Pardini, A Uccelli and G Mancardi: Autologous haematopoietic stem-cell transplantation in multiple sclerosis: benefits and risks. Neurol Sci 30 Suppl 2, S175-7 (2009)
265. A Uccelli and G Mancardi: Stem cell transplantation in multiple sclerosis. Curr Opin Neurol 23, 218-25 (2010)
266. A Nasef, N Ashammakhi and L Fouillard: Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms. Regen Med 3, 531-46 (2008)
267. AJ Nauta, AB Kruisselbrink, E Lurvink, R Willemze and WE Fibbe: Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 177, 2080-7 (2006) (Pubitemid 44200965)
268. M Rafei, PM Campeau, A Aguilar-Mahecha, M Buchanan, P Williams, E Birman, S Yuan, YK Young, MN Boivin, K Forner, M Basik and J Galipeau: Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J Immunol 182, 5994-6002 (2009)
269. G Constantin, S Marconi, B Rossi, S Angiari, L Calderan, E Anghileri, B Gini, SD Bach, M Martinello, F Bifari, M Galie, E Turano, S Budui, A Sbarbati, M Krampera and B Bonetti: Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Stem Cells 27, 2624-35 (2009)
270. S Slavin, BG Kurkalli and D Karussis: The potential use of adult stem cells for the treatment of multiple sclerosis and other neurodegenerative disorders. Clin Neurol Neurosurg 110, 943-6 (2008)
271. S Pluchino, A Quattrini, E Brambilla, A Gritti, G Salani, G Dina, R Galli, U Del Carro, S Amadio, A Bergami, R Furlan, G Comi, AL Vescovi and G Martino: Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422, 688-94 (2003) (Pubitemid 36514101)
272. S Pluchino, A Gritti, E Blezer, S Amadio, E Brambilla, G Borsellino, C Cossetti, U Del Carro, G Comi, B t Hart, A Vescovi and G Martino: Human neural stem cells ameliorate autoimmune encephalomyelitis in nonhuman primates. Ann Neurol 66, 343-54 (2009)
273. M Aharonowiz, O Einstein, N Fainstein, H Lassmann, B Reubinoff and T Ben-Hur: Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis. PLoS One 3, e3145 (2008)
274. CC Shih, SJ Forman, P Chu and M Slovak: Human embryonic stem cells are prone to generate primitive, undifferentiated tumors in engrafted human fetal tissues in severe combined immunodeficient mice. Stem Cells Dev 16, 893-902 (2007)
275. PS Knoepfler: Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 27, 1050-6 (2009)
276. A Vats, RC Bielby, NS Tolley, R Nerem and JM Polak: Stem cells. Lancet 366, 592-602 (2005) (Pubitemid 41149084)
277. C Foroni, R Galli, B Cipelletti, A Caumo, S Alberti, R Fiocco and A Vescovi: Resilience to transformation and inherent genetic and functional stability of adult neural stem cells ex vivo. Cancer Res 67, 3725-33 (2007) (Pubitemid 46762158)
278. E Gerdoni, B Gallo, S Casazza, S Musio, I Bonanni, E Pedemonte, R Mantegazza, F Frassoni, G Mancardi, R Pedotti and A Uccelli: Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol 61, 219-27 (2007) (Pubitemid 46557346)
279. T Schinkothe, W Bloch and A Schmidt: In vitro secreting profile of human mesenchymal stem cells. Stem Cells Dev 17, 199-206 (2008)
280. CP Hofstetter, EJ Schwarz, D Hess, J Widenfalk, A El Manira, DJ Prockop and L Olson: Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A 99, 2199-204 (2002) (Pubitemid 34169038)
281. F Soldner, D Hockemeyer, C Beard, Q Gao, GW Bell, EG Cook, G Hargus, A Blak, O Cooper, M Mitalipova, O Isacson and R Jaenisch: Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136, 964-77 (2009)
282. IH Park, N Arora, H Huo, N Maherali, T Ahfeldt, A Shimamura, MW Lensch, C Cowan, K Hochedlinger and GQ Daley: Disease-specific induced pluripotent stem cells. Cell 134, 877-86 (2008)
283. JT Dimos, KT Rodolfa, KK Niakan, LM Weisenthal, H Mitsumoto, W Chung, GF Croft, G Saphier, R Leibel, R Goland, H Wichterle, CE Henderson and K Eggan: Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218-21 (2008)
284. AD Ebert, J Yu, FF Rose, Jr., VB Mattis, CL Lorson, JA Thomson and CN Svendsen: Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-80 (2009)
285. F Jia, KD Wilson, N Sun, DM Gupta, M Huang, Z Li, NJ Panetta, ZY Chen, RC Robbins, MA Kay, MT Longaker and JC Wu: A nonviral minicircle vector for deriving human iPS cells. Nat Methods 7, 197-9 (2010)
286. L Warren, PD Manos, T Ahfeldt, YH Loh, H Li, F Lau, W Ebina, PK Mandal, ZD Smith, A Meissner, GQ Daley, AS Brack, JJ Collins, C Cowan, TM Schlaeger and DJ Rossi: Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-30 (2010)