Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5799-5802

  Reynolds, Aaron ^a   Hanani, Raphy ^a   Hibbs, David ^b   Damont, Annelaure ^c   Pozzo, Eleonora Da ^d   Selleri, Silvia ^e   Dollé, Frédéric ^c   Martini, Claudia ^d   Kassiou, Michael ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^d UNIVERSITY OF PISA   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Microglia; Neurodegeneration; Neuroprotection; Peripheral type benzodiazepine receptor; Pyrazolo 1,5 a pyrimidine; Steroidogenesis; Translocator protein; TSPO

Indexed keywords

ACETAMIDE DERIVATIVE; ALKYL ETHER; ANXIOLYTIC AGENT; CARRIER PROTEIN; LIGAND; NEUROPROTECTIVE AGENT; PREGNENOLONE; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; COMPUTER MODEL; NEUROPROTECTION; PHARMACOPHORE; STEROIDOGENESIS;

ACETAMIDES; ANIMALS; CARRIER PROTEINS; CELL LINE, TUMOR; ETHERS; LIGANDS; PREGNENOLONE; PROTEIN BINDING; PYRAZOLES; PYRIDINES; RATS; RECEPTORS, GABA-A;

RATTUS;

EID: 77957577508     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.135     Document Type: Article

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