Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells

British Journal of Cancer

Volumn 85, Issue 11, 2001, Pages 1771-1780

  Maaser, K ^a   Hopfner M ^a   Jansen, A ^a   Weisinger, G ^b   Gavish, M ^c   Kozikowski, A P ^d   Weizman, A ^b,e   Carayon, P ^f   Riecken, E O ^a   Zeitz, M ^a   Scherubl H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b TEL AVIV UNIVERSITY   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^e GEHA MENTAL HEALTH CENTER   (Israel)

^f SANOFI   (France)

Author keywords

Apoptosis; Cell cycle; Cell proliferation; Colorectal cancer; Peripheral benzodiazepine receptor

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE RECEPTOR; CASPASE 3; FGIN 1 27; INDOLEACETIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; LIGAND; MESSENGER RNA; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PERIPHERAL BENZODIAZEPINE RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; COLORECTAL CANCER; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG TARGETING; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ADULT; AGED; APOPTOSIS; BENZODIAZEPINONES; CELL CYCLE; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; G0 PHASE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; INDOLEACETIC ACIDS; INTRACELLULAR MEMBRANES; ISOQUINOLINES; LIGANDS; MEMBRANE POTENTIALS; MIDDLE AGED; MITOCHONDRIA; RECEPTORS, GABA-A; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0035977186     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.2181     Document Type: Article

References (64)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane
3. Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors
4. Specific binding of benzodiazepines to human breast cancer cell lines
5. The peripheral benzodiazepine receptors: A review
6. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities
7. 3H)diazepam binding
8. Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis
9. A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands
10. Peripheral benzodiazepine receptor modulation with phagocyte differentiation
11. Interaction of calcium channel blockers with non-neuronal benzodiazepine binding sites
12. Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line
13. Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study
14. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3.3′ tetraethylbenzimidazolearbocyanine iodide (JC-1)
15. Development of a monoclonal antibody to immunocytochemical analysis of the cellular localization of the peripheral benzodiazepine receptor
16. Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species
17. Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells
18. Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: Action via peripheral-type benzodiazepine receptor and independent mechanisms
19. Biochemical, physiological, and pathological aspects of the peripheral benzodiazepine receptor
20. Enigma of the peripheral benzodiazepine receptor
21. Determination of cell number in monolayer cultures
22. A receptors in cholecystokinin-secreting gut neuroendocrine murine STC-1 cells
23. (x) antigen defined by MAb AM-3 is an independent prognostic marker in colorectal carcinoma patients
24. Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer
25. Colorectal cancer: New aspects of molecular biology and immunology and their clinical applications
26. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: Correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol
27. Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control
28. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection
29. Expression of functional P2-purinergic receptors in primary cultures of human colorectal carcinoma cells
30. Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine
31. Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries
32. Increase in peripheral benzodiazepine binding sites in colonic adenocarcinoma
33. Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands
34. Molecular and functional properties of mitochondrial benzodiazepine receptors
35. Inhibition of rat pituitary tumor cell proliferation by benzodiazepines in vitro
36. Peripheral benzodiazepine binding sites in Nb 2 node lymphoma cells: Effects on prolactin-stimulated proliferation and ornithine decarboxylase activity
37. Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B 16 melanoma cells
38. Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore
39. Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N (1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies
40. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
41. Functional hierarchy of simultaneously expressed adhesion receptors: Integrin alpha2beta 1 but ot CD44 mediates MV3 melanoma cell migration and matrix reorganization within three-dimensional hyaluronan-containing collagen matrices
42. Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line
43. Mitochondrial permeability transition triggers lymphocyte apoptosis
44. Characterization of peripheral benzodiazepine receptors in purified large mammal pancreatic islets
45. Inhibition of growth factor-induced DNA synthesis in astrocytes by ligands of peripheral-type benzodiazepine receptors
46. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
47. Caspases: The proteases of the apoptotic pathway
48. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: Biological role in steroidogenic cell function
49. Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro
50. Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications
51. Lonidamine triggers apoptosis via a direct. Bcl-2-inhibited effect on the mitochondrial permeability transition pore
52. The expression of peripheral benzodiazepine receptors in human skin: The relationship with epidermal cell differentiation
53. Mitochondria as regulators of apoptosis: Doubt no more
54. Micromolar-affinity benzodiazepine receptors regulate voltage-sensitive calcium channels in nerve terminal preparations
55. Benzodiazepine receptor agonists modulate thymocyte apoptosis through reduction of the mitochondrial transmembrane potential
56. Potential role of peripheral benzodiazepine receptors in inflammatory responses
57. Up-regulation of peripheral benzodiazepine receptor system in hepatocellular carcinoma
58. Peripheral type benzodiazepine receptors
59. An integrated set of methods for routine flow cytometric DNA analysis
60. Benzodiazepines that bind at peripheral sites inhibit cell proliferation
61. Structural requirements for the blinding of benzodiazepines to their peripheral-type sites
62. Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22 a benzazepine
63. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
64. Mitochondrial damage as a source of diseases and aging: A strategy of how to fight these