Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions

Biochemical Pharmacology

Volumn 59, Issue 10, 2000, Pages 1305-1314

  Klegeris, Andis ^a   McGeer, Edith G ^a   McGeer, Patrick L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cytokines; Glutamate; Inflammation; Macrophages; Peripheral benzodiazepine receptors; Reactive oxygen intermediates

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE RECEPTOR; CARBAMAZEPINE; CELL SURFACE RECEPTOR; DEXAMETHASONE; GLUTAMIC ACID; INTERLEUKIN 1BETA; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NORDIHYDROGUAIARETIC ACID; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; MONONUCLEAR CELL; NEUROBLASTOMA CELL; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTE; PRIORITY JOURNAL; RAT; RESPIRATORY BURST;

ANIMALS; ANTIGENS, CD; ANTIGENS, SURFACE; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CELLS, CULTURED; GLUTAMIC ACID; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-1; ISOQUINOLINES; MACROPHAGES, PERITONEAL; MALE; RATS; RATS, WISTAR; RECEPTORS, IGG; RESPIRATORY BURST; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034657024     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00252-5     Document Type: Article

References (65)

1. A-receptor subtypes Clinical efficacy and selectivity of benzodiazepine site ligands . Ann Med. 29:1997;275-282.
2. A receptors. Trends Pharmacol Sci. 18:1997;425-429.
3. Snyder S.H., McEnery M.W., Verma A. Molecular mechanisms of peripheral benzodiazepine receptors. Neurochem Res. 15:1990;119-123.
4. Zisterer D.M., Williams D.C. Peripheral-type benzodiazepine receptors. Gen Pharmacol. 29:1997;305-314.
5. Rocca P., Bellone G., Benna P., Bergamasco B., Ravizza L., Ferrero P. Peripheral-type benzodiazepine receptors and diazepam binding inhibitor-like immunoreactivity distribution in human peripheral blood mononuclear cells. Immunopharmacology. 25:1993;163-178.
6. Zavala F., Haumont J., Lenfant M. Interaction of benzodiazepines with mouse macrophages. Eur J Pharmacol. 106:1984;561-566.
7. Diorio D., Welner S.A., Butterworth R.F., Meaney M.J., Suranyi-Cadotte B.E. Peripheral benzodiazepine binding sites in Alzheimer's disease frontal cortex. Neurobiol Aging. 12:1991;255-258.
8. Junck L., Olson J.M., Ciliax B.J., Koeppe R.A., Watkins G.L., Jewett D.M., McKeever P.E., Wieland D.M., Kilbourn M.R., Starosta-Rubinstein S., Mancini W.R., Kuhl D.E., Greenberg H.S., Young A.B. PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. Ann Neurol. 26:1989;752-758.
9. McGeer E.G., Singh E.A., McGeer P.L. Peripheral-type benzodiazepine binding in Alzheimer disease. Alzheimer Dis Assoc Disord. 2:1988;331-336.
10. Saura J., Luque J.M., Cesura A.M., Da Prada M., Chan-Palay V., Huber G., Loffler J., Richards J.G. Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience. 62:1994;15-30.
11. 3H]Ro5-4864 benzodiazepine binding in the kainate lesioned striatum and Huntington's diseased basal ganglia. Brain Res. 248:1982;396-401.
12. Vowinckel E., Reutens D., Becher B., Verge G., Evans A., Owens T., Antel J.P. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res. 50:1997;345-353.
13. 3H]PK11195 binding to activated microglia . J Neurocytol. 26:1997;77-82.
14. Gehlert D.R., Stephenson D.T., Schober D.A., Rash K., Clemens J.A. Increased expression of peripheral benzodiazepine receptors in the facial nucleus following motor neuron axotomy. Neurochem Int. 31:1997;705-713.
15. 3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion. J Cereb Blood Flow Metab. 11:1991;314-322.
16. Lacor P., Gandolfo P., Tonon M.-C., Brault E., Dalibert I., Schumacher M., Benavides J., Ferzaz B. Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration A role for PBR in neurosteroidogenesis . Brain Res. 815:1999;70-80.
17. Canat X., Carayon P., Bouaboula M., Cahard D., Shire D., Roque C., Le Fur G., Casellas P. Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells. Life Sci. 52:1993;107-118.
18. Ruff M.R., Pert C.B., Weber R.J., Wahl L.M., Wahl S.M., Paul S.M. Benzodiazepine receptor-mediated chemotaxis of human monocytes. Science. 229:1985;1281-1283.
19. Park C.H., Carboni E., Wood P.L., Gee K.W. Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line. Glia. 16:1996;65-70.
20. Canat X., Guillaumont A., Bouaboula M., Poinot-Chazel C., Deroco J.-M., Carayon P., Le Fur G., Casellas P. Peripheral benzodiazepine receptor modulation with phagocyte differentiation. Biochem Pharmacol. 46:1993;551-554.
21. Waterfield J.D., McGeer E.G., McGeer P.L. The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model. Rheumatology. 38:1999;1068-1073.
22. Ross R.A., Biedler J.L., Spengler B.A., Reis D.J. Neurotransmitter-synthesizing enzymes in 14 human neuroblastoma cell lines. Cell Mol Neurobiol. 1:1981;301-312.
23. Klegeris A., McGeer P.L. Inhibition of respiratory burst in macrophages by complement receptor blockade. Eur J Pharmacol. 260:1994;273-277.
24. Beutler H.-O., Michal G. L-Glutamate. Determination with glutamate dehydrogenase, diaphorase, and tetrazolium salts. Bergmeyer H.U., Gawehn K. Methods of Enzymatic Analysis. Vol. 4:1974;1708-1713 Academic Press, New York.
25. - in the macrophage-induced glutamate-dependent cytotoxicity to neurons. J Immunol. 152:1994;3578-3585.
26. Klegeris A., McGeer P.L. β-Amyloid protein enhances macrophage production of oxygen free radicals and glutamate. J Neurosci Res. 49:1997;229-235.
27. Klegeris A., Walker D.G., McGeer P.L. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells. J Neuroimmunol. 78:1997;152-161.
28. Klegeris A., Walker D.G., McGeer P.L. Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α Brain Res. 747:1997;114-121.
29. Decker T., Lohmann-Matthes M.-L. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods. 15:1988;61-69.
30. Mosmann T. Rapid colorimetric assay for cellular growth and survival Application to proliferation and cytotoxicity assays . J Immunol Methods. 65:1983;55-63.
31. Hansen M.B., Nielsen S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods. 119:1989;203-210.
32. Loughlin A.J., Woodroofe M.N., Cuzner M.L. Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide Effects on interferon-gamma induced activation . Immunology. 75:1992;170-175.
33. McGeer P.L., McGeer E.G. The inflammatory response system of brain Implications for therapy of Alzheimer and other neurodegenerative diseases . Brain Res Rev. 21:1995;195-218.
34. Bellavite P. The superoxide-forming enzymatic system of phagocytes. Free Radic Biol Med. 4:1988;225-261.
35. Klegeris A., McGeer P.L. Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants. J Neuroimmunol. 53:1994;83-90.
36. Caldiroli E., De Ponti F., Cosentino M., Marino F., Fietta A.M., Taddei M., Tartara A., Zibetti A., Mazzone A., Lecchini S., Frigo G.M. Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors. Immunopharmacol Immunotoxicol. 19:1997;367-382.
37. Goldfarb G., Belghiti J., Gautero H., Boivin P. In vitro effect of benzodiazepines on polymorphonuclear leukocyte oxidative activity. Anesthesiology. 60:1984;57-60.
38. 1 cells stimulated by arachidonic acid. Int J Immunopharmacol. 9:1987;269-274.
39. Zavala F., Taupin V., Descamps-Latscha B. In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin-1, tumor necrosis factor and interleukin-6. J Pharmacol Exp Ther. 255:1990;442-450.
40. Matsumoto T., Ogata M., Koga K., Shigematsu A. Effect of peripheral benzodiazepine receptor ligands on lipopolysaccharide-induced tumor necrosis factor activity in thioglycolate-treated mice. Antimicrob Agents Chemother. 38:1994;812-816.
41. Bessler H., Weizman R., Gavish M., Notti I., Djaldetti M. Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells. J Neuroimmunol. 38:1992;19-26.
42. Neary J.T., Jorgensen S.L., Oracion A.M., Bruce J.H., Norenberg M.D. Inhibition of growth factor induced DNA synthesis in astrocytes by ligands of peripheral type benzodiazepine receptors. Brain Res. 675:1995;27-30.
43. Combs C.K., Johnson D.E., Cannady S.B., Lehman T.M., Landreth G.E. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins. J Neurosci. 19:1999;928-939.
44. Dzenko K.A., Weltzien R.B., Pachter J.S. Suppression of A β-induced monocyte neurotoxicity by antiinflammatory compounds. J Neuroimmunol. 80:1997;6-12.
45. Flavin M.P., Ho L.T., Coughlin K. Neurotoxicity of soluble macrophage products in vitro - influence of dexamethasone. Exp Neurol. 145:1997;462-470.
46. Giulian D., Haverkamp L.J., Yu J.H., Karshin W.L., Li J., Kirkpatrick J., Kuo Y.-M., Roher A.E. Specific domains of β-amyloid from Alzheimer plaque elicit neuronal killing in human microglia. J Neurosci. 16:1996;6021-6037.
47. Klegeris A., Walker D.G., McGeer P.L. Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs). Neuropharmacology. 38:1999;1017-1025.
48. 2 and a β-adrenergic agonist. Glia. 11:1994;383-386.
49. Ferrarese C., Marzorati C., Perego M., Bianchi G., Cavarretta R., Pierpaoli C., Moretti G., Frattola L. Effect of anticonvulsant drugs on peripheral benzodiazepine receptors of human lymphocytes. Neuropharmacology. 34:1995;427-431.
50. Martini C., Lucacchini A., Hrelia S., Rossi C.A. Central- and peripheral-type benzodiazepine receptors. Adv Biochem Psychopharmacol. 41:1986;1-10.
51. Hillestad L., Hansen T., Melsom H., Drivenes A. Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration. Clin Pharmacol Ther. 16:1974;479-484.
52. Mandelli M., Tognoni G., Garattini S. Clinical pharmacokinetics of diazepam. Clin Pharmacokinet. 3:1978;72-91.
53. McEnery M.W., Snowman A.M., Trifiletti R.R., Snyder S.H. Isolation of the mitochondrial benzodiazepine receptor Association with the voltage-dependent anion channel and the adenine nucleotide carrier . Proc Natl Acad Sci USA. 89:1992;3170-3174.
54. Woods M.J., Williams D.C. Multiple forms and locations for the peripheral-type benzodiazepine receptor. Biochem Pharmacol. 52:1996;1805-1814.
55. Miccoli L., Oudard S., Beurdeley-Thomas A., Dutrillaux B., Poupon M.-F. Effect of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide (PK11195), a specific ligand of the peripheral benzodiazepine receptor, on the lipid fluidity of mitochondria in human glioma cells. Biochem Pharmacol. 58:1999;715-721.
56. Tenn C.C., Neu J.M., Niles L.P. PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum. Br J Pharmacol. 119:1996;223-228.
57. Hirsch T., Decaudin D., Susin S.A., Marchetti P., Larochette N., Resche-Rigon M., Kroemer G. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res. 241:1998;426-434.
58. Fonlupt P., Croset M., Lagarde M. Benzodiazepine analogues inhibit arachidonate-induced aggregation and thromboxane synthesis in human platelets. Br J Pharmacol. 101:1990;920-924.
59. Van Eldik L.J., Watterson D.M. Calmodulin and calcium signal transduction An introduction . Van Eldik L.J., Watterson D.M. Calmodulin and Calcium Signal Transduction. 1998;1-15 Academic Press, New York.
60. Kovacs E.J., Radzioch D., Young H.A., Varesio L. Differential inhibition of IL-1 and TNF-α mRNA expression by agents which block second messenger pathways in murine macrophages. J Immunol. 141:1988;3101-3105.
61. Nakano M., Saito S., Nakano Y., Yamasu H., Matsuura M., Shinomiya H. Intracellular protein phosphorylation in murine peritoneal macrophages in response to bacterial lipopolysaccharide (LPS) Effects of kinase-inhibitors and LPS-induced tolerance . Immunobiology. 187:1993;272-282.
62. Holian A., Jordan M.K., Nguyen H.V., Devenyi Z.J. Inhibition of macrophage activation by isoquinolinesulfonamides, phenothiazines, and a naphthalenesulfonamide. J Cell Physiol. 137:1988;45-54.
63. Gorecka-Tisera A.M., McCulloch M.A., Borle A.B. The effect of calmodulin antagonists on the activation of RAW-264 macrophage-like cells for tumor cell killing. Immunopharmacology. 12:1986;59-67.
64. Gumina R.J., Freire-Moar J., DeYoung L., Webb D.R., Devens B.H. Transduction of the IFN-γ signal for HLA-DR expression in the promonocytic line THP-1 involves a late-acting PKC activity. Cell Immunol. 138:1991;265-279.
65. Klein J.B., Schepers T.M., Dean W.L., Sonnenfeld G., McLeish K.R. Role of intracellular calcium concentration and protein kinase C activation in IFN-γ stimulation of U937 cells. J Immunol. 144:1990;4305-4311.