메뉴 건너뛰기




Volumn 626, Issue 2-3, 2010, Pages 131-138

Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo

Author keywords

Anxiety; Benzodiazepine; Cancer; Diazepam; Ehrlich cell; TSPO

Indexed keywords

4' CHLORODIAZEPAM; CARRIER PROTEIN; CLONAZEPAM; DIAZEPAM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; REACTIVE OXYGEN METABOLITE; TRANSLOCATOR PROTEIN 18; UNCLASSIFIED DRUG;

EID: 70649091117     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.09.036     Document Type: Article
Times cited : (25)

References (52)
  • 1
    • 0034257080 scopus 로고    scopus 로고
    • Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines
    • Beinlich A., Strohmeier R., Kaufmann M., and Kuhl H. Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines. Biochemical Pharmacology 60 (2000) 397-402
    • (2000) Biochemical Pharmacology , vol.60 , pp. 397-402
    • Beinlich, A.1    Strohmeier, R.2    Kaufmann, M.3    Kuhl, H.4
  • 4
    • 14844340591 scopus 로고    scopus 로고
    • Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation
    • Corsi L., Geminiani E., Avallone R., and Baraldi M. Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation. Life Sciences 76 (2005) 2523-2533
    • (2005) Life Sciences , vol.76 , pp. 2523-2533
    • Corsi, L.1    Geminiani, E.2    Avallone, R.3    Baraldi, M.4
  • 5
    • 0016829152 scopus 로고
    • New concepts on the mechanism of action of benzodiazepines
    • Costa E., Guidotti A., Mao C.C., and Suria A. New concepts on the mechanism of action of benzodiazepines. Life Sciences 17 (1975) 167-185
    • (1975) Life Sciences , vol.17 , pp. 167-185
    • Costa, E.1    Guidotti, A.2    Mao, C.C.3    Suria, A.4
  • 7
    • 62949201532 scopus 로고    scopus 로고
    • Chemotherapeutic potential of two gallic acid derivative compounds from leaves of Casearia sylvestris Sw (Flacourtiaceae)
    • Da Silva S.L., Chaar Jda S., and Yano T. Chemotherapeutic potential of two gallic acid derivative compounds from leaves of Casearia sylvestris Sw (Flacourtiaceae). European Journal of Pharmacology 608 (2009) 76-83
    • (2009) European Journal of Pharmacology , vol.608 , pp. 76-83
    • Da Silva, S.L.1    Chaar Jda, S.2    Yano, T.3
  • 10
    • 38349097606 scopus 로고    scopus 로고
    • Melatonin and vitamin C administration ameliorate diazepam-induced oxidative stress and cell proliferation in the liver of rats
    • El-Sokkary G.H. Melatonin and vitamin C administration ameliorate diazepam-induced oxidative stress and cell proliferation in the liver of rats. Cell Proliferation 41 (2008) 168-176
    • (2008) Cell Proliferation , vol.41 , pp. 168-176
    • El-Sokkary, G.H.1
  • 11
    • 44349158929 scopus 로고    scopus 로고
    • Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone
    • Enouri S.S., Kerr C.L., McDonell W.N., and Dyson D.H. Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone. American Journal of Veterinary Research 69 (2008) 586-595
    • (2008) American Journal of Veterinary Research , vol.69 , pp. 586-595
    • Enouri, S.S.1    Kerr, C.L.2    McDonell, W.N.3    Dyson, D.H.4
  • 12
    • 0035906835 scopus 로고    scopus 로고
    • Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species
    • Fennell D.A., Corbo M., Pallaska A., and Cotter F.E. Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species. British Journal of Cancer 84 (2001) 1397-1404
    • (2001) British Journal of Cancer , vol.84 , pp. 1397-1404
    • Fennell, D.A.1    Corbo, M.2    Pallaska, A.3    Cotter, F.E.4
  • 13
    • 0028031729 scopus 로고
    • In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells
    • Garnier M., Dimchev A.B., Boujrad N., Price J.M., Musto N.A., and Papadopoulos V. In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Molecular Pharmacology 45 (1994) 201-211
    • (1994) Molecular Pharmacology , vol.45 , pp. 201-211
    • Garnier, M.1    Dimchev, A.B.2    Boujrad, N.3    Price, J.M.4    Musto, N.A.5    Papadopoulos, V.6
  • 15
    • 0242299669 scopus 로고    scopus 로고
    • Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression
    • Han Z., Slack R.S., Li W., and Papadopoulos V. Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression. Journal of Receptor and Signal Transduction Research 23 (2003) 225-238
    • (2003) Journal of Receptor and Signal Transduction Research , vol.23 , pp. 225-238
    • Han, Z.1    Slack, R.S.2    Li, W.3    Papadopoulos, V.4
  • 16
    • 0033558247 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol
    • Hardwick M., Fertikh D., Culty M., Li H., Vidic B., and Papadopoulos V. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Research 59 (1999) 831-842
    • (1999) Cancer Research , vol.59 , pp. 831-842
    • Hardwick, M.1    Fertikh, D.2    Culty, M.3    Li, H.4    Vidic, B.5    Papadopoulos, V.6
  • 17
    • 0013835819 scopus 로고
    • The immediate cause of death in mice with Ehrlich's ascites carcinoma
    • Hartveit F. The immediate cause of death in mice with Ehrlich's ascites carcinoma. Acta Pathologica et Microbiologica Scandinavica 65 (1965) 359-365
    • (1965) Acta Pathologica et Microbiologica Scandinavica , vol.65 , pp. 359-365
    • Hartveit, F.1
  • 18
    • 0024541441 scopus 로고
    • Simultaneous measurement by flow cytometry of phagocytosis and hydrogen peroxide production of neutrophils in whole blood
    • Hasui M., Hirabayashi Y., and Kobayashi Y. Simultaneous measurement by flow cytometry of phagocytosis and hydrogen peroxide production of neutrophils in whole blood. Journal of Immunological Methods 117 (1989) 53-58
    • (1989) Journal of Immunological Methods , vol.117 , pp. 53-58
    • Hasui, M.1    Hirabayashi, Y.2    Kobayashi, Y.3
  • 19
    • 33646869489 scopus 로고    scopus 로고
    • Effectors and signaling events activated by cell shrinkage in Ehrlich ascites tumor cells: implications for cell proliferation and programmed cell death
    • Hoffmann E.K., and Pedersen S.F. Effectors and signaling events activated by cell shrinkage in Ehrlich ascites tumor cells: implications for cell proliferation and programmed cell death. Advances in Experimental Medicine and Biology 559 (2004) 169-178
    • (2004) Advances in Experimental Medicine and Biology , vol.559 , pp. 169-178
    • Hoffmann, E.K.1    Pedersen, S.F.2
  • 20
    • 33745745762 scopus 로고    scopus 로고
    • Development of ligands for the peripheral benzodiazepine receptor
    • James M.L., Selleri S., and Kassiou M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13 (2006) 1991-2001
    • (2006) Current Medicinal Chemistry , vol.13 , pp. 1991-2001
    • James, M.L.1    Selleri, S.2    Kassiou, M.3
  • 21
    • 0018730471 scopus 로고
    • The influence of diazepam administration in rats bearing the R3230AC mammary carcinoma
    • Karmali R.A., Volkman A., Muse P., and Louis T.M. The influence of diazepam administration in rats bearing the R3230AC mammary carcinoma. Prostaglandins and Medicine 3 (1979) 193-198
    • (1979) Prostaglandins and Medicine , vol.3 , pp. 193-198
    • Karmali, R.A.1    Volkman, A.2    Muse, P.3    Louis, T.M.4
  • 22
    • 0018861425 scopus 로고
    • Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam
    • Karmali R.A., Volkman A., Spivey W., Muse P., and Louis T.M. Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. Prostaglandins and Medicine 4 (1980) 239-246
    • (1980) Prostaglandins and Medicine , vol.4 , pp. 239-246
    • Karmali, R.A.1    Volkman, A.2    Spivey, W.3    Muse, P.4    Louis, T.M.5
  • 23
    • 0009541114 scopus 로고    scopus 로고
    • Effect of haloperidol on the development of the solid Ehrlich tumor in mice
    • Kleeb S.R., Xavier J.G., Frussa-Filho R., and Dagli M.L. Effect of haloperidol on the development of the solid Ehrlich tumor in mice. Life Sciences 60 (1997) PL69-PL74
    • (1997) Life Sciences , vol.60
    • Kleeb, S.R.1    Xavier, J.G.2    Frussa-Filho, R.3    Dagli, M.L.4
  • 24
    • 2342633234 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways
    • Kletsas D., Li W., Han Z., and Papadopoulos V. Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. Biochemical Pharmacology 67 (2004) 1927-1932
    • (2004) Biochemical Pharmacology , vol.67 , pp. 1927-1932
    • Kletsas, D.1    Li, W.2    Han, Z.3    Papadopoulos, V.4
  • 26
    • 0035970108 scopus 로고    scopus 로고
    • Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide
    • Li H., Yao Z., Degenhardt B., Teper G., and Papadopoulos V. Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 1267-1272
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , pp. 1267-1272
    • Li, H.1    Yao, Z.2    Degenhardt, B.3    Teper, G.4    Papadopoulos, V.5
  • 27
    • 33845929203 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation
    • Li W., Hardwick M.J., Rosenthal D., Culty M., and Papadopoulos V. Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation. Biochemical Pharmacology 73 (2007) 491-503
    • (2007) Biochemical Pharmacology , vol.73 , pp. 491-503
    • Li, W.1    Hardwick, M.J.2    Rosenthal, D.3    Culty, M.4    Papadopoulos, V.5
  • 28
    • 70449092383 scopus 로고    scopus 로고
    • Effect of a seashell protein Haishengsu on the immunological function of mice with Ehrlich ascites tumor
    • (Electronic publication ahead of print)
    • Li G.Y., Liu J.Z., Chen S.G., Wang C.B., Bin Z., and Wang L.X. Effect of a seashell protein Haishengsu on the immunological function of mice with Ehrlich ascites tumor. Immunopharmacology and Immunotoxicology (2009) (Electronic publication ahead of print)
    • (2009) Immunopharmacology and Immunotoxicology
    • Li, G.Y.1    Liu, J.Z.2    Chen, S.G.3    Wang, C.B.4    Bin, Z.5    Wang, L.X.6
  • 29
    • 0027770697 scopus 로고
    • The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia
    • Lin D., Chang Y.J., Strauss III J.F., and Miller W.L. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. Genomics 18 (1993) 643-650
    • (1993) Genomics , vol.18 , pp. 643-650
    • Lin, D.1    Chang, Y.J.2    Strauss III, J.F.3    Miller, W.L.4
  • 30
    • 0038042230 scopus 로고    scopus 로고
    • Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues
    • Liu J., Matyakhina L., Han Z., Sandrini F., Bei T., Stratakis C.A., and Papadopoulos V. Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues. Faseb Journal 17 (2003) 1189-1191
    • (2003) Faseb Journal , vol.17 , pp. 1189-1191
    • Liu, J.1    Matyakhina, L.2    Han, Z.3    Sandrini, F.4    Bei, T.5    Stratakis, C.A.6    Papadopoulos, V.7
  • 32
    • 33646569979 scopus 로고    scopus 로고
    • Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats
    • Mukhopadhyay S., Mukherjee S., and Das S.K. Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats. Glycoconjugate Journal 23 (2006) 199-207
    • (2006) Glycoconjugate Journal , vol.23 , pp. 199-207
    • Mukhopadhyay, S.1    Mukherjee, S.2    Das, S.K.3
  • 33
    • 0028834106 scopus 로고
    • Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation
    • Nagy J.A., Masse E.M., Herzberg K.T., Meyers M.S., Yeo K.T., Yeo T.K., Sioussat T.M., and Dvorak H.F. Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. Cancer Research 55 (1995) 360-368
    • (1995) Cancer Research , vol.55 , pp. 360-368
    • Nagy, J.A.1    Masse, E.M.2    Herzberg, K.T.3    Meyers, M.S.4    Yeo, K.T.5    Yeo, T.K.6    Sioussat, T.M.7    Dvorak, H.F.8
  • 35
    • 0025254066 scopus 로고
    • The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis
    • Papadopoulos V., Mukhin A.G., Costa E., and Krueger K.E. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. Journal of Biological Chemistry 265 (1990) 3772-3779
    • (1990) Journal of Biological Chemistry , vol.265 , pp. 3772-3779
    • Papadopoulos, V.1    Mukhin, A.G.2    Costa, E.3    Krueger, K.E.4
  • 37
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano H., Carney D., and Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates 7 (2004) 97-110
    • (2004) Drug Resistance Updates , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 38
    • 0018929548 scopus 로고
    • Surface antigen on Ehrlich ascites tumor cells
    • Pessina A., Brambilla P., and Mocarelli P. Surface antigen on Ehrlich ascites tumor cells. Biomedicine 33 (1980) 105-109
    • (1980) Biomedicine , vol.33 , pp. 105-109
    • Pessina, A.1    Brambilla, P.2    Mocarelli, P.3
  • 39
    • 67651042798 scopus 로고    scopus 로고
    • Paracrine action of sFLT-1 secreted by stably-transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo
    • Ramachandra S., D'Souza S.S., Gururaj A.E., Shaila M.S., and Salimath B.P. Paracrine action of sFLT-1 secreted by stably-transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo. Journal of Gene Medicine 11 (2009) 422-434
    • (2009) Journal of Gene Medicine , vol.11 , pp. 422-434
    • Ramachandra, S.1    D'Souza, S.S.2    Gururaj, A.E.3    Shaila, M.S.4    Salimath, B.P.5
  • 40
    • 0032887572 scopus 로고    scopus 로고
    • Effects of diazepam on Mycobacterium bovis-induced infection in hamsters
    • Revista brasileira de pesquisas medicas e biologicas/Sociedade Brasileira de Biofisica... et al.
    • Righi D.A., Pinheiro S.R., Guerra J.L., and Palermo-Neto J. Effects of diazepam on Mycobacterium bovis-induced infection in hamsters. Brazilian Journal of Medical and Biological Research 32 (1999) 1145-1153 Revista brasileira de pesquisas medicas e biologicas/Sociedade Brasileira de Biofisica... et al.
    • (1999) Brazilian Journal of Medical and Biological Research , vol.32 , pp. 1145-1153
    • Righi, D.A.1    Pinheiro, S.R.2    Guerra, J.L.3    Palermo-Neto, J.4
  • 41
    • 0029070313 scopus 로고
    • Relation of benzodiazepine use to the risk of selected cancers: breast, large bowel, malignant melanoma, lung, endometrium, ovary, non-Hodgkin's lymphoma, testis, Hodgkin's disease, thyroid, and liver
    • Rosenberg L., Palmer J.R., Zauber A.G., Warshauer M.E., Strom B.L., Harlap S., and Shapiro S. Relation of benzodiazepine use to the risk of selected cancers: breast, large bowel, malignant melanoma, lung, endometrium, ovary, non-Hodgkin's lymphoma, testis, Hodgkin's disease, thyroid, and liver. American Journal of Epidemiology 141 (1995) 1153-1160
    • (1995) American Journal of Epidemiology , vol.141 , pp. 1153-1160
    • Rosenberg, L.1    Palmer, J.R.2    Zauber, A.G.3    Warshauer, M.E.4    Strom, B.L.5    Harlap, S.6    Shapiro, S.7
  • 43
    • 33644535162 scopus 로고    scopus 로고
    • Diazepam effects on Ehrlich tumor growth and macrophage activity in mice
    • Sakai M., Fonseca E.S., Dagli M.L., and Palermo-Neto J. Diazepam effects on Ehrlich tumor growth and macrophage activity in mice. Life Sciences 78 (2006) 1777-1783
    • (2006) Life Sciences , vol.78 , pp. 1777-1783
    • Sakai, M.1    Fonseca, E.S.2    Dagli, M.L.3    Palermo-Neto, J.4
  • 45
    • 0037189119 scopus 로고    scopus 로고
    • Effect of beta-carotene on the development of the solid Ehrlich tumor in mice
    • Salgado Oloris S.C., Dagli M.L., and Guerra J.L. Effect of beta-carotene on the development of the solid Ehrlich tumor in mice. Life Sciences 71 (2002) 717-724
    • (2002) Life Sciences , vol.71 , pp. 717-724
    • Salgado Oloris, S.C.1    Dagli, M.L.2    Guerra, J.L.3
  • 46
    • 0030864541 scopus 로고    scopus 로고
    • Early tumor effect on splenic Th lymphocytes in mice
    • Segura J.A., Barbero L.G., and Marquez J. Early tumor effect on splenic Th lymphocytes in mice. FEBS Letters 414 (1997) 1-6
    • (1997) FEBS Letters , vol.414 , pp. 1-6
    • Segura, J.A.1    Barbero, L.G.2    Marquez, J.3
  • 48
    • 0028362187 scopus 로고
    • Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis
    • Taketani S., Kohno H., Okuda M., Furukawa T., and Tokunaga R. Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis. The Journal of Biological Chemistry 269 (1994) 7527-7531
    • (1994) The Journal of Biological Chemistry , vol.269 , pp. 7527-7531
    • Taketani, S.1    Kohno, H.2    Okuda, M.3    Furukawa, T.4    Tokunaga, R.5
  • 50
    • 4644295513 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro
    • Weisinger G., Kelly-Hershkovitz E., Veenman L., Spanier I., Leschiner S., and Gavish M. Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro. Biochemistry 43 (2004) 12315-12321
    • (2004) Biochemistry , vol.43 , pp. 12315-12321
    • Weisinger, G.1    Kelly-Hershkovitz, E.2    Veenman, L.3    Spanier, I.4    Leschiner, S.5    Gavish, M.6
  • 51
    • 0031457965 scopus 로고    scopus 로고
    • Benzodiazepines, anxiety and immunity
    • Zavala F. Benzodiazepines, anxiety and immunity. Pharmacology & Therapeutics 75 (1997) 199-216
    • (1997) Pharmacology & Therapeutics , vol.75 , pp. 199-216
    • Zavala, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.