The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders

Journal of Neuropathology and Experimental Neurology

Volumn 67, Issue 10, 2008, Pages 1001-1010

  Venneti, Sriram ^a   Wang, Guoji ^a   Nguyen, Jason ^a   Wiley, Clayton A ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

DAA1106; Microglia; Neurological disorders; Peripheral benzodiazepine receptor; PK11195; Positron emission tomography imaging

Indexed keywords

BENZODIAZEPINE RECEPTOR; DAA 1106; N (2,5 DIMETHOXYBENZYL) N (4 FLUORO 2 PHENOXYPHENYL)ACETAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT; TRITIUM; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; DIPHENYL ETHER DERIVATIVE; ISOQUINOLINE DERIVATIVE;

AGED; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPSY; BINDING AFFINITY; BRAIN INFARCTION; CELL ACTIVATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; MAJOR CLINICAL STUDY; MALE; MICROGLIA; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; AUTORADIOGRAPHY; BRAIN; COMPARATIVE STUDY; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOLOGY; SCINTISCANNING;

ACETAMIDES; AGED; AGED, 80 AND OVER; AUTORADIOGRAPHY; BRAIN; FEMALE; HUMANS; INFLAMMATION; ISOQUINOLINES; MALE; MICROGLIA; MIDDLE AGED; NERVOUS SYSTEM DISEASES; PHENYL ETHERS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 54449090610     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e318188b204     Document Type: Article

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