메뉴 건너뛰기




Volumn 745, Issue , 2012, Pages 154-180

ECVAM and new technologies for toxicity testing

Author keywords

[No Author keywords available]

Indexed keywords

COSMETIC;

EID: 84859963780     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3055-1_10     Document Type: Article
Times cited : (29)

References (112)
  • 1
    • 57749176099 scopus 로고    scopus 로고
    • Committee on Toxicity Testing and Assessment of Environmental Agents Washington, DC: National Academies Press
    • Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC: National Academies Press, 2007: Available at: http://www.nap.edu/catalog.php?record-id-11970#toc.
    • (2007) National Research Council. Toxicity Testing in the 21st Century: A Vision and A Strategy
  • 2
    • 79956348442 scopus 로고    scopus 로고
    • Alternative (non-animal) methods for cosmetics testing: Current status and future prospects-2010
    • Adler S, Basketter D, Creton S et al. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol 2011; 85:367-485.
    • Arch Toxicol , vol.2011 , Issue.85 , pp. 367-485
    • Adler, S.1    Basketter, D.2    Creton, S.3
  • 4
    • 84889717873 scopus 로고    scopus 로고
    • OECD Paris: Organisation for Economic Co-operation and Development
    • OECD. Information webpage on work on endocrine disruptors. Paris: Organisation for Economic Co-operation and Development, 2011: Available at: http://www.oecd.org/document/61/0,3746,en- 2649-34377-2348733-1-1-1-1,00.html.
    • Information Webpage on Work on Endocrine Disruptors , vol.2011
  • 5
    • 84889718976 scopus 로고    scopus 로고
    • Statement on the Scientific Validity of the Embryonic Stem Cell Test (EST)-an in Vitro Test for Embryotoxicity
    • EC ECVAM.
    • EC ECVAM. Statement on the Scientific Validity of the Embryonic Stem Cell Test (EST)-an In Vitro Test for Embryotoxicity. Ispra: European Centre for the Validation of Alternative Methods, 2001: Available at http://ecvam.jrc.it/ publication/Embryotoxicity-statements.pdf.
    • (2001) Ispra: European Centre for the Validation of Alternative Methods
  • 6
    • 0036098620 scopus 로고    scopus 로고
    • The ECVAM international validation study on in vitro embryotoxicity tests: Results of the definitive phase and evaluation of prediction models
    • Genschow E, Spielmann H, Scholz G et al. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. Altern Lab Anim-ATLA 2002; 30(2):151-176.
    • (2002) Altern Lab Anim-ATLA , vol.30 , Issue.2 , pp. 151-176
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3
  • 8
    • 21544473568 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and noncarcinogens I. Sensitivity, specificity and relative predictivity
    • Kirkland D, Aardema M, Henderson L et al. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and noncarcinogens I. Sensitivity, specificity and relative predictivity. Mutat Res 2005; 584:1-256.
    • (2005) Mutat Res , vol.584 , pp. 1-256
    • Kirkland, D.1    Aardema, M.2    Henderson, L.3
  • 9
    • 22844434663 scopus 로고    scopus 로고
    • Genotoxicity and mutagenicity
    • Maurici D, Aardema M, Corvi R et al. Genotoxicity and mutagenicity. Altern Lab Anim-ATLA 2005; 33(Suppl 1):117-130.
    • (2005) Altern Lab Anim-ATLA , vol.33 , Issue.SUPPL. 1 , pp. 117-130
    • Maurici, D.1    Aardema, M.2    Corvi, R.3
  • 10
    • 77955095115 scopus 로고    scopus 로고
    • International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility
    • Aardema MJ, Barnett BC, Khambatta Z et al. International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility. Mutat Res 2010; 701(2):123-131.
    • (2010) Mutat Res , vol.701 , Issue.2 , pp. 123-131
    • Aardema, M.J.1    Barnett, B.C.2    Khambatta, Z.3
  • 11
    • 33847325174 scopus 로고    scopus 로고
    • How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM workshop
    • Kirkland D, Pfuhler S, Tweats D et al. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM workshop. Mutat Res 2007; 628:31-55.
    • (2007) Mutat Res , vol.628 , pp. 31-55
    • Kirkland, D.1    Pfuhler, S.2    Tweats, D.3
  • 12
    • 33746309471 scopus 로고    scopus 로고
    • High-specificity and high-sensitivity genotoxicity assessment in a human cell line: Validation of the GreenScreen HC GADD45a-GFP genotoxicity assay
    • Hastwell PW, Chai LL, Roberts KJ et al. High-specificity and high-sensitivity genotoxicity assessment in a human cell line: validation of the GreenScreen HC GADD45a-GFP genotoxicity assay. Mutat Res 2006; 607:160-175.
    • (2006) Mutat Res , vol.607 , pp. 160-175
    • Hastwell, P.W.1    Chai, L.L.2    Roberts, K.J.3
  • 14
    • 79955462525 scopus 로고    scopus 로고
    • The influence of scoring method on variability in results obtained with the comet assay
    • Azqueta A, Meier S, Priestley C et al. The influence of scoring method on variability in results obtained with the comet assay. Mutagenesis 2011; 26(3):393-399.
    • (2011) Mutagenesis , vol.26 , Issue.3 , pp. 393-399
    • Azqueta, A.1    Meier, S.2    Priestley, C.3
  • 15
    • 33846132354 scopus 로고    scopus 로고
    • In vivo erythrocyte micronucleus assay. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion on nonhematopoietic target cells and a single dose-level limit test
    • Hayashi M, MacGregor JT, Gatehouse DG et al. In vivo erythrocyte micronucleus assay. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion on nonhematopoietic target cells and a single dose-level limit test. Mutat Res 2007; 627:10-30.
    • (2007) Mutat Res , vol.627 , pp. 10-30
    • Hayashi, M.1    MacGregor, J.T.2    Gatehouse, D.G.3
  • 16
    • 72449195675 scopus 로고    scopus 로고
    • Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-report from an ECVAM workshop
    • Pfuhler S, Kirkland D, Kasper P et al. Reduction of use of animals in regulatory genotoxicity testing: identification and implementation opportunities-report from an ECVAM workshop. Mutat Res 2009; 680(1-2):31.
    • (2009) Mutat Res , vol.680 , Issue.1-2 , pp. 31
    • Pfuhler, S.1    Kirkland, D.2    Kasper, P.3
  • 17
    • 0026683779 scopus 로고
    • Interaction and distinction of genotoxic and nongenotoxic events in carcinogenesis
    • Yamasaki H, Mesnil M, Nakasawa H. Interaction and distinction of genotoxic and nongenotoxic events in carcinogenesis. Toxicol Lett 1992; 64-65:597-604.
    • (1992) Toxicol Lett , vol.64-65 , pp. 597-604
    • Yamasaki, H.1    Mesnil, M.2    Nakasawa, H.3
  • 18
    • 79956355865 scopus 로고    scopus 로고
    • ECVAM prevalidation of three cell transformation assays
    • Vanparys PH, Corvi R, Aardema M et al. ECVAM prevalidation of three cell transformation assays. ALTEX 2010; 27:267-270.
    • ALTEX , vol.2010 , Issue.27 , pp. 267-270
    • Vanparys, P.H.1    Corvi, R.2    Aardema, M.3
  • 19
    • 84859983778 scopus 로고    scopus 로고
    • ESAC opinion based on the ESAC peer review of an ECVAM-coordinated prevalidation study concerning three protocols of the Cell Transformation Assay (CTA) for in vitro carcinogenicity testing
    • EC ECVAM.
    • EC ECVAM. ESAC opinion based on the ESAC peer review of an ECVAM-coordinated prevalidation study concerning three protocols of the Cell Transformation Assay (CTA) for in vitro carcinogenicity testing. Ispra: European Centre for the Validation of Alternative Methods, 2011.
    • (2011) Ispra: European Centre for the Validation of Alternative Methods
  • 20
    • 84859958978 scopus 로고    scopus 로고
    • ESAC Working Group Peer Review Consensus Report on an ECVAM-coordinated study concerning three protocols of the Cell Transformation Assay (CTA) for in vitro carcinogenicity testing
    • EC ECVAM
    • EC ECVAM. ESAC Working Group Peer Review Consensus Report on an ECVAM-coordinated study concerning three protocols of the Cell Transformation Assay (CTA) for in vitro carcinogenicity testing. Ispra: European Centre for the Validation of Alternative Methods, 2011.
    • (2011) Ispra: European Centre for the Validation of Alternative Methods
  • 21
    • 84859991854 scopus 로고    scopus 로고
    • ECVAM recommendation on the in vitro Cell Transformation Assay for carcinogenicity testing
    • EC ECVAM.
    • EC ECVAM. ECVAM recommendation on the in vitro Cell Transformation Assay for carcinogenicity testing. Ispra: European Centre for the Validation of Alternative Methods, 2011.
    • (2011) Ispra: European Centre for the Validation of Alternative Methods
  • 22
    • 60249097808 scopus 로고    scopus 로고
    • Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy
    • Walsh MJ, Bruce SW, Pant K et al. Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy. Toxicol 2009; 258:33-38.
    • (2009) Toxicol , vol.258 , pp. 33-38
    • Walsh, M.J.1    Bruce, S.W.2    Pant, K.3
  • 23
    • 65949113139 scopus 로고    scopus 로고
    • Image analysis and automatic classification of transformed foci
    • Urani C, Stefanini FM, Bussinelli L et al. Image analysis and automatic classification of transformed foci. J Microsc 2009; 234:269-279.
    • (2009) J Microsc , vol.234 , pp. 269-279
    • Urani, C.1    Stefanini, F.M.2    Bussinelli, L.3
  • 24
    • 79956366141 scopus 로고    scopus 로고
    • Bhas cell transformation assay as a predictor of carcinogenicity
    • Special Issue
    • Poth A, Kunz S, Heppenheimer A. Bhas cell transformation assay as a predictor of carcinogenicity. ALTEX 2007; 14 (Special Issue):519-521.
    • (2007) ALTEX , vol.14 , pp. 519-521
    • Poth, A.1    Kunz, S.2    Heppenheimer, A.3
  • 25
    • 76549098490 scopus 로고    scopus 로고
    • Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents
    • Ao L, Liu JY, Liu WB et al. Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents. Toxicol In Vitro 2010; 24:430-438.
    • Toxicol in Vitro , vol.2010 , Issue.24 , pp. 430-438
    • Ao, L.1    Liu, J.Y.2    Liu, W.B.3
  • 26
    • 77958467782 scopus 로고    scopus 로고
    • Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens
    • Rohrbeck A, Salinas G, Maaser K et al. Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens. Toxicol Sci 2010; 118:31-41.
    • Toxicol Sci , vol.2010 , Issue.118 , pp. 31-41
    • Rohrbeck, A.1    Salinas, G.2    Maaser, K.3
  • 27
    • 61849180355 scopus 로고    scopus 로고
    • Automated soft agar assay for the high-throughput screening of anticancer compounds
    • Thierbach R, Steinberg P. Automated soft agar assay for the high-throughput screening of anticancer compounds. Anal Biochem 2009; 87:318-320.
    • (2009) Anal Biochem , vol.87 , pp. 318-320
    • Thierbach, R.1    Steinberg, P.2
  • 28
    • 31444451811 scopus 로고    scopus 로고
    • Non-Genotoxic Carcinogen Study Group in the Environmental Mutagen Society of Japan. An inter-laboratory collaborative study by the Non-Genotoxic Carcinogen Study Group in Japan, on a cell transformation assay for tumour promoters using Bhas 42 cells
    • Ohmori K, Umeda M, Tanaka N et al. Non-Genotoxic Carcinogen Study Group in the Environmental Mutagen Society of Japan. An inter-laboratory collaborative study by the Non-Genotoxic Carcinogen Study Group in Japan, on a cell transformation assay for tumour promoters using Bhas 42 cells. Altern Lab Anim-ATLA 2005; 33(6):619-639.
    • (2005) Altern Lab Anim-ATLA , vol.33 , Issue.6 , pp. 619-639
    • Ohmori, K.1    Umeda, M.2    Tanaka, N.3
  • 30
    • 21444432708 scopus 로고    scopus 로고
    • Gene expression profile analysis: An emerging approach to investigate mechanisms of genotoxicity
    • Aubrecht J, Caba E. Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity. Pharmacogenomics 2005; 6:419-428.
    • (2005) Pharmacogenomics , vol.6 , pp. 419-428
    • Aubrecht, J.1    Caba, E.2
  • 31
    • 19544375991 scopus 로고    scopus 로고
    • Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver
    • Ellinger-Ziegelbauer H, Stuart B, Wahle B et al. Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver. Mutat Res 2005; 575:61-84.
    • (2005) Mutat Res , vol.575 , pp. 61-84
    • Ellinger-Ziegelbauer, H.1    Stuart, B.2    Wahle, B.3
  • 32
    • 33644777676 scopus 로고    scopus 로고
    • Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use
    • Corvi R, Ahr HJ, Albertini S et al. Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use. Environ Health Perspect 2006; 114:420-429.
    • (2006) Environ Health Perspect , vol.114 , pp. 420-429
    • Corvi, R.1    Ahr, H.J.2    Albertini, S.3
  • 33
    • 22844432843 scopus 로고    scopus 로고
    • Alternative (non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects
    • Subchapter 3.4. Skin Sensitisation Eskes C, Zuang V, eds
    • Basketter D, Casati S, Gerberick F et al. Subchapter 3.4. Skin Sensitisation. In: Eskes C, Zuang V, eds. Alternative (non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects. Altern Lab Anim-ATLA 2005; 33(Suppl 1):83-103.
    • (2005) Altern Lab Anim-ATLA , vol.33 , Issue.SUPPL.1 , pp. 83-103
    • Basketter, D.1    Casati, S.2    Gerberick, F.3
  • 34
    • 20144389652 scopus 로고    scopus 로고
    • Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. The report and recommendations of ECVAM workshop 51
    • Casati S, Aeby P, Basketter DA et al. Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. The report and recommendations of ECVAM workshop 51. Altern Lab Anim- ATLA 2005; 33(1):47-62.
    • (2005) Altern Lab Anim- ATLA , vol.33 , Issue.1 , pp. 47-62
    • Casati, S.1    Aeby, P.2    Basketter, D.A.3
  • 35
    • 79952041429 scopus 로고    scopus 로고
    • The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories
    • Natsch A, Bauch C, Foertsch L et al. The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: results of a ring-study in five laboratories. Toxicol In Vitro 2011; 25(3):733-744.
    • (2011) Toxicol in Vitro , vol.25 , Issue.3 , pp. 733-744
    • Natsch, A.1    Bauch, C.2    Foertsch, L.3
  • 37
    • 22844446713 scopus 로고    scopus 로고
    • Alternative (non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects
    • Subchapter 3.3. Eye Irritation Eskes C, Zuang V, eds.
    • Eskes C, Bessou S, Bruner L et al. Subchapter 3.3. Eye Irritation. In: Eskes C, Zuang V, eds. Alternative (non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects. Altern Lab Anim- ATLA 2005; 33(Suppl 1):47-81.
    • (2005) Altern Lab Anim- ATLA , vol.33 , Issue.SUPPL. 1 , pp. 47-81
    • Eskes, C.1    Bessou, S.2    Bruner, L.3
  • 38
    • 72249104697 scopus 로고    scopus 로고
    • A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches
    • Scott L, Eskes C, Hoffmann S et al. A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches. Toxicol In Vitro 2010; 24(1):1-9.
    • (2010) Toxicol in Vitro , vol.24 , Issue.1 , pp. 1-9
    • Scott, L.1    Eskes, C.2    Hoffmann, S.3
  • 39
    • 0036974321 scopus 로고    scopus 로고
    • Extent of initial corneal injury as the mechanistic basis for ocular irritation: Key findings and recommendations for the development of alternative assays
    • Maurer JK, Parker RD, Jester JV. Extent of initial corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays. Regul Toxicol Pharmacol 2002; 36:106-117.
    • (2002) Regul Toxicol Pharmacol , vol.36 , pp. 106-117
    • Maurer, J.K.1    Parker, R.D.2    Jester, J.V.3
  • 40
    • 0042697149 scopus 로고    scopus 로고
    • Sensory nerves, neurogenic inflammation and pain: Missing components of alternative irritation strategies? A review and a potential strategy
    • Garle MJ, Fry JR. Sensory nerves, neurogenic inflammation and pain: missing components of alternative irritation strategies? A review and a potential strategy. Altern Lab Anim-ATLA 2003; 31(3):295-316.
    • (2003) Altern Lab Anim-ATLA , vol.31 , Issue.3 , pp. 295-316
    • Garle, M.J.1    Fry, J.R.2
  • 41
    • 84889744212 scopus 로고    scopus 로고
    • ESAC Statement on the scientific validity of the Episkin test (an in vitro test for skin corrosivity)
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the scientific validity of the Episkin test (an in vitro test for skin corrosivity). Ispra: European Centre for the Validation of Alternative Methods, 1998: Available at: http://ecvam.jrc.it/ publication/EPISKIN-statement.pdf.
    • (1998) Ispra: European Centre for the Validation of Alternative Methods
  • 42
    • 84889761065 scopus 로고    scopus 로고
    • ESAC Statement on the scientific validity of the rat skin transcutaneous electrical resistance (TER) test (an in vitro test for skin corrosivity)
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the scientific validity of the rat skin transcutaneous electrical resistance (TER) test (an in vitro test for skin corrosivity). Ispra: European Centre for the Validation of Alternative Methods, 1998: Available at: http://ecvam.jrc.it/publication/TER-statement.pdf.
    • (1998) Ispra: European Centre for the Validation of Alternative Methods
  • 43
    • 84889728650 scopus 로고    scopus 로고
    • ESAC Statement on the application of the EpiDerm human skin model for skin corrosivity testing
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the application of the EpiDerm human skin model for skin corrosivity testing. Ispra: European Centre for the Validation of Alternative Methods, 2000: Available at: http://ecvam.jrc.it/publication/ EpiDerm-statement.pdf.
    • (2000) Ispra: European Centre for the Validation of Alternative Methods
  • 44
    • 84889705811 scopus 로고    scopus 로고
    • ESAC Statement on the application of the Corrositex assay for skin corrosivity testing
    • EC ECVAM.
    • EC ECVAM. ESAC Statement on the application of the Corrositex assay for skin corrosivity testing. Ispra: European Centre for the Validation of Alternative Methods, 2000. Available at: http://ecvam.jrc. it/publication/CRTX- statement.pdf.
    • (2000) Ispra: European Centre for the Validation of Alternative Methods
  • 45
    • 84889734240 scopus 로고    scopus 로고
    • ESAC statement on the application of the skinethicTM human skin model
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the Application of the SkinethicTM Human Skin Model. Ispra: European Centre for the Validation of Alternative Methods, 2006: Available at: http://ecvam.jrc.it/publication/ESAC25-statement-SKINETHIC- correction-on181206-C.pdf
    • (2006) Ispra: European Centre for the Validation of Alternative Methods
  • 46
    • 84889748964 scopus 로고    scopus 로고
    • ESAC statement on the scientific validity of an in vitro test method for skin corrosivity testing
    • EC ECVAM Available at:
    • EC ECVAM. ESAC Statement on the scientific validity of an in vitro test method for skin corrosivity testing. Ispra: European Centre for the Validation of Alternative Methods, 2009: Available at: http://ecvam.jrc.it/publication/ ESAC30-skincorrosion-revised-20100921.pdf.
    • (2009) Ispra: European Centre for the Validation of Alternative Methods
  • 47
    • 84889698809 scopus 로고    scopus 로고
    • ESAC Statement on the validity of in vitro tests for skin irritation
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the validity of in vitro tests for skin irritation. Ispra: European Centre for the Validation of Alternative Methods, 2007: Available at: http://ecvam.jrc.it/publication/ESAC26- statement- SkinIrritation-20070525-C.pdf.
    • (2007) Ispra: European Centre for the Validation of Alternative Methods
  • 48
    • 84889746848 scopus 로고    scopus 로고
    • ESAC Statement on the scientific validity of in vitro tests for skin irritation testing
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the scientific validity of in vitro tests for skin irritation testing. Ispra: European Centre for the Validation of Alternative Methods, 2008: Available at: http://ecvam.jrc.it/publication/ESAC- Statement-SkinEthic+EpiDerm%20FINAL%200812-01.pdf.
    • (2008) Ispra: European Centre for the Validation of Alternative Methods
  • 49
    • 0024444685 scopus 로고
    • Epidermal damage induced by irritants in man: A light and electron microscopic study
    • Willis CM, Stephens CJ, Wilkinson JD. Epidermal damage induced by irritants in man: a light and electron microscopic study. J Invest Dermatol 1989; 93:695-699.
    • (1989) J Invest Dermatol , vol.93 , pp. 695-699
    • Willis, C.M.1    Stephens, C.J.2    Wilkinson, J.D.3
  • 50
    • 0025726928 scopus 로고
    • Selective expression of immune-associated surface antigens by keratinocytes in irritant contact dermatitis
    • Willis CM, Stephens CJ, Wilkinson JD. Selective expression of immune-associated surface antigens by keratinocytes in irritant contact dermatitis. J Invest Dermatol 1991; 96:505-511.
    • (1991) J Invest Dermatol , vol.96 , pp. 505-511
    • Willis, C.M.1    Stephens, C.J.2    Wilkinson, J.D.3
  • 51
    • 20944439962 scopus 로고    scopus 로고
    • Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27 and CXCL8) alarm signals after allergen and irritant exposure
    • Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S et al. Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27 and CXCL8) alarm signals after allergen and irritant exposure. Exp Dermatol 2005; 14:109-116.
    • (2005) Exp Dermatol , vol.14 , pp. 109-116
    • Spiekstra, S.W.1    Toebak, M.J.2    Sampat-Sardjoepersad, S.3
  • 52
    • 44849107049 scopus 로고    scopus 로고
    • Skin irritation and sensitization: Mechanisms and new approaches for risk assessment
    • Fluhr JW, Darlenski R, Angelova-Fischer I et al. Skin irritation and sensitization: mechanisms and new approaches for risk assessment. Skin Pharmacol Physiol 2008; 21:124-135.
    • (2008) Skin Pharmacol Physiol , Issue.21 , pp. 124-135
    • Fluhr, J.W.1    Darlenski, R.2    Angelova- Fischer, I.3
  • 53
    • 84889695975 scopus 로고    scopus 로고
    • ESAC Statement on the performance under un GHS of three in vitro assays for skin irritation testing and the adaptation of the reference chemicals and defined accuracy values of the ECVAM skin irritation performances standards
    • EC ECVAM
    • EC ECVAM. ESAC Statement on the performance under UN GHS of three in vitro assays for skin irritation testing and the adaptation of the reference chemicals and defined accuracy values of the ECVAM skin irritation performances standards. Ispra: European Centre for the Validation of Alternative Methods, 2009: Available at: http://ecvam.jrc.it/publication/ESAC31-skin-irritation- statement-20090922.pdf.
    • (2009) Ispra: European Centre for the Validation of Alternative Methods
  • 55
    • 9144267257 scopus 로고    scopus 로고
    • The nonclassical export routes: FGF1 and IL-1alpha point the way
    • Prudovsky I, Mandinova A, Soldi R et al. The nonclassical export routes: FGF1 and IL-1alpha point the way. J Cell Sci 2003; 116(24):4871-4881.
    • (2003) J Cell Sci , vol.116 , Issue.24 , pp. 4871-4881
    • Prudovsky, I.1    Mandinova, A.2    Soldi, R.3
  • 56
    • 0038701886 scopus 로고    scopus 로고
    • The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes
    • Nickel W. The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur J Biochem 2003; 270:2109-2119.
    • (2003) Eur J Biochem , vol.270 , pp. 2109-2119
    • Nickel, W.1
  • 57
    • 35349018379 scopus 로고    scopus 로고
    • The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis
    • Borlon C, Godard P, Eskes C et al. The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis. Toxicology 2007; 241:157-166.
    • (2007) Toxicology , vol.241 , pp. 157-166
    • Borlon, C.1    Godard, P.2    Eskes, C.3
  • 58
    • 66849097664 scopus 로고    scopus 로고
    • ECVAM key area topical toxicity: Update on activities
    • Special Issue
    • Zuang V, Eskes C, Griesinger C et al. ECVAM key area topical toxicity: update on activities. AATEX 2007; 14(Special Issue):523-528.
    • (2007) AATEX , vol.14 , pp. 523-528
    • Zuang, V.1    Eskes, C.2    Griesinger, C.3
  • 60
    • 79953141208 scopus 로고    scopus 로고
    • Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact
    • Smijs TG, Bouwstra JA. Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact. J Biomed Nanotechnol 2010; 6(5):469-484.
    • J Biomed Nanotechnol 2010 , vol.6 , Issue.5 , pp. 469-484
    • Smijs, T.G.1    Bouwstra, J.A.2
  • 61
    • 73949137818 scopus 로고    scopus 로고
    • Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality?
    • Baroli B. Penetration of nanoparticles and nanomaterials in the skin: fiction or reality? J Pharm Sci. 2010; 99(1):21-50.
    • (2010) J Pharm Sci. , vol.99 , Issue.1 , pp. 21-50
    • Baroli, B.1
  • 62
    • 79953152973 scopus 로고    scopus 로고
    • New nanosized technologies for dermal and transdermal drug delivery. A review
    • Schroeter A, Engelbrecht T, Neubert RH et al. New nanosized technologies for dermal and transdermal drug delivery. A review. J Biomed Nanotechnol 2010; 6(5):511-528.
    • J Biomed Nanotechnol 2010 , vol.6 , Issue.5 , pp. 511-528
    • Schroeter, A.1    Engelbrecht, T.2    Neubert, R.H.3
  • 63
    • 0034819568 scopus 로고    scopus 로고
    • Percutaneous penetration/dermal absorption of hair dyes in vitro
    • Steiling W, Kreutz J, Hofer H. Percutaneous penetration/dermal absorption of hair dyes in vitro. Toxicol In Vitro 2001; 15(4-5):565-570.
    • (2001) Toxicol in Vitro , vol.15 , Issue.4-5 , pp. 565-570
    • Steiling, W.1    Kreutz, J.2    Hofer, H.3
  • 67
    • 0033753349 scopus 로고    scopus 로고
    • Comparative in vitro-in vivo percutaneous absorption of pesticide propoxur
    • Van der Sandt JJM, Meuling WJA, Elliott GR et al. Comparative in vitro-in vivo percutaneous absorption of pesticide propoxur. Toxicol Sci 2000; 58:15-22.
    • (2000) Toxicol Sci , vol.58 , pp. 15-22
    • Van Der Sandt Jjm1    Wja, M.2    Elliott, G.R.3
  • 68
    • 58149191280 scopus 로고    scopus 로고
    • Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review
    • Barbero AM, Frasch HF. Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. Toxicol In Vitro 2009; 23(1):1-13.
    • (2009) Toxicol in Vitro , vol.23 , Issue.1 , pp. 1-13
    • Barbero, A.M.1    Frasch, H.F.2
  • 69
    • 78649907180 scopus 로고    scopus 로고
    • Validation of a static Franz diffusion cell system for in vitro permeation studies
    • Ng SF, Rouse JJ, Sanderson FD et al. Validation of a static Franz diffusion cell system for in vitro permeation studies. AAPS Pharm Sci Tech 2010; 11(3):1432-1441.
    • (2010) AAPS Pharm Sci Tech , vol.11 , Issue.3 , pp. 1432-1441
    • Ng, S.F.1    Rouse, J.J.2    Sanderson, F.D.3
  • 70
    • 84889700718 scopus 로고    scopus 로고
    • Evaluations and predictions of dermal absorption of toxic chemicals
    • EDETOX Project.
    • EDETOX Project. Evaluations and predictions of dermal absorption of toxic chemicals. Newcastle-Upon-Tyne: EDETOX Project, 2004: Available at: http://research.ncl.ac.uk/edetox/EDETOX%20PDF%20Amended.pdf.
    • (2004) Newcastle-Upon-Tyne: EDETOX Project
  • 71
    • 1342326138 scopus 로고    scopus 로고
    • EDETOX Evaluations and predictions of dermal absorption of toxic chemicals
    • Williams FM. EDETOX Evaluations and predictions of dermal absorption of toxic chemicals. Int Arch Occup Environ Health 2004; 77(2):150-151.
    • (2004) Int Arch Occup Environ Health , vol.77 , Issue.2 , pp. 150-151
    • Williams, F.M.1
  • 72
    • 2342620755 scopus 로고    scopus 로고
    • In vitro predictions of skin absorption of caffeine, testosterone and benzoic acid: A multi-centre comparison study
    • van de Sandt JJ, van Burgsteden JA, Cage S et al. In vitro predictions of skin absorption of caffeine, testosterone and benzoic acid: a multi-centre comparison study. Regul Toxicol Pharmacol 2004; 39(3):271-281.
    • (2004) Regul Toxicol Pharmacol , vol.39 , Issue.3 , pp. 271-281
    • Van De Sandt, J.J.1    Van Burgsteden, J.A.2    Cage, S.3
  • 73
    • 20144388993 scopus 로고    scopus 로고
    • Inter- and intralaboratory variation of in vitro diffusion cell measurements: An international multicenter study using quasi-standardized methods and materials
    • Chilcott RP, Barai N, Beezer AE et al. Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials. J Pharm Sci 2005; 94(3):632-638.
    • (2005) J Pharm Sci , vol.94 , Issue.3 , pp. 632-638
    • Chilcott, R.P.1    Barai, N.2    Beezer, A.E.3
  • 74
    • 0035857715 scopus 로고    scopus 로고
    • Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption
    • Schmook FP, Meingassner JG, Billich A. Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Int J Pharm 2001; 215(1-2):51-56.
    • (2001) Int J Pharm , vol.215 , Issue.1-2 , pp. 51-56
    • Schmook, F.P.1    Meingassner, J.G.2    Billich, A.3
  • 75
    • 0035222638 scopus 로고    scopus 로고
    • Reconstructed skin equivalents for assessing percutaneous drug absorption from pharmaceutical formulations
    • Zghoul N, Fuchs R, Lehr CM, Schaefer UF. Reconstructed skin equivalents for assessing percutaneous drug absorption from pharmaceutical formulations. ALTEX 2001; 18(2):103-6.
    • (2001) ALTEX , vol.18 , Issue.2 , pp. 103-106
    • Zghoul, N.1    Fuchs, R.2    Lehr, C.M.3    Schaefer, U.F.4
  • 76
    • 20444375525 scopus 로고    scopus 로고
    • The human epidermis models EpiSkin, SkinEthic and EpiDerm: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity and substance transport
    • Netzlaff F, Lehr CM, Wertz PW et al. The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity and substance transport. Eur J Pharm Biopharm 2005; 60(2):167-178.
    • (2005) Eur J Pharm Biopharm , vol.60 , Issue.2 , pp. 167-178
    • Netzlaff, F.1    Lehr, C.M.2    Wertz, P.W.3
  • 77
    • 53949103329 scopus 로고    scopus 로고
    • Reconstructed epidermis and full-thickness skin for absorption testing: Influence of the vehicles used on steroid permeation
    • Schafer-Korting M, Mahmoud A, Lombardi Borgia S et al. Reconstructed epidermis and full-thickness skin for absorption testing: influence of the vehicles used on steroid permeation. Altern Lab Anim-ATLA 2008; 36(4):441-52.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.4 , pp. 441-452
    • Schafer-Korting, M.1    Mahmoud, A.2    Lombardi Borgia, S.3
  • 78
    • 72049101914 scopus 로고    scopus 로고
    • The Phenion full-thickness skin model for percutaneous absorption testing
    • Ackermann K, Borgia SL, Korting HC et al. The Phenion full-thickness skin model for percutaneous absorption testing. Skin Pharmacol Physiol 2010; 23(2):105-112.
    • (2010) Skin Pharmacol Physiol , vol.23 , Issue.2 , pp. 105-112
    • Ackermann, K.1    Borgia, S.L.2    Korting, H.C.3
  • 79
    • 33746311297 scopus 로고    scopus 로고
    • Reconstructed human epidermis for skin absorption testing: Results of the German prevalidation study
    • Schafer-Korting M, Bock U, Gamer A et al. Reconstructed human epidermis for skin absorption testing: results of the German prevalidation study. Altern Lab Anim-ATLA 2006; 34(3):283-294.
    • (2006) Altern Lab Anim-ATLA , vol.34 , Issue.3 , pp. 283-294
    • Schafer-Korting, M.1    Bock, U.2    Gamer, A.3
  • 80
    • 45549105564 scopus 로고    scopus 로고
    • The use ofreconstructed human epidermis for skin absorption testing: Results of the validation study
    • Schafer-Korting M, BockU, Diembeck W et al. The use ofreconstructed human epidermis for skin absorption testing: Results of the validation study. Altern Lab Anim-ATLA 2008; 36(2):161-187.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.2 , pp. 161-187
    • Schafer-Korting, M.1    Bock, U.2    Et Al., D.W.3
  • 81
    • 79956212332 scopus 로고    scopus 로고
    • Three-dimensional skin models as tools for transdermal drug delivery: Challenges and limitations
    • Van Gele M, Geusens B, Brochez L et al. Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations. Expert Opin Drug Deliv 2011; 8(6):705-720.
    • (2011) Expert Opin Drug Deliv , vol.8 , Issue.6 , pp. 705-720
    • Van Gele, M.1    Geusens, B.2    Brochez, L.3
  • 82
    • 80052835638 scopus 로고    scopus 로고
    • Mathematical models of skin permeability: An overview
    • Mitragotri S, Anissimov YG, Bunge AL et al. Mathematical models of skin permeability: An overview. Int J Pharm 2011; 418(1):115-29.
    • (2011) Int J Pharm , vol.418 , Issue.1 , pp. 115-129
    • Mitragotri, S.1    Anissimov, Y.G.2    Bunge, A.L.3
  • 83
    • 78349309848 scopus 로고    scopus 로고
    • Validated models for predicting skin penetration from different vehicles
    • Ghafourian T, Samaras EG, Brooks JD et al. Validated models for predicting skin penetration from different vehicles. Eur J Pharm Sci 2010; 41(5):612-616.
    • (2010) Eur J Pharm Sci , vol.41 , Issue.5 , pp. 612-616
    • Ghafourian, T.1    Samaras, E.G.2    Brooks, J.D.3
  • 84
    • 0028043667 scopus 로고
    • EC/COLIPA project on in vitro phototoxicity testing: First results obtained with the Balb/c 3T3 cell phototoxicity assay
    • Spielmann H, Balls M, Brand M et al. EC/COLIPA project on in vitro phototoxicity testing: first results obtained with the Balb/c 3T3 cell phototoxicity assay. Toxicol In Vitro 1994; 8:793-796.
    • (1994) Toxicol in Vitro , vol.8 , pp. 793-796
    • Spielmann, H.1    Balls, M.2    Brand, M.3
  • 85
    • 0031873718 scopus 로고    scopus 로고
    • The international EU/COLIPA in vitro phototoxicity validation study: Results of phase II (blind trial), part 1: The 3T3 NRU phototoxicity test
    • Spielmann H, Balls M, Dupuis J et al. The international EU/COLIPA In vitro phototoxicity validation study: results of phase II (blind trial), part 1: the 3T3 NRU phototoxicity test. Toxicol In Vitro 1998; 12:305-327.
    • (1998) Toxicol in Vitro , vol.12 , pp. 305-327
    • Spielmann, H.1    Balls, M.2    Dupuis, J.3
  • 86
    • 84889738770 scopus 로고    scopus 로고
    • EC. Commission Directive 2000/33/EC of 25 April 2000 adapting to technical progress for the 27th time Council Directive 67/548/EC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Annex V B.41 Phototoxicity-in vitro 3T3 NRU phototoxicity test
    • EC. Commission Directive 2000/33/EC of 25 April 2000 adapting to technical progress for the 27th time Council Directive 67/548/EC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Annex V B.41 Phototoxicity-in vitro 3T3 NRU phototoxicity test. Off J Eur Comm 2000; L136:98-107.
    • Off J Eur Comm , vol.2000 L136 , pp. 98-107
  • 87
    • 84925560200 scopus 로고    scopus 로고
    • OECD guidelines for the testing of chemicals Nr. 432
    • OECD Paris: Organisation for Economic Co-operation and Development
    • OECD. OECD guidelines for the testing of chemicals Nr. 432. In vitro 3T3 NRU phototoxicity test. Paris: Organisation for Economic Co-operation and Development, 2004.
    • (2004) Vitro 3T3 NRU Phototoxicity Test
  • 88
    • 0028264372 scopus 로고
    • Quantitative in vitro assessment of phototoxicity using a human skin model, Skin2
    • Edwards SM, Donnelly TA, Sayre RM et al. Quantitative in vitro assessment of phototoxicity using a human skin model, Skin2. Photodermatol Photoimmunol Photomed 1994; 10:111-117.
    • (1994) Photodermatol Photoimmunol Photomed , vol.10 , pp. 111-117
    • Edwards, S.M.1    Donnelly, T.A.2    Sayre, R.M.3
  • 89
    • 0000899278 scopus 로고    scopus 로고
    • Entwicklung eines in vitro Tests auf dermale Phototoxizitaet in einem Modell menschlicher Epidermis (EpiDermTM)
    • Liebsch M, Barrabas C, Traue T et al. Entwicklung eines in vitro Tests auf dermale Phototoxizitaet in einem Modell menschlicher Epidermis (EpiDermTM). ALTEX 1997; 14:165-174.
    • (1997) ALTEX , vol.14 , pp. 165-174
    • Liebsch, M.1    Barrabas, C.2    Traue, T.3
  • 90
    • 0029078525 scopus 로고
    • Application of the human dermal model Skin2 ZK 1350 to phototoxicity and skin corrosivity testing
    • Liebsch M, Döring B, Donelly TA et al. Application of the human dermal model Skin2 ZK 1350 to phototoxicity and skin corrosivity testing. Toxicol In Vitro 1995; 9:557-562.
    • (1995) Toxicol in Vitro , vol.9 , pp. 557-562
    • Liebsch, M.1    Döring, B.2    Donelly, T.A.3
  • 91
    • 0030670490 scopus 로고    scopus 로고
    • In vitro assessment of phototoxicity
    • Api AM. In vitro assessment of phototoxicity. In Vitro Toxicol 1997; 10:339-350.
    • (1997) Vitro Toxicol , vol.10 , pp. 339-350
    • Api, A.M.1
  • 95
    • 35648982470 scopus 로고    scopus 로고
    • Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests
    • Kejlovà K, Jrovà D, Bendovà H et al. Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests. Toxicol In Vitro 2007; 21(7):1298-303.
    • (2007) Toxicol in Vitro , vol.21 , Issue.7 , pp. 1298-1303
    • Kejlovà, K.1    Jrovà, D.2    Bendovà, H.3
  • 96
    • 77957354095 scopus 로고    scopus 로고
    • An evaluation of chemical photoreactivity and the relationship to photogenotoxicity
    • Lynch AM, Smith MD, Lane AS et al. An evaluation of chemical photoreactivity and the relationship to photogenotoxicity. Regul Toxicol Pharmacol 2010; 58(2):219-223.
    • (2010) Regul Toxicol Pharmacol , vol.58 , Issue.2 , pp. 219-223
    • Lynch, A.M.1    Smith, M.D.2    Lane, A.S.3
  • 97
    • 0000806003 scopus 로고    scopus 로고
    • The use of biokinetics and in vitro methods in toxicological risk evaluation
    • Blaauboer BJ, Bayliss MK, Castell JV et al. The use of biokinetics and in vitro methods in toxicological risk evaluation. Altern Lab Anim-ATLA 1996; 24(4):473-497.
    • (1996) Altern Lab Anim-ATLA , vol.24 , Issue.4 , pp. 473-497
    • Blaauboer, B.J.1    Bayliss, M.K.2    Castell, J.V.3
  • 98
    • 0036975586 scopus 로고    scopus 로고
    • The necessity of biokinetic information in the interpretation of in vitro toxicity data
    • Blaauboer BJ. The necessity of biokinetic information in the interpretation of in vitro toxicity data. Altern Lab Anim-ATLA 2002; 30(Suppl 2):85-91.
    • (2002) Altern Lab Anim-ATLA , vol.30 , Issue.SUPPL. 2 , pp. 85-91
    • Blaauboer, B.J.1
  • 99
    • 0036891062 scopus 로고    scopus 로고
    • In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15
    • Boobis A, Gundert-Remy U, Kremers P et al. In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15. Eur J Pharm Sci 2002; 17:183-193.
    • (2002) Eur J Pharm Sci , vol.17 , pp. 183-193
    • Boobis, A.1    Gundert-Remy, U.2    Kremers, P.3
  • 100
    • 27944458924 scopus 로고    scopus 로고
    • An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery
    • Parrott N, Paquereau N, Coassolo P et al. An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery. J Pharm Sci 2005; 94:2327-2343.
    • (2005) J Pharm Sci , vol.94 , pp. 2327-2343
    • Parrott, N.1    Paquereau, N.2    Coassolo, P.3
  • 102
    • 15244344542 scopus 로고    scopus 로고
    • Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man
    • Parrott N, Jones H, Paquereau N et al. Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man. Basic Clin Pharmacol Toxicol 2005; 96:193-199.
    • (2005) Basic Clin Pharmacol Toxicol , vol.96 , pp. 193-199
    • Parrott, N.1    Jones, H.2    Paquereau, N.3
  • 103
    • 0037452445 scopus 로고    scopus 로고
    • Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
    • Theil FP, Guentert TW, Haddad S et al. Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol Lett 2003; 138:29-49.
    • (2003) Toxicol Lett , vol.138 , pp. 29-49
    • Theil, F.P.1    Guentert, T.W.2    Haddad, S.3
  • 104
    • 33646124969 scopus 로고    scopus 로고
    • A novel strategy for physiologically based predictions of human pharmacokinetics
    • Jones HM, Parrott N, Jorga K et al. A novel strategy for physiologically based predictions of human pharmacokinetics. Clin Pharmacokinet 2006; 45:511-542.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 511-542
    • Jones, H.M.1    Parrott, N.2    Jorga, K.3
  • 105
    • 10744231168 scopus 로고    scopus 로고
    • Application of the CFU-GM assay to predict acute drug-induced neutropenia: An international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics
    • Pessina A, Albella B, Bayo M et al. Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicol Sci 2003; 75:355-367.
    • (2003) Toxicol Sci , vol.75 , pp. 355-367
    • Pessina, A.1    Albella, B.2    Bayo, M.3
  • 106
    • 2942754297 scopus 로고    scopus 로고
    • Use and application of stem cells in toxicology
    • Davila JC, Cezar GG, Thiede M et al. Use and application of stem cells in toxicology. Toxicol Sci 2004; 79:214-223.
    • (2004) Toxicol Sci , vol.79 , pp. 214-223
    • Davila, J.C.1    Cezar, G.G.2    Thiede, M.3
  • 107
    • 33845810079 scopus 로고    scopus 로고
    • Scoring CFU-GM colonies in vitro by data fusion: A first account
    • Crosta G, Fumarola L, Malerba I et al. Scoring CFU-GM colonies in vitro by data fusion: A first account. Exp Hematol 2007; 35(1):1-12.
    • (2007) Exp Hematol , vol.35 , Issue.1 , pp. 1-12
    • Crosta, G.1    Fumarola, L.2    Malerba, I.3
  • 108
    • 33645959506 scopus 로고    scopus 로고
    • Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
    • Burczynski ME, Dorner AJ. Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies. Pharmacogenomics 2006; 7:187-202.
    • (2006) Pharmacogenomics , vol.7 , pp. 187-202
    • Burczynski, M.E.1    Dorner, A.J.2
  • 109
    • 2342475704 scopus 로고    scopus 로고
    • Zebrafish: A preclinical model for drug screening
    • Parng C, Seng WL, Semino C et al. Zebrafish: a preclinical model for drug screening. Assay Drug Dev Technol 2002; 1:41-48.
    • (2002) Assay Drug Dev Technol , vol.1 , pp. 41-48
    • Parng, C.1    Seng, W.L.2    Semino, C.3
  • 110
    • 37849024323 scopus 로고    scopus 로고
    • A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine
    • van Vliet E, Morath S, Eskes C et al. A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine. Neurotoxicology 2008; 29(1):1-12.
    • (2008) Neurotoxicology , vol.29 , Issue.1 , pp. 1-12
    • Van Vliet, E.1    Morath, S.2    Eskes, C.3
  • 111
    • 35648983397 scopus 로고    scopus 로고
    • Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects
    • van Vliet E, Stoppini L, Balestrino M et al. Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects. Neurotoxicology 2007; 28(6):1136-1146.
    • (2007) Neurotoxicology , vol.28 , Issue.6 , pp. 1136-1146
    • Van Vliet, E.1    Stoppini, L.2    Balestrino, M.3
  • 112
    • 84859992736 scopus 로고    scopus 로고
    • ECVAMs Database Service on Alternative Methods (DB-ALM)-Online
    • Special Issue
    • Roi AJ, Flego M. ECVAMs Database Service on Alternative Methods (DB-ALM)-Online. ALTEX 2006; 23(Special Issue):177-180.
    • (2006) ALTEX , vol.23 , pp. 177-180
    • Roi, A.J.1    Flego, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.