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Volumn 24, Issue 4, 1996, Pages 473-497

The Use of Biokinetics and In Vitro Methods in Toxicological Risk Evaluation: The Report and Recommendations of ECVAM Workshop 15

(16)  Blaauboer, Bas J a   Bayliss, Martin K b   Castell, José V c   Evelo, Chris T A d   Frazier, John M e   Groen, Kees f   Gülden, Michael g   Guillouzo, André h   Hissink, Arendina M i   Houston, J Brian j   Johanson, Gunnar k   De Jongh, Joost a   Kedderis, Gregory L l   Reinhardt, Christoph A m   Van De Sandt, Johannes J M i   Semino, Giovanna n  


Author keywords

[No Author keywords available]

Indexed keywords


EID: 0000806003     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (32)

References (82)
  • 1
    • 0008511303 scopus 로고
    • ECVAM News & Views
    • Anon. (1994). ECVAM News & Views. ATLA 22, 7-11.
    • (1994) ATLA , vol.22 , pp. 7-11
  • 6
    • 0002252722 scopus 로고
    • Physiologically based pharmacokinetic modelling in toxicology
    • (ed. A. W. Hayes), New York: Raven Press
    • Andersen, M.E. & Krishnan, K. (1994). Physiologically based pharmacokinetic modelling in toxicology. In Principles and Methods of Toxicology, 3rd edn (ed. A. W. Hayes), pp. 149-188. New York: Raven Press.
    • (1994) Principles and Methods of Toxicology, 3rd Edn , pp. 149-188
    • Andersen, M.E.1    Krishnan, K.2
  • 7
    • 0018760585 scopus 로고
    • A structure-activity relationship of some chlorinated hydrocarbons
    • Sato, A. & Nakajima, T. (1979). A structure-activity relationship of some chlorinated hydrocarbons. Archives of Environmental Health 79, 69-75.
    • (1979) Archives of Environmental Health , vol.79 , pp. 69-75
    • Sato, A.1    Nakajima, T.2
  • 10
    • 0026457029 scopus 로고
    • Methods of determining plasma and tissue binding of drugs
    • Pacifici, G.M. & Viani, A, (1992). Methods of determining plasma and tissue binding of drugs. Clinical Pharmacokinetics 23, 449-468.
    • (1992) Clinical Pharmacokinetics , vol.23 , pp. 449-468
    • Pacifici, G.M.1    Viani, A.2
  • 12
    • 0024312687 scopus 로고
    • Correlation of tissue, blood and air partition coefficients of volatile organic chemicals
    • Patterson. S. & Mackay, D. (1989). Correlation of tissue, blood and air partition coefficients of volatile organic chemicals. British Journal of Industrial Medicine 46, 321-328.
    • (1989) British Journal of Industrial Medicine , vol.46 , pp. 321-328
    • Patterson, S.1    Mackay, D.2
  • 13
    • 0028925028 scopus 로고
    • A biologicallybased algorithm for predicting human tissue-blood partition coefficients of organic chemicals
    • Poulin, P. & Krishnan, K. (1995). A biologicallybased algorithm for predicting human tissue-blood partition coefficients of organic chemicals. Human and Experimental Toxicology 14, 273-280.
    • (1995) Human and Experimental Toxicology , vol.14 , pp. 273-280
    • Poulin, P.1    Krishnan, K.2
  • 15
    • 0027772182 scopus 로고
    • Prediction of the partition coefficient of lipophilic compounds in the air-mammal tissue system
    • Connell, DW., Braddock, R.D. & Mani, S.V. (1993). Prediction of the partition coefficient of lipophilic compounds in the air-mammal tissue system. Science of the Total Environment Suppl. 2, 1383-1396.
    • (1993) Science of the Total Environment Suppl. , vol.2 , pp. 1383-1396
    • Connell, D.W.1    Braddock, R.D.2    Mani, S.V.3
  • 16
    • 0004686913 scopus 로고
    • Computation of partition coefficients from molecular structures by a fragment addition method
    • (ed. S.H. Yalkowsky, A.A. Sinkula & S.C. Valvani), New York: Marcel Dekker
    • Chou, J.T. & Jurs, P.C. (1980). Computation of partition coefficients from molecular structures by a fragment addition method. In Physical and Chemical Properties of Drugs (ed. S.H. Yalkowsky, A.A. Sinkula & S.C. Valvani), pp. 163-199. New York: Marcel Dekker.
    • (1980) Physical and Chemical Properties of Drugs , pp. 163-199
    • Chou, J.T.1    Jurs, P.C.2
  • 17
    • 0008430511 scopus 로고
    • Molecular connectivity as a descriptor of structure for SAR analysis
    • (ed. S.H. Yalkowsky, A.A. Sinkula & S.C. Valvani), New York: Marcel Dekker
    • Kier, L.B. (1980). Molecular connectivity as a descriptor of structure for SAR analysis In Physical and Chemical Properties of Drugs (ed. S.H. Yalkowsky, A.A. Sinkula & S.C. Valvani), pp. 277-319. New York: Marcel Dekker.
    • (1980) Physical and Chemical Properties of Drugs , pp. 277-319
    • Kier, L.B.1
  • 18
    • 0000845392 scopus 로고
    • Drug transport across gastrointestinal epithelia
    • (ed. L.R. Johnson), New York: Raven Press
    • Jackson, J. (1987). Drug transport across gastrointestinal epithelia. In Physiology of the Gastrointestinal Tract, 2nd edn. (ed. L.R. Johnson), pp. 1597-1621. New York: Raven Press.
    • (1987) Physiology of the Gastrointestinal Tract, 2nd Edn. , pp. 1597-1621
    • Jackson, J.1
  • 19
    • 0027958693 scopus 로고
    • Intestinal absorptive function
    • Spiller, R.C. (1994). Intestinal absorptive function. Gut 35, Suppl. 1, S5-S9.
    • (1994) Gut , vol.35 , Issue.1 SUPPL.
    • Spiller, R.C.1
  • 20
    • 0022637262 scopus 로고
    • Postprandial patterns of canine jejunal motility and transit of luminal content
    • Scheman, M. & Ehrlein, H.J. (1986). Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology 90, 991-1000.
    • (1986) Gastroenterology , vol.90 , pp. 991-1000
    • Scheman, M.1    Ehrlein, H.J.2
  • 21
    • 0016051664 scopus 로고
    • A re-evaluation of the importance of partition coefficients in the gastrointestinal absorption of nutrients
    • Houston, J.B., Upshall, D.J. & Bridges, J.W. (1974) A re-evaluation of the importance of partition coefficients in the gastrointestinal absorption of nutrients. Journal of Pharmacology and Experimental Therapeutics 189, 244-254.
    • (1974) Journal of Pharmacology and Experimental Therapeutics , vol.189 , pp. 244-254
    • Houston, J.B.1    Upshall, D.J.2    Bridges, J.W.3
  • 22
    • 0028282707 scopus 로고
    • Incorporation of pharmacokinetics in non-cancer risk assessment: Example with chloropentafluorobenzene
    • Clewell, H.J. 3rd & Jarnot B.J. (1994). Incorporation of pharmacokinetics in non-cancer risk assessment: example with chloropentafluorobenzene. Risk Analysis 14, 265-276.
    • (1994) Risk Analysis , vol.14 , pp. 265-276
    • Clewell III, H.J.1    Jarnot, B.J.2
  • 23
    • 0021279862 scopus 로고
    • A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans
    • Ramsey, C.J. & Andersen, M.E. (1994). A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicology and Applied Pharmacology 73, 159-175.
    • (1994) Toxicology and Applied Pharmacology , vol.73 , pp. 159-175
    • Ramsey, C.J.1    Andersen, M.E.2
  • 24
    • 0026096428 scopus 로고
    • Gastrointestinal absorption of xenobiotics in physiologically-based pharmacokinetic models: A two-compartment description
    • Staats, D.A., Fisher, J.W. & Connolly, R.B. (1991). Gastrointestinal absorption of xenobiotics in physiologically-based pharmacokinetic models: a two-compartment description. Drug Metabolism and Disposition 19, 144-148.
    • (1991) Drug Metabolism and Disposition , vol.19 , pp. 144-148
    • Staats, D.A.1    Fisher, J.W.2    Connolly, R.B.3
  • 25
    • 2742514657 scopus 로고
    • A multi-compartment sequential transport model of the gastrointestinal absorption
    • abstract
    • Semino, G., Lilly, P.D. & Andersen, M.E. (1995). A multi-compartment sequential transport model of the gastrointestinal absorption. The Toxicologist 15, 273 (abstract).
    • (1995) The Toxicologist , vol.15 , pp. 273
    • Semino, G.1    Lilly, P.D.2    Andersen, M.E.3
  • 26
    • 0026658925 scopus 로고
    • A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethylacrylate and its implication for risk assessment
    • Frederick, C.B., Potter, D.W., Chang-Mateau, M.I. & Andersen, M.E. (1992). A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethylacrylate and its implication for risk assessment. Toxicology and Applied Pharmacology 114, 246-260.
    • (1992) Toxicology and Applied Pharmacology , vol.114 , pp. 246-260
    • Frederick, C.B.1    Potter, D.W.2    Chang-Mateau, M.I.3    Andersen, M.E.4
  • 30
    • 0024593744 scopus 로고
    • Characterisation of the human colon carcinoma cell line (CaCo-2) as a model system for intestinal epithelial permeability
    • Hidalgo, I.J., Raub T.J. & Borchardt R.T. (1989). Characterisation of the human colon carcinoma cell line (CaCo-2) as a model system for intestinal epithelial permeability. Gastroenterology 96, 736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 31
    • 0028113469 scopus 로고
    • Differentiated intestinal epithelial cell lines as in vitro models for predicting the intestinal absorption of drugs
    • Wils, P., Warnery A., Phung-Ba, V. & Scherman, D. (1994). Differentiated intestinal epithelial cell lines as in vitro models for predicting the intestinal absorption of drugs. Cell Biology and Toxicology 10, 393-397.
    • (1994) Cell Biology and Toxicology , vol.10 , pp. 393-397
    • Wils, P.1    Warnery, A.2    Phung-Ba, V.3    Scherman, D.4
  • 32
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artusson, P. & Karlsson, J. (1991). Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochemical and Biophysical Research Communications 175, 880-885.
    • (1991) Biochemical and Biophysical Research Communications , vol.175 , pp. 880-885
    • Artusson, P.1    Karlsson, J.2
  • 34
    • 0003209993 scopus 로고
    • Advances in physiological modelling approaches for understanding the disposition of inhaled vapors
    • (ed. D.E. Gardner, J.D. Crapo & R.O. McClellan), New York: Raven Press
    • Gargas, M., Medlinsky, M A. & Andersen, M.E. (1993). Advances in physiological modelling approaches for understanding the disposition of inhaled vapors. In Toxicology of the Lung (ed. D.E. Gardner, J.D. Crapo & R.O. McClellan), pp. 461-483. New York: Raven Press.
    • (1993) Toxicology of the Lung , pp. 461-483
    • Gargas, M.1    Medlinsky, M.A.2    Andersen, M.E.3
  • 35
    • 0026172007 scopus 로고
    • Modelling of respiratory exchange of polar solvents
    • Johanson, G. (1991). Modelling of respiratory exchange of polar solvents. Annals of Occupational Hygiene 35, 323-339.
    • (1991) Annals of Occupational Hygiene , vol.35 , pp. 323-339
    • Johanson, G.1
  • 37
    • 0025737963 scopus 로고
    • A model for the uptake of inhaled vapors in the nose of the dog during cyclic breathing
    • Gerde, P. & Dahl, A.R. (1991) A model for the uptake of inhaled vapors in the nose of the dog during cyclic breathing. Toxicology and Applied Pharmacology 109, 276-288.
    • (1991) Toxicology and Applied Pharmacology , vol.109 , pp. 276-288
    • Gerde, P.1    Dahl, A.R.2
  • 38
    • 0026101428 scopus 로고
    • Dynamics of soluble gas exchange in the airways. II. Effects of breathing conditions
    • Tsu, M.E., Babb, A.L., Sugiyama, E.M. & Hlastala, M.O. (1991). Dynamics of soluble gas exchange in the airways. II. Effects of breathing conditions. Respiratory Physiology 83, 261-276.
    • (1991) Respiratory Physiology , vol.83 , pp. 261-276
    • Tsu, M.E.1    Babb, A.L.2    Sugiyama, E.M.3    Hlastala, M.O.4
  • 39
    • 0025157094 scopus 로고
    • First-pass metabolism of inspired ethyl acetate in the upper respiratory tracts of the F344 rat and Syrian hamster
    • Morris, J.B. (1990). First-pass metabolism of inspired ethyl acetate in the upper respiratory tracts of the F344 rat and Syrian hamster. Toxicology and Applied Pharmacology 102, 331-345
    • (1990) Toxicology and Applied Pharmacology , vol.102 , pp. 331-345
    • Morris, J.B.1
  • 40
    • 77957182406 scopus 로고
    • Species differences in upper respiratory tract deposition of acetone and ethanol vapors
    • Morris, J.B., Clay, R.J. & Cavanagh. D.G. (1986). Species differences in upper respiratory tract deposition of acetone and ethanol vapors. Fundamental and Applied Toxicology 7, 671-680.
    • (1986) Fundamental and Applied Toxicology , vol.7 , pp. 671-680
    • Morris, J.B.1    Clay, R.J.2    Cavanagh, D.G.3
  • 41
    • 0026608832 scopus 로고
    • Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation
    • Johanson, G. & Filser, J.G. (1992). Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation. Archives of Toxicology 66, 291-295.
    • (1992) Archives of Toxicology , vol.66 , pp. 291-295
    • Johanson, G.1    Filser, J.G.2
  • 42
    • 0013880081 scopus 로고
    • Disposition and retention models for internal dosimetry of the human respiratory tract
    • Task Group on Lung Dynamics
    • Anon. (1966). Disposition and retention models for internal dosimetry of the human respiratory tract (Task Group on Lung Dynamics), Health Physics 12, 173-207.
    • (1966) Health Physics , vol.12 , pp. 173-207
  • 43
    • 0342702933 scopus 로고
    • Pulmonary retention of particles and fibers: Biokinetics and effects of exposure concentrations
    • (ed. R.O. McClellan & R.F. Henderson), Washington, DC: Taylor & Francis
    • Snipes, M.B (1995). Pulmonary retention of particles and fibers: biokinetics and effects of exposure concentrations. In Concepts in Inhalation Toxicology (ed. R.O. McClellan & R.F. Henderson), pp. 225-255. Washington, DC: Taylor & Francis.
    • (1995) Concepts in Inhalation Toxicology , pp. 225-255
    • Snipes, M.B.1
  • 44
    • 0021245711 scopus 로고
    • Physicochemical processes and the formulation of dosimetry models
    • Overton, J.H. (1984). Physicochemical processes and the formulation of dosimetry models. Journal of Toxicology and Environmental Health 13, 273-294
    • (1984) Journal of Toxicology and Environmental Health , vol.13 , pp. 273-294
    • Overton, J.H.1
  • 45
    • 0027203293 scopus 로고
    • Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the Beagle dog. III. Mechanisms of dosimetry
    • Gerde, P., Muggenburg, B.A. & Henderson, R.F. (1993). Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the Beagle dog. III. Mechanisms of dosimetry. Toxicology and Applied Pharmacology 121, 328-334.
    • (1993) Toxicology and Applied Pharmacology , vol.121 , pp. 328-334
    • Gerde, P.1    Muggenburg, B.A.2    Henderson, R.F.3
  • 46
    • 0025972798 scopus 로고
    • Particle-associated polycyclic aromatic hydrocarbons: A reappraisal of their possible role in pulmonary carcinogenesis
    • Gerde, P., Medinsky, M.A. & Bond, J.A. (1991). Particle-associated polycyclic aromatic hydrocarbons: a reappraisal of their possible role in pulmonary carcinogenesis. Toxicology and Applied Pharmacology 108, 1-13.
    • (1991) Toxicology and Applied Pharmacology , vol.108 , pp. 1-13
    • Gerde, P.1    Medinsky, M.A.2    Bond, J.A.3
  • 48
    • 0027955474 scopus 로고
    • A domain mosaic model of the skin barrier
    • Stockholm
    • Forslind, B. (1994). A domain mosaic model of the skin barrier Acta Dermato-Venereologica (Stockholm) 74, 1-6.
    • (1994) Acta Dermato-Venereologica , vol.74 , pp. 1-6
    • Forslind, B.1
  • 49
  • 50
    • 0027524257 scopus 로고
    • Species specific cutaneous biotransformation of the pesticide propoxur during percutaneous absorption in vitro
    • van de Sandt, J.J.M., Rutten, A.A.J.J.L. & van Ommen, B (1993). Species specific cutaneous biotransformation of the pesticide propoxur during percutaneous absorption in vitro. Toxicology and Applied Pharmacology 123, 144-150.
    • (1993) Toxicology and Applied Pharmacology , vol.123 , pp. 144-150
    • Van De Sandt, J.J.M.1    Rutten, A.A.J.J.L.2    Van Ommen, B.3
  • 51
    • 0022544142 scopus 로고
    • The isolated perfused porcine skin flap (IPPSF). I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies
    • Riviere, J.E., Bowman, K.F , Monteiro-Riviere, N.A., Dix, L P. & Carver. M P. (1986). The isolated perfused porcine skin flap (IPPSF). I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies. Fundamental and Applied Toxicology 7, 444-453.
    • (1986) Fundamental and Applied Toxicology , vol.7 , pp. 444-453
    • Riviere, J.E.1    Bowman, K.F.2    Monteiro-Riviere, N.A.3    Dix, L.P.4    Carver, M.P.5
  • 53
    • 0028898732 scopus 로고
    • Quantitative structureactivity relationships for skin permeability
    • Barratt, M.D. (1995). Quantitative structureactivity relationships for skin permeability. Toxicology in Vitro 9, 27-37.
    • (1995) Toxicology In Vitro , vol.9 , pp. 27-37
    • Barratt, M.D.1
  • 54
    • 0024601153 scopus 로고
    • Transdermal drug transport and metabolism II. The role of competing kinetic events
    • Potts, R.O., McNeill, S C., Desbonnet, C.R. & Wakshull, E. (1989) Transdermal drug transport and metabolism II. The role of competing kinetic events. Pharmaceutical Research 6, 119-124.
    • (1989) Pharmaceutical Research , vol.6 , pp. 119-124
    • Potts, R.O.1    McNeill, S.C.2    Desbonnet, C.R.3    Wakshull, E.4
  • 55
    • 0026783752 scopus 로고
    • Pharmacokinetic implications of changing blood flow in skin
    • Riviere, J.E. & Williams, P.L. (1992). Pharmacokinetic implications of changing blood flow in skin. Journal of Pharmaceutical Sciences 81, 601-602
    • (1992) Journal of Pharmaceutical Sciences , vol.81 , pp. 601-602
    • Riviere, J.E.1    Williams, P.L.2
  • 57
    • 0027423294 scopus 로고
    • The blood-brain barrier in vitro: The second decade
    • Joo, F. (1993). The blood-brain barrier in vitro: the second decade. Neurochemistry International 23, 499-521.
    • (1993) Neurochemistry International , vol.23 , pp. 499-521
    • Joo, F.1
  • 59
    • 2742533455 scopus 로고    scopus 로고
    • The blood-brain barrier in vitro: Characterisation and potential use for pharmacotoxicological screening
    • in press
    • Heller, N., Gloor, S. & Reinhardt, C.A. The blood-brain barrier in vitro: characterisation and potential use for pharmacotoxicological screening In Vitro Toxicology, in press.
    • In Vitro Toxicology
    • Heller, N.1    Gloor, S.2    Reinhardt, C.A.3
  • 61
    • 0024267858 scopus 로고
    • Characterisation of an "in vitro" blood-brain barrier: Effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs
    • van Bree, J.B.M.M., De Boer, A.G., Danhof, M., Ginsel, L.A. & Breimer, D.D. (1988). Characterisation of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs. Journal of Pharmacology and Experimental Therapeutics 247, 1233-1239.
    • (1988) Journal of Pharmacology and Experimental Therapeutics , vol.247 , pp. 1233-1239
    • Van Bree, J.B.M.M.1    De Boer, A.G.2    Danhof, M.3    Ginsel, L.A.4    Breimer, D.D.5
  • 62
    • 0029073495 scopus 로고
    • Selective drug transport and P-glycoprotein activity in an in vitro blood-brain barrier model
    • Joly, B., Fardel, O, Cecchelii, R., Chesné, C., Puozzo, C. & Guillouzo, A. (1995). Selective drug transport and P-glycoprotein activity in an in vitro blood-brain barrier model. Toxicology in Vitro 9, 357-364.
    • (1995) Toxicology In Vitro , vol.9 , pp. 357-364
    • Joly, B.1    Fardel, O.2    Cecchelii, R.3    Chesné, C.4    Puozzo, C.5    Guillouzo, A.6
  • 63
    • 0025265046 scopus 로고
    • An easier reproducible and mass-production method to study the blood-brain barrier "in vitro"
    • Dehouck, M.P., Méresse, S., Delorme, J., Fruchart, J.C. & Cecchelii, R. (1990). An easier reproducible and mass-production method to study the blood-brain barrier "in vitro". Journal of Neurochemistry 54, 1798-1801.
    • (1990) Journal of Neurochemistry , vol.54 , pp. 1798-1801
    • Dehouck, M.P.1    Méresse, S.2    Delorme, J.3    Fruchart, J.C.4    Cecchelii, R.5
  • 64
    • 2742589285 scopus 로고    scopus 로고
    • Characterization of the Madin-Darby canine kidney (MDCK) cell as an in vitro model of the blood-brain barrier
    • in press
    • Veronesi, B. Characterization of the Madin-Darby canine kidney (MDCK) cell as an in vitro model of the blood-brain barrier. Neurotoxicology, in press.
    • Neurotoxicology
    • Veronesi, B.1
  • 65
    • 0023132476 scopus 로고
    • Clearance approaches in pharmacology
    • Wilkinson, G.R. (1987). Clearance approaches in pharmacology. Pharmacological Reviews 39, 1-47.
    • (1987) Pharmacological Reviews , vol.39 , pp. 1-47
    • Wilkinson, G.R.1
  • 66
    • 0018967595 scopus 로고
    • Interspecies variation in liver weight, hepatic blood flow and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin
    • Boxenbaum, H. (1980). Interspecies variation in liver weight, hepatic blood flow and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin. Journal of Biokinetics and Biopharmaceutics 8, 165-176.
    • (1980) Journal of Biokinetics and Biopharmaceutics , vol.8 , pp. 165-176
    • Boxenbaum, H.1
  • 67
    • 0028342648 scopus 로고
    • Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
    • Houston, J.B. (1994). Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochemical Pharmacology 47, 1469-1479.
    • (1994) Biochemical Pharmacology , vol.47 , pp. 1469-1479
    • Houston, J.B.1
  • 70
    • 0011929434 scopus 로고
    • Prediction of chemical pharmacokinetics in vivo using freshly isolated hepatocytes in vitro
    • Kedderis, G.L., Held, S.D. & Gargas, M.L. (1993). Prediction of chemical pharmacokinetics in vivo using freshly isolated hepatocytes in vitro. ISSX Proceedings 4, 61.
    • (1993) ISSX Proceedings , vol.4 , pp. 61
    • Kedderis, G.L.1    Held, S.D.2    Gargas, M.L.3
  • 71
    • 0011929435 scopus 로고
    • Kinetics of acrylonitrile biotransformation by isolated rat hepatocytes
    • Kedderis, G.L , Held, S D. & Bartra, R. (1995). Kinetics of acrylonitrile biotransformation by isolated rat hepatocytes. The Toxicologist 15, 283-284.
    • (1995) The Toxicologist , vol.15 , pp. 283-284
    • Kedderis, G.L.1    Held, S.D.2    Bartra, R.3
  • 72
    • 0025689878 scopus 로고
    • The prediction of the intrinsic clearance of loxtidine from kinetic studies in rat, dog and human hepatocytes
    • Bayliss, M.K., Bell, J A, Jenner, W.N & Wilson, K. (1990). The prediction of the intrinsic clearance of loxtidine from kinetic studies in rat, dog and human hepatocytes. Biochemical Society Transactions 18, 1198-1199.
    • (1990) Biochemical Society Transactions , vol.18 , pp. 1198-1199
    • Bayliss, M.K.1    Bell, J.A.2    Jenner, W.N.3    Wilson, K.4
  • 73
    • 0022872403 scopus 로고
    • A physiologically based simulation approach for determining metabolic constants from gas uptake data
    • Gargas, M.L., Andersen, M.E. & Clewell, H.J. 3rd (1986). A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicology and Applied Pharmacology 86, 341-352.
    • (1986) Toxicology and Applied Pharmacology , vol.86 , pp. 341-352
    • Gargas, M.L.1    Andersen, M.E.2    Clewell III, H.J.3
  • 74
    • 2742513530 scopus 로고
    • A physiologically based biokinetic (PBPK) model for acrylonitrile (ACN) in the rat
    • Gargas, M.L., Kedderis, G.L., Fennell, T.R. & Andersen, M.E. (1990). A physiologically based biokinetic (PBPK) model for acrylonitrile (ACN) in the rat. The Toxicologist 10, 216.
    • (1990) The Toxicologist , vol.10 , pp. 216
    • Gargas, M.L.1    Kedderis, G.L.2    Fennell, T.R.3    Andersen, M.E.4
  • 75
    • 0027424629 scopus 로고
    • Physiologically based toxicokinetic modelling of 1,3-butadine: Lung metabolism becomes more important at low doses
    • Evelo, C.T.A., Oostendorp, J.G.M., Ten Berge, W.F. & Borm, P.J.A. (1993). Physiologically based toxicokinetic modelling of 1,3-butadine: lung metabolism becomes more important at low doses. Environmental Health Perspectives 101. 496-502.
    • (1993) Environmental Health Perspectives , vol.101 , pp. 496-502
    • Evelo, C.T.A.1    Oostendorp, J.G.M.2    Ten Berge, W.F.3    Borm, P.J.A.4
  • 76
    • 0028129033 scopus 로고
    • Future perspectives on toxicokinetics: A regulator's view
    • Rauws, A.G & Groen, K. (1994). Future perspectives on toxicokinetics: a regulator's view. Drug Information Journal 28, 295-300.
    • (1994) Drug Information Journal , vol.28 , pp. 295-300
    • Rauws, A.G.1    Groen, K.2
  • 77
    • 0001701879 scopus 로고
    • Inclusion of physicochemical data in quantitative comparisons of in vitro and in vivo toxic potencies
    • Gülden M., Seibert, H. & Voss J-U. (1994). Inclusion of physicochemical data in quantitative comparisons of in vitro and in vivo toxic potencies. ATLA 22, 185-192.
    • (1994) ATLA , vol.22 , pp. 185-192
    • Gülden, M.1    Seibert, H.2    Voss, J.-U.3
  • 78
    • 0024955695 scopus 로고
    • MEIC: A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
    • Bondesson, I., Ekwall, B., Hellberg, S., Romert, L., Stenberg, K., & Walum, E (1989). MEIC: a new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology 5, 331-347.
    • (1989) Cell Biology and Toxicology , vol.5 , pp. 331-347
    • Bondesson, I.1    Ekwall, B.2    Hellberg, S.3    Romert, L.4    Stenberg, K.5    Walum, E.6
  • 79
    • 0027942071 scopus 로고
    • The use of cultured skeletal muscle cells in testing for acute systemic toxicity
    • Gülden, M , Seibert H. & Voss, J-U. (1994). The use of cultured skeletal muscle cells in testing for acute systemic toxicity. Toxicology in Vitro 8, 779-782.
    • (1994) Toxicology In Vitro , vol.8 , pp. 779-782
    • Gülden, M.1    Seibert, H.2    Voss, J.-U.3
  • 80
    • 0028077291 scopus 로고
    • An in vitro testing strategy for the classification and labelling of chemicals according to their potential acute lethal potency
    • Seibert, H., Gülden, M. & Voss, J-U. (1994). An in vitro testing strategy for the classification and labelling of chemicals according to their potential acute lethal potency. Toxicology in Vitro 8, 847-850.
    • (1994) Toxicology In Vitro , vol.8 , pp. 847-850
    • Seibert, H.1    Gülden, M.2    Voss, J.-U.3


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