In vivo erythrocyte micronucleus assay. III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 627, Issue 1, 2007, Pages 10-30

  Hayashi, Makoto ^a   MacGregor, James T ^b   Gatehouse, David G ^c   Blakey, David H ^d   Dertinger, Stephen D ^e   Abramsson Zetterberg, Lilianne ^f   Krishna, Gopala ^g   Morita, Takeshi ^a   Russo, Antonella ^h   Asano, Norihide ⁱ   Suzuki, Hiroshi ^j   Ohyama, Wakako ^k   Gibson, Dave ^l  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Toxicology Consulting Services   (United States)

^c UK   (United Kingdom)

^d HEALTH CANADA   (Canada)

^e LITRON LABORATORIES   (United States)

^f NATIONAL FOOD ADMINISTRATION   (Sweden)

^g MGI Pharma ^*  (United States)

^h UNIVERSITY OF PADOVA   (Italy)

ⁱ NITTO DENKO CORPORATION   (Japan)

^j N   (Japan)

^k YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^l PROCTER AND GAMBLE COMPANY   (United States)

more..

Author keywords

Automation; Colon micronucleus assay; Flow cytometry; Germ cell micronucleus assay; Liver micronucleus assay; Micronucleus assay; Rat blood micronucleus assay; Skin micronucleus assay; Validation

Indexed keywords

CD71 ANTIBODY; ENZYME; LYMPHOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANALYTICAL ERROR; ARTICLE; AUTOMATION; BIOLOGICAL ACTIVITY; BLOOD; BLOOD CELL; BONE MARROW; CELL MATURATION; CELL POPULATION; CHROMOSOME DAMAGE; CLINICAL PROTOCOL; COLON; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); ERYTHROCYTE MICRONUCLEUS ASSAY; EXPERIMENTAL RAT; FLOW CYTOMETRY; FLUORESCENCE; GENETIC SCREENING; GENOTOXICITY; GERM CELL; HEMATOPOIETIC CELL; IN VIVO STUDY; LABORATORY; LIVER; LIVER CELL; LIVER METABOLISM; LIVER RESECTION; MEDICAL LITERATURE; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRODUCIBILITY; RETICULOCYTE; RISK ASSESSMENT; RODENT; SAMPLE; SCORING SYSTEM; SKIN; SPECIES DIFFERENCE; SPLEEN FUNCTION; TARGET CELL; VALIDATION PROCESS;

ANIMALS; BONE MARROW; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HEMATOPOIETIC SYSTEM; IMAGE PROCESSING, COMPUTER-ASSISTED; MICRONUCLEUS TESTS; RATS; REPRODUCIBILITY OF RESULTS; RETICULOCYTES;

ANIMALIA; MUS; RATTUS; RODENTIA;

EID: 33846132354     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.08.010     Document Type: Article

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