-
1
-
-
0001880943
-
Toxicity testing: Strategies and conduct
-
ed. D.B. Clayson, I.C. Munro, P. Shubik & J.A. Seenberg. Amsterdam, The Netherlands: Elsevier
-
Kroes, R. & Feron, V.J. (1990). Toxicity testing: strategies and conduct. In Progress in Predictive Toxicology (ed. D.B. Clayson, I.C. Munro, P. Shubik & J.A. Seenberg), pp. 15-39. Amsterdam, The Netherlands: Elsevier.
-
(1990)
Progress in Predictive Toxicology
, pp. 15-39
-
-
Kroes, R.1
Feron, V.J.2
-
4
-
-
12244307923
-
-
EU (1986). Council Directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other purposes (Directive 86/609/EEC). Official Journal of the European Communities L358, 1-29
-
EU (1986). Council Directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other purposes (Directive 86/609/EEC). Official Journal of the European Communities L358, 1-29.
-
-
-
-
6
-
-
0031804201
-
13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): Alternative testing methodologies and conceptual issues
-
Blaauboer, B.J., Balls, M., Barratt, M., Casati, S., Coecke, S., Mohamed, M.K., Moore, J., Rall, D., Smith, K.R., Tennant, R., Schwetz, B.A., Stokes, W.S. & Younes, M. (1998). 13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies and conceptual issues. Environmental Health Perspectives 106, Suppl. 2, 413-418.
-
(1998)
Environmental Health Perspectives
, vol.106
, Issue.SUPPL. 2
, pp. 413-418
-
-
Blaauboer, B.J.1
Balls, M.2
Barratt, M.3
Casati, S.4
Coecke, S.5
Mohamed, M.K.6
Moore, J.7
Rall, D.8
Smith, K.R.9
Tennant, R.10
Schwetz, B.A.11
Stokes, W.S.12
Younes, M.13
-
7
-
-
0034123724
-
Prediction of toxicity from chemical structure
-
Barratt, M.D. (2000). Prediction of toxicity from chemical structure. Cellular and Biological Toxicology 16, 1-13.
-
(2000)
Cellular and Biological Toxicology
, vol.16
, pp. 1-13
-
-
Barratt, M.D.1
-
8
-
-
18344391612
-
Methods of in vitro toxicology
-
Eisenbrand, G., Pool-Zobel, B., Baker, V., Balls, M., Blaauboer, B.J., Boobis, A., Carere, A., Kevekordes, S., Lhuguenot, J-C., Pieters, R. & Kleiner, J. (2002). Methods of in vitro toxicology. Food and Chemical Toxicology 40, 193-236.
-
(2002)
Food and Chemical Toxicology
, vol.40
, pp. 193-236
-
-
Eisenbrand, G.1
Pool-Zobel, B.2
Baker, V.3
Balls, M.4
Blaauboer, B.J.5
Boobis, A.6
Carere, A.7
Kevekordes, S.8
Lhuguenot, J.-C.9
Pieters, R.10
Kleiner, J.11
-
9
-
-
0032901303
-
Microarrays and toxicology: The advent of toxicogenomics
-
Nuwaysir, E.F., Bittner, M., Trent, J., Barrett, J.C. & Afshari, C.A. (1999). Microarrays and toxicology: the advent of toxicogenomics. Molecular Carcinogenesis 24, 153-159.
-
(1999)
Molecular Carcinogenesis
, vol.24
, pp. 153-159
-
-
Nuwaysir, E.F.1
Bittner, M.2
Trent, J.3
Barrett, J.C.4
Afshari, C.A.5
-
10
-
-
0034825987
-
The use of genomics technology to investigate gene expression changes in cultured human liver cells
-
Harries, H.M., Fletcher, S.T., Duggan, C.M. & Baker, V.A. (2001). The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicology in Vitro 15, 399-405.
-
(2001)
Toxicology in Vitro
, vol.15
, pp. 399-405
-
-
Harries, H.M.1
Fletcher, S.T.2
Duggan, C.M.3
Baker, V.A.4
-
11
-
-
0036311882
-
Alternative (non-animal) methods for chemicals testing: Current status and future prospects
-
Worth, A.P. & Balls, M. (2002). Alternative (non-animal) methods for chemicals testing: current status and future prospects. ATLA 30, Suppl. 1, 1-125.
-
(2002)
ATLA
, vol.30
, Issue.SUPPL. 1
, pp. 1-125
-
-
Worth, A.P.1
Balls, M.2
-
12
-
-
0020644295
-
Screening of toxic compounds in mammalian cell cultures
-
Ekwall, B. (1983). Screening of toxic compounds in mammalian cell cultures. Annals of the New York Academy of Sciences 407, 64-77.
-
(1983)
Annals of the New York Academy of Sciences
, vol.407
, pp. 64-77
-
-
Ekwall, B.1
-
13
-
-
0029185921
-
Determinations of critical cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell cultures
-
Forsby, A., Pilli, F., Bianchi, V. & Walum, E.A. (1995). Determinations of critical cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell cultures. ATLA 23, 800-811.
-
(1995)
ATLA
, vol.23
, pp. 800-811
-
-
Forsby, A.1
Pilli, F.2
Bianchi, V.3
Walum, E.A.4
-
14
-
-
0036298076
-
The applicability of in vitro-derived data in hazard identification and characterisation of chemicals
-
Blaauboer, B.J. (2002). The applicability of in vitro-derived data in hazard identification and characterisation of chemicals. Environmental Toxicology and Pharmacology 11, 213-225.
-
(2002)
Environmental Toxicology and Pharmacology
, vol.11
, pp. 213-225
-
-
Blaauboer, B.J.1
-
15
-
-
0026766484
-
Models for the in vitro assessment of neurotoxicity in the nervous system in relation to xenobiotic and neurotrophic factor-mediated events
-
Atterwill, C., Johnston, H. & Thomas, S.M. (1992). Models for the in vitro assessment of neurotoxicity in the nervous system in relation to xenobiotic and neurotrophic factor-mediated events. Neurotoxicology 13, 39-54.
-
(1992)
Neurotoxicology
, vol.13
, pp. 39-54
-
-
Atterwill, C.1
Johnston, H.2
Thomas, S.M.3
-
16
-
-
0001815771
-
In vitro toxicity testing: Purpose, validation and strategy
-
Flint, O.P. (1990). In vitro toxicity testing: purpose, validation and strategy. ATLA 18, 11-18.
-
(1990)
ATLA
, vol.18
, pp. 11-18
-
-
Flint, O.P.1
-
18
-
-
0000319985
-
The use of liver cell cultures derived from different mammalian species in in vitro toxicological studies: Implementation in extrapolation models?
-
Blaauboer, B.J., Wortelboer, H.M. & Mennes, W.C. (1990). The use of liver cell cultures derived from different mammalian species in in vitro toxicological studies: implementation in extrapolation models? ATLA 18, 251-258.
-
(1990)
ATLA
, vol.18
, pp. 251-258
-
-
Blaauboer, B.J.1
Wortelboer, H.M.2
Mennes, W.C.3
-
19
-
-
0021279862
-
A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
-
Ramsey, J.C. & Andersen, M.E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicology and Applied Pharmacology 73, 159-175.
-
(1984)
Toxicology and Applied Pharmacology
, vol.73
, pp. 159-175
-
-
Ramsey, J.C.1
Andersen, M.E.2
-
20
-
-
0002715928
-
A multiple dose-route physiological model for volatile chemicals using ACSL/PC
-
ed. F.E. Cellier. San Diego, CA, USA: Society for Computer Simulation
-
Clewell, H.J. & Andersen, M.E. (1986). A multiple dose-route physiological model for volatile chemicals using ACSL/PC. In Languages for Continuous Simulation (ed. F.E. Cellier), pp. 95. San Diego, CA, USA: Society for Computer Simulation.
-
(1986)
Languages for Continuous Simulation
, pp. 95
-
-
Clewell, H.J.1
Andersen, M.E.2
-
21
-
-
0030806348
-
Physiological parameter values for physiologically based pharmacokinetic models
-
Brown, R.P., Delp, M.D., Lindstedt, S.L., Rhomberg, L.R. & Beliles, R.P. (1997). Physiological parameter values for physiologically based pharmacokinetic models. Toxicology and Industrial Health 13, 407-484.
-
(1997)
Toxicology and Industrial Health
, vol.13
, pp. 407-484
-
-
Brown, R.P.1
Delp, M.D.2
Lindstedt, S.L.3
Rhomberg, L.R.4
Beliles, R.P.5
-
22
-
-
0025804183
-
Correlation between oral drug absorption in humans an apparent drug permeability coefficients in human intestinal epithelial (CaCo2) cells
-
Artursson, P. & Karlsson, J. (1991). Correlation between oral drug absorption in humans an apparent drug permeability coefficients in human intestinal epithelial (CaCo2) cells. Biochemical and Biophysical Research Communications 175, 880-885.
-
(1991)
Biochemical and Biophysical Research Communications
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
23
-
-
0031413702
-
Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
-
Artursson, P. & Borchardt, R.T. (1997). Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharmacological Research 14, 1655-1658.
-
(1997)
Pharmacological Research
, vol.14
, pp. 1655-1658
-
-
Artursson, P.1
Borchardt, R.T.2
-
24
-
-
0033883959
-
Application of a dynamic in vitro gastrointestinal tract model to study the availability of food mutagens, using heterocyclic aromatic amines as model compounds
-
Krul, C., Luiten-Schuite, A., Baandagger, R., Verhagen, H., Mohn, G., Feron, V. & Havenaar, R. (2000). Application of a dynamic in vitro gastrointestinal tract model to study the availability of food mutagens, using heterocyclic aromatic amines as model compounds. Food and Chemical Toxicology 38, 783-792.
-
(2000)
Food and Chemical Toxicology
, vol.38
, pp. 783-792
-
-
Krul, C.1
Luiten-Schuite, A.2
Baandagger, R.3
Verhagen, H.4
Mohn, G.5
Feron, V.6
Havenaar, R.7
-
25
-
-
0035286778
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
Artursson, P., Palm, K. & Luthman, K. (2001). Caco-2 monolayers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 46, 27-43.
-
(2001)
Advanced Drug Delivery Reviews
, vol.46
, pp. 27-43
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
26
-
-
0036096659
-
Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption
-
Moss, G.P., Dearden, J.C., Patel, H. & Cronin, M.T. (2002). Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption. Toxicology in Vitro 16, 299-317.
-
(2002)
Toxicology in Vitro
, vol.16
, pp. 299-317
-
-
Moss, G.P.1
Dearden, J.C.2
Patel, H.3
Cronin, M.T.4
-
27
-
-
0031889726
-
An investigation of the mechanism of flux across polydimethylsiloxane membranes by use of quantitative structure-permeability relationships
-
Cronin, M.T., Dearden, J.C., Gupta, R. & Moss, G.P. (1998). An investigation of the mechanism of flux across polydimethylsiloxane membranes by use of quantitative structure-permeability relationships. Journal of Pharmacy and Pharmacology 50, 143-152.
-
(1998)
Journal of Pharmacy and Pharmacology
, vol.50
, pp. 143-152
-
-
Cronin, M.T.1
Dearden, J.C.2
Gupta, R.3
Moss, G.P.4
-
28
-
-
0035200306
-
In vitro models of the intestinal barrier. The report and recommendations of ECVAM workshop 46
-
Le Ferrec, E., Chesne, C., Artusson, P., Brayden, D., Fabre, G., Gires, P., Guillou, F., Rousset, M., Rubas, W. & Scarino, M.L. (2001). In vitro models of the intestinal barrier. The report and recommendations of ECVAM workshop 46. ATLA 29, 649-668.
-
(2001)
ATLA
, vol.29
, pp. 649-668
-
-
Le Ferrec, E.1
Chesne, C.2
Artusson, P.3
Brayden, D.4
Fabre, G.5
Gires, P.6
Guillou, F.7
Rousset, M.8
Rubas, W.9
Scarino, M.L.10
-
30
-
-
0028925028
-
A biologically-based algorithm for predicting human tissue: Blood partition coefficients of organic chemicals
-
Poulin, P. & Krishnan, K. (1995). A biologically-based algorithm for predicting human tissue: blood partition coefficients of organic chemicals. Human and Experimental Toxicology 14, 273-280.
-
(1995)
Human and Experimental Toxicology
, vol.14
, pp. 273-280
-
-
Poulin, P.1
Krishnan, K.2
-
31
-
-
0030052475
-
A tissue composition-based algorithm for predicting tissue: Air partition coefficients of organic chemicals
-
Poulin, P. & Krishnan, K. (1996). A tissue composition-based algorithm for predicting tissue: air partition coefficients of organic chemicals. Toxicology and Applied Pharmacology 136, 126-130.
-
(1996)
Toxicology and Applied Pharmacology
, vol.136
, pp. 126-130
-
-
Poulin, P.1
Krishnan, K.2
-
32
-
-
0031413080
-
A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans
-
DeJongh, J., Verhaar, H.J. & Hermens, J.L.M. (1997). A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans. Archives of Toxicology 72, 17-25.
-
(1997)
Archives of Toxicology
, vol.72
, pp. 17-25
-
-
DeJongh, J.1
Verhaar, H.J.2
Hermens, J.L.M.3
-
33
-
-
0034659425
-
Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds
-
Meulenberg, C.J. & Vijverberg, H.P. (2000). Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds. Toxicology and Applied Pharmacology 165, 206-216.
-
(2000)
Toxicology and Applied Pharmacology
, vol.165
, pp. 206-216
-
-
Meulenberg, C.J.1
Vijverberg, H.P.2
-
34
-
-
0036282060
-
Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices
-
De Kanter, R., De Jager, M.H., Draaisma, A.L., Jurva, J.U., Olinga, P., Meijer, D.K. & Groothuis, G.M. (2002). Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica 32, 349-362.
-
(2002)
Xenobiotica
, vol.32
, pp. 349-362
-
-
De Kanter, R.1
De Jager, M.H.2
Draaisma, A.L.3
Jurva, J.U.4
Olinga, P.5
Meijer, D.K.6
Groothuis, G.M.7
-
35
-
-
0344333422
-
Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices
-
Houston, J.B. & Carlile, D.J. (1997). Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. Drug Metabolism Reviews 29, 891-922.
-
(1997)
Drug Metabolism Reviews
, vol.29
, pp. 891-922
-
-
Houston, J.B.1
Carlile, D.J.2
-
36
-
-
0030799001
-
The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data
-
Obach, R.S., Baxter, J.G., Liston, T.E., Silber, B.M., Jones, B.C., MacIntyre, F., Rance, D.J. & Wastall, P. (1997). The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. Journal of Pharmacology and Experimental Therapeutics 283, 46-58.
-
(1997)
Journal of Pharmacology and Experimental Therapeutics
, vol.283
, pp. 46-58
-
-
Obach, R.S.1
Baxter, J.G.2
Liston, T.E.3
Silber, B.M.4
Jones, B.C.5
MacIntyre, F.6
Rance, D.J.7
Wastall, P.8
-
37
-
-
0029898283
-
The use of in vitro cytotoxicity measurements for the prediction of the skin corrosivity potential of acids: A QSAR method
-
Barratt, M.D., Dixit, M.B. & Jones, P.A. (1996). The use of in vitro cytotoxicity measurements for the prediction of the skin corrosivity potential of acids: a QSAR method. Toxicology in Vitro 10, 283-290.
-
(1996)
Toxicology in Vitro
, vol.10
, pp. 283-290
-
-
Barratt, M.D.1
Dixit, M.B.2
Jones, P.A.3
-
38
-
-
0028956183
-
The chemistry of contact allergy: Why is a molecule allergenic?
-
Basketter, D.A., Dooms-Goossens, A., Karlberg, A.T. & Lepoittevin, J.P. (1995). The chemistry of contact allergy: why is a molecule allergenic? Contact Dermatitis 32, 65-73.
-
(1995)
Contact Dermatitis
, vol.32
, pp. 65-73
-
-
Basketter, D.A.1
Dooms-Goossens, A.2
Karlberg, A.T.3
Lepoittevin, J.P.4
-
39
-
-
0032916246
-
The integrated use of alternative methods in toxicological risk evaluation. ECVAM Integrated Testing Strategies Task Force Report 1
-
Blaauboer, B.J., Barratt, M.D. & Houston, J.B. (1999). The integrated use of alternative methods in toxicological risk evaluation. ECVAM Integrated Testing Strategies Task Force Report 1. ATLA 27, 229-237.
-
(1999)
ATLA
, vol.27
, pp. 229-237
-
-
Blaauboer, B.J.1
Barratt, M.D.2
Houston, J.B.3
-
40
-
-
0023158895
-
Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
-
Andersen, M.E., Clewell, H.J., 3rd, Gargas, M.L., Smith, F.A. & Reitz, R.H. (1987). Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicology and Applied Pharmacology 87, 185-205.
-
(1987)
Toxicology and Applied Pharmacology
, vol.87
, pp. 185-205
-
-
Andersen, M.E.1
Clewell H.J. III2
Gargas, M.L.3
Smith, F.A.4
Reitz, R.H.5
-
41
-
-
0002385233
-
An integrated approach to the prediction of systemic toxicity using biokinetic models and biological in vitro test methods
-
ed. M. Balls, A-M. van Zeller & M.E. Halder. Amsterdam, The Netherlands: Elsevier
-
Blaauboer, B.J., Forsby, A., Houston, J.B., Beckman, M., Combes, R. D. & DeJongh, J. (2000). An integrated approach to the prediction of systemic toxicity using biokinetic models and biological in vitro test methods. In Progress in the Reduction Refinement and Replacement of Animal Experimentation (ed. M. Balls, A-M. van Zeller & M.E. Halder), pp. 525-536. Amsterdam, The Netherlands: Elsevier.
-
(2000)
Progress in the Reduction Refinement and Replacement of Animal Experimentation
, pp. 525-536
-
-
Blaauboer, B.J.1
Forsby, A.2
Houston, J.B.3
Beckman, M.4
Combes, R.D.5
DeJongh, J.6
-
42
-
-
0023751819
-
Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PBPK) model for methylene chloride: Implications for risk assessment
-
Reitz, R.H., Mendrala, A.L., Park, C.N., Andersen, M.E. & Guengerich, F.P. (1988). Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PBPK) model for methylene chloride: implications for risk assessment. Toxicology Letters 43, 97-116.
-
(1988)
Toxicology Letters
, vol.43
, pp. 97-116
-
-
Reitz, R.H.1
Mendrala, A.L.2
Park, C.N.3
Andersen, M.E.4
Guengerich, F.P.5
-
43
-
-
0027207828
-
Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing
-
Clewell, H.J., 3rd (1993). Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing. Toxicology Letters 68, 101-117.
-
(1993)
Toxicology Letters
, vol.68
, pp. 101-117
-
-
Clewell H.J. III1
|