Genotoxicity and mutagenicity

ATLA Alternatives to Laboratory Animals

Volumn 33, Issue SUPPL. 1, 2005, Pages 117-130

  Maurici, Daniela ^a   Aardema, Marilyn ^b   Corvi, Raffaella ^a   Kleber, Marcus ^c   Krul, Cyrille ^d   Laurent, Christian ^e   Loprieno, Nicola ^f   Pasanen, Markku ^g,h   Pfuhler, Stefan ⁱ   Phillips, Barry ^j   Sabbioni, Enrico ^a   Sanner, Tore ^k   Vanparys, Philippe ^l  

^a JOINT RESEARCH CENTRE   (Italy)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c Department of Intellectual Capital   (Germany)

^d TNO   (Netherlands)

^e EFSA   (Belgium)

^f UNIVERSITY OF PISA   (Italy)

^g NATIONAL AGENCY FOR MEDICINES   (Finland)

^h UNIVERSITY OF OULU   (Finland)

ⁱ Wella AG   (Germany)

^j Research Animals Department   (United Kingdom)

^k OSLO UNIVERSITY HOSPITAL   (Norway)

^l JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TESTING REPLACEMENT; CHROMOSOME ABERRATION; COMET ASSAY; DNA DAMAGE; DNA SYNTHESIS; GENE MUTATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METHODOLOGY; MICRONUCLEUS TEST; MITOTIC RECOMBINATION; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SISTER CHROMATID EXCHANGE; TOXICITY TESTING; TOXICOGENETICS; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS; ANIMAL; ANIMAL TESTING ALTERNATIVE; ARTICLE; CARCINOGEN TESTING; CELL CULTURE; CHEMISTRY; CLASSIFICATION; EUROPEAN UNION; LEGAL ASPECT; MUTAGEN TESTING; SAFETY; STANDARD; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

CARCINOGEN; COSMETIC; MUTAGENIC AGENT;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CELLS, CULTURED; CONSUMER PRODUCT SAFETY; COSMETICS; EUROPEAN UNION; HUMANS; MUTAGENICITY TESTS; MUTAGENS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22844434663     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290503301s13     Document Type: Review

References (74)

1. Anderson, D. & Plewa, M.J. (1998). The international "Comet assay workshop". Mutagenesis 13, 67-73.
2. Baker, R.S., Bonin, A.M., Arlauskas, A., He, S. & Coombs, M.M. (1992). Tumorigenicity of cyclopenta(a)phenanthrene derivatives and micronucleus induction in mouse skin. Carcinogenesis 13, 329-332.
3. Criswell, K.A., Krishna, G., Zielinski, D., Urda, G.A., Juneau, P., Bulera, S. & Bleavins, M.R. (2003). Validation of a flow cytometric acridine orange micronuclei methodology in rats. Mutation Research 528, 1-18.
4. Haesen, S., Timmermans, M. & Kirsch-Volders, M. (1993). Induction of micronuclei and karyotype aberrations during in vivo mouse skin carcinogenesis. Carcinogenesis 14, 2319-2327.
5. He, S.I. & Baker, R.S. (1989). Initiating carcinogen, triethylenemelamine, induces micronuclei in skin target cells. Environmental and Molecular Mutagenesis 14, 1-5.
6. Torous, D.K., Hall, N.E., Murante, F.G., Gleason, S.E., Tometsko, C.R. & Dertinger, S.D. (2003). Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. Toxicological Sciences 74, 309-314.
7. Evans, H.J. (1976). Cytological methods for detecting chemical mutagens. In Chemical Mutagens, Principles and Methods for their Detection (ed. A. Hollaender), Vol. 4, pp. 1-29. New York, USA, and London, UK: Plenum Press.
8. Galloway, S.M. & Buckton, K.E. (1978). Chromosome aberration and sister chromatic exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals. Environmental and Molecular Mutagenesis 10 (suppl.10), 1-175.
9. Huang, Y., Chang, C.C. & Trosko, J.E. (1983). Aphidicolin - induced endoreduplication in Chinese hamster cells. Cancer Research 43, 1362-1364.
10. Locke-Huhle, C. (1983). Endoreduplication in Chinese hamster cells during alpha-radiation induced G2 arrest. Mutation Research 119, 403-413.
11. Morita, T., Nagaki, T., Fukuda, I. & Okumura, K. (1992). Clastogenicity of low pH to Various Cultured Mammalian Cells. Mutation Research 268, 297-305.
12. Richardson, C. (1989). Analysis of data from in vitro cytogenetic assays. In Statistical Evaluation of Mutagenicity Test Data (ed. D.J. Kirkland), pp. 141-154. Cambridge, UK: Cambridge University Press.
13. Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M. Jr, Brusick, D., Ashby, J. & Myhr, B.C. (1991). International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9. Mutation Research 257, 147-204.
14. Ames, B., Lee, F.D. & Durston, W.E. (1973). An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proceeding of the National Academy of Sciences of the USA 70, 782-786.
15. Ames, B.N., Mccann, J. & Yamasaki, E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity Test. Mutation Research 31, 347-364.
16. Maron, D.M. & Ames, B.N. (1983). Revised methods for the Salmonella mutagenicity test. Mutation Research 113, 173-215.
17. Zimmermann, F. (1975). Procedures used in the induction of mitotic recombination and mutation in the yeast Saccharomyces cerevisiae. Mutation Research 31, 71-86.
18. Hannan, M.A. & Nasim, A. (1978). Mutagenicity and recombinogenicity of daunomycin in Saccharomyces cerevisiae. Cancer Letters 5, 319-324.
19. Mondon, P. & Shahin, M.M. (1992). Protective effect of two sunscreens against lethal and genotoxic effects of UVB in V79 Chinese hamster cells and Saccharomyces cerevisiae strains XV185-14C and D5. Mutation Research 279, 121-128.
20. Sorenson, W.G., Simpson, J.P. & Ong, T.M. (1981). Comparison of mutagenic and recombinogenic effects of some adenine analogues in Saccharomyces cerevisiae D7. Mutation Research 82, 95-100.
21. Zimmermann, F.K. & Vig, B.K. (1975). Mutagen specificity in the induction of mitotic crossing-over in Saccharomyces cerevisiae. Molecular & General Genetics 139, 255-268.
22. Zimmermann, F.K., von Borstel, R.C., von Halle, E.S., Parry, J.M., Siebert, D., Zetterberg, G., Barale, R. & Loprieno, N. (1984). Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research 133, 199-244.
23. Chu, E.H.Y. & Mailing, H.V. (1968). Mammalian Cell Genetics. II. Chemical Induction of Specific Locus Mutations in Chinese Hamster Cells In vitro. Proceedings of the National Academy of Sciences of the USA 61, 1306-1312.
24. Clive, D., Flamm, W.G., Machesko, M.R. & Bernheim, N.J. (1972). A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutation Research 16(7), 77-87.
25. Aaron, C.S., Bolcsfoldi, G., Glatt, H.R., Moore, M., Nishi, Y., Stankowski, L., Theiss, J. & Thompson, E. (1994). Mammalian Cell Gene Mutation Assays Working Group Report. Report of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Research 312, 235-239.
26. Aaron, C.S. & Stankowski, Jr.L.F. (1989). Comparison of the AS52/XPRT and the CHO/HPRT assays: Evaluation of six drug candidates. Mutation Research 223, 121-128.
27. Liber, H.L. & Thilly, W.G. (1982). Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutation Research 94, 467-485.
28. Moore, M.M., De Marini, D.M., DeSerres, F.J. & Tindall, K.R., eds (1987). Banbury Report 28: Mammalian Cell Mutagenesis. New York, USA: Cold Spring Harbor Laboratory.
29. Moore, M.M., Harrington-Brock, K., Doerr, C.L. & Dearfield, K.L. (1989). Differential mutant quantitation at the mouse lymphoma TK and CHO HGPRT loci. Mutagenesis 4, 394-403.
30. Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M., Brusick, D., Ashby, J. & Myhr B.C. (1991). Genotoxicity Under Extreme Culture Conditions. A report from ICPEMC Task Group 9. Mutation Research 257, 147-204.
31. Williams, G.M. (1976). Carcinogen-induced DNA repair in primary rat liver cell cultures: a possible screen for chemical carcinogens. Cancer Letters 1, 231-236.
32. Casciano, D.A. (2000). Development and utilization of primary hepatocyte culture systems to evaluate metabolism, DNA binding, and DNA repair of xenobiotics. Drug Metabolism Reviews 32, 1-13.
33. Williams, G.M. (1977). Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. Cancer Research 37, 1845-1851.
34. Hagmar, L., Stromberg, U., Tinnerberg, H. & Mikoczy, Z. (2001). The usefulness of cytogenetic biomarkers as intermediate endpoints in carcinogenesis. International Journal of Hygiene and Environmental Health 204, 43-47.
35. Russo, A. (2000). In vivo cytogenetics: mammalian germ cells. Mutation Research 455, 167-89.
36. Evans, H.J., Nearly, G.J. & Williamson F.S. (1959). The relative biological efficiency of single doses of fast neutrons and gamma rays in Vicia faba roots and the effect of oxygen. Part II. Chromosome damage: the production of micronuclei. International Journal of Radiation Biology 1, 230-240.
37. Aardema, M.J. & Kirsch-Volders, M. (2001). The in vitro micronucleus assay. In Genetic Toxicology and Cancer Risk Assessment (ed. W.N. Choy). Basel, Switzerland: Marcel Dekker.
38. Garriott, M.L., Phelps, J.B. & Hoffman, W.P. (2002). A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity. Mutation Research 517, 123-134.
39. Kirsch-Volders, M., Sofuni, T., Aardema, M., Albertini, S., Eastmond, D., Fenech, M., Ishidate, M. Jr, Kirchner, S., Lorge, E., Morita, T., Norppa, H., Surralles, J., Vanhauwaert, A. & Wakata, A. (2003). Report from the in vitro micronucleus assay working group. Mutation Research 540, 153-163.
40. Meintieres, S., Biola, A., Pallardy, M. & Marzin, D. (2001). Apoptosis can be a confusing factor in in vitro clastogenic assays. Mutagenesis 16, 243-250.
41. Erratum in: Mutagenesis 16, 453.
42. Meintieres, S., Biola, A., Pallardy, M. & Marzin, D. (2003). Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and Molecular Mutagenesis 41, 14-27.
43. Phelps, J.B., Hoffman, W.P. & Garriott, M.L. (2003). Relative percent cell survival and positive response in the in vitro micronucleus test. Mutation Research 537, 115-116.
44. Phelps, J.B., Garriott, M.L. & Hoffman, W.P. (2002). A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity. Mutation Research 521, 103-112.
45. von der Hude, W., Kaiweit, S., Engelhardt, G., McKiernan, S., Kasper, P., Slacik-Erben, R., Miltenburger, H.G., Honarvar, N., Fahrig, R., Gorlitz, B., Albertini, S., Kirchner, S., Utesch, D., Potter-Locher, F., Stopper, H. & Madle, S. (2000). In vitro micronucleus assay with Chinese hamster V79 cells results of a collaborative study with in situ exposure to 26 chemical substances. Mutation Research 468, 137-163.
46. Singh, N.P., McCoy, M.T., Tice, R.R. & Schneider, E.L. (1988). A simple technique for quantification of low levels of damage in individual cells. Experimental Cell Research 175, 184-191.
47. Tice, R.R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J.C. & Sasaki, Y.F. (2000). The single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environmental and Molecular Mutagenesis 35, 206-221.
48. Hartmann, A., Agurell, E., Beevers, C., Brendler-Schwaab, S., Burlinson, B., Clay, P., Collins, A., Smith, A., Speit, G., Thybaud, V. & Tice, R.R. (2003). Recommendations for conducting the in vivo alkaline Comet assay. Mutagenesis 18, 45-51.
49. Ostiling, O. & Johanson, K.J. (1987). Microelectrophoretic study of radiation-induced DNA damage in individual cells. Biochemical and Biophysical Research Communications 123, 291-298.
50. Roberts, M.J., Wondrak, G.T., Laurean, D.C., Jacobson, M.K. & Jacobson, E.L. (2003). DNA damage by carbonyl stress in human skin cells. Mutation Research 522, 45-46.
51. Thein, N., Moller, P., Amtoft, H., Vogel, U., Korsholm, B., Autrup, H. & Wallin, H. (2000). A strong genotoxic effect in mouse skin of a single painting of coal tar in hairless mice and in Muta™ Mouse. Mutation Research 468, 117-124.
52. Woods, J.A., Traynor, N.J., Brancaleon, L. & Moseley, H. (2004). The effect of Photofrin on DNA strand breaks and base oxication in HaCaT keratinocytes: A Comet assay study. Photochemistry and Photobiology, 79, 105-113.
53. Yendle, J.E., Tinwell, H., Elliott, B.M. & Ashby, J. (1997). The genetic toxicity of time: importance of DNA-unwinding time to the outcome of single-cell gel electrophoresis assays. Mutation Research 375, 125-136.
54. Emri, G., Wenczl, E., Van Erp, P., Jans, J., Roza, L., Horkay, I. & Schothorst, A.A. (2000). Low doses of UVB or UVA induce chromosomal aberrations in cultured human skin cells. Journal of Investigative Dermatology 115, 435-440.
55. Heimann, R. & Rice, R.C. (1983). Polycyclic aromatic hydrocarbon toxicity and induction of metabolism in cultivated esophageal and epidermal keratinocytes. Cancer Research 43, 4856-4862.
56. Kukkelhoven, M.W.A.C. (1985). Covalent binding of benzo(a)pyrene metabolites to DNA of cultured human hair follicle keratinocytes. Archives of Toxicology 57, 6-12.
57. Kuroki, T., Nemoto, N. & Kitano, Y. (1980). Metabolism of benzo(a)pyrene in human epidermal keratinocytes in culture. Carcinogenesis 1, 559-565.
58. Kuroki, T., Hosomi, J., Chida, K., Hosoi, J. & Nemoto, N. (1987). Inter-individual variation of arylhydrocarbon-hydroxylase activity in cultured epidermal and dermal cells. Japanese Journal of Cancer Research 78, 45-53.
59. Lofti, C.F.P. & Machado-Santelli, G.M. (1996). Comparative analysis of colchicines induced micronuclei in different cell types in vitro. Mutation Research 349, 77-832.
60. Nishikawa, T., Haresaku, M., Adachi, K., Masuda, M. & Hayashi, M. (1999). Study of a rat skin in vivo micronucleus test: data generated by mitomycin C and methyl methanesulfonate. Mutation Research 444, 159-166.
61. Nishikawa, T. Haresaku, M., Fukushima, A., Nakamura, T., Adachi, K., Masuda, M. & Hayashi, M. (2002). Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five skin carcinogens. Mutation Research 513, 93-102.
62. Van Pelt, F.N., Meierink, Y.J., Blaauboer, B.J. & Weterings, P.J. (1990). Immunohistochemical detection of cytochrome P450 isoenzymes in cultured human epidermal cells. Journal of Histochemistry and Cytochemistry 38, 1847-1851.
63. Van Pelt, F.N., Haring, R.M., Overkamp, M.J. & Weterings, P.J. (1991). Micronucleus formation in cultured human keratinocytes following exposure to mitomycin C and cyclophosphamide. Mutation Research 252, 45-50.
64. Van Pelt, F.N., Haring, R.M. & Weterings, P.J. (1991). Micronucleus formation in cultured human keratinocytes: Involvement of intercellular bioactivation. Toxicology in Vitro 5, 515-518.
65. Aardema, M. & MacGregor, J.T. (2002). Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "omics" technologies. Mutation Research 499, 13-25.
66. Corton, J.C. & Stauber, A.J. (2000). Toward construction of a transcript profile database predictive of chemical toxicity. Toxicological Sciences 58, 217-219.
67. Farr, S. & Dunn, R.T. (1999). Concise review: gene expression applied to toxicology. Toxicological Sciences 50, 1-9.
68. Holmes, E.W., Nicholson, J.K. & Tranter, G. (2001). Metabonomic characterisation of genetic variation in toxicological and metabolic responses using probabilistic neural networks. Chemical Research in Toxicology 14, 182-191.
69. Nuwayysir, E.F., Bittner, M., Trent, J., Barrett, J.C. & Afshari, C.A. (1999). Microarray and toxicology: the advent of toxicogenomics. Molecular Carcinogenesis 24, 153-159.
70. Pennie, W.A. (2000). Use of cDNA microarray to probe and understand the toxicological consequences of altered gene expression. Toxicology Letters 112/113, 473-477.
71. Rockett, J.C. & Dix, D.J. (1999). Application of DNA arrays to toxicology. Environmetnal Health Perspectives 107, 681-685.
72. Criswell, K.A., Krishna, G., Zielinski, D., Urda, G.A., Juneau, P., Bulera, S. & Bleavins, M.R. (2003). Validation of a flow cytometric acridine orange micronuclei methodology in rats. Mutation Research 528, 1-18.
73. Dertinger, S.D., Chen, Y., Miller, R.K., Brewer, K.J., Smudzin, T., Torous, D.K., Hall, N.E., Olvany, K.A., Murante, F.G. & Tometsko, C.R. (2003). Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans. Mutation Research 542, 77-87.
74. Torous, D.K., Hall, N.E., Murante, F.G., Gleason, S.E., Tometsko, C.R. & Dertinger, S.D. (2003). Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. Toxicological Sciences 74, 309-314.