The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

Toxicology in Vitro

Volumn 25, Issue 3, 2011, Pages 733-744

  Natsch, Andreas ^a   Bauch, Caroline ^b   Foertsch, Leslie ^c   Gerberick, Frank ^c   Norman, Kimberly ^d   Hilberer, Allison ^d   Inglis, Heather ^d   Landsiedel, Robert ^b   Onken, Stefan ^e   Reuter, Hendrik ^e   Schepky, Andreas ^e   Emter, Roger ^a  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

^b BASF SE   (Germany)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d Institute for in Vitro Sciences Inc (IIVS)   (United States)

^e BEIERSDORF AG   (Germany)

Author keywords

Alternatives to animal tests; Inter laboratory reproducibility; Intralaboratory reproducibility; KeratinoSens; Reporter gene; Skin sensitization; Transferability

Indexed keywords

LUCIFERASE;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; PREDICTION; QUALITATIVE ANALYSIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REPORTER GENE; REPRODUCIBILITY; SKIN SENSITIZATION;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; CELL LINE; DERMATITIS, CONTACT; GENE EXPRESSION REGULATION; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNIZATION; KERATINOCYTES; LUCIFERASES; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SKIN TESTS; XENOBIOTICS;

ANIMALIA;

EID: 79952041429     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.12.014     Document Type: Article

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