A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches

Toxicology in Vitro

Volumn 24, Issue 1, 2010, Pages 1-9

  Scott, Laurie ^a   Eskes, Chantra ^b   Hoffmann, Sebastian ^b   Adriaens, Els ^c   Alepée, Nathalie ^d   Bufo, Monica ^e   Clothier, Richard ^f   Facchini, Davide ^g   Faller, Claudine ^h   Guest, Robert ⁱ   Harbell, John ^j   Hartung, Thomas ^b   Kamp, Hennicke ^k   Varlet, Béatrice Le ^l   Meloni, Marisa ^m   McNamee, Pauline ^a   Osborne, Rosemarie ^a   Pape, Wolfgang ⁿ   Pfannenbecker, Uwe ⁿ   Prinsen, Menk ^o   Seaman, Christopher ^p   Spielmann, Horst ^q   Stokes, William ^r   Trouba, Kevin ^a   Berghe, Christine Van den ^d   Goethem, Freddy Van ^s   Vassallo, Marco ^e   Vinardell, Pilar ^t   Zuang, Valérie ^b   more..

^a PROCTER AND GAMBLE COMPANY   (United States)

^b JOINT RESEARCH CENTRE   (Italy)

^c GHENT UNIVERSITY   (Belgium)

^d L ORÉAL RECHERCHE   (France)

^e Res Pharma Srl   (Italy)

^f UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^g INTEGRA   (Italy)

^h Wella Cosmital SA   (Switzerland)

ⁱ Harlan   (Switzerland)

^j MARY KAY INC   (United States)

^k BASF SE   (Germany)

^l Parfums Christian Dior   (France)

^m VitroScreen   (Italy)

ⁿ BEIERSDORF AG   (Germany)

^o TNO   (Netherlands)

^p GLAXOSMITHKLINE   (United Kingdom)

^q FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^r NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^s JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^t UNIVERSITY OF BARCELONA   (Spain)

more..

Author keywords

Alternatives; In vitro tests; Ocular irritation

Indexed keywords

ALCOHOL; ALKALI; AROMATIC AMINE; BLEACHING AGENT; CATIONIC SURFACTANT; EPOXIDE; ESTER; ETHER DERIVATIVE; HALIDE; KETONE; ORGANIC SOLVENT; PEROXIDE; POLYETHER; SURFACTANT;

ACCURACY; ANALYTIC METHOD; CELL FUNCTION; CHEMOSIS; CHORIOALLANTOIS; CONJUNCTIVA DISEASE; CORNEA OPACITY; CYTOTOXICITY; EUROPE; EYE IRRITATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INJURY SEVERITY; IRIS DISEASE; ISOLATED ORGAN; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; REVIEW; TISSUE GRAFT; TOXICITY TESTING; WORKSHOP;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CATTLE; CHICKENS; EPITHELIUM, CORNEAL; EUROPEAN UNION; EYE; EYE DISEASES; HUMANS; IRRITANTS; LEGISLATION, DRUG; RABBITS; REPRODUCIBILITY OF RESULTS; SWINE; TOXICOLOGY;

EID: 72249104697     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.05.019     Document Type: Review

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